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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/39370?offset=70</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31064/cgaln</guid>
	<pubDate>Wed, 22 Feb 2017 05:14:15 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31064/cgaln</link>
	<title><![CDATA[Cgaln]]></title>
	<description><![CDATA[<p>Cgaln (Coarse grained alignment) is a program designed to align a pair of whole genomic sequences of not only bacteria but also entire chromosomes of vertebrates on a nominal desktop computer. Cgaln performs an alignment job in two steps, at the block level and then at the nucleotide level. The former "coarse-grained" alignment can explore genomic rearrangements and reduce the regions to be analyzed in the next step. The latter is devoted to detailed alignment within the limited regions found in the first stage. The output of Cgaln is 'glocal' in the sense that rearrangements are taken into consideration while each alignable region is extended as long as possible. Thus, Cgaln is not only fast and memory-efficient, but also can filter noisy outputs without missing the most important homologous segment pairs.</p>
<p>http://www.iam.u-tokyo.ac.jp/chromosomeinformatics/rnakato/cgaln/</p><p>Address of the bookmark: <a href="http://www.iam.u-tokyo.ac.jp/chromosomeinformatics/rnakato/cgaln/" rel="nofollow">http://www.iam.u-tokyo.ac.jp/chromosomeinformatics/rnakato/cgaln/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/30744/binc-2017</guid>
	<pubDate>Wed, 01 Feb 2017 09:36:22 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/30744/binc-2017</link>
	<title><![CDATA[BINC 2017]]></title>
	<description><![CDATA[<p><span>Pondicherry University,Puducherry,on behalf of Department of Biotechnology, Government of India, conducted the BINC examination in&nbsp;</span><span style="color: blue;">2015 and 2016.&nbsp;</span><span>The objective of this examination is to certify bioinformatics professionals, trained formally as well as self-trained.</span><span style="color: blue;">Registration for BINC 2017 examination will open from January 29,2017 to February 28,2017.</span><span>&nbsp;</span></p><p><span>Pondicherry University, Puducherry has been identified as a nodal agency by the Department of Biotechnology, Govt. of India to coordinate this examination along with nine centres namely, </span></p><p><span>Pune University, Pune; </span></p><p><span>Anna University, Chennai; </span></p><p><span>Bose Institute, Kolkata; </span></p><p><span>Institute of Bioinformatics &amp; Applied Biotechnology, Bangalore; </span></p><p><span>North-Eastern Hill University, Shillong, University of Hyderabad, Hyderabad; </span></p><p><span>University of Kerala, Thiruvananthapuram; </span></p><p><span>Jawaharlal Nehru University, New Delhi and </span></p><p><span>Assam Agricultural University, Guwahati.</span><span style="color: blue;"><strong>&nbsp;</strong></span></p><p><span style="color: blue;"><strong>In the BINC 2015 and 2016 examination, 23 candidates and five candidates were certified respectively.</strong></span><span>&nbsp;DBT has agreed to fund Research fellowships for all the BINC qualified Indian nationals to pursue Ph.D. in Indian Institutes/Universities. </span></p><p><span>Note that the candidate must possess a postgraduate degree(or equivalent) &amp; meet the criteria of the institutes/universities in order to avail research fellowship. </span></p><p><span>In addition, cash prize of Rs. 10,000/- will be awarded to the top 10 BINC qualifiers.</span></p><p><span>More at&nbsp;http://www.pondiuni.edu.in/exams/binc/</span></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30829/mercator</guid>
	<pubDate>Mon, 06 Feb 2017 04:20:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30829/mercator</link>
	<title><![CDATA[Mercator]]></title>
	<description><![CDATA[<p><span>Our basic strategy in building homology maps is to use exons that are orthologous in multiple genomes as map "anchors." Given K genomes, the steps in the map construction are as follows:</span></p>
<ul>
<li>For each genome, obtain a set of exon annotations. These annotations can be a combination of both exon predictions (e.g. Genscan) and annotations that have been experimentally verified (e.g. RefSeq). Ideally, we would like to have these annotations be as sensitive as possible. Specificity is not a concern, as incorrect annotations are not likely not have significant alignments with other gene annotations.</li>
<li>Compare all exons against all exons in other genomes and record significant alignments between exons. Currently, we use&nbsp;<a href="https://www.biostat.wisc.edu/~cdewey/mercator/#refBLAT">BLAT</a>&nbsp;to do this all-vs-all comparison with alignments being performed in protein space.</li>
<li>Construct a graph with each vertex corresponding to a exon and edges between vertices whose corresponding exons have significant alignments.</li>
<li>Identify cliques in this graph. These cliques are potential anchors to be used in the map.</li>
<li>Starting with the largest cliques (those that have exons in all or most of the genomes), join neighboring (adjacent in genomic coordinates, in each genome) cliques to form&nbsp;runs. Smaller cliques that are inconsistent with runs formed by larger cliques are filtered out. After the smallest cliques have been considered, cliques that are not part of a run are discarded.</li>
<li>The extents of each run in each genome are outputted as orthologous segments. The cliques from each run are used to output the exact genomic coordinates of anchors within each orthologous segment. These anchors can be used by genomic alignment programs (such as&nbsp;<a href="https://www.biostat.wisc.edu/~cdewey/mercator/#refMAVID">MAVID</a>) to do a detailed alignment of each orthologous segment.</li>
</ul>
<p>https://www.biostat.wisc.edu/~cdewey/mercator/</p><p>Address of the bookmark: <a href="https://www.biostat.wisc.edu/~cdewey/mercator/" rel="nofollow">https://www.biostat.wisc.edu/~cdewey/mercator/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/30889/phd-program-in-computer-science-at-university-of-essex</guid>
  <pubDate>Sat, 11 Feb 2017 13:11:36 -0600</pubDate>
  <link></link>
  <title><![CDATA[PhD program in Computer Science at University of Essex]]></title>
  <description><![CDATA[
<p>As part of the PhD program in Computer Science at University of Essex, I am looking for a PhD student in computational and synthetic biology.<br />The ideal candidate is interested in designing new biological design automation methods for genome scale projects and/or network modelling of genomic, transcriptomic and proteomic data.<br />Candidates interested in developing optimization algorithms for biological problems are encouraged to apply as well.<br />A summary of the research work in the lab can be found on o this page.</p>

<p>Candidates interested in the position should contact me in advance by email to: g.stracquadanio@essex.ac.uk</p>

<p>The deadline for the application is 28/02/2017; info about the application can be found on the Essex CSEE website.</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30966/maftools</guid>
	<pubDate>Thu, 16 Feb 2017 11:16:01 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30966/maftools</link>
	<title><![CDATA[MafTools]]></title>
	<description><![CDATA[<p>maftools - An R package to summarize, analyze and visualize MAF files. <a href="https://github.com/PoisonAlien/maftools#introduction"></a>Introduction.</p>
<p>With advances in Cancer Genomics, Mutation Annotation Format (MAF) is being widley accepted and used to store variants detected. <a href="http://cancergenome.nih.gov">The Cancer Genome Atlas</a> Project has seqenced over 30 different cancers with sample size of each cancer type being over 200. The <a href="https://wiki.nci.nih.gov/display/TCGA/TCGA+MAF+Files">resulting data</a> consisting of genetic variants is stored in the form of <a href="https://wiki.nci.nih.gov/display/TCGA/Mutation+Annotation+Format+%28MAF%29+Specification">Mutation Annotation Format</a>. This package attempts to summarize, analyze, annotate and visualize MAF files in an efficient manner either from TCGA sources or any in-house studies as long as the data is in MAF format. Maftools can also handle ICGC Simple Somatic Mutation format.</p>
<p>maftools is on <img src="https://assets-cdn.github.com/images/icons/emoji/unicode/1f449.png" alt=":point_right:" width="20" height="20" style="border: 0px;"> <a href="http://biorxiv.org/content/early/2016/05/11/052662">bioRxiv</a> <img src="https://assets-cdn.github.com/images/icons/emoji/bowtie.png" alt=":bowtie:" title=":bowtie:" width="20" height="20" style="border: 0px; text-align: absmiddle;"></p>
<p>Please cite the below if you find this tool useful for you.</p>
<p>Mayakonda, A. and H.P. Koeffler, Maftools: Efficient analysis, visualization and summarization of MAF files from large-scale cohort based cancer studies. bioRxiv, 2016. doi: <a href="http://dx.doi.org/10.1101/052662">http://dx.doi.org/10.1101/052662</a></p><p>Address of the bookmark: <a href="https://github.com/PoisonAlien/maftools" rel="nofollow">https://github.com/PoisonAlien/maftools</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/33691/annotationsketch</guid>
	<pubDate>Sun, 25 Jun 2017 17:54:22 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/33691/annotationsketch</link>
	<title><![CDATA[AnnotationSketch]]></title>
	<description><![CDATA[<p><span>The&nbsp;</span><em>AnnotationSketch</em><span>&nbsp;module is a versatile and efficient C-based drawing library for GFF3-compatible genomic annotations. It is included in the&nbsp;</span><em>GenomeTools</em><span>&nbsp;</span><a href="http://genometools.org/pub">distribution</a><span>. Additionally, bindings to the&nbsp;</span><a href="http://www.lua.org/">Lua</a><span>,&nbsp;</span><a href="http://www.python.org/">Python</a><span>&nbsp;and&nbsp;</span><a href="http://www.ruby-lang.org/en">Ruby</a><span>programming languages are provided.</span></p>
<p><span>http://genometools.org/annotationsketch.html</span></p><p>Address of the bookmark: <a href="http://genometools.org/annotationsketch.html" rel="nofollow">http://genometools.org/annotationsketch.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31123/biodownloader</guid>
	<pubDate>Sat, 25 Feb 2017 17:52:33 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31123/biodownloader</link>
	<title><![CDATA[BioDownloader]]></title>
	<description><![CDATA[<p><strong><em>BioDownloader</em></strong> is a program for downloading and/or updating files from ftp/http servers. The program has unique features that are specifically designed to deal with bioinformatics data files and servers:</p>
<ul>
<li>optimized to work with vast amount of data and very large file sets (~ 10,000 - 100,000).</li>
<li>allows the selective retrieval of only the required files (file masks, ls-lR parsing, recursive search, updates)</li>
<li>has a built-in repository containing the settings for the most common bioinformatics download needs</li>
<li>built-in wizard for batch post-processing of downloaded files (archive extraction, file conversion, etc.)</li>
<li>capable of performing multiple download or update tasks simultaneously</li>
</ul>
<p>BioDownloader has a built-in repository containing the settings for common bioinformatics file-synchronization needs, including the Protein Data Bank (PDB) and National Center for Biotechnology Information (NCBI) databases. It can post-process downloaded files, including archive extraction and file conversions.</p>
<p>http://dunbrack.fccc.edu/BioDownloader/</p><p>Address of the bookmark: <a href="http://dunbrack.fccc.edu/BioDownloader/" rel="nofollow">http://dunbrack.fccc.edu/BioDownloader/</a></p>]]></description>
	<dc:creator>Surabhi Chaudhary</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38515/genome-annotation-using-maker-tutorial</guid>
	<pubDate>Thu, 20 Dec 2018 17:39:23 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38515/genome-annotation-using-maker-tutorial</link>
	<title><![CDATA[Genome Annotation using MAKER tutorial !]]></title>
	<description><![CDATA[<p><a href="http://www.yandell-lab.org/software/maker.html">MAKER</a><span>&nbsp;is a great tool for annotating a reference genome using empirical and&nbsp;</span><em>ab initio</em><span>gene predictions.&nbsp;</span><a href="http://gmod.org/wiki/Main_Page">GMOD</a><span>, the umbrella organization that includes MAKER, has some nice tutorials online for running MAKER. However, these were quite simplified examples and it took a bit of effort to wrap my head completely around everything. Here I will describe a&nbsp;</span><em>de novo</em><span>&nbsp;genome annotation for&nbsp;</span><em>Boa constrictor</em><span>&nbsp;in detail, so that there is a record and that it is easy to use this as a guide to annotate any genome.</span></p><p>Address of the bookmark: <a href="https://www.biostars.org/p/261203/" rel="nofollow">https://www.biostars.org/p/261203/</a></p>]]></description>
	<dc:creator>Shruti Paniwala</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31024/dagchainer-computing-chains-of-syntenic-genes-in-complete-genomes</guid>
	<pubDate>Fri, 17 Feb 2017 16:13:35 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31024/dagchainer-computing-chains-of-syntenic-genes-in-complete-genomes</link>
	<title><![CDATA[DAGchainer: Computing Chains of Syntenic Genes in Complete Genomes]]></title>
	<description><![CDATA[<p>The DAGchainer software computes chains of syntenic genes found within complete genome sequences. As input, DAGchainer accepts a list of gene pairs with sequence homology along with their genome coordinates. Using a scoring function which accounts for the distance between neighboring genes on each DNA molecule and the BLAST E-value score between homologs, maximally scoring chains of ordered gene pairs are computed and reported. This algorithm can be used to mine large evolutionary conserved regions of genomes between two organisms. Alternatively, by examining colinear sets of homologous genes found within a single genome, segmental genome duplications can be revealed.</p>
<p>This software distribution includes both the DAGchainer utility and a Java-based graphical interface that allows the inputs and outputs to be navigated and interrogated dynamically.</p><p>Address of the bookmark: <a href="http://dagchainer.sourceforge.net/" rel="nofollow">http://dagchainer.sourceforge.net/</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31089/conpade-genome-assembly-ploidy-estimation-from-next-generation-sequencing-data</guid>
	<pubDate>Fri, 24 Feb 2017 04:55:41 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31089/conpade-genome-assembly-ploidy-estimation-from-next-generation-sequencing-data</link>
	<title><![CDATA[ConPADE: Genome Assembly Ploidy Estimation from Next-Generation Sequencing Data]]></title>
	<description><![CDATA[<p><span>ConPADE (Contig Ploidy and Allele Dosage Estimation), a probabilistic method that estimates the ploidy of any given contig/scaffold based on its allele proportions. In the process, they report findings regarding errors in sequencing. The method can be used for whole genome shotgun (WGS) sequencing data. They also show applicability of the method for variant calling and allele dosage estimation. Results for simulated and real datasets are discussed and provide evidence that ConPADE performs well as long as enough sequencing coverage is available, or the true contig ploidy is low.&nbsp;</span></p>
<p><span>https://github.com/microsoftgenomics</span></p><p>Address of the bookmark: <a href="https://github.com/microsoftgenomics" rel="nofollow">https://github.com/microsoftgenomics</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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