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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/37584?offset=40</link>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/27695/the-kingsley-lab</guid>
  <pubDate>Fri, 03 Jun 2016 09:55:10 -0500</pubDate>
  <link></link>
  <title><![CDATA[The Kingsley Lab]]></title>
  <description><![CDATA[
<p>The Molecular Basis of Vertebrate Evolution. Naturally occurring species show spectacular differences in morphology, physiology, behavior, disease susceptibility, and life span. Although the genomes of many organisms have now been completely sequenced, Kingsley lab still know relatively little about the specific DNA sequence changes that underlie interesting species-specific traits. Kingsley lab laboratory is using a combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control evolutionary change in vertebrates.</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/40945/the-clark-lab</guid>
  <pubDate>Fri, 07 Feb 2020 13:57:24 -0600</pubDate>
  <link></link>
  <title><![CDATA[The Clark Lab]]></title>
  <description><![CDATA[
<p>Study the process of Adaptive Evolution, during which species adopt novel traits to overcome challenges. We retrace the evolutionary histories of genomic elements to determine the changes underlying adaptation and to discover previously unknown genetic networks. These discoveries have already led to advances in human health, species conservation, and molecular biology. </p>

<p>More at http://clark.genetics.utah.edu/</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/43329/postdoc-position-at-kiel-university-germany</guid>
  <pubDate>Sat, 28 Aug 2021 01:16:55 -0500</pubDate>
  <link></link>
  <title><![CDATA[Postdoc position at Kiel University, Germany]]></title>
  <description><![CDATA[
<p>In the Genomic Microbiology Group of Prof. Tal Dagan at the Institute<br />of Microbiology at Kiel University, Germany, a</p>

<p>Postdoc position (m/w/d)</p>

<p>in the field of computational evolutionary microbiology is available<br />for an initially limited period of 36 months at the earliest possible<br />date. The weekly working time corresponds to 100% of full employment<br />(If the legal requirements under collective bargaining law are met, the<br />tariff grouping is carried out up to pay scale 13 TV-L. The obligation<br />to teach amounts to 4 hours.</p>

<p>The Genomic Microbiology Group research interests are focused on<br />microbial genome evolution with an emphasis on the study of lateral gene<br />transfer. In our research we use both computational and experimental<br />approaches (see www.uni-kiel.de/genomik). The position offers the<br />opportunity to develop an independent research profile within the group<br />research focus. The successful applicant is expected to be involved<br />in teaching of bioinformatics and molecular evolution, including the<br />development of teaching materials (lectures/exercises/short videos).</p>

<p>Your profile:<br />· Doctoral or PhD degree in Molecular Evolution, Bioinformatics or<br />related fields.<br />· Knowledge and experience in programming (e.g., Python) and<br />biostatistical analysis (e.g., with R or MatLab).<br />· Any of the following expertise is an advantage: the analysis of<br />genomic or transcriptomic data, phylogenetic reconstruction,<br />comparative genomics.<br />· Good oral and written communication skills in English.<br />· Ability to teach in German is an advantage (alternatively, an<br />indication to do so from the 2nd year on).<br />· Skills and motivation to communicate and interact with other<br />scientists.<br /> <br />The Christian-Albrechts-University sees itself as a modern and<br />cosmopolitan employer. We welcome your application regardless of your age,<br />gender, cultural and social background, religion, ideology, disability<br />or sexual identity. We promote equality of the sexes.</p>

<p>The Christian-Albrechts-University is committed to the employment of<br />people with disabilities. Preference will be given to applications from<br />severely handicapped persons and persons of equal standing, provided<br />they are suitable.</p>

<p>We expressly welcome applications from people with a migration background.</p>

<p>For enquiries regarding the position, teaching obligations and research<br />topic please contact Prof. Tal Dagan: tdagan@ifam.uni-kiel.de.</p>

<p>Applications should be submitted by email to Mrs. Haacks<br />(dhaacks@ifam.uni-kiel.de) as a single PDF and include: (1) a letter of<br />motivation (max 1 page, Arial 11, line spacing 1.15), (2) CV, (3) PhD<br />certificate. Please use 'GMG postdoc application - [your name]'<br />as a subject.</p>

<p>Please, refrain from sending us application photos.</p>

<p>Application deadline:  August 31 2021 or until the position is<br />filled. Interviews will take place during September/October 2021. The<br />planned starting date for the position is flexible (but in 2021).</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/43823/the-helsinki-summer-school-on-mathematical-ecology-and-evolution</guid>
  <pubDate>Thu, 10 Mar 2022 01:06:28 -0600</pubDate>
  <link></link>
  <title><![CDATA[The Helsinki Summer School on Mathematical Ecology and Evolution]]></title>
  <description><![CDATA[
<p>https://wiki.helsinki.fi/display/BioMath/The+Helsinki+Summer+School+on+Mathematical+Ecology+and+Evolution+2022</p>

<p>This is the seventh school of a biennial series of international summer schools on mathematical ecology and evolution in Finland, organised by the Biomathematics Group of the University of Helsinki. The series of The Helsinki Summer School on Mathematical Ecology and Evolution is part of the EMS-ESMTB Schools in Applied Mathematics.</p>

<p>After the two-year break forced upon by the pandemic, we are looking forward to continue this series in August 2022, if only the covid situation permits.</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44727/postdoctoral-scholar-in-bacterial-evolution-at-pathogen-and-microbiome-institute-at-northern-arizona-university</guid>
  <pubDate>Fri, 13 Dec 2024 12:49:16 -0600</pubDate>
  <link></link>
  <title><![CDATA[Postdoctoral Scholar in Bacterial Evolution at Pathogen and Microbiome Institute at Northern Arizona University]]></title>
  <description><![CDATA[
<p>We are pleased to announce a Postdoctoral Scholar position to study<br />bacterial evolution at the Pathogen and Microbiome Institute at<br />Northern Arizona University with Professor Paul Keim. The scholar<br />will have the opportunity also work with Professor Sam Sheppard at<br />The University of Oxford on joint projects. See our recent paper<br />on interspecific gene flow in Campylobacter. (DOI:<br />https://doi.org/10.1128/mbio.00581-24)</p>

<p>The job description: "This research position focuses on the science<br />of bacterial evolution. It will consist of researching theoretical<br />principles, but could include translational applications. Phylogenomic<br />and bioinformatic analysis of bacterial populations in nature or<br />in laboratory experiments will be a key component of the work. Prior<br />experience is an asset though training will be possible at PMI.<br />Likewise, laboratory microbiological, molecular, and biochemical<br />skills are an asset though not essential. Communication and critical<br />thinking skills are essential for performing the work and for<br />communicating to the local and international scientific communities.<br />Participating in team or independent grant writing to obtain research<br />funding will be required. Student mentoring is a part of the NAU<br />mission and is a partial expectation."</p>

<p>https://hr.peoplesoft.nau.edu/psp/ph92prta/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&amp;Action=U&amp;FOCUS=Applicant&amp;SiteId=1&amp;JobOpeningId=608024&amp;PostingSeq=1</p>

<p>Northern Arizona University is located in Flagstaff, Arizona, a<br />beautiful mountain town with a surprisingly vibrant restaurant<br />scene. Located a little over an hour from the Grand Canyon and ~45<br />min from Sedona, Flagstaff is a hiker's paradise. In fact, the city<br />of Flagstaff operates more than 50 miles of unpaved trails and there<br />are, on average, 266 sunny days per year with which to enjoy them.<br />At 7000 ft in elevation, Flagstaff experiences all four seasons,<br />but thesummers are mild and, in the winter, you can be on the ski<br />slopes within 30 min! https://www.flagstaffarizona.org/</p>

<p>As mentioned, joint projects with Professor Sheppard at Oxford<br />University are possible, including travel to his laboratory in the<br />United Kingdom. https://www.biology.ox.ac.uk/people/samuel-sheppard</p>

<p>Contact Information:<br />Paul.Keim@nau.edu</p>

<p>Paul S. Keim, Ph.D.<br />Regents Professor, &amp;<br />Cowden Endowed Chair of Microbiology<br />Northern Arizona University<br />Flagstaff, AZ 86011-4073</p>

<p>Paul S Keim</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/45115/postdoctoral-fellow-in-genomics-and-comparative-genomics</guid>
  <pubDate>Thu, 09 Apr 2026 02:12:32 -0500</pubDate>
  <link></link>
  <title><![CDATA[Postdoctoral Fellow in Genomics and Comparative Genomics]]></title>
  <description><![CDATA[
<p>Environnement de travail (Work environment):<br />The successful candidate will join a dynamic research group working<br />on the ecology and evolution of host'parasite'environment<br />interactions in non-model organisms, particularly snail vectors and<br />its trematode parasites. She/He will conduct genomic analyses aimed at<br />understanding host'parasite coevolution and the genetic architecture<br />of resistance in the invasive snail Pseudosuccinea columella to the<br />zoonotic parasite Fasciola hepatica. This thematic line is embedded<br />within the regional scientific project InvaSnail financed by the<br />ExposUM initiative from the Montpellier. The position is based in<br />Montpellier, a vibrant scientific hub in Southern France internationally<br />recognized for excellence in ecology and evolutionary biology. The IHPE<br />laboratory provides a collaborative research environment with access<br />to high-performance computing facilities, sequencing platforms, and<br />strong interdisciplinary interactions across research institutions in<br />the Montpellier area. University</p>

<p>Main mission:</p>

<p>Develop and implement strategies for whole-genome sequencing of non-model<br />species<br />Generate high-quality de novo genome assemblies using short- and long-read<br />sequencing technologies<br />Perform genome annotation and structural/functional characterization<br />Conduct comparative genomic analyses across related species or populations<br />Design and implement genome-wide association studies (GWAS) to identify<br />loci associated with phenotypic or adaptive traits<br />Integrate genomic, phenotypic, and environmental datasets<br />Contribute to the development of reproducible bioinformatics pipelines</p>

<p>ActivitÃ©s (Activities):</p>

<p>Lead the genomic component of the research project<br />High-molecular-weight DNA extraction optimization<br />Long-read genome assembly (PacBio HiFi / ONT)<br />Genome polishing and quality assessment (BUSCO, QUAST)<br />Structural and functional annotation<br />Variant discovery (SNPs, indels, SVs)<br />Population genomic analyses (FST, demographic inference)<br />Mixed-model GWAS accounting for structure<br />Workflow development (Snakemake/Nextflow)<br />HPC-based pipeline implementation<br />Publish results in peer-reviewed journals<br />Present findings at international conferences<br />Collaborate with experimental and computational team members<br />Contribute to project development<br />Mentor graduate students when appropriate</p>

<p>More at https://evol.mcmaster.ca/brian/evoldir/PostDocs//MontpellierU.ComparativeGenomics</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/37794/mimicree2-genome-wide-forward-simulations-of-evolve-and-resequencing-studies</guid>
	<pubDate>Fri, 28 Sep 2018 09:21:14 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/37794/mimicree2-genome-wide-forward-simulations-of-evolve-and-resequencing-studies</link>
	<title><![CDATA[MimicrEE2: Genome-wide forward simulations of Evolve and Resequencing studies]]></title>
	<description><![CDATA[<p><span>MimicrEE2, a multi-threaded Java program for genome-wide forward simulations of evolving populations. MimicrEE2 enables the convenient usage of available genomic resources, supports biological particulars of model organism frequently used in E&amp;R studies and offers a wide range of different adaptive models (selective sweeps, polygenic adaptation, epistasis). MimicrEE2 runs on any computer with Java installed. It is distributed under the GPLv3 license at&nbsp;</span><a href="https://sourceforge.net/projects/mimicree2/">https://sourceforge.net/projects/mimicree2/</a><span>.</span></p><p>Address of the bookmark: <a href="https://sourceforge.net/projects/mimicree2/" rel="nofollow">https://sourceforge.net/projects/mimicree2/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40140/alf-a-simulation-framework-for-genome-evolution</guid>
	<pubDate>Tue, 22 Oct 2019 22:05:58 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40140/alf-a-simulation-framework-for-genome-evolution</link>
	<title><![CDATA[ALF--a simulation framework for genome evolution.]]></title>
	<description><![CDATA[<p style="color: #000000; font-size: small; font-style: normal; font-weight: 400; text-align: -webkit-left;"><span style="color: #4d4d4d; font-size: small; font-style: normal; font-weight: 400; text-align: left; background-color: #ffffff; float: none;">Artificial Life Framework (ALF)</span> simulates a root genome into a number of related genomes. Result files include the resulting gene sequences, true tree and true MSAs. A description of ALF can be found in the following article:</p>
<p style="color: #000000; font-size: small; font-style: normal; font-weight: 400; text-align: -webkit-left;">Daniel A Dalquen, Maria Anisimova, Gaston H Gonnet, Christophe Dessimoz: ALF - A Simulation Framework for Genome Evolution.<span>&nbsp;</span><em>Mol Biol Evol</em>, 29(4):1115-1123, April 2012.<br><a href="http://mbe.oxfordjournals.org/content/29/4/1115" target="_blank">http://mbe.oxfordjournals.org/content/29/4/1115</a></p><p>Address of the bookmark: <a href="http://alfsim.org/#index" rel="nofollow">http://alfsim.org/#index</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42907/lecturer-in-evolutionary-biology-bioinformatics-at-department-of-zoology-te-tari-matai-kararehe-division-of-sciences-te-rohe-a-ahikaroa</guid>
  <pubDate>Tue, 23 Feb 2021 02:05:15 -0600</pubDate>
  <link></link>
  <title><![CDATA[Lecturer in Evolutionary Biology (Bioinformatics) at DEPARTMENT of ZOOLOGY | TE TARI MĀTAI KARAREHE DIVISION of SCIENCES | TE ROHE A AHIKAROA]]></title>
  <description><![CDATA[
<p>DEPARTMENT of ZOOLOGY | TE TARI MĀTAI KARAREHE<br />DIVISION of SCIENCES | TE ROHE A AHIKAROA</p>

<p>Applications are invited for the position of Lecturer in Evolutionary Biology (Bioinformatics).</p>

<p>We are seeking a person with a relevant doctorate, and demonstrated potential to develop as an outstanding researcher and teacher in evolutionary bioinformatics in the Department of Zoology. The position affords an exciting opportunity for an emerging scholar to research and teach in a vibrant and diverse Department. The successful candidate will develop a transformative and collaborative research program, supporting the university's commitment to excellence in research.</p>

<p>Your skills and experience</p>

<p>A PhD with a background in analysis of high-throughput sequencing data and evolutionary biology.<br />Knowledge of and familiarity with a range of bioinformatics skills, concepts, and practices as they relate to the biology of animals, including genomic, transcriptomic and metabarcoding data analyses.<br />A strong interest, and experience, in research and teaching of bioinformatics and evolutionary genomics.<br />An ability to contribute to teaching and learning environments that support engagement of students and staff with bioinformatics and genomics.<br />Be committed to and or have established connections or track record of working with national and local bioinformaticians. <br />Be committed to being a productive collaborator with a track record of working collegially.<br />Further details</p>

<p>This is a confirmation-path (tenure track) position at the level of Lecturer. The successful candidate is expected to take up duties by 1 July 2021.</p>

<p>To see a full job description and to apply online go to: https://otago.taleo.net/careersection/2/jobdetail.ftl?job=2100342</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44219/chromosome-breakpoint-a-breakup-to-remember</guid>
	<pubDate>Tue, 07 Mar 2023 13:31:54 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44219/chromosome-breakpoint-a-breakup-to-remember</link>
	<title><![CDATA[Chromosome breakpoint - a breakup to remember]]></title>
	<description><![CDATA[<div><div><div><div><div><div><div><div><div><div><p>Chromosome breakpoint refers to the physical location where a chromosome is broken and rearranged. Chromosome breakage can occur spontaneously or be induced by environmental factors such as radiation, chemicals, or viruses. The rearrangement of genetic material resulting from a chromosome breakpoint can have important consequences, including the development of genetic diseases, chromosomal abnormalities, or cancer.</p><p>Chromosome breakpoints can occur in two ways: interstitial or terminal. Interstitial breakpoints occur within the chromosome, while terminal breakpoints occur at the end of the chromosome. Terminal breakpoints can lead to the loss of genetic material, whereas interstitial breakpoints can result in the duplication or deletion of genetic material.</p><p>Chromosome breakpoints can be detected using a variety of techniques, including cytogenetic analysis, fluorescence in situ hybridization (FISH), and molecular methods such as polymerase chain reaction (PCR) and next-generation sequencing (NGS). These techniques can also help identify the exact location of the breakpoint and the nature of the rearrangement, such as translocations, inversions, deletions, or duplications.</p><p>Translocations are one of the most common types of chromosome rearrangements caused by breakpoints. In a translocation, genetic material is exchanged between two different chromosomes, resulting in a balanced or unbalanced distribution of genetic material. Unbalanced translocations can cause genetic diseases or developmental abnormalities, while balanced translocations can be inherited without any apparent phenotypic effects.</p><p>Inversions occur when a chromosome segment is inverted, resulting in a change in the order of genetic material. Inversions can be pericentric, involving the centromere, or paracentric, not involving the centromere. Inversions can cause genetic diseases or phenotypic effects if they disrupt the function of essential genes or regulatory elements.</p><p>Deletions and duplications are caused by interstitial breakpoints that result in the loss or gain of genetic material. Deletions can cause genetic diseases or developmental abnormalities if they involve essential genes or regulatory elements. Duplications can also have phenotypic effects, depending on the location and size of the duplicated segment.</p><p>Chromosome breakpoints can also be involved in the formation of complex chromosomal rearrangements, such as ring chromosomes or dicentric chromosomes. These complex rearrangements can have important clinical implications, as they can cause genetic diseases or cancer.</p><p>In conclusion, chromosome breakpoints are important genetic events that can lead to the rearrangement of genetic material and have important clinical implications. The detection and characterization of chromosome breakpoints using cytogenetic, molecular, and genomic methods are essential for the diagnosis, prognosis, and treatment of genetic diseases and cancer. Further research is needed to understand the molecular mechanisms underlying chromosome breakage and to develop new therapies targeting these events.</p></div></div></div></div></div></div></div></div></div></div>]]></description>
	<dc:creator>BioStar</dc:creator>
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