<![CDATA[BOL: Related items]]> https://bioinformaticsonline.com/related/36890?offset=170 https://bioinformaticsonline.com/bookmarks/view/37785/haplomerger2-rebuilding-both-haploid-sub-assemblies-from-high-heterozygosity-diploid-genome-assembly Thu, 27 Sep 2018 07:08:47 -0500 https://bioinformaticsonline.com/bookmarks/view/37785/haplomerger2-rebuilding-both-haploid-sub-assemblies-from-high-heterozygosity-diploid-genome-assembly <![CDATA[HaploMerger2: rebuilding both haploid sub-assemblies from high-heterozygosity diploid genome assembly]]> HM2 can process any diploid assemblies, but it is especially suitable for diploid assemblies with high heterozygosity (≥3%), which can be difficult for other tools. This pipeline also implements flexible and sensitive assembly error detection, a hierarchical scaffolding procedure and a reliable gap-closing method for haploid sub-assemblies.

Source code, executables and the testing dataset are freely available at https://github.com/mapleforest/HaploMerger2/releases/.

Address of the bookmark: https://github.com/mapleforest/HaploMerger2/releases/

]]> BioStar https://bioinformaticsonline.com/bookmarks/view/38008/quast-lg-versatile-genome-assembly-evaluation Thu, 25 Oct 2018 10:46:55 -0500 https://bioinformaticsonline.com/bookmarks/view/38008/quast-lg-versatile-genome-assembly-evaluation <![CDATA[QUAST-LG: Versatile genome assembly evaluation]]> QUAST-LG-a tool that compares large genomic de novo assemblies against reference sequences and computes relevant quality metrics. Since genomes generally cannot be reconstructed completely due to complex repeat patterns and low coverage regions, we introduce a concept of upper bound assembly for a given genome and set of reads, and compute theoretical limits on assembly correctness and completeness. Using QUAST-LG, we show how close the assemblies are to the theoretical optimum, and how far this optimum is from the finished reference.

AVAILABILITY AND IMPLEMENTATION:

http://cab.spbu.ru/software/quast-lg

Address of the bookmark: http://cab.spbu.ru/software/quast-lg/

]]> Jit https://bioinformaticsonline.com/bookmarks/view/38176/asciigenome-genome-browser-based-on-command-line-interface-and-designed-for-running-from-console-terminals Fri, 09 Nov 2018 13:50:04 -0600 https://bioinformaticsonline.com/bookmarks/view/38176/asciigenome-genome-browser-based-on-command-line-interface-and-designed-for-running-from-console-terminals <![CDATA[ASCIIGenome: genome browser based on command line interface and designed for running from console terminals.]]> ASCIIGenome is a genome browser based on command line interface and designed for running from console terminals.

Since ASCIIGenome does not require a graphical interface it is particularly useful for quickly visualizing genomic data on remote servers while offering flexibility similar to popular GUI viewers like IGV.

Documentation is at readthedocs/asciigenome.

 

Address of the bookmark: https://github.com/dariober/ASCIIGenome

]]> Neel https://bioinformaticsonline.com/bookmarks/view/38443/genoplotr-plot-gene-and-genome-maps-project Wed, 12 Dec 2018 08:33:41 -0600 https://bioinformaticsonline.com/bookmarks/view/38443/genoplotr-plot-gene-and-genome-maps-project <![CDATA[genoPlotR - plot gene and genome maps project!]]> genoPlotR is a R package to produce reproducible, publication-grade graphics of gene and genome maps. It allows the user to read from usual format such as protein table files and blast results, as well as home-made tabular files.

Features

  • Linear representation of several segments of DNA
  • Comparisons represented by areas between the segments (like Artemis, for example)
  • Reads from common formats: Genbank, EMBL, blast, Mauve, and from user-generated tab files
  • Plot several subsegments of the same segment on the same line, separated by a //
  • Automatic or manual placement of the segments on the plot
  • Add annotations to all the lines
  • Create smart, automatic annotations for genomes, based on gene names
  • Add a user-generated tree
  • Add a global scale or a scale to each line
  • Use user-defined graphical functions to represent genes

Address of the bookmark: http://genoplotr.r-forge.r-project.org/

]]> Abhimanyu Singh https://bioinformaticsonline.com/bookmarks/view/38561/hawkeye-an-interactive-visual-analytics-tool-for-genome-assemblies Tue, 01 Jan 2019 11:56:17 -0600 https://bioinformaticsonline.com/bookmarks/view/38561/hawkeye-an-interactive-visual-analytics-tool-for-genome-assemblies <![CDATA[Hawkeye: an interactive visual analytics tool for genome assemblies]]> Genome sequencing remains an inexact science, and genome sequences can contain significant errors if they are not carefully examined. Hawkeye is our new visual analytics tool for genome assemblies, designed to aid in identifying and correcting assembly errors. Users can analyze all levels of an assembly along with summary statistics and assembly metrics, and are guided by a ranking component towards likely mis-assemblies. Hawkeye is freely available and released as part of the open source AMOS project http://amos.sourceforge.net/hawkeye.

https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-3-r34

Address of the bookmark: http://amos.sourceforge.net/wiki/index.php?title=Hawkeye

]]> Abhimanyu Singh https://bioinformaticsonline.com/bookmarks/view/38672/ltr-retriever-accurately-identifies-and-annotates-ltr-retrotransposons-and-use-lai-to-evaluates-the-continuity-of-genome-assemblies Sun, 13 Jan 2019 07:14:31 -0600 https://bioinformaticsonline.com/bookmarks/view/38672/ltr-retriever-accurately-identifies-and-annotates-ltr-retrotransposons-and-use-lai-to-evaluates-the-continuity-of-genome-assemblies <![CDATA[LTR_retriever: accurately identifies and annotates LTR retrotransposons and use LAI to evaluates the continuity of genome assemblies.]]> LTR_retriever is a command line program (in Perl) for accurate identification of LTR retrotransposons (LTR-RTs) from outputs of LTRharvest, LTR_FINDER, and/or MGEScan-LTR and generating non-redundant LTR-RT library for genome annotations.

By default, the program will generate whole-genome LTR-RT annotation and the LTR Assembly Index (LAI) for evaluations of the assembly continuity of the input genome. Users can also run LAI separately (see Usage).

Address of the bookmark: https://github.com/oushujun/LTR_retriever

]]> Neel https://bioinformaticsonline.com/bookmarks/view/39253/gmass-a-novel-measure-for-genomeassembly-structural-similarity Sun, 14 Apr 2019 20:35:40 -0500 https://bioinformaticsonline.com/bookmarks/view/39253/gmass-a-novel-measure-for-genomeassembly-structural-similarity <![CDATA[GMASS: a novel measure for genomeassembly structural similarity]]>

The GMASS score is a novel measure for representing structural similarity between two assemblies. It will contribute to the understanding of assembly output and developing de novo assemblers.

https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-2710-z

Address of the bookmark: http://bioinfo.konkuk.ac.kr/GMASS/htdocs/syncircos.php

]]> Abhimanyu Singh https://bioinformaticsonline.com/bookmarks/view/40140/alf-a-simulation-framework-for-genome-evolution Tue, 22 Oct 2019 22:05:58 -0500 https://bioinformaticsonline.com/bookmarks/view/40140/alf-a-simulation-framework-for-genome-evolution <![CDATA[ALF--a simulation framework for genome evolution.]]> Artificial Life Framework (ALF) simulates a root genome into a number of related genomes. Result files include the resulting gene sequences, true tree and true MSAs. A description of ALF can be found in the following article:

Daniel A Dalquen, Maria Anisimova, Gaston H Gonnet, Christophe Dessimoz: ALF - A Simulation Framework for Genome Evolution. Mol Biol Evol, 29(4):1115-1123, April 2012.
http://mbe.oxfordjournals.org/content/29/4/1115

Address of the bookmark: http://alfsim.org/#index

]]> Jit https://bioinformaticsonline.com/bookmarks/view/40598/mitoz-a-toolkit-for-animal-mitochondrial-genome-assembly-annotation-and-visualization Fri, 24 Jan 2020 04:09:15 -0600 https://bioinformaticsonline.com/bookmarks/view/40598/mitoz-a-toolkit-for-animal-mitochondrial-genome-assembly-annotation-and-visualization <![CDATA[MitoZ: a toolkit for animal mitochondrial genome assembly, annotation and visualization]]> MitoZ is a Python3-based toolkit which aims to automatically filter pair-end raw data (fastq files), assemble genome, search for mitogenome sequences from the genome assembly result, annotate mitogenome (genbank file as result), and mitogenome visualization. MitoZ is available from https://github.com/linzhi2013/MitoZ.

https://academic.oup.com/nar/article/47/11/e63/5377471

Address of the bookmark: https://github.com/linzhi2013/MitoZ

]]> Jit https://bioinformaticsonline.com/researchlabs/view/40881/liu-lab Tue, 04 Feb 2020 06:27:02 -0600 <![CDATA[Liu Lab]]> Shirley is a computational biologist with expertise in cancer epigenetics. Her research focuses on algorithm development and integrative mining from big data generated on microarrays, massively parallel sequencing, and other high throughput techniques to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance.

https://liulab-dfci.github.io/software/

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