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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/4183?offset=100</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/38226/ncbi-to-assist-in-virus-hunting-data-science-hackathon</guid>
	<pubDate>Thu, 15 Nov 2018 12:55:01 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/38226/ncbi-to-assist-in-virus-hunting-data-science-hackathon</link>
	<title><![CDATA[NCBI to assist in Virus Hunting Data Science Hackathon]]></title>
	<description><![CDATA[<p>NCBI Hackathon are pleased to announce the second installment of the&nbsp;<a href="https://ncbiinsights.ncbi.nlm.nih.gov/2017/11/30/ncbi-southern-california-genomics-hackathon-january/" target="_blank">SoCal Bioinformatics Hackathon</a>. From January 9-11, 2019, the&nbsp;<a href="https://www.ncbi.nlm.nih.gov/" target="_blank">NCBI</a>&nbsp;will help run a bioinformatics hackathon in Southern California hosted by the&nbsp;<a href="http://www.csrc.sdsu.edu/" target="_blank">Computational Sciences Research Center</a>&nbsp;at&nbsp;<a href="http://www.sdsu.edu/" target="_blank">San Diego State University</a>!</p><p><span>NCBI Hackathon</span>&nbsp;specifically looking for folks who have experience in computational virus hunting or adjacent fields to identify known, taxonomically-definable and novel viruses from a few hundred thousand metagenomic datasets that we&rsquo;ll put on cloud infrastructure. This event is for researchers, including students and postdocs, who are already engaged in the use of bioinformatics data or in the development of pipelines for virological analyses from high-throughput experiments. If this describes you, please&nbsp;<a href="https://goo.gl/forms/kDnSG0IAZD62XQRe2" target="_blank">apply</a>! The event is open to anyone selected for the hackathon and willing to travel to SDSU (see below).</p><p>https://ncbiinsights.ncbi.nlm.nih.gov/2018/11/09/ncbi-sdsu-virus-hunting-data-science-hackathon-january-2019/</p>]]></description>
	<dc:creator>BioStar</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44173/mpxv-bookmarks</guid>
	<pubDate>Mon, 19 Dec 2022 01:58:20 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44173/mpxv-bookmarks</link>
	<title><![CDATA[MPXV Bookmarks]]></title>
	<description><![CDATA[<p>MPVX infection across the globe</p>
<p><a href="https://www.google.com/url?q=https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html&amp;sa=D&amp;source=docs&amp;ust=1671439883060005&amp;usg=AOvVaw39WwSqp2A5TD8KjRvaaxzW" target="_blank">https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html</a></p><p>Address of the bookmark: <a href="https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html" rel="nofollow">https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41886/coronavirus-sars-cov-2</guid>
	<pubDate>Wed, 17 Jun 2020 11:18:24 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41886/coronavirus-sars-cov-2</link>
	<title><![CDATA[Coronavirus SARS-CoV-2]]></title>
	<description><![CDATA[<p><span>Used Nanographics Vj, our real-time molecular visualization and animation software, to create this video showing the structure of the virus. In the video, you can see the latest theory on how the RNA is organized inside of the virus particle.</span></p>
<p><span><span>On this page, you can download&nbsp;</span><a href="https://nanographics.at/projects/sars-cov-2/sars-cov-2-renders.zip">high resolution images</a><span>&nbsp;of our renderings. We made them with transparent background, so that you can use it in your work. As the research progresses, we will keep updating the model as well as the images on this page, so stay tuned!</span></span></p>
<p>&nbsp;</p><p>Address of the bookmark: <a href="https://nanographics.at/projects/sars-cov-2/" rel="nofollow">https://nanographics.at/projects/sars-cov-2/</a></p>]]></description>
	<dc:creator>Shruti Paniwala</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/2423/cancers-origins-revealed</guid>
	<pubDate>Thu, 15 Aug 2013 13:06:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/2423/cancers-origins-revealed</link>
	<title><![CDATA[Cancer's origins revealed]]></title>
	<description><![CDATA[<p>Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.<br /><br />More at &gt;&gt; http://www.sanger.ac.uk/about/press/2013/130814.html</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/4297/how-genes-are-regulated-transcription-factors</guid>
	<pubDate>Thu, 05 Sep 2013 16:54:19 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/4297/how-genes-are-regulated-transcription-factors</link>
	<title><![CDATA[How Genes are Regulated: Transcription Factors]]></title>
	<description><![CDATA[<iframe src="http://player.vimeo.com/video/30034882?byline=0" width="" height="" frameborder="0" webkitAllowFullScreen allowFullScreen></iframe>Each cell in our body inherits the same master copy of DNA, but different cell types use it differently. Transcription Factors help influence which genes are used in which cell. Understanding how these dynamic proteins physically interact with DNA allows us to better understand and model their binding to DNA and their regulation of gene expression.  Scientific Direction by the Wasserman Lab at the University of British Columbia: http://www.cmmt.ubc.ca/research/investigators/wasserman/lab  Animation and editing by Blair Lyons of Stroma Studios: http://www.stromastudios.com]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/4943/molecular-genetics-lecture</guid>
	<pubDate>Fri, 27 Sep 2013 04:24:45 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/4943/molecular-genetics-lecture</link>
	<title><![CDATA[Molecular Genetics Lecture]]></title>
	<description><![CDATA[<p><span>"Robert Sapolsky makes interdisciplinary connections between behavioral biology and molecular genetic influences. He relates protein synthesis and point mutations to microevolutionary change, and discusses conflicting theories of gradualism and punctuated equilibrium and the influence of epigenetics on development theories."&nbsp;</span></p>
<p><span>"<span><strong>Robert Sapolsky</strong> is an American neuroendocrinologist, professor of biology, neuroscience, and neurosurgery at Stanford University, researcher and author" ----Wikipedia</span></span></p><p>Address of the bookmark: <a href="http://www.youtube.com/watch?v=_dRXA1_e30o" rel="nofollow">http://www.youtube.com/watch?v=_dRXA1_e30o</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/8639/edit-dna</guid>
	<pubDate>Wed, 05 Mar 2014 02:27:54 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/8639/edit-dna</link>
	<title><![CDATA[Edit DNA !!!]]></title>
	<description><![CDATA[<p>A genome-engineering tool known as Crispr may allow scientists to alter the DNA of humans, animals and plants, a research breakthrough that promises to make a significant impact on science and fighting diseases, according to a <a href="http://www.nytimes.com/2014/03/04/health/a-powerful-new-way-to-edit-dna.html">March 3 story in the <em>New York Times</em></a>. Scientists hope Crispr might also be used for genomic surgery, as it were, to correct errant genes that cause disease.</p><p>A rescently publication paper ( http://jb.asm.org/content/169/12/5429.long )shows significance of an unusual repeated DNA sequences next to a gene in a common bacterium, and their scientific significance. The sequences, it turns out, are part of a sophisticated immune system that bacteria use to fight viruses. And that system, whose very existence was unknown until about seven years ago, may provide scientists with unprecedented power to rewrite the code of life. This means a genome can be edited, much as a writer might change words or fix spelling errors. It allows &ldquo;customizing the genome of any cell or any species at will,&rdquo;.</p><p>Reference:</p><p>http://www.prweb.com/releases/2014/03/prweb11636031.htm</p><p>http://www.nytimes.com/2014/03/04/health/a-powerful-new-way-to-edit-dna.html?hpw&amp;rref=health</p><p>http://jb.asm.org/content/169/12/5429.long</p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30831/fsa-fast-statistical-alignment</guid>
	<pubDate>Mon, 06 Feb 2017 04:26:01 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30831/fsa-fast-statistical-alignment</link>
	<title><![CDATA[FSA: Fast Statistical Alignment]]></title>
	<description><![CDATA[<p><span>FSA is a probabilistic multiple sequence alignment algorithm which uses a "distance-based" approach to aligning homologous protein, RNA or DNA sequences. Much as distance-based phylogenetic reconstruction methods like Neighbor-Joining build a phylogeny using only pairwise divergence estimates, FSA builds a multiple alignment using only pairwise estimations of homology. This is made possible by the sequence annealing technique for constructing a multiple alignment from pairwise comparisons, developed by Ariel Schwartz in&nbsp;</span><a href="http://www.eecs.berkeley.edu/Pubs/TechRpts/2007/EECS-2007-39.html">"Posterior Decoding Methods for Optimization and Control of Multiple Alignments</a><span>."</span></p>
<p>FSA brings the high accuracies previously available only for small-scale analyses of proteins or RNAs to large-scale problems such as aligning thousands of sequences or megabase-long sequences. FSA introduces several novel methods for constructing better alignments:</p>
<ul>
<li>FSA uses machine-learning techniques to estimate gap and substitution parameters on the fly for each set of input sequences. This "query-specific learning" alignment method makes FSA very robust: it can produce superior alignments of sets of homologous sequences which are subject to very different evolutionary constraints.</li>
<li>FSA is capable of aligning hundreds or even thousands of sequences using a randomized inference algorithm to reduce the computational cost of multiple alignment. This randomized inference can be over ten times faster than a direct approach with little loss of accuracy.</li>
<li>FSA can quickly align very long sequences using the "anchor annealing" technique for resolving anchors and projecting them with transitive anchoring. It then stitches together the alignment between the anchors using the methods described above.</li>
<li>The included GUI, MAD (Multiple Alignment Display), can display the intermediate alignments produced by FSA, where each character is colored according to the probability that it is correctly aligned (see the picture and&nbsp;<a href="http://fsa.sourceforge.net/images/Suchard_SIV.fsa.mov">movie</a>&nbsp;at the top of the page).</li>
</ul>
<p><span>You can see more information on the&nbsp;</span><a href="http://fsa.sourceforge.net/FAQ.html">FAQ</a><span>.&nbsp;</span></p>
<p>&nbsp;</p><p>Address of the bookmark: <a href="http://fsa.sourceforge.net/" rel="nofollow">http://fsa.sourceforge.net/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/32465/tetra-nucleotide-analysis</guid>
	<pubDate>Thu, 04 May 2017 05:07:41 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/32465/tetra-nucleotide-analysis</link>
	<title><![CDATA[Tetra-Nucleotide Analysis]]></title>
	<description><![CDATA[<p>A tetra-nucleotide is a fragment of DNA sequence with 4 bases (e.g. AGTC or TTGG). Pride&nbsp;<em>et al.</em>&nbsp;(2003) showed that the frequency of tetra-nucleotides in bacterial genomes contain useful, albeit weak, phylogenetic signals. Even though tetra-nucleotide analysis (TNA) utilizes the information of whole genome, it is evident that it cannot replace other alignment-based phylogenetic methods such as&nbsp;<a href="https://chunlab.wordpress.com/orthoani/">OrthoANI</a>&nbsp;or&nbsp;16S rRNA phylogeny. However, TNA can be useful for&nbsp;phylogenetic characterization when whole genome or 16S rRNA gene information is not available. For example, a partial genomic fragment obtained from a metagenome can be identified by TNA (Teeling&nbsp;<em>et al.</em>, 2004). TNA is also fast enough that it can be&nbsp;used&nbsp;as a search engine against a large genome database.</p><p>Address of the bookmark: <a href="https://chunlab.wordpress.com/tetra-nucleotide-analysis/" rel="nofollow">https://chunlab.wordpress.com/tetra-nucleotide-analysis/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34386/slidesort-bpr</guid>
	<pubDate>Mon, 20 Nov 2017 09:19:52 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34386/slidesort-bpr</link>
	<title><![CDATA[SLIDESORT-BPR]]></title>
	<description><![CDATA[<p>Chromosomal rearrangement events are caused by abnormal breaking and rejoining of DNA molecules. They are responsible for many of the cancer related diseases. Detecting the DNA breaking and repairing mechanism, therefore, may offer vital clues about the pathologic causes and diagnostic/therapeutic target of these diseases. But this effort also poses considerable challenges, because the structural variations and the genomes are different from one person to another. Intermediate comparison via reference genome could lead to the loss information. Unlike the current methods which make use the reference genome, we developed a method to detect the breakpoint reads directly from observing the differences between two (or more) NGS short reads samples. Slidesort-BPR is a command line tool implemented in C++.</p><p>Address of the bookmark: <a href="https://github.com/ewijaya/slidesort-bpr" rel="nofollow">https://github.com/ewijaya/slidesort-bpr</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
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