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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/38804?offset=150</link>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/36644/tacoa-taxonomic-classification-of-environmental-genomic-fragments-using-a-kernelized-nearest-neighbor-approach</guid>
	<pubDate>Tue, 15 May 2018 09:52:28 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/36644/tacoa-taxonomic-classification-of-environmental-genomic-fragments-using-a-kernelized-nearest-neighbor-approach</link>
	<title><![CDATA[TACOA: Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach]]></title>
	<description><![CDATA[TACOA is a software that can accurately predict the taxonomic origin of genomic fragments from metagenomic data sets by combining the advantages of the k -NN approach with a smoothing kernel function. 

TACOA can be easily installed and run on a desktop computer, therefore allowing researchers to locally analyze their metagenomic sequence data or integrate it into their pipelines.<p>Address of the bookmark: <a href="http://www.cebitec.uni-bielefeld.de/index.php/2-uncategorised/99-tacoa" rel="nofollow">http://www.cebitec.uni-bielefeld.de/index.php/2-uncategorised/99-tacoa</a></p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/37788/s-plot2-creates-an-interactive-two-dimensional-heatmap-of-sequences</guid>
	<pubDate>Fri, 28 Sep 2018 05:36:19 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/37788/s-plot2-creates-an-interactive-two-dimensional-heatmap-of-sequences</link>
	<title><![CDATA[S-plot2: creates an interactive, two-dimensional heatmap of sequences]]></title>
	<description><![CDATA[<p><span>S-plot2 creates an interactive, two-dimensional heatmap capturing the similarities and dissimilarities in nucleotide usage between genomic sequences (partial or complete). In S-plot2, whole eukaryotic chromosomes and smaller prokaryotic genomes can be efficiently compared. The tool includes functionality to extract, analyze, and automate BLAST queries of regions of interest within the heatmap. This facilitates the investigation of quickly evolving coding regions, novel coding regions, and laterally transferred elements.</span></p>
<p><span>http://www.putonti-lab.com/uploads/4/5/3/0/45307835/s-plot2_tutorial.pdf</span></p>
<p><span>http://journals.sagepub.com/doi/pdf/10.1177/1176934318797354</span></p><p>Address of the bookmark: <a href="https://bitbucket.org/lkalesinskas/splot" rel="nofollow">https://bitbucket.org/lkalesinskas/splot</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38678/upho-scripts-for-homology-and-orthology-assessment-from-genomic-sequences</guid>
	<pubDate>Mon, 14 Jan 2019 10:36:42 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38678/upho-scripts-for-homology-and-orthology-assessment-from-genomic-sequences</link>
	<title><![CDATA[UPhO: Scripts for homology and orthology assessment from genomic sequences.]]></title>
	<description><![CDATA[<p>UPhO finds orthologs with and without inparalogs from input gene family trees. Refer to the Documentation.pdf for more detailed explanations on its usage, installation and dependencies. Type UPhO.py -h for help.</p>
<p>The only input requierement for UPhO is a tree (or trees) in Newick format in which the leaves are named with a species idenfifier, a field separator, and sequence identifier. By default, the field separator is the character "|" but custom delimiters can be defined. Examples of trees to test UPhO are provided in the TestData folder.</p><p>Address of the bookmark: <a href="https://github.com/ballesterus/UPhO" rel="nofollow">https://github.com/ballesterus/UPhO</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40814/accesssyri-finding-genomic-rearrangements-and-local-sequence-differences-from-whole-genome-assemblies</guid>
	<pubDate>Sat, 01 Feb 2020 13:38:49 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40814/accesssyri-finding-genomic-rearrangements-and-local-sequence-differences-from-whole-genome-assemblies</link>
	<title><![CDATA[AccessSyRI: finding genomic rearrangements and local sequence differences from whole-genome assemblies]]></title>
	<description><![CDATA[<p><span>Access</span><span>SyRI: finding genomic rearrangements and</span><span>local sequence differences from whole-</span><span>genome assemblies</span><span><br></span></p>
<p><span><span>SyRI, a pairwise whole-genome comparison tool for chromosome-level assemblies. SyRI starts by finding rearranged regions and then searches for differences in the sequences, which are distinguished for residing in syntenic or rearranged regions. This distinction is important as rearranged regions are inherited differently compared to syntenic regions.</span></span></p>
<p><span><a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1911-0">https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1911-0</a></span></p><p>Address of the bookmark: <a href="https://github.com/schneebergerlab/syri" rel="nofollow">https://github.com/schneebergerlab/syri</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44414/reconplot-an-r-package-for-the-visualization-and-interpretation-of-genomic-rearrangements</guid>
	<pubDate>Thu, 14 Dec 2023 12:33:19 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44414/reconplot-an-r-package-for-the-visualization-and-interpretation-of-genomic-rearrangements</link>
	<title><![CDATA[ReConPlot: an R package for the visualization and interpretation of genomic rearrangements]]></title>
	<description><![CDATA[<p>ReConPlot (REarrangement and COpy Number PLOT), an R package that provides functionalities for the joint visualization of SCNAs and SVs across one or multiple chromosomes. ReConPlot is based on the popular ggplot2 package, thus allowing customization of plots and the generation of publication-quality figures with minimal effort.</p><p>Address of the bookmark: <a href="https://academic.oup.com/bioinformatics/article/39/12/btad719/7460198?login=false" rel="nofollow">https://academic.oup.com/bioinformatics/article/39/12/btad719/7460198?login=false</a></p>]]></description>
	<dc:creator>LEGE</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</guid>
	<pubDate>Wed, 13 Aug 2025 19:56:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</link>
	<title><![CDATA[dna2bit: an ultra-fast and accurate genomic distance estimation software]]></title>
	<description><![CDATA[<p dir="auto">dna2bit: an ultra-fast and accurate genomic distance estimation software</p>
<div dir="auto"><a href="https://github.com/lijuzeng/dna2bit#compilation"></a></div>
<p dir="auto">dna2bit is a software tool developed in C++11, leveraging the capabilities of OpenMP for parallel computing and the popcount technique for efficient bit manipulation.&nbsp;</p><p>Address of the bookmark: <a href="https://github.com/lijuzeng/dna2bit" rel="nofollow">https://github.com/lijuzeng/dna2bit</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/40589/new-layout-for-blast-ftp-database-site</guid>
	<pubDate>Tue, 21 Jan 2020 11:57:11 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/40589/new-layout-for-blast-ftp-database-site</link>
	<title><![CDATA[New Layout for BLAST ftp Database Site]]></title>
	<description><![CDATA[<p>As announced previously, the new default database version for&nbsp;<a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/12/18/blast-2-10-0/" target="_blank" title="Follow link">BLAST+</a>&nbsp;is&nbsp;<a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/30/protein-blastdbs-accession-based/" target="_blank" title="Follow link">dbV5</a>.&nbsp; To complete this transition, the&nbsp;<a href="ftp://ftp.ncbi.nlm.nih.gov/blast/db/" target="_blank" title="Follow link">ftp database site</a>&nbsp;will be updated to support this change.&nbsp; We expect this change to happen around February 4<sup>th</sup>, please adjust your scripts or procedures accordingly.</p><p>Here is a list of what is changing:</p><ol>
<li>All databases at the root level will be dbV5.</li>
<li>The dbV5 file naming, &nbsp;&ldquo;_v5&rdquo; will be removed. Databases with &nbsp;no &ldquo;_vX&rdquo; descriptor will be dbV5.</li>
<li>dbV4 tarballs will be renamed with "_v4", files included in tarball will not be renamed.</li>
<li>dbV4 databases will be moved to a v4 subdirectory.</li>
<li>As of 1/13/20 the Cloud directory will be frozen with no more new entries.</li>
<li>The will be no more updates to dbV4 databases.</li>
<li>The FASTA directory will contain nr, nt, swissprot, and pdbaa files.</li>
</ol><p>If you have any questions or concerns, please contact&nbsp;<a href="mailto:blast-help@ncbi.nlm.nih.gov" target="_blank" title="Follow link">blast-help@ncbi.nlm.nih.gov</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/32849/car-reconstructing-contiguous-regions-of-an-ancestral-genome</guid>
	<pubDate>Thu, 18 May 2017 05:24:01 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/32849/car-reconstructing-contiguous-regions-of-an-ancestral-genome</link>
	<title><![CDATA[CAR: Reconstructing Contiguous Regions of an Ancestral Genome]]></title>
	<description><![CDATA[<div id="abstract-1">
<p id="p-5">We describe a new method for predicting the ancestral order and orientation of those intervals from their observed adjacencies in modern species. We combine the results from this method with data from chromosome painting experiments to produce a map of an early mammalian genome that accounts for 96.8% of the available human genome sequence data. The precision is further increased by mapping inversions as small as 31 bp. Analysis of the predicted evolutionary breakpoints in the human lineage confirms certain published observations but disagrees with others. Although only a few mammalian genomes are currently sequenced to high precision, our theoretical analyses and computer simulations indicate that our results are reasonably accurate and that they will become highly accurate in the foreseeable future. Our methods were developed as part of a project to reconstruct the genome sequence of the last ancestor of human, dogs, and most other placental mammals;</p>
</div><p>Address of the bookmark: <a href="http://www.bx.psu.edu/miller_lab/car/" rel="nofollow">http://www.bx.psu.edu/miller_lab/car/</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/39872/miropeats-discovers-regions-of-sequence-similarity-amongst-any-set-of-dna-sequences</guid>
	<pubDate>Mon, 26 Aug 2019 17:55:24 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/39872/miropeats-discovers-regions-of-sequence-similarity-amongst-any-set-of-dna-sequences</link>
	<title><![CDATA[Miropeats: discovers regions of sequence similarity amongst any set of DNA sequences]]></title>
	<description><![CDATA[<p><span>Miropeats discovers regions of sequence similarity amongst any set of DNA sequences and then presents this similarity information graphically. Sequence similarity searching is a very general tool that forms the basis of many different biological sequence analyses but it is limited by the verbosity of traditional alignment presentation styles. Miropeats enhances the utility of conventional DNA sequence comparisons when looking at long lengths of sequence similarity by summarizing extensive large scale sequence similarities on a single page of graphics. The latest version of Miropeats can be used as a general pairwise alignment program or in its traditional role sorting out a big mess of overlapping or similar regions.</span></p><p>Address of the bookmark: <a href="http://www.littlest.co.uk/software/bioinf/old_packages/miropeats/" rel="nofollow">http://www.littlest.co.uk/software/bioinf/old_packages/miropeats/</a></p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/2645/dna-bending-propensity-in-the-presence-of-base-mismatches-implications-for-dna-repair</guid>
	<pubDate>Mon, 19 Aug 2013 16:01:44 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/2645/dna-bending-propensity-in-the-presence-of-base-mismatches-implications-for-dna-repair</link>
	<title><![CDATA[DNA Bending Propensity in the Presence of Base Mismatches: Implications for DNA Repair]]></title>
	<description><![CDATA[<p>Understanding how the human body recognizes damaged DNA and initiates repair fascinates Michael Feig, professor of biochemistry and molecular biology at Michigan State University. Feig studies the proteins MutS and MSH2-MSH6, which recognize defective DNA and initiate DNA repair. Natural DNA repair occurs when proteins like MutS (the primary protein responsible for recognizing a variety of DNA mismatches) scan the DNA, identify a defect, and recruit other enzymes to carry out the actual repair.</p><p><em>Results from computer simulations show that it is energetically less expensive to bend mismatch-containing, defective DNA (G:T, C:C, C:T, G:A, G:G, T:T, A:A, A+:C) vs. non-defective DNA (containing A:T or G:C base pairs). DNA repair mechanisms likely take advantage of this feature to detect defective DNA based on an increased bending propensity.</em></p><p>http://www.tacc.utexas.edu/news/feature-stories/2013/how-dna-repair-helps-prevent-cancer</p><p>http://pubs.acs.org/doi/abs/10.1021/jp403127a</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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