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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/40611?offset=320</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44581/biokit-a-set-of-tools-dedicated-to-bioinformatics-data-visualisation</guid>
	<pubDate>Tue, 18 Jun 2024 02:04:39 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44581/biokit-a-set-of-tools-dedicated-to-bioinformatics-data-visualisation</link>
	<title><![CDATA[BioKit: a set of tools dedicated to bioinformatics, data visualisation]]></title>
	<description><![CDATA[<p><span>BioKit is a set of tools dedicated to bioinformatics, data visualisation (</span><a href="https://biokit.readthedocs.io/en/latest/references.html#module-biokit.viz" title="biokit.viz"><code><span>biokit.viz</span></code></a><span>), access to online biological data (e.g. UniProt, NCBI thanks to bioservices). It also contains more advanced tools related to data analysis (e.g.,&nbsp;</span><a href="https://biokit.readthedocs.io/en/latest/references.html#module-biokit.stats" title="biokit.stats"><code><span>biokit.stats</span></code></a><span>). Since R is quite common in bioinformatics, we also provide a convenient module to run R inside your Python scripts or shell (:mod:biokit.rtools module).</span></p><p>Address of the bookmark: <a href="https://biokit.readthedocs.io/en/latest/index.html" rel="nofollow">https://biokit.readthedocs.io/en/latest/index.html</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/10741/managing-and-analyzing-next-generation-sequence-data</guid>
	<pubDate>Sat, 10 May 2014 06:28:06 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/10741/managing-and-analyzing-next-generation-sequence-data</link>
	<title><![CDATA[Managing and Analyzing Next-Generation Sequence Data]]></title>
	<description><![CDATA[<p>Centralized Bioinformatics Core Facilities provide shared resources for the computational and IT requirements of the investigators in their department or institution. As such, they must be able to effectively react to new types of experimental technology. Recently faced with an unprecedented flood of data generated by the next generation of DNA sequencers, these groups found it necessary to respond quickly and efficiently to the informatics and infrastructure demands. Centralized Facilities newly facing this challenge need to anticipate time and design considerations of necessary components, including infrastructure upgrades, staffing, and tools for data analyses and management ...</p>
<p>More at http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369</p><p>Address of the bookmark: <a href="http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369" rel="nofollow">http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/33869/import-r-data</guid>
	<pubDate>Wed, 12 Jul 2017 08:30:46 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/33869/import-r-data</link>
	<title><![CDATA[Import R Data]]></title>
	<description><![CDATA[<p>It is often necessary to import sample textbook data into R before you start working on your homework.</p><div id="node-69"><div><p><strong>Excel File</strong></p><p>Quite frequently, the sample data is in&nbsp;<span>Excel&nbsp;</span>format, and needs to be imported into R prior to use. For this, we can use the function&nbsp;<span>read.xls&nbsp;</span>from the&nbsp;<span>gdata&nbsp;</span>package. It reads from an Excel spreadsheet and returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/data-frame">data frame</a>. The following shows how to load an Excel spreadsheet named&nbsp;<span>"mydata.xls"</span>. This method requires Perl runtime to be present in the system.</p><blockquote><div id="listing-68"><span><a></a></span>&gt;&nbsp;library(gdata)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;gdata&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.xls)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.xls("mydata.xls")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;first&nbsp;sheet</div></blockquote><p>Alternatively, we can use the function&nbsp;<span>loadWorkbook&nbsp;</span>from the&nbsp;<span>XLConnect&nbsp;</span>package to read the entire workbook, and then load the worksheets with&nbsp;<span>readWorksheet</span>. The&nbsp;<span>XLConnect&nbsp;</span>package requires Java to be pre-installed.</p><blockquote><div id="listing-69"><span><a></a></span>&gt;&nbsp;library(XLConnect)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;XLConnect&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;wk&nbsp;=&nbsp;loadWorkbook("mydata.xls")&nbsp;<br /><span><a></a></span>&gt;&nbsp;df&nbsp;=&nbsp;readWorksheet(wk,&nbsp;sheet="Sheet1")</div></blockquote><p>&nbsp;</p><h4><a></a>Minitab File</h4><p>If the data file is in&nbsp;<span>Minitab Portable Worksheet&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.mtp&nbsp;</span>from the&nbsp;<span>foreign&nbsp;</span>package. It returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/list">list</a>&nbsp;of components in the Minitab worksheet.</p><blockquote><div id="listing-70"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.mtp)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.mtp("mydata.mtp")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;.mtp&nbsp;file</div></blockquote><p>&nbsp;</p><h4><a></a>SPSS File</h4><p>For the data files in&nbsp;<span>SPSS&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.spss&nbsp;</span>also from the&nbsp;<span>foreign&nbsp;</span>package. There is a&nbsp;<span>"to.data.frame"&nbsp;</span>option for choosing whether a data frame is to be returned. By default, it returns a list of components instead.</p><blockquote><div id="listing-71"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.spss)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.spss("myfile",&nbsp;to.data.frame=TRUE)</div></blockquote><p>&nbsp;</p><h4><a></a>Table File</h4><p>A data table can resides in a text file. The cells inside the table are separated by blank characters. Here is an example of a table with 4 rows and 3 columns.</p><blockquote><div id="listing-72"><span><a></a></span>100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3&nbsp;<br /><span><a></a></span>400&nbsp;&nbsp;&nbsp;a4&nbsp;&nbsp;&nbsp;b4</div></blockquote><p>Now copy and paste the table above in a file named&nbsp;<span>"mydata.txt"&nbsp;</span>with a text editor. Then load the data into the workspace with the function&nbsp;<span>read.table</span>.</p><blockquote><div id="listing-73"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.table("mydata.txt")&nbsp;&nbsp;#&nbsp;read&nbsp;text&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;print&nbsp;data&nbsp;frame&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;&nbsp;V1&nbsp;V2&nbsp;V3&nbsp;<br /><span><a></a></span>1&nbsp;100&nbsp;a1&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;200&nbsp;a2&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;300&nbsp;a3&nbsp;b3&nbsp;<br /><span><a></a></span>4&nbsp;400&nbsp;a4&nbsp;b4</div></blockquote><p>For further detail of the function&nbsp;<span>read.table</span>, please consult the R documentation.</p><blockquote><div id="listing-74"><span><a></a></span>&gt;&nbsp;help(read.table)</div></blockquote><p>&nbsp;</p><h4><a></a>CSV File</h4><p>The sample data can also be in&nbsp;<span>comma separated values&nbsp;</span>(CSV) format. Each cell inside such data file is separated by a special character, which usually is a comma, although other characters can be used as well.</p><p>The first row of the data file should contain the column names instead of the actual data. Here is a sample of the expected format.</p><blockquote><div id="listing-75"><span><a></a></span>Col1,Col2,Col3&nbsp;<br /><span><a></a></span>100,a1,b1&nbsp;<br /><span><a></a></span>200,a2,b2&nbsp;<br /><span><a></a></span>300,a3,b3</div></blockquote><p>After we copy and paste the data above in a file named&nbsp;<span>"mydata.csv"&nbsp;</span>with a text editor, we can read the data with the function&nbsp;<span>read.csv</span>.</p><blockquote><div id="listing-76"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.csv("mydata.csv")&nbsp;&nbsp;#&nbsp;read&nbsp;csv&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;Col1&nbsp;Col2&nbsp;Col3&nbsp;<br /><span><a></a></span>1&nbsp;&nbsp;100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;&nbsp;200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;&nbsp;300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3</div></blockquote><p>In various European locales, as the comma character serves as the decimal point, the function&nbsp;<span>read.csv2&nbsp;</span>should be used instead. For further detail of the&nbsp;<span>read.csv&nbsp;</span>and&nbsp;<span>read.csv2&nbsp;</span>functions, please consult the R documentation.</p><blockquote><div id="listing-77"><span><a></a></span>&gt;&nbsp;help(read.csv)</div></blockquote><p>&nbsp;</p><h4><a></a>Working Directory</h4><p>Finally, the code samples above assume the data files are located in the R&nbsp;<span>working</span>&nbsp;<span>directory</span>, which can be found with the function&nbsp;<span>getwd</span>.</p><blockquote><div id="listing-78"><span><a></a></span>&gt;&nbsp;getwd()&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;get&nbsp;current&nbsp;working&nbsp;directory</div></blockquote><p>You can select a different working directory with the function&nbsp;<span>setwd()</span>, and thus avoid entering the full path of the data files.</p><blockquote><div id="listing-79"><span><a></a></span>&gt;&nbsp;setwd("")&nbsp;&nbsp;&nbsp;#&nbsp;set&nbsp;working&nbsp;directory</div></blockquote><p>Note that the forward slash should be used as the path separator even on Windows platform.</p><blockquote><div id="listing-80"><span><a></a></span>&gt;&nbsp;setwd("C:/MyDoc")</div></blockquote></div></div>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/42324/comparative-genomics-data-set-including-240-mammals-released</guid>
	<pubDate>Thu, 19 Nov 2020 06:45:39 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/42324/comparative-genomics-data-set-including-240-mammals-released</link>
	<title><![CDATA[Comparative Genomics Data Set Including 240 Mammals Released !]]></title>
	<description><![CDATA[<p>The genome of 130 mammals was sequenced by a large international consortium and the data was analyzed together with 110 existing genomes to allow scientists to identify the important positions in the DNA. This report, published in Nature today will help advance research on human disease mutations and inform how best to protect endangered species.</p><p>In addition to the knowledge of the human genome, all these genomes, widely sampled across mammals, can be used to research how particular organisms respond to different conditions. Some otters, for example, have a thick, water-resistant shell, and some rodents, but not all, have adapted to hibernation. These animal traits will help us to understand human traits, such as metabolic diseases.</p><p><img src="https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41586-020-2876-6/MediaObjects/41586_2020_2876_Fig1_HTML.png?as=webp" alt="image" style="border: 0px; border: 0px;"></p><p>With climate change and more animal ecosystems being threatened by human activity, the protection of endangered species is becoming increasingly important. Scientists have historically researched several people in various populations of a species to understand the genetic variation that occurs in that species. This is important for understanding how particular species can be protected. In this study, animals on the Red List of Endangered Species of the International Union for Conservation of Nature had fewer differences in their genomes, which is consistent with their endangered status.</p><p>Ref @&nbsp;A comparative genomics multitool for scientific discovery and conservation&nbsp;https://www.nature.com/articles/s41586-020-2876-6</p><p>&nbsp;Data at&nbsp;http://zoonomiaproject.org/</p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44557/fundamentals-of-data-visualization-by-claus-o-wilke</guid>
	<pubDate>Sat, 08 Jun 2024 16:07:19 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44557/fundamentals-of-data-visualization-by-claus-o-wilke</link>
	<title><![CDATA[Fundamentals of Data Visualization by Claus O. Wilke]]></title>
	<description><![CDATA[<p><span><span>The book is meant as a guide to making visualizations that accurately reflect the data, tell a story, and look professional. It has grown out of my experience of working with students and postdocs in my laboratory on thousands of data visualizations. Over the years, I have noticed that the same issues arise over and over. I have attempted to collect my accumulated knowledge from these interactions in the form of this book.</span></span></p>
<p><span>The entire book is written in R Markdown, using RStudio as my text editor and the&nbsp;</span><span>bookdown</span><span>&nbsp;package to turn a collection of markdown documents into a coherent whole. The book&rsquo;s source code is hosted on GitHub, at&nbsp;</span><a href="https://github.com/clauswilke/dataviz">https://github.com/clauswilke/dataviz</a><span>.&nbsp;</span></p><p>Address of the bookmark: <a href="https://clauswilke.com/dataviz/" rel="nofollow">https://clauswilke.com/dataviz/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42985/janggu-deep-learning-for-genomics</guid>
	<pubDate>Tue, 23 Mar 2021 05:14:43 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42985/janggu-deep-learning-for-genomics</link>
	<title><![CDATA[Janggu - Deep learning for Genomics]]></title>
	<description><![CDATA[<p><span>Janggu is a python package that facilitates deep learning in the context of genomics. The package is freely available under a GPL-3.0 license.</span></p>
<p><span>Detail tutorial at&nbsp;https://janggu.readthedocs.io/en/latest/</span></p>
<p><span>USE cases</span></p>
<p><span>https://github.com/wkopp/janggu_usecases</span></p><p>Address of the bookmark: <a href="https://github.com/BIMSBbioinfo/janggu" rel="nofollow">https://github.com/BIMSBbioinfo/janggu</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/2423/cancers-origins-revealed</guid>
	<pubDate>Thu, 15 Aug 2013 13:06:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/2423/cancers-origins-revealed</link>
	<title><![CDATA[Cancer's origins revealed]]></title>
	<description><![CDATA[<p>Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.<br /><br />More at &gt;&gt; http://www.sanger.ac.uk/about/press/2013/130814.html</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/3918/the-human-genome-project-video-3d-animation-introduction-low</guid>
	<pubDate>Sat, 24 Aug 2013 19:01:19 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/3918/the-human-genome-project-video-3d-animation-introduction-low</link>
	<title><![CDATA[The Human Genome Project Video   3D Animation Introduction Low)]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/YxoQFSBwyms" frameborder="0" allowfullscreen></iframe>]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/4762/how-dna-is-packaged-advanced</guid>
	<pubDate>Mon, 23 Sep 2013 18:08:34 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/4762/how-dna-is-packaged-advanced</link>
	<title><![CDATA[How DNA is Packaged (Advanced)]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/gbSIBhFwQ4s" frameborder="0" allowfullscreen></iframe>Each chromosome consists of one continuous thread-like molecule of DNA coiled tightly around proteins, and contains a portion of the 6,400,000,000 basepairs (DNA building blocks) that make up your DNA. 
Originally created for DNA Interactive ( http://www.dnai.org ).
TRANSCRIPT: In this animation we'll see the remarkable way our DNA is tightly packed up to fit into the nucleus of every cell. The process starts with assembly of a nucleosome, which is formed when eight separate histone protein subunits attach to the DNA molecule. The combined tight loop of DNA and protein is the nucleosome. Six nucleosomes are coiled together and these then stack on top of each other. The end result is a fiber of packed nucleosomes known as chromatin. This structure, is then looped and further packaged using other proteins (which are not shown here) to give the final "chromosomal" shapes. It is this remarkable multiple folding which allows six feet of DNA to fit into the nucleus of each cell in our body. And a typical cell nucleus is so small that ten thousand could fit on the tip of a needle. It is important to realize that chromosomes are not always present, they form only when cells are dividing. At other times, as we can see here at the end of cell division, our DNA becomes less highly organized.)]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42965/nucl2vec-local-alignment-of-dna-sequences-using-distributed-vector-representation</guid>
	<pubDate>Tue, 16 Mar 2021 05:45:44 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42965/nucl2vec-local-alignment-of-dna-sequences-using-distributed-vector-representation</link>
	<title><![CDATA[Nucl2Vec: Local alignment of DNA sequences using Distributed Vector Representation]]></title>
	<description><![CDATA[<p><span>We demonstrate a novel approach for</span><span>local alignment of DNA reads with respect to reference genome.</span><span>For this process we have used Skip-gram model for creating</span><span>encoding(Nucl2Vec) and k-nearest neighbor for the alignment.</span><span>With our new approach we have reduced computation cost for</span><span>local alignment , while achieving accuracy comparable to existing</span><span>defacto standard BWA-MEM tool.</span> </p>
<p><em>https://prakharg24.github.io/papers/401851.full.pdf</em></p><p>Address of the bookmark: <a href="https://prakharg24.github.io/papers/401851.full.pdf" rel="nofollow">https://prakharg24.github.io/papers/401851.full.pdf</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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