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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/38829?offset=220</link>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/33869/import-r-data</guid>
	<pubDate>Wed, 12 Jul 2017 08:30:46 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/33869/import-r-data</link>
	<title><![CDATA[Import R Data]]></title>
	<description><![CDATA[<p>It is often necessary to import sample textbook data into R before you start working on your homework.</p><div id="node-69"><div><p><strong>Excel File</strong></p><p>Quite frequently, the sample data is in&nbsp;<span>Excel&nbsp;</span>format, and needs to be imported into R prior to use. For this, we can use the function&nbsp;<span>read.xls&nbsp;</span>from the&nbsp;<span>gdata&nbsp;</span>package. It reads from an Excel spreadsheet and returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/data-frame">data frame</a>. The following shows how to load an Excel spreadsheet named&nbsp;<span>"mydata.xls"</span>. This method requires Perl runtime to be present in the system.</p><blockquote><div id="listing-68"><span><a></a></span>&gt;&nbsp;library(gdata)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;gdata&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.xls)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.xls("mydata.xls")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;first&nbsp;sheet</div></blockquote><p>Alternatively, we can use the function&nbsp;<span>loadWorkbook&nbsp;</span>from the&nbsp;<span>XLConnect&nbsp;</span>package to read the entire workbook, and then load the worksheets with&nbsp;<span>readWorksheet</span>. The&nbsp;<span>XLConnect&nbsp;</span>package requires Java to be pre-installed.</p><blockquote><div id="listing-69"><span><a></a></span>&gt;&nbsp;library(XLConnect)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;XLConnect&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;wk&nbsp;=&nbsp;loadWorkbook("mydata.xls")&nbsp;<br /><span><a></a></span>&gt;&nbsp;df&nbsp;=&nbsp;readWorksheet(wk,&nbsp;sheet="Sheet1")</div></blockquote><p>&nbsp;</p><h4><a></a>Minitab File</h4><p>If the data file is in&nbsp;<span>Minitab Portable Worksheet&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.mtp&nbsp;</span>from the&nbsp;<span>foreign&nbsp;</span>package. It returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/list">list</a>&nbsp;of components in the Minitab worksheet.</p><blockquote><div id="listing-70"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.mtp)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.mtp("mydata.mtp")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;.mtp&nbsp;file</div></blockquote><p>&nbsp;</p><h4><a></a>SPSS File</h4><p>For the data files in&nbsp;<span>SPSS&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.spss&nbsp;</span>also from the&nbsp;<span>foreign&nbsp;</span>package. There is a&nbsp;<span>"to.data.frame"&nbsp;</span>option for choosing whether a data frame is to be returned. By default, it returns a list of components instead.</p><blockquote><div id="listing-71"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.spss)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.spss("myfile",&nbsp;to.data.frame=TRUE)</div></blockquote><p>&nbsp;</p><h4><a></a>Table File</h4><p>A data table can resides in a text file. The cells inside the table are separated by blank characters. Here is an example of a table with 4 rows and 3 columns.</p><blockquote><div id="listing-72"><span><a></a></span>100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3&nbsp;<br /><span><a></a></span>400&nbsp;&nbsp;&nbsp;a4&nbsp;&nbsp;&nbsp;b4</div></blockquote><p>Now copy and paste the table above in a file named&nbsp;<span>"mydata.txt"&nbsp;</span>with a text editor. Then load the data into the workspace with the function&nbsp;<span>read.table</span>.</p><blockquote><div id="listing-73"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.table("mydata.txt")&nbsp;&nbsp;#&nbsp;read&nbsp;text&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;print&nbsp;data&nbsp;frame&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;&nbsp;V1&nbsp;V2&nbsp;V3&nbsp;<br /><span><a></a></span>1&nbsp;100&nbsp;a1&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;200&nbsp;a2&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;300&nbsp;a3&nbsp;b3&nbsp;<br /><span><a></a></span>4&nbsp;400&nbsp;a4&nbsp;b4</div></blockquote><p>For further detail of the function&nbsp;<span>read.table</span>, please consult the R documentation.</p><blockquote><div id="listing-74"><span><a></a></span>&gt;&nbsp;help(read.table)</div></blockquote><p>&nbsp;</p><h4><a></a>CSV File</h4><p>The sample data can also be in&nbsp;<span>comma separated values&nbsp;</span>(CSV) format. Each cell inside such data file is separated by a special character, which usually is a comma, although other characters can be used as well.</p><p>The first row of the data file should contain the column names instead of the actual data. Here is a sample of the expected format.</p><blockquote><div id="listing-75"><span><a></a></span>Col1,Col2,Col3&nbsp;<br /><span><a></a></span>100,a1,b1&nbsp;<br /><span><a></a></span>200,a2,b2&nbsp;<br /><span><a></a></span>300,a3,b3</div></blockquote><p>After we copy and paste the data above in a file named&nbsp;<span>"mydata.csv"&nbsp;</span>with a text editor, we can read the data with the function&nbsp;<span>read.csv</span>.</p><blockquote><div id="listing-76"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.csv("mydata.csv")&nbsp;&nbsp;#&nbsp;read&nbsp;csv&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;Col1&nbsp;Col2&nbsp;Col3&nbsp;<br /><span><a></a></span>1&nbsp;&nbsp;100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;&nbsp;200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;&nbsp;300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3</div></blockquote><p>In various European locales, as the comma character serves as the decimal point, the function&nbsp;<span>read.csv2&nbsp;</span>should be used instead. For further detail of the&nbsp;<span>read.csv&nbsp;</span>and&nbsp;<span>read.csv2&nbsp;</span>functions, please consult the R documentation.</p><blockquote><div id="listing-77"><span><a></a></span>&gt;&nbsp;help(read.csv)</div></blockquote><p>&nbsp;</p><h4><a></a>Working Directory</h4><p>Finally, the code samples above assume the data files are located in the R&nbsp;<span>working</span>&nbsp;<span>directory</span>, which can be found with the function&nbsp;<span>getwd</span>.</p><blockquote><div id="listing-78"><span><a></a></span>&gt;&nbsp;getwd()&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;get&nbsp;current&nbsp;working&nbsp;directory</div></blockquote><p>You can select a different working directory with the function&nbsp;<span>setwd()</span>, and thus avoid entering the full path of the data files.</p><blockquote><div id="listing-79"><span><a></a></span>&gt;&nbsp;setwd("")&nbsp;&nbsp;&nbsp;#&nbsp;set&nbsp;working&nbsp;directory</div></blockquote><p>Note that the forward slash should be used as the path separator even on Windows platform.</p><blockquote><div id="listing-80"><span><a></a></span>&gt;&nbsp;setwd("C:/MyDoc")</div></blockquote></div></div>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/38226/ncbi-to-assist-in-virus-hunting-data-science-hackathon</guid>
	<pubDate>Thu, 15 Nov 2018 12:55:01 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/38226/ncbi-to-assist-in-virus-hunting-data-science-hackathon</link>
	<title><![CDATA[NCBI to assist in Virus Hunting Data Science Hackathon]]></title>
	<description><![CDATA[<p>NCBI Hackathon are pleased to announce the second installment of the&nbsp;<a href="https://ncbiinsights.ncbi.nlm.nih.gov/2017/11/30/ncbi-southern-california-genomics-hackathon-january/" target="_blank">SoCal Bioinformatics Hackathon</a>. From January 9-11, 2019, the&nbsp;<a href="https://www.ncbi.nlm.nih.gov/" target="_blank">NCBI</a>&nbsp;will help run a bioinformatics hackathon in Southern California hosted by the&nbsp;<a href="http://www.csrc.sdsu.edu/" target="_blank">Computational Sciences Research Center</a>&nbsp;at&nbsp;<a href="http://www.sdsu.edu/" target="_blank">San Diego State University</a>!</p><p><span>NCBI Hackathon</span>&nbsp;specifically looking for folks who have experience in computational virus hunting or adjacent fields to identify known, taxonomically-definable and novel viruses from a few hundred thousand metagenomic datasets that we&rsquo;ll put on cloud infrastructure. This event is for researchers, including students and postdocs, who are already engaged in the use of bioinformatics data or in the development of pipelines for virological analyses from high-throughput experiments. If this describes you, please&nbsp;<a href="https://goo.gl/forms/kDnSG0IAZD62XQRe2" target="_blank">apply</a>! The event is open to anyone selected for the hackathon and willing to travel to SDSU (see below).</p><p>https://ncbiinsights.ncbi.nlm.nih.gov/2018/11/09/ncbi-sdsu-virus-hunting-data-science-hackathon-january-2019/</p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40573/de-novo-genome-assembly-for-illumina-data</guid>
	<pubDate>Mon, 20 Jan 2020 05:13:29 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40573/de-novo-genome-assembly-for-illumina-data</link>
	<title><![CDATA[De novo Genome Assembly for Illumina Data]]></title>
	<description><![CDATA[<p>Written and maintained by <a href="mailto:simon.gladman@unimelb.edu.au">Simon Gladman</a> - Melbourne Bioinformatics (formerly VLSCI)</p>
<p>Protocol Overview / Introduction</p>
<p>In this protocol we discuss and outline the process of de novo assembly for small to medium sized genomes.</p>
<p>https://www.melbournebioinformatics.org.au/tutorials/tutorials/assembly/assembly-protocol/</p><p>Address of the bookmark: <a href="https://www.melbournebioinformatics.org.au/tutorials/tutorials/assembly/assembly-protocol/" rel="nofollow">https://www.melbournebioinformatics.org.au/tutorials/tutorials/assembly/assembly-protocol/</a></p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42419/biojupies-automatically-generates-rna-seq-data-analysis-notebooks</guid>
	<pubDate>Sun, 20 Dec 2020 11:43:45 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42419/biojupies-automatically-generates-rna-seq-data-analysis-notebooks</link>
	<title><![CDATA[BioJupies: Automatically Generates RNA-seq Data Analysis Notebooks]]></title>
	<description><![CDATA[<p>With BioJupies you can produce in seconds a customized, reusable, and interactive report from your own raw or processed RNA-seq data through a simple user interface</p>
<p>BioJupies now supports user accounts! Sign in from the top right corner of the page for access to unlimited private notebooks, RNA-seq datasets and alignment jobs.</p><p>Address of the bookmark: <a href="https://amp.pharm.mssm.edu/biojupies/" rel="nofollow">https://amp.pharm.mssm.edu/biojupies/</a></p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44557/fundamentals-of-data-visualization-by-claus-o-wilke</guid>
	<pubDate>Sat, 08 Jun 2024 16:07:19 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44557/fundamentals-of-data-visualization-by-claus-o-wilke</link>
	<title><![CDATA[Fundamentals of Data Visualization by Claus O. Wilke]]></title>
	<description><![CDATA[<p><span><span>The book is meant as a guide to making visualizations that accurately reflect the data, tell a story, and look professional. It has grown out of my experience of working with students and postdocs in my laboratory on thousands of data visualizations. Over the years, I have noticed that the same issues arise over and over. I have attempted to collect my accumulated knowledge from these interactions in the form of this book.</span></span></p>
<p><span>The entire book is written in R Markdown, using RStudio as my text editor and the&nbsp;</span><span>bookdown</span><span>&nbsp;package to turn a collection of markdown documents into a coherent whole. The book&rsquo;s source code is hosted on GitHub, at&nbsp;</span><a href="https://github.com/clauswilke/dataviz">https://github.com/clauswilke/dataviz</a><span>.&nbsp;</span></p><p>Address of the bookmark: <a href="https://clauswilke.com/dataviz/" rel="nofollow">https://clauswilke.com/dataviz/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</guid>
	<pubDate>Wed, 13 Aug 2025 19:56:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44876/dna2bit-an-ultra-fast-and-accurate-genomic-distance-estimation-software</link>
	<title><![CDATA[dna2bit: an ultra-fast and accurate genomic distance estimation software]]></title>
	<description><![CDATA[<p dir="auto">dna2bit: an ultra-fast and accurate genomic distance estimation software</p>
<div dir="auto"><a href="https://github.com/lijuzeng/dna2bit#compilation"></a></div>
<p dir="auto">dna2bit is a software tool developed in C++11, leveraging the capabilities of OpenMP for parallel computing and the popcount technique for efficient bit manipulation.&nbsp;</p><p>Address of the bookmark: <a href="https://github.com/lijuzeng/dna2bit" rel="nofollow">https://github.com/lijuzeng/dna2bit</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/36616/srbreak-a-read-depth-and-split-read-framework-to-identify-breakpoints-of-different-events-inside-simple-copy-number-variable-regions</guid>
	<pubDate>Tue, 15 May 2018 04:42:11 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/36616/srbreak-a-read-depth-and-split-read-framework-to-identify-breakpoints-of-different-events-inside-simple-copy-number-variable-regions</link>
	<title><![CDATA[SRBreak: A Read-Depth and Split-Read Framework to Identify Breakpoints of Different Events Inside Simple Copy-Number Variable Regions]]></title>
	<description><![CDATA[SRBreak is a read-depth and split-read package written in R for identifying copy-number variants in next-generation sequencing datasets.

Note: SBReak was designed to work for multiple samples. It can work for &gt;= 2 samples, but we suggest that users should use &gt;= 5 samples as in the work tested in our paper.<p>Address of the bookmark: <a href="https://github.com/hoangtn/SRBreak" rel="nofollow">https://github.com/hoangtn/SRBreak</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/35148/mojolicious-a-next-generation-web-framework-for-the-perl-programming-language</guid>
	<pubDate>Fri, 12 Jan 2018 16:48:10 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/35148/mojolicious-a-next-generation-web-framework-for-the-perl-programming-language</link>
	<title><![CDATA[mojolicious: a next generation web framework for the Perl programming language.]]></title>
	<description><![CDATA[<p><span>Back in the early days of the web, many people learned Perl because of a wonderful Perl library called&nbsp;</span><a href="https://metacpan.org/module/CGI" target="_blank">CGI</a><span>. It was simple enough to get started without knowing much about the language and powerful enough to keep you going, learning by doing was much fun. While most of the techniques used are outdated now, the idea behind it is not. Mojolicious is a new endeavor to implement this idea using bleeding edge technologies.</span></p>
<h2>Features</h2>
<ul>
<li>An amazing&nbsp;<strong>real-time web framework</strong>, allowing you to easily grow single file prototypes into well-structured MVC web applications.
<ul>
<li>Powerful out of the box with RESTful routes, plugins, commands, Perl-ish templates, content negotiation, session management, form validation, testing framework, static file server, CGI/<a href="http://plackperl.org/" target="_blank">PSGI</a>&nbsp;detection, first class Unicode support and much more for you to discover.</li>
</ul>
</li>
<li>A powerful&nbsp;<strong>web development toolkit</strong>, that you can use for all kinds of applications, independently of the web framework.
<ul>
<li>Full stack HTTP and WebSocket client/server implementation with IPv6, TLS, SNI, IDNA, HTTP/SOCKS5 proxy, UNIX domain socket, Comet (long polling), Promises/A+, keep-alive, connection pooling, timeout, cookie, multipart and gzip compression support.</li>
<li>Built-in non-blocking I/O web server, supporting multiple event loops as well as optional pre-forking and hot deployment, perfect for building highly scalable web services.</li>
<li>JSON and HTML/XML parser with CSS selector support.</li>
</ul>
</li>
<li>Very clean, portable and object-oriented pure-Perl API with no hidden magic and no requirements besides Perl 5.24.0 (versions as old as 5.10.1 can be used too, but may require additional CPAN modules to be installed)</li>
<li>Fresh code based upon years of experience developing&nbsp;<a href="http://catalystframework.org/" target="_blank">Catalyst</a>, free and open source.</li>
<li>Hundreds of 3rd party&nbsp;<a href="https://metacpan.org/requires/distribution/Mojolicious">extensions</a>&nbsp;and high quality spin-off projects like the&nbsp;<a href="https://metacpan.org/pod/Minion">Minion</a>&nbsp;job queue.</li>
</ul>
<p>http://mojolicious.org/</p><p>Address of the bookmark: <a href="http://mojolicious.org/" rel="nofollow">http://mojolicious.org/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/39190/chipulate-a-python3-framework-to-simulate-read-counts-in-a-chip-seq-experiment</guid>
	<pubDate>Mon, 25 Mar 2019 12:46:47 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/39190/chipulate-a-python3-framework-to-simulate-read-counts-in-a-chip-seq-experiment</link>
	<title><![CDATA[ChIPulate: A Python3 framework to simulate read counts in a ChIP-seq experiment]]></title>
	<description><![CDATA[<p><span style="color: #202020; font-size: 13px; font-style: normal; font-weight: 400; text-align: start; background-color: #ffffff; float: none;">ChIP-seq simulation pipeline, ChIPulate, we assess the impact of various biological and experimental sources of variation on several outcomes of a ChIP-seq experiment, viz., the recoverability of the TF binding motif, accuracy of TF-DNA binding detection, the sensitivity of inferred TF-DNA binding strength, and number of replicates needed to confidently infer binding strength.<span> <br></span></span></p><p>Address of the bookmark: <a href="https://github.com/vishakad/chipulate" rel="nofollow">https://github.com/vishakad/chipulate</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44481/unialigner-a-parameter-free-framework-for-fast-sequence-alignment</guid>
	<pubDate>Fri, 08 Mar 2024 23:36:12 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44481/unialigner-a-parameter-free-framework-for-fast-sequence-alignment</link>
	<title><![CDATA[UniAligner: a parameter-free framework for fast sequence alignment]]></title>
	<description><![CDATA[<p>UniAligner (formerly, TandemAligner) is the first parameter-free algorithm for sequence alignment that introduces a sequence-dependent alignment scoring that automatically changes for any pair of compared sequences. Classical alignment approaches, such as the Smith-Waterman algorithm, that work well for most sequences, fail to construct biologically adequate alignments of extra-long tandem repeats (ETRs), such as human centromeres and immunoglobulin loci. This limitation was overlooked in the previous studies since the sequences of the centromeres and other ETRs across multiple genomes only became available recently.</p>
<p>More at https://www.nature.com/articles/s41592-023-01970-4</p><p>Address of the bookmark: <a href="https://github.com/seryrzu/unialigner" rel="nofollow">https://github.com/seryrzu/unialigner</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
</item>

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