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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/37830?offset=340</link>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40583/trelliscope-flexibly-visualize-large-complex-data-in-great-detail-from-within-the-r-statistical-programming-environment</guid>
	<pubDate>Tue, 21 Jan 2020 04:22:49 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40583/trelliscope-flexibly-visualize-large-complex-data-in-great-detail-from-within-the-r-statistical-programming-environment</link>
	<title><![CDATA[Trelliscope: flexibly visualize large, complex data in great detail from within the R statistical programming environment.]]></title>
	<description><![CDATA[<p>Trelliscope provides a way to flexibly visualize large, complex data in great detail from within the R statistical programming environment. Trelliscope is a component in the<span>&nbsp;</span><a href="http://deltarho.org/docs-trelliscope/deltarho.org">DeltaRho</a><span>&nbsp;</span>environment.</p>
<p>For those familiar with<span>&nbsp;</span><a href="http://cm.bell-labs.com/cm/ms/departments/sia/project/trellis/">Trellis Display</a>,<span>&nbsp;</span><a href="http://docs.ggplot2.org/0.9.3.1/facet_wrap.html">faceting in ggplot</a>, or the notion of<span>&nbsp;</span><a href="http://en.wikipedia.org/wiki/Small_multiple">small multiples</a>, Trelliscope provides a scalable way to break a set of data into pieces, apply a plot method to each piece, and then arrange those plots in a grid and interactively sort, filter, and query panels of the display based on metrics of interest. With Trelliscope, we are able to create multipanel displays on data with a very large number of subsets and view them in an interactive and meaningful way.</p><p>Address of the bookmark: <a href="http://deltarho.org/docs-trelliscope/#introduction" rel="nofollow">http://deltarho.org/docs-trelliscope/#introduction</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44257/calculate-the-significance-of-the-difference-between-two-trends</guid>
	<pubDate>Tue, 14 Mar 2023 05:41:53 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44257/calculate-the-significance-of-the-difference-between-two-trends</link>
	<title><![CDATA[Calculate the significance of the difference between two trends]]></title>
	<description><![CDATA[<div><div><div><div><div><div><div><div><div><div><p>To calculate the significance of the difference between two trends, you can use a statistical test such as a t-test or ANOVA (analysis of variance). Here are the general steps to follow:</p><ol>
<li>
<p>Define your null hypothesis (H0) and alternative hypothesis (H1). For example, H0 might be that there is no significant difference between the two trends, while H1 might be that there is a significant difference.</p>
</li>
<li>
<p>Collect data on the two trends. Make sure that the data is independent, normally distributed, and has equal variances.</p>
</li>
<li>
<p>Calculate the means and standard deviations of each trend.</p>
</li>
<li>
<p>Calculate the test statistic using a t-test or ANOVA. The test statistic will depend on the specific test you choose, but it will generally compare the difference in means between the two trends to the variability within each trend.</p>
</li>
<li>
<p>Determine the p-value associated with the test statistic. The p-value represents the probability of obtaining a test statistic as extreme as the one you calculated, assuming that the null hypothesis is true.</p>
</li>
<li>
<p>Compare the p-value to your chosen significance level (usually 0.05 or 0.01). If the p-value is less than or equal to the significance level, reject the null hypothesis and conclude that there is a significant difference between the two trends. If the p-value is greater than the significance level, fail to reject the null hypothesis and conclude that there is not enough evidence to support a significant difference.</p>
</li>
</ol><p>It's important to note that the specific details of each step will depend on the type of test you choose and the software you use to perform the analysis.</p><p>The most common methods for comparing means include:</p><table>
<thead>
<tr><th>Methods</th><th>R function</th><th>Description</th></tr>
</thead>
<tbody>
<tr>
<td>T-test</td>
<td>t.test()</td>
<td>Compare two groups (parametric)</td>
</tr>
<tr>
<td>Wilcoxon test</td>
<td>wilcox.test()</td>
<td>Compare two groups (non-parametric)</td>
</tr>
<tr>
<td>ANOVA</td>
<td>aov() or anova()</td>
<td>Compare multiple groups (parametric)</td>
</tr>
<tr>
<td>Kruskal-Wallis</td>
<td>kruskal.test()</td>
<td>Compare multiple groups (non-parametric)<br /><br /></td>
</tr>
</tbody>
</table></div></div></div></div></div></div></div></div></div></div>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</guid>
	<pubDate>Wed, 13 Aug 2025 19:56:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</link>
	<title><![CDATA[dna2bit: an ultra-fast and accurate genomic distance estimation software]]></title>
	<description><![CDATA[<p dir="auto">dna2bit: an ultra-fast and accurate genomic distance estimation software</p>
<div dir="auto"><a href="https://github.com/lijuzeng/dna2bit#compilation"></a></div>
<p dir="auto">dna2bit is a software tool developed in C++11, leveraging the capabilities of OpenMP for parallel computing and the popcount technique for efficient bit manipulation.&nbsp;</p><p>Address of the bookmark: <a href="https://github.com/lijuzeng/dna2bit" rel="nofollow">https://github.com/lijuzeng/dna2bit</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/35119/frontend-perl-web-framework-documentation-andrej-sali-lab</guid>
	<pubDate>Mon, 08 Jan 2018 22:32:03 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/35119/frontend-perl-web-framework-documentation-andrej-sali-lab</link>
	<title><![CDATA[Frontend: Perl Web framework documentation - Andrej Sali Lab]]></title>
	<description><![CDATA[<p><span>The frontend is a set of Perl classes that displays the web interface, allowing a user to upload their input files, start a job, display a list of all jobs in the system, and get back job results. The main&nbsp;</span><a href="https://saliweb.readthedocs.io/en/latest/modules/frontend.html#saliwebfrontend" title="saliwebfrontend"><code><span>saliwebfrontend</span></code></a><span>&nbsp;class must be subclassed for each web service. This class is then used to display the web pages using a set of CGI scripts that are set up automatically by the build system.</span></p><p>Address of the bookmark: <a href="https://saliweb.readthedocs.io/en/latest/frontend.html" rel="nofollow">https://saliweb.readthedocs.io/en/latest/frontend.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38489/biotite-a-general-framework-for-computational-biology</guid>
	<pubDate>Mon, 17 Dec 2018 18:52:27 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38489/biotite-a-general-framework-for-computational-biology</link>
	<title><![CDATA[Biotite: A general framework for computational biology]]></title>
	<description><![CDATA[<p><span>The package is open source and freely available at GitHub (</span><span><a href="https://github.com/biotite-dev/biotite" target="_blank">https://github.com/biotite-dev/biotite</a></span><span>). This package is simple to use especially for the beginners in programming and computationally efficient because of the implementation of Numpy and Cython.&nbsp;Biotite consists of four sub packages: sequence, structure, databases, and application. The&nbsp;</span><em>sequence</em><span>&nbsp;and&nbsp;</span><em>structure</em><span>&nbsp;modules serve for the analysis of sequence and structural data analysis respectively,&nbsp;</span><em>database</em><span>&nbsp;downloads files from the other databases such as RCSB PDB, and&nbsp;</span><em>application</em><span>&nbsp;provides interface for external software.&nbsp;</span></p>
<p><span><span>The&nbsp;</span><em>Biotite</em><span>&nbsp;package bundles popular tasks in computational biology into an unifying framework, which is easy to use on the one hand side, but is also computationally efficient due to intensive usage of&nbsp;</span><em>NumPy</em><span>&nbsp;and&nbsp;</span><em>Cython</em><span>. This package focuses on working with sequence and structure data and supports various file formats and analysis and manipulation functions.</span></span></p><p>Address of the bookmark: <a href="https://github.com/biotite-dev/biotite" rel="nofollow">https://github.com/biotite-dev/biotite</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42201/rosettaantibodydesign-rabd-a-general-framework-for-computational-antibody-design</guid>
	<pubDate>Sun, 20 Sep 2020 06:03:42 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42201/rosettaantibodydesign-rabd-a-general-framework-for-computational-antibody-design</link>
	<title><![CDATA[RosettaAntibodyDesign (RAbD): A general framework for computational antibody design]]></title>
	<description><![CDATA[<p><strong>RosettaAntibodyDesign (RAbD)</strong>&nbsp;is a generalized framework for the design of antibodies, in which a user can easily tailor the run to their project needs.&nbsp;<strong>The algorithm is meant to sample the diverse sequence, structure, and binding space of an antibody-antigen complex.</strong>&nbsp;It can be used for a multitude of project types, from denovo design to redesigns that improve binding affinity, optimize stability, or manipulate function.</p>
<p>The framework is based on rigorous bioinformatic analysis and rooted very much on our&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/21035459">recent clustering</a>&nbsp;of antibody CDR regions. It uses the&nbsp;<strong>North/Dunbrack CDR definition</strong>&nbsp;as outlined in the North/Dunbrack clustering paper.</p>
<p>More at</p>
<p>https://www.rosettacommons.org/docs/latest/application_documentation/antibody/RosettaAntibodyDesign</p>
<p>https://bio-jade.readthedocs.io/en/latest/installation.html</p><p>Address of the bookmark: <a href="https://www.rosettacommons.org/docs/latest/application_documentation/antibody/RosettaAntibodyDesign" rel="nofollow">https://www.rosettacommons.org/docs/latest/application_documentation/antibody/RosettaAntibodyDesign</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/843/structural-polymorphism-analysis-from-ngs-data</guid>
  <pubDate>Sat, 13 Jul 2013 17:12:47 -0500</pubDate>
  <link></link>
  <title><![CDATA[Structural polymorphism analysis from NGS data]]></title>
  <description><![CDATA[
<p>The LabEx BASC (Biodiversity, Agroecosystems, Society, Climate), a network of 13 laboratories of the Paris-Saclay Scientific Cluster, is seeking a bioinformatician to analyze Next Generation Sequencing (NGS) data analysis. In the context of a flagship project aiming at understanding and improving the adaptive capacity of agroecosystems it will be critical to establish a link between sequence variation, functional variation, gene/protein expression and phenotypic adaptation.</p>

<p>The successful candidate will be in charge of the detection of polymorphisms including structural variants, of the comparison of multiple and diverse genomes of a same species and of the construction of pan- and core-genomes. These challenging tasks will require bioinformatics developments and implementation of methods for accommodating the high level of repetitiveness of complex genomes. The tools will be integrated into pipelines and made available to end-users through the Galaxy platform. The bioinformatician will therefore also have to provide researchers with advices on their experimental designs in order to ensure compliance of produced datasets with pipelines requirements. He/she will be hosted by a bioinformatics/informatics team (7 people) (http://moulon.inra.fr/index.php/fr/equipestransversales/atelier-de-bioinformatique) which has computational facilities and expertise in NGS data analysis, and will benefit as well from national and international collaborative networks (Aplibio http://www.renabi.fr/platforms/aplibio/, Transplant http://transplantdb.eu, AMAIZING http://www.amaizing.fr/).</p>

<p>The position requires a doctoral degree (PhD) in bioinformatics with strong expertise in script writing (Python/Perl) and pipeline development. </p>

<p>Applicants should send a CV and the names of 2 referees willing to provide a letter of recommendation to joets@moulon.inra.fr.</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/2054/postdoc-positions-mammalian-transcriptome-evolution-at-sib</guid>
  <pubDate>Mon, 12 Aug 2013 19:58:33 -0500</pubDate>
  <link></link>
  <title><![CDATA[Postdoc Positions - Mammalian Transcriptome Evolution at SIB]]></title>
  <description><![CDATA[
<p>BIOINFORMATICS POSTDOC IN FUNCTIONAL EVOLUTIONARY GENOMICS</p>

<p>Center for Integrative Genomics, University of Lausanne, Switzerland</p>

<p>Two postdoctoral positions (2 years with possible extensions up to 5 years) are available immediately in the evolutionary genomics group of Henrik Kaessmann.</p>

<p>We are seeking highly qualified and enthusiastic applicants with strong skills in computational biology/bioinformatics, preferably also with experience in data mining and comparative or evolutionary genome analysis.</p>

<p>We have been interested in a range of topics related to the functional evolution of genomes from primates (e.g., the emergence of new genes and their functions) and other mammals (e.g., the origin and evolution of mammalian sex chromosomes). In the framework of a recently launched series of projects, a large amount of transcriptome and genome (e.g., epigenome) data are being produced by the wet lab unit of the group using next generation sequencing technologies for a unique collection of tissues from representative mammals and outgroup species (e.g., birds). Topics of current projects based on these data include the origins and/or evolution of protein-coding genes, alternative splicing, microRNAs, long noncoding RNAs, and dosage compensation.</p>

<p>The postdoctoral fellow will perform integrated evolutionary/bioinformatics analyses based on data produced in the lab and available genomic data. The specific project will be developed together with the candidate.</p>

<p>The language of the institute is English, and its members form an international group that is rapidly expanding. The institute is located in Lausanne, a beautiful city at Lake Geneva.</p>

<p>For more information on the group and our institute more generally, please refer to our website: http://www.unil.ch/cig/page7858_en.html</p>

<p>Please submit a CV, statement of research interest, and names of three references to: Henrik Kaessmann (Henrik.Kaessmann@unil.ch).</p>

<p>Webpage : http://www.unil.ch/cig/page7858.html</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/6961/research-assistant-national-bureau-of-animal-genetic-resources</guid>
  <pubDate>Tue, 03 Dec 2013 06:17:34 -0600</pubDate>
  <link></link>
  <title><![CDATA[Research Assistant @ NATIONAL BUREAU OF ANIMAL GENETIC RESOURCES]]></title>
  <description><![CDATA[
<p>NATIONAL BUREAU OF ANIMAL GENETIC RESOURCES<br />Near Basant Vihar G.T. Road Bypass<br />P.O. Box No.129, Karnal-132001 (Haryana)</p>

<p>WALK-IN-INTERVIEW</p>

<p>A walk-in-Interview is proposed to be held at National Bureau of Animal Genetic Resources, Karnal (Haryana)-132001 at 11:30 AM on 18.12.2013 to select One RA and One SRF as per details given below:</p>

<p>1. One post of Research Associate under DBT sponsored Support under BIPP for the “SanGenix: A comprehensive Next Generation Sequence (NGS) data analysis solution” as Grants in AID. Thepost duration is Upto 31st March 2015 or earlier.</p>

<p>2. One post of Senior Research Fellow under NAIP (Component-4) Bioprospecting of genes and allele mining for abiotic stress tolerance. The post duration is Upto 31st March 2014 or earlier</p>

<p>Essential Qualifications: Ph.D. in Bioinformatics/ Computer Application or<br />First Class Masters degree in Bioinformatics/ Computer Application with two years experience as evidenced by Publications.</p>

<p>Desirable: Experience in the field of handling Next generation Sequencing Data.</p>

<p>Emolument: Rs. 22,000/- per month + HRA as per admissibility</p>

<p>Age Limit:</p>

<p>40 years for Men<br />45 years for women as on date of interview</p>

<p>Research Associate: ONE</p>

<p>Duration of engagement: Upto</p>

<p>31st March 2015 or earlier &amp; Coterminus with the project</p>

<p>Responsibilities: To help the PI for Beta testing and development of the SanGenix Tool for NGS data.</p>

<p>Essential Qualifications: First Class Masters’ degree in Bioinformatics/Biotechnology.</p>

<p>Desirable: Experience in the field of Biotechnology/ Bioinformatics</p>

<p>Emoluments:</p>

<p>Rs. 16,000/- per month + HRA as per admissibility.<br />Senior Research Fellow: ONE<br />Duration of engagement: Upto 31st March 2014 or earlier &amp; Coterminus with the project</p>

<p>Age Limit</p>

<p>35 years for men<br />40 years for women as on date of interview</p>

<p>Note: Relaxation in age will be admissible for SC/ST &amp; OBC candidates as per Govt. of India /ICAR norms</p>

<p>1. The applicants must bring with them original documents and brief of research work done during post graduation along with a set of photocopy and latest two passport size photographs.<br />2. A panel of selected candidates will also be made which may be utilized for filling of positions of shorter durations in future if demand arises.<br />3. Experience certificate in original, if any 4. The above positions are purely on temporary basis and are co-terminus with the project. No TA/DA will be paid to attend the interview.<br />5. Any other clarifications can be had on the date of interview.<br />6. The Director’s decision will be final and binding on all respects.</p>

<p>Advertisement: http://210.212.93.85/rasrfadvertise.pdf</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/10881/special-project-scientist-%E2%80%93-sorghum-genomics</guid>
  <pubDate>Tue, 20 May 2014 00:34:39 -0500</pubDate>
  <link></link>
  <title><![CDATA[Special Project Scientist – Sorghum Genomics]]></title>
  <description><![CDATA[
<p>ICRISAT is seeking applications from Indian Nationals for a Special Project Scientist to work on a sorghum genomics activities related to sequencing/re-sequencing projects utilizing New Generation Sequencing platforms.</p>

<p>The Job detail</p>

<p>    Advancing the SNP-discovery and polymorphism assessment work across several germplasm panels representing global genetic diversity<br />    Population genetic and genomic analyses, testing the hypothesis related to adaptation in multiple geographic regions<br />    Develop SNP assays from large scale GBS and other re-sequencing data for several target traits utilizing available phenotyping data<br />    Combined analyses of genotypic and phenotypic data for discovery of marker-trait associations, and conducting GWAS<br />    Processing, analyzing, and archiving large-scale genomic data sets, assessing data quality, conducting analyses, interpreting findings, and communicating findings to others including preparation of reports, presentations, posters and journal articles<br />    Providing support to MSc and PhD students on topic related to its major core of research<br />    Any other work assigned by the supervisor</p>

<p>The Person:</p>

<p>    PhD in bioinformatics, genetics, computational biology preferably with 1 to 2 years of experience;<br />    familiar with standard bioinformatics tools and scripting languages and emerging and evolving software platforms relevant to bioinformatics and computational biology;<br />    ability to create new analytical pipelines; experience with handling large data sets;<br />    ability to program in at least two of the following: C++, PERL, Python, R, Java.<br />    will use next-generation sequencing technologies to generate marker data for genetic mapping and transcriptome data for expression QTL mapping, and will be responsible for data generation as well as data analysis.</p>

<p>Period and Remuneration: The assignment is for a period of two years, and can be extended for another year depending on performance. ICRISAT pays a very attractive all inclusive lump sum assignment fee payable in Indian Rupees.</p>

<p>How to Apply: Please send your application by email to icrisatjobs@cgiar.org, stating the job title (Special project Scientist-Sorghum Genomics) clearly in the subject column, addressed to the Director, Human Resources and Operations, ICRISAT, Patancheru, Andhra Pradesh 502 324, India, latest by 10 June 2014. The application should include an up-to-date Curriculum Vitae, a short statement of competencies and experience for the position, and the names and addresses (including phone/e-mail) of three referees. Only short-listed candidates will be contacted.</p>

<p>More at: http://www.icrisat.org/careers/Special-Project-Scientist-Sorghum-Genomics.htm</p>
]]></description>
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