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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/42042?offset=50</link>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/28997/braker-pipeline-for-fully-automated-prediction-of-protein-coding-genes-with-genemark-eset-and-augustus-in-novel-eukaryotic-genomes</guid>
	<pubDate>Thu, 01 Sep 2016 08:02:59 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/28997/braker-pipeline-for-fully-automated-prediction-of-protein-coding-genes-with-genemark-eset-and-augustus-in-novel-eukaryotic-genomes</link>
	<title><![CDATA[BRAKER: pipeline for fully automated prediction of protein coding genes with GeneMark-ES/ET and AUGUSTUS in novel eukaryotic genomes]]></title>
	<description><![CDATA[<p><span>Gene finding in eukaryotic genomes is notoriously difficult to automate. The task is to design a work flow with a minimal set of tools that would reach state-of-the-art performance across a wide range of species. GeneMark-ET is a gene prediction tool that incorporates RNA-Seq data into unsupervised training and subsequently generates ab initio gene predictions. AUGUSTUS is a gene finder that usually requires supervised training and uses information from RNA-Seq reads in the prediction step. Complementary strengths of GeneMark-ET and AUGUSTUS provided motivation for designing a new combined tool for automatic gene prediction.</span></p>
<p>http://www.ncbi.nlm.nih.gov/pubmed/26559507</p><p>Address of the bookmark: <a href="http://bioinf.uni-greifswald.de/bioinf/braker/" rel="nofollow">http://bioinf.uni-greifswald.de/bioinf/braker/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/32379/enrichr-a-comprehensive-gene-set-enrichment-analysis</guid>
	<pubDate>Thu, 27 Apr 2017 05:42:09 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/32379/enrichr-a-comprehensive-gene-set-enrichment-analysis</link>
	<title><![CDATA[Enrichr: a comprehensive gene set enrichment analysis]]></title>
	<description><![CDATA[<p><span>Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at:&nbsp;</span><a href="http://amp.pharm.mssm.edu/Enrichr" target="">http://amp.pharm.mssm.edu/Enrichr</a><span>.</span></p>
<p>https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw377</p><p>Address of the bookmark: <a href="http://amp.pharm.mssm.edu/Enrichr/" rel="nofollow">http://amp.pharm.mssm.edu/Enrichr/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/33791/slactree-svg-large-annotated-circular-tree-drawing</guid>
	<pubDate>Mon, 03 Jul 2017 08:02:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/33791/slactree-svg-large-annotated-circular-tree-drawing</link>
	<title><![CDATA[slacTree: SVG Large Annotated Circular Tree drawing]]></title>
	<description><![CDATA[<p>A simple, extensible, Perl script for producing figures of large phylogenetic trees.</p>
<ul>
<li>While there are many other tree drawing programs, slacTree was originally written in 2009 to fill a need for producing publication quality figures of circular trees with more than 1000 taxa with custom annotations</li>
<li>Because it is a single Perl script with very few dependencies, it is easy to run, and easy to further customize</li>
<li>SVG is used because it is a scalable format allowing for very small representations of entire trees or highly magnified regions with unlimited resolution</li>
<li>Circular and radial trees are more compact than linear representations</li>
<li></li>
</ul>
<h2>&nbsp;</h2><p>Address of the bookmark: <a href="https://github.com/mccrowjp/slacTree" rel="nofollow">https://github.com/mccrowjp/slacTree</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/37957/base-a-practical-de-novo-assembler-for-large-genomes-using-long-ngs-reads</guid>
	<pubDate>Fri, 19 Oct 2018 07:25:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/37957/base-a-practical-de-novo-assembler-for-large-genomes-using-long-ngs-reads</link>
	<title><![CDATA[BASE: a practical de novo assembler for large genomes using long NGS reads]]></title>
	<description><![CDATA[<p><span>new&nbsp;</span><em>de novo</em><span>&nbsp;assembler called BASE. It enhances the classic seed-extension approach by indexing the reads efficiently to generate adaptive seeds that have high probability to appear uniquely in the genome. Such seeds form the basis for BASE to build extension trees and then to use reverse validation to remove the branches based on read coverage and paired-end information, resulting in high-quality consensus sequences of reads sharing the seeds. Such consensus sequences are then extended to contigs.</span></p><p>Address of the bookmark: <a href="https://github.com/dhlbh/BASE" rel="nofollow">https://github.com/dhlbh/BASE</a></p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40699/kevler-reference-free-variant-discovery-in-large-eukaryotic-genomes</guid>
	<pubDate>Tue, 28 Jan 2020 03:21:53 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40699/kevler-reference-free-variant-discovery-in-large-eukaryotic-genomes</link>
	<title><![CDATA[Kevler: Reference-free variant discovery in large eukaryotic genomes]]></title>
	<description><![CDATA[<p><span>Welcome to&nbsp;</span><span>kevlar</span><span>, software for predicting&nbsp;</span><em>de novo</em><span>&nbsp;genetic variants without mapping reads to a reference genome! kevlar's&nbsp;</span><em>k</em><span>-mer abundance based method calls single nucleotide variants (SNVs), multinucleotide variants (MNVs), insertion/deletion variants (indels), and structural variants (SVs) simultaneously with a single simple model.&nbsp;</span></p>
<p><span>More at&nbsp;<a href="https://kevlar.readthedocs.io/en/latest/">https://kevlar.readthedocs.io/en/latest/</a></span></p>
<p><span><a href="https://www.cell.com/iscience/pdf/S2589-0042(19)30259-7.pdf">https://www.cell.com/iscience/pdf/S2589-0042(19)30259-7.pdf</a></span></p><p>Address of the bookmark: <a href="https://github.com/kevlar-dev/kevlar" rel="nofollow">https://github.com/kevlar-dev/kevlar</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/34146/phylogenetic-molecular-genetics-terms-and-definitions</guid>
	<pubDate>Tue, 08 Aug 2017 08:20:31 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/34146/phylogenetic-molecular-genetics-terms-and-definitions</link>
	<title><![CDATA[Phylogenetic &amp; Molecular Genetics Terms and Definitions]]></title>
	<description><![CDATA[<p><strong>analog </strong>-- A feature that appears similar in two taxa which have originated from two different ancestors.</p><p><strong>ancestor</strong> -- Any organism, population, or species from which some other organism, population, or species is descended by reproduction.</p><p><strong>apomorphy </strong>-- specialized (=derived) characters of an organism.</p><p><strong>basal group</strong> -- The earliest diverging group within a clade; for instance, to hypothesize that sponges are basal animals is to suggest that the lineage(s) leading to sponges diverged from the lineage that gave rise to all other animals.</p><p><strong>biological classification </strong>-- The orderly arrangement of organisms in hierarchical system that ideally reflects evolutionary history.</p><p><strong>cDNA</strong> -- Complementary DNA; DNA that is synthesized, by reverse transcriptase, from a Messenger RNA template ( Messenger RNA contains the coded information for protein synthesis).</p><p><strong>character</strong> -- Heritable trait possessed by an organism.</p><p><strong>character state</strong> -- characters are usually described in terms of their states, for example: "hair present" vs. "hair absent," where "hair" is the character, and "present" and "absent" are its states.</p><p><strong>clade</strong> -- A monophyletic taxon; a group of organisms which includes the most recent common ancestor of all of its members and all of the descendants of that most recent common ancestor. From the Greek word "klados", meaning branch or twig.</p><p><strong>cladogenesis</strong> -- The development of a new clade; the splitting of a single lineage into two distinct lineages; speciation.</p><p><strong>cladogram</strong> -- A diagram, resulting from a cladistic analysis, which depicts a hypothetical branching sequence of lineages leading to the taxa under consideration. The points of branching within a cladogram are called nodes. All taxa occur at the endpoints of the cladogram.</p><p><strong>convergence</strong> -- Similarities which have arisen independently in two or more organisms that are not closely related. Contrast with homology.&nbsp;</p><p><strong>crown group</strong> -- All the taxa descended from a major cladogenesis event, recognized by possessing the clade's synapomorphy. See: stem group.</p><p><strong>derived</strong> -- Describes a character state that is present in one or more subclades, but not all, of a clade under consideration. A derived character state is inferred to be a modified version of the primitive condition of that character, and to have arisen later in the evolution of the clade. For example, "presence of hair" is a primitive character state for all mammals, whereas the "hairlessness" of whales is a derived state for one subclade within the Mammalia.</p><p><strong>diversity</strong> -- Term used to describe numbers of taxa, or variation in morphology.&nbsp;</p><p><strong>evolution</strong> -- Darwin's definition: descent with modification. The term has been variously used and abused since Darwin to include everything from the origin of man to the origin of life.</p><p><strong>evolutionary tree</strong> -- A diagram which depicts the hypothetical phylogeny of the taxa under consideration. The points at which lineages split represent ancestor taxa to the descendant taxa appearing at the terminal points of the cladogram.</p><p><strong>expressed sequence tag (EST)</strong> -- A partial coding sequence isolated at random from a cDNA library, used for identification and mapping of coding sequences, for discovery of new genes and (by reference to sequence data banks) for discovery of identities with other genes.</p><p><strong>extinction</strong> -- When all the members of a clade or taxon die, the group is said to be extinct.</p><p><strong>genetic marker -- </strong>A DNA sequence that can be recognized and thus used to characterize the larger DNA sequence and the chromosome in which it occurs.&nbsp;</p><p><strong>homolog </strong>-- A feature that appears similar in two or more taxa with a common ancestor that also possessed that feature.</p><p><strong>homology</strong> -- Two structures are considered homologous when they are inherited from a common ancestor which possessed the structure. This may be difficult to determine when the structure has been modified through descent.</p><p><strong>hypothesis</strong> -- A concept or idea that can be falsified by various scientific methods.</p><p><strong>ingroup</strong> -- In a cladistic analysis, the set of taxa which are hypothesized to be more closely related to each other than any are to the outgroup.</p><p><strong>lineage</strong> -- Any continuous line of descent; any series of organisms connected by reproduction by parent of offspring.</p><p><strong>monophyletic</strong> -- Term applied to a group of organisms which includes the most recent common ancestor of all of its members and all of the descendants of that most recent common ancestor. A monophyletic group is called a clade.</p><p><strong>outgroup</strong> -- In a cladistic analysis, any taxon used to help resolve the polarity of characters, and which is hypothesized to be less closely related to each of the taxa under consideration than any are to each other.</p><p><strong>paraphyletic</strong> -- Term applied to a group of organisms which includes the most recent common ancestor of all of its members, but not all of the descendants of that most recent common ancestor.</p><p><strong>parsimony</strong> -- Refers to a rule used to choose among possible cladograms, which states that the cladogram implying the least number of changes in character states is the best.</p><p><strong>phylogenetics</strong> -- Field of biology that deals with the relationships between organisms. It includes the discovery of these relationships, and the study of the causes behind this pattern.</p><p><strong>phylogeny</strong> -- The evolutionary relationships among organisms; the patterns of lineage branching produced by the true evolutionary history of the organisms being considered.</p><p><strong>plesiomorphy</strong> -- A primitive character state for the taxa under consideration.</p><p><strong>polarity of characters</strong> -- The states of characters used in a cladistic analysis, either original or derived. Original characters are those acquired by an ancestor deeper in the phylogeny than the most recent common ancestor of the taxa under consideration. Derived characters are those acquired by the most recent common ancestor of the taxa under consideration.</p><p><strong>polyphyletic</strong> -- Term applied to a group of organisms which does not include the most recent common ancestor of those organisms; the ancestor does not possess the character shared by members of the group.</p><p><strong>primitive</strong> -- Describes a character state that is present in the common ancestor of a clade. A primitive character state is inferred to be the original condition of that character within the clade under consideration. For example, "presence of hair" is a primitive character state for all mammals, whereas the "hairlessness" of whales is a derived state for one subclade within the Mammalia.</p><p><strong>radiation</strong> -- Event of rapid cladogenesis, believed to occur under conditions where a new feature permits a lineage to move into a new niche or new habitat, and is then called an adaptive radiation.</p><p><strong>rank</strong> -- In traditional taxonomy, taxa are ranked according to their level of inclusiveness. Thus a genus contains one or more species, a family includes one or more genera, and so on.</p><p><strong>relatedness</strong> -- Two clades are more closely related when they share a more recent common ancestor between them than they do with any other clade.</p><p><strong>repetitive DNA</strong> -- Sequences of DNA that are found to be repeated, sometimes thousands of times over.&nbsp;&nbsp;</p><p><strong>reticulation</strong> -- Joining of separate lineages on a phylogenetic tree, generally through hybridization or through lateral gene transfer. Fairly common in certain land plant clades; reticulation is thought to be rare among metazoans.</p><p><strong>selection</strong> -- Process which favors one feature of organisms in a population over another feature found in the population. This occurs through differential reproduction -- those with the favored feature produce more offspring than those with the other feature, such that they become a greater percentage of the population in the next generation.</p><p><strong>sister group</strong> -- The two clades resulting from the splitting of a single lineage.</p><p><strong>stem group</strong> -- All the taxa in a clade preceding a major cladogenesis event. They are often difficult to recognize because they may not possess synapomorpies found in the crown group.</p><p><strong>sympleisiomorphy</strong> &ndash; A ancestral character shared by the taxa under consideration</p><p><strong>synapomorphy</strong> -- A character which is derived, and because it is shared by the taxa under consideration, is used to infer common ancestry (shared derived state).</p><p><strong>synteny</strong> -- Portions of chromosomes in which gene order is conserved.&nbsp;</p><p><strong>systematics</strong> -- Field of biology that deals with the diversity of life. Systematics is usually divided into the two areas of phylogenetics and taxonomy.</p><p><strong>taxon</strong> -- Any named group of organisms, not necessarily a clade</p><p><strong>taxonomy</strong> -- The science of naming and classifying organisms.&nbsp;</p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
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