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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/38006?offset=510</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34049/libsvm-a-library-for-support-vector-machines</guid>
	<pubDate>Wed, 02 Aug 2017 06:49:05 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34049/libsvm-a-library-for-support-vector-machines</link>
	<title><![CDATA[LIBSVM -- A Library for Support Vector Machines]]></title>
	<description><![CDATA[<p><strong>LIBSVM&nbsp;</strong>is an integrated software for support vector classification, (C-SVC,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#nuandone">nu-SVC</a>), regression (epsilon-SVR,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#nuandone">nu-SVR</a>) and distribution estimation (<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#nuandone">one-class SVM</a>). It supports multi-class classification.</p>
<p>Since version 2.8, it implements an SMO-type algorithm proposed in this paper:<br>R.-E. Fan, P.-H. Chen, and C.-J. Lin.&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/papers/quadworkset.pdf">Working set selection using second order information for training SVM</a>. Journal of Machine Learning Research 6, 1889-1918, 2005. You can also find a pseudo code there. (<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/faq.html#f203">how to cite LIBSVM</a>)</p>
<p><span style="color: #ff0000;">Our goal is to help users from other fields to easily use SVM as a tool.&nbsp;</span><strong>LIBSVM&nbsp;</strong>provides a simple interface where users can easily link it with their own programs. Main features of&nbsp;<strong>LIBSVM</strong>&nbsp;include</p>
<ul>
<li>Different SVM formulations</li>
<li>Efficient multi-class classification</li>
<li>Cross validation for model selection</li>
<li>Probability estimates</li>
<li>Various kernels (including precomputed kernel matrix)</li>
<li>Weighted SVM for unbalanced data</li>
<li>Both C++ and&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#java">Java</a>&nbsp;sources</li>
<li><a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#GUI">GUI</a>&nbsp;demonstrating SVM classification and regression</li>
<li><a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#python">Python</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#R">R</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#matlab">MATLAB</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#perl">Perl</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#ruby">Ruby</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#weka">Weka</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#lisp">Common LISP</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#clisp">CLISP</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#haskell">Haskell</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#ocaml">OCaml</a>,&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#labview">LabVIEW</a>, and&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#PHP">PHP</a>&nbsp;interfaces.&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#csharp">C# .NET</a>&nbsp;code and&nbsp;<a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/#cuda">CUDA</a>&nbsp;extension is available.&nbsp;<br>It's also included in some data mining environments:&nbsp;<a href="http://rapid-i.com/">RapidMiner</a>,&nbsp;<a href="http://pcp.sourceforge.net/">PCP</a>, and&nbsp;<a href="http://lionoso.org/">LIONsolver</a>.</li>
<li>Automatic model selection which can generate contour of cross validation accuracy.</li>
<li></li>
</ul>
<p>https://www.csie.ntu.edu.tw/~cjlin/libsvm/</p><p>Address of the bookmark: <a href="https://www.csie.ntu.edu.tw/~cjlin/libsvm/" rel="nofollow">https://www.csie.ntu.edu.tw/~cjlin/libsvm/</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/37529/bokeh-an-interactive-visualization-library-that-targets-modern-web-browsers-for-presentation</guid>
	<pubDate>Fri, 10 Aug 2018 18:43:08 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/37529/bokeh-an-interactive-visualization-library-that-targets-modern-web-browsers-for-presentation</link>
	<title><![CDATA[Bokeh: An interactive visualization library that targets modern web browsers for presentation]]></title>
	<description><![CDATA[<p id="about">Bokeh is an interactive visualization library that targets modern web browsers for presentation. Its goal is to provide elegant, concise construction of versatile graphics, and to extend this capability with high-performance interactivity over very large or streaming datasets. Bokeh can help anyone who would like to quickly and easily create interactive plots, dashboards, and data applications.</p>
<p>To get started using Bokeh to make your visualizations, see the&nbsp;<a href="https://bokeh.pydata.org/en/latest/docs/user_guide.html#userguide">User Guide</a>.</p>
<p>To see examples of how you might use Bokeh with your own data, check out the&nbsp;<a href="https://bokeh.pydata.org/en/latest/docs/gallery.html#gallery">Gallery</a>.</p>
<p>A complete API reference of Bokeh is at&nbsp;<a href="https://bokeh.pydata.org/en/latest/docs/reference.html#refguide">Reference Guide</a>.</p>
<p>If you are interested in contributing to Bokeh, or extending the library, see the&nbsp;<a href="https://bokeh.pydata.org/en/latest/docs/dev_guide.html#devguide">Developer Guide</a>.</p><p>Address of the bookmark: <a href="https://bokeh.pydata.org/en/latest/" rel="nofollow">https://bokeh.pydata.org/en/latest/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/view/19838</guid>
	<pubDate>Sat, 27 Dec 2014 13:30:15 -0600</pubDate>
	<link>https://bioinformaticsonline.com/view/19838</link>
	<title><![CDATA[Interview with a bioinformatician series ...]]></title>
	<description><![CDATA[<p>The aim of this series to interviews some notable bioinformaticians to get their views on various aspects of bioinformatics research. Hopefully these answers will prove useful to others in the field, especially to those who are just starting their bioinformatics careers.<br /><br />This series will be available at BOL every fortnight.<br /><br /><br /><br /></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/32134/lifemap</guid>
	<pubDate>Mon, 10 Apr 2017 05:42:37 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/32134/lifemap</link>
	<title><![CDATA[Lifemap]]></title>
	<description><![CDATA[<p><strong>Lifemap</strong> is an interactive tool to explore the WHOLE NCBI TAXONOMY. The concept used in <strong>Lifemap</strong> is similar to the one used in cartography with tools like Google Maps&copy; or Open Street Maps: exploring is done by zooming and panning.</p>
<div>
<p>&nbsp;The current tree contains ALL species present in NCBI taxonomy as of <span style="text-decoration: underline;">October 18th, 2016</span>: 1,135,169 species including 10,545 Archaea, 418,777 Bacteria and 705,847 Eukaryotes. The Lifemap tree is updated every two weeks.</p>
</div>
<p>&nbsp;All the nodes in the tree are clickable. This displays various information and options:</p>
<ul>
<li>The species name (and the associated common name if there is one)</li>
<li>The rank (kingdom, family, class, species...)</li>
<li>Ability to go to the corresponding node/species on NCBI web site (displayed in a new window)</li>
<li>Possibility to download the corresponding subtree in newick extended format</li>
<li>Possibilty to get the whole lineage from the current node/tip to the root of the tree.</li>
</ul><p>Address of the bookmark: <a href="http://lifemap-ncbi.univ-lyon1.fr/" rel="nofollow">http://lifemap-ncbi.univ-lyon1.fr/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/33960/mgra-breakpoint-graphs-and-ancestral-genome-reconstructions</guid>
	<pubDate>Tue, 25 Jul 2017 08:48:25 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/33960/mgra-breakpoint-graphs-and-ancestral-genome-reconstructions</link>
	<title><![CDATA[MGRA: Breakpoint graphs and ancestral genome reconstructions]]></title>
	<description><![CDATA[<p>MGRA (Multiple Genome Rearrangements and Ancestors) is a tool for reconstruction of ancestor genomes and evolutionary history of extant genomes.</p>
<p>It takes as an input a set of genomes represented as sequences of genes (or synteny blocks) and produces such sequences for ancestral genomes at the internal nodes of the phylogenetic tree.</p>
<p>The phylogenetic tree may be also specified completely or partially, in the latter case MGRA can reconstruct conserved ancestral regions (CARs) of the ancestral genome of interest.</p>
<p>Since version 2 MGRA supports gene insertion and deletions in addition to genome rearrangements and allows the input genomes to have different gene content.</p>
<p>It also can reconstruct most plausible phylogenetic tree based on the rearrangement characters.</p><p>Address of the bookmark: <a href="http://mgra.cblab.org/" rel="nofollow">http://mgra.cblab.org/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34377/genomicus-genome-browser-that-enables-users-to-navigate-in-genomes-in-several-dimensions</guid>
	<pubDate>Sat, 18 Nov 2017 16:10:16 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34377/genomicus-genome-browser-that-enables-users-to-navigate-in-genomes-in-several-dimensions</link>
	<title><![CDATA[Genomicus: genome browser that enables users to navigate in genomes in several dimensions]]></title>
	<description><![CDATA[<p>Genomicus is a genome browser that enables users to navigate in genomes in several dimensions: linearly along chromosome axes, transversaly across different species, and chronologicaly along evolutionary time.</p>
<p>Once a query gene has been entered, it is displayed in its genomic context in parallel to the genomic context of all its orthologous and paralogous copies in all the other sequenced metazoan genomes. Moreover, Genomicus stores and displays the predicted ancestral genome structure in all the ancestral species within the phylogenetic range of interest.</p>
<p>All the data on extant species displayed in this browser are from&nbsp;<a href="http://www.ensembl.org/">Ensembl</a>.</p><p>Address of the bookmark: <a href="http://genomicus.biologie.ens.fr/genomicus-90.01/cgi-bin/search.pl" rel="nofollow">http://genomicus.biologie.ens.fr/genomicus-90.01/cgi-bin/search.pl</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34488/scripts-for-the-analysis-of-hgt-in-genome-sequence-data</guid>
	<pubDate>Wed, 29 Nov 2017 16:44:10 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34488/scripts-for-the-analysis-of-hgt-in-genome-sequence-data</link>
	<title><![CDATA[Scripts for the analysis of HGT in genome sequence data.]]></title>
	<description><![CDATA[<p><span>Scripts for the analysis of HGT in genome sequence data</span></p><p>Address of the bookmark: <a href="https://github.com/reubwn/hgt" rel="nofollow">https://github.com/reubwn/hgt</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34569/ksnp30-snp-detection-and-phylogenetic-analysis-of-genomes-without-genome-alignment-or-reference-genome</guid>
	<pubDate>Fri, 08 Dec 2017 16:48:40 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34569/ksnp30-snp-detection-and-phylogenetic-analysis-of-genomes-without-genome-alignment-or-reference-genome</link>
	<title><![CDATA[kSNP3.0: SNP detection and phylogenetic analysis of genomes without genome alignment or reference genome]]></title>
	<description><![CDATA[<p><span>Sept. 20, 2017 Version 3.1 released. Major upgrade. Version 3.1 fixes the problems with SNP annotation that arose when NCBI discontinued use of GI numbers. Please read carefully the Preface (page 3) and the File of annotated genomes section (pages 9-10) in the version 3.1 User Guide. Thanks to Tom Slezak for revsing the get_genbank_file3 script and to Tod Stuber (USDA) for testing version 3.1 even though he doesn't need the annotation feature. All users are encouraged to upgrade to version 3.1.&nbsp;<br></span></p><p>Address of the bookmark: <a href="https://sourceforge.net/projects/ksnp/files/" rel="nofollow">https://sourceforge.net/projects/ksnp/files/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/34707/string-graph-based-genome-assembly-software-and-tools</guid>
	<pubDate>Tue, 19 Dec 2017 17:17:38 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/34707/string-graph-based-genome-assembly-software-and-tools</link>
	<title><![CDATA[String graph based genome assembly software and tools !]]></title>
	<description><![CDATA[<p>In&nbsp;<a href="https://en.wikipedia.org/wiki/Graph_theory" title="Graph theory">graph theory</a>, a&nbsp;<strong>string graph</strong>&nbsp;is an&nbsp;<a href="https://en.wikipedia.org/wiki/Intersection_graph" title="Intersection graph">intersection graph</a>&nbsp;of&nbsp;<a href="https://en.wikipedia.org/wiki/Curve" title="Curve">curves</a>&nbsp;in the plane; each curve is called a "string".&nbsp; String graphs were first proposed by E. W. Myers in a&nbsp;<a href="http://bioinformatics.oxfordjournals.org/content/21/suppl_2/ii79.full.pdf+html">2005 publication</a>.&nbsp;In&nbsp;recent&nbsp;<a href="http://genome.cshlp.org/content/early/2012/01/22/gr.126953.111">Genome Research paper</a>&nbsp;describing an innovative approach for assembling large genomes from NGS data caught our attention for several reasons. i) it give different "string graph" prospective of long lasting genome assembly problem ii) the&nbsp;paper is coauthored by Jared Simpson, the developer of&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694472/">ABySS assembler</a>&nbsp;and Richard Durbin. iii)&nbsp;Simpson-Durbin algorithm is that it does not rely on de Bruijn graphs, and instead employs a different graph construction approach called &lsquo;string graph&rsquo;.</p><p>Following are the genome assembly tools based on string graph:</p><p>1.SGA (String Graph Assembler)&nbsp;https://github.com/jts/sga</p><p>Assembles large genomes from high coverage short read data. SGA is designed as a modular set of programs, which are used to form an assembly pipeline. SGA implements a set of assembly algorithms based on the FM-index. As the FM-index is a compressed data structure, the algorithms are very memory efficient. The SGA assembly has three distinct phases. The first phase corrects base calling errors in the reads. The second phase assembles contigs from the corrected reads. The third phase uses paired end and/or mate pair data to build scaffolds from the contigs. The output of this software is a PDF report that allows the properties of the genome and data quality to be visually explored. By providing more information to the user at the start of an assembly project, this software will help increase awareness of the factors that make a given assembly easy or difficult, assist in the selection of software and parameters and help to troubleshoot an assembly if it runs into problems.</p><p>2.&nbsp;SAGE: String-overlap Assembly of GEnomes&nbsp;https://github.com/lucian-ilie/SAGE2</p><p>SAGE, for de novo genome assembly. As opposed to most assemblers, which are de Bruijn graph based, SAGE uses the string-overlap graph. SAGE builds upon great existing work on string-overlap graph and maximum likelihood assembly, bringing an important number of new ideas, such as the efficient computation of the transitive reduction of the string overlap graph, the use of (generalized) edge multiplicity statistics for more accurate estimation of read copy counts, and the improved use of mate pairs and min-cost flow for supporting edge merging. The assemblies produced by SAGE for several short and medium-size genomes compared favourably with those of existing leading assemblers.</p><p>3. FSG: Fast String Graph</p><p>The new integrated assembler has been assessed on a standard benchmark, showing that fast string graph (FSG) is significantly faster than SGA while maintaining a moderate use of main memory, and showing practical advantages in running FSG on multiple threads. Moreover, we have studied the effect of coverage rates on the running times.</p><p>4.&nbsp;&nbsp;BASE&nbsp;https://github.com/dhlbh/BASE</p><p>It enhances the classic seed-extension approach by indexing the reads efficiently to generate adaptive seeds that have high probability to appear uniquely in the genome. Such seeds form the basis for BASE to build extension trees and then to use reverse validation to remove the branches based on read coverage and paired-end information, resulting in high-quality consensus sequences of reads sharing the seeds. Such consensus sequences are then extended to contigs.&nbsp;BASE is a practically efficient tool for constructing contig, with significant improvement in quality for long NGS reads. It is relatively easy to extend BASE to include scaffolding.</p><p>5.&nbsp;Fermi&nbsp;https://github.com/lh3/fermi/</p><p>Fermi is a de novo assembler with a particular focus on assembling Illumina&nbsp;short sequence reads from a mammal-sized genome. In addition to the role of a&nbsp;typical assembler, fermi also aims to preserve heterozygotes which are often&nbsp;collapsed by other assemblers. Its ultimate goal is to find a minimal set of&nbsp;unitigs to represent all the information in raw reads.</p><p>If you want to learn about String Graph assembler, please read the following papers -</p><p>i)&nbsp;<a href="http://bioinformatics.oxfordjournals.org/content/21/suppl_2/ii79.full.pdf+html">The Fragment Assembly String Graph - E. W. Myers</a></p><p>This paper describes the String Graph concept.</p><p>ii)&nbsp;<a href="http://bioinformatics.oxfordjournals.org/content/26/12/i367.full#ref-20">Efficient construction of an assembly string graph using the FM-index - Jared T. Simpson and Richard Durbin</a></p><p>This earlier paper from Simpson and Durbin</p><p>iii)&nbsp;<a href="http://genome.cshlp.org/content/early/2012/01/22/gr.126953.111">Efficient de novo assembly of large genomes using compressed data structures - Jared T. Simpson and Richard Durbin</a></p><p>&nbsp;</p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/35135/alitv%E2%80%94interactive-visualization-of-whole-genome-comparisons</guid>
	<pubDate>Wed, 10 Jan 2018 07:08:17 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/35135/alitv%E2%80%94interactive-visualization-of-whole-genome-comparisons</link>
	<title><![CDATA[AliTV—interactive visualization of whole genome comparisons]]></title>
	<description><![CDATA[<p>AliTV, which provides interactive visualization of whole genome alignments. AliTV reads multiple whole genome alignments or automatically generates alignments from the provided data. Optional feature annotations and phylo- genetic information are supported. The user-friendly, web-browser based and highly customizable interface allows rapid exploration and manipulation of the visualized data as well as the export of publication-ready high-quality figures. AliTV is freely available at&nbsp;<a href="https://github.com/AliTVTeam/AliTV">https://github.com/AliTVTeam/AliTV</a></p>
<p>https://alitvteam.github.io/AliTV/</p><p>Address of the bookmark: <a href="https://github.com/AliTVTeam/AliTV" rel="nofollow">https://github.com/AliTVTeam/AliTV</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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