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<channel>
	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/42672?</link>
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	<description><![CDATA[]]></description>
	
	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/35798/an-introduction-to-applied-bioinformatics</guid>
	<pubDate>Fri, 02 Mar 2018 04:26:38 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/35798/an-introduction-to-applied-bioinformatics</link>
	<title><![CDATA[An Introduction to Applied Bioinformatics]]></title>
	<description><![CDATA[<p>IAB is primarily being developed by&nbsp;<a href="http://caporasolab.us/people/greg-caporaso/">Greg Caporaso</a>(GitHub/Twitter:&nbsp;<a href="https://github.com/gregcaporaso">@gregcaporaso</a>) in the&nbsp;<a href="http://www.caporasolab.us/">Caporaso Lab</a>&nbsp;at&nbsp;<a href="http://www.nau.edu/">Northern Arizona University</a>. You can find information on the courses I teach on&nbsp;<a href="http://www.caporasolab.us/teaching">my teaching website</a>&nbsp;and information on my research and lab on&nbsp;<a href="http://www.caporasolab.us/">my lab website</a>.</p>
<p>&nbsp;</p><p>Address of the bookmark: <a href="http://readiab.org/" rel="nofollow">http://readiab.org/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/35805/python-learning-resources-for-bioinformatics-and-computational-biologist</guid>
	<pubDate>Fri, 02 Mar 2018 06:54:15 -0600</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/35805/python-learning-resources-for-bioinformatics-and-computational-biologist</link>
	<title><![CDATA[Python learning resources for bioinformatics and computational biologist !]]></title>
	<description><![CDATA[<p>Python is a general-purpose language, which means it can be used to build just about anything, which will be made easy with the right tools/libraries.</p><p>Professionally, Python is great for backend web development, data analysis, artificial intelligence, and scientific computing. Many developers have also used Python to build productivity tools, games, and desktop apps, so there are plenty of resources to help you learn how to do those as well.</p><p>For pros and cons visit&nbsp;http://www.bestprogramminglanguagefor.me/why-learn-python and&nbsp;http://bioinformaticsonline.com/discussion/view/459/python-vs-perl</p><p>More resources at&nbsp;https://github.com/CodementorIO/Python-Learning-Resources</p><p>Following are the list of useful python programming resources:</p><ul>
<li><a href="http://www.oreilly.com/programming/free/20-python-libraries-you-arent-using-but-should.csp">20 Python Libraries You Aren't Using (But Should)</a>&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="https://en.wikibooks.org/wiki/A_Beginner%27s_Python_Tutorial">A Beginner's Python Tutorial</a></li>
<li><a href="https://python.swaroopch.com/">A Byte of Python</a>&nbsp;(3.x) (HTML, PDF, EPUB, Mobi)</li>
<li><a href="https://github.com/RafeKettler/magicmethods">A Guide to Python's Magic Methods</a>&nbsp;- Rafe Kettler</li>
<li><a href="http://www.oreilly.com/programming/free/files/a-whirlwind-tour-of-python.pdf">A Whirlwind Tour of Python</a>&nbsp;- Jake VanderPlas (PDF)&nbsp;<a href="http://www.oreilly.com/programming/free/a-whirlwind-tour-of-python.csp?download=yes">(EPUB, MOBI)</a></li>
<li><a href="http://automatetheboringstuff.com/chapter0/">Automate the Boring Stuff</a>&nbsp;- Al Sweigart</li>
<li><a href="http://biopython.org/DIST/docs/tutorial/Tutorial.pdf">Biopython</a>&nbsp;(PDF)</li>
<li><a href="http://github.com/thewhitetulip/build-app-with-python-antitextbook">Build applications in Python the antitextbook</a>&nbsp;(3.x) (HTML, PDF, EPUB, Mobi)</li>
<li><a href="https://www.packtpub.com/packt/free-ebook/python-machine-learning-algorithms">Building Machine Learning Systems with Python</a>&nbsp;- Willi Richert &amp; Luis Pedro Coelho, Packt.&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://www.itmaybeahack.com/book/oodesign-python-2.1/latex/BuildingSkillsinOODesign.pdf">Building Skills in Object-Oriented Design (Python)</a>&nbsp;(PDF) (2.1.1)</li>
<li><a href="http://www.itmaybeahack.com/book/python-2.6/latex/BuildingSkillsinPython.pdf">Building Skills in Python</a>&nbsp;(PDF) (2.6)</li>
<li><a href="http://python.net/~goodger/projects/pycon/2007/idiomatic/handout.html">Code Like a Pythonista: Idiomatic Python</a></li>
<li><a href="https://www.codecademy.com/learn/python">CodeCademy Python</a></li>
<li><a href="http://composingprograms.com/">Composing Programs</a>&nbsp;(3.x)</li>
<li><a href="https://web.archive.org/web/20161016153130/http://www.brpreiss.com/books/opus7/html/book.html">Data Structures and Algorithms in Python</a>&nbsp;- B. R. Preiss (PDF)</li>
<li><a href="http://getpython3.com/diveintopython3/">Dive into Python 3</a>&nbsp;- Mark Pilgrim (3.0)
<ul>
<li><a href="http://www.diveintopython.net/">Dive into Python</a>&nbsp;- Mark Pilgrim (2.3)</li>
</ul>
</li>
<li><a href="http://www.labri.fr/perso/nrougier/from-python-to-numpy/">From Python to NumPy</a></li>
<li><a href="http://www.fullstackpython.com/">Full Stack Python</a></li>
<li><a href="http://www.oreilly.com/programming/free/functional-programming-python.csp">Functional Programming in Python</a>&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://python.cs.southern.edu/pythonbook/pythonbook.pdf">Fundamentals of Python Programming</a>&nbsp;- Richard L. Halterman (PDF) (3.2)</li>
<li><a href="https://developers.google.com/edu/python/">Google's Python Class</a>&nbsp;(2.4 - 2.x)</li>
<li><a href="https://google.github.io/styleguide/pyguide.html">Google's Python Style Guide</a></li>
<li><a href="http://inventwithpython.com/hacking/chapters/">Hacking Secret Cyphers with Python</a>&nbsp;- Al Sweigart (3.3)</li>
<li><a href="http://www.oreilly.com/programming/free/hadoop-with-python.csp">Hadoop with Python</a>&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://ianozsvald.com/HighPerformancePythonfromTrainingatEuroPython2011_v0.2.pdf">High Performance Python</a>&nbsp;(PDF)</li>
<li><a href="http://docs.python-guide.org/en/latest/">Hitchhiker's Guide to Python!</a>&nbsp;(2.6)</li>
<li><a href="http://www.oreilly.com/programming/free/files/how-to-make-mistakes-in-python.pdf">How to Make Mistakes in Python</a>&nbsp;- Mike Pirnat (PDF) (1st edition)</li>
<li><a href="http://interactivepython.org/courselib/static/thinkcspy/index.html">How to Think Like a Computer Scientist: Learning with Python, Interactive Edition</a>&nbsp;(3.2)
<ul>
<li><a href="http://www.greenteapress.com/thinkpython/thinkCSpy/">How to Think Like a Computer Scientist: Learning with Python</a>&nbsp;- Allen B. Downey, Jeff Elkner and Chris Meyers (2.4)</li>
<li><a href="http://www.greenteapress.com/thinkpython/">Think Python</a>&nbsp;- Allen B. Downey (2.x &amp; 3.0)</li>
</ul>
</li>
<li><a href="http://book.pythontips.com/en/latest/index.html">Intermediate Python</a>&nbsp;- Muhammad Yasoob Ullah Khalid (1st edition)</li>
<li><a href="http://opentechschool.github.io/python-beginners/en/">Introduction to Programming with Python</a>&nbsp;(3.3)
<ul>
<li><a href="http://python-ebook.blogspot.co.uk/">Introduction to Programming Using Python</a>&nbsp;- Cody Jackson (1st edition) (2.3)</li>
</ul>
</li>
<li><a href="http://kracekumar.com/post/71171551647/introduction-to-python">Introduction to Python</a>&nbsp;- Kracekumar (2.7.3)</li>
<li><a href="http://inventwithpython.com/chapters/">Invent Your Own Computer Games With Python</a>&nbsp;- Al Sweigart (3.1)</li>
<li><a href="http://learnpythonbreakpython.com/">Learn Python, Break Python</a></li>
<li><a href="https://learnxinyminutes.com/docs/python/">Learn Python in Y minutes</a></li>
<li><a href="http://learnpythonthehardway.org/book/">Learn Python The Hard Way</a>&nbsp;(2.5 - 2.6)</li>
<li><a href="https://www.ida.liu.se/~732A47/literature/PythonBook.pdf">Learn to Program Using Python</a>&nbsp;- Cody Jackson (PDF)</li>
<li><a href="https://www.packtpub.com/packt/free-ebook/learning-python">Learning Python</a>&nbsp;- Fabrizio Romano, Packt.&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://www.alan-g.me.uk/">Learning to Program</a></li>
<li><a href="https://github.com/jrjohansson/scientific-python-lectures">Lectures on scientific computing with python</a>&nbsp;- J.R. Johansson (2.7)</li>
<li><a href="http://inventwithpython.com/pygame/chapters/">Making Games with Python &amp; Pygame</a>&nbsp;- Al Sweigart (2.7)</li>
<li><a href="http://www.clips.ua.ac.be/sites/default/files/modeling-creativity.pdf">Modeling Creativity: Case Studies in Python</a>&nbsp;- Tom D. De Smedt (PDF)</li>
<li><a href="http://www.nltk.org/book/">Natural Language Processing with Python</a>&nbsp;(3.x)</li>
<li><a href="https://en.wikibooks.org/wiki/Non-Programmer%27s_Tutorial_for_Python_3">Non-Programmer's Tutorial for Python 3</a>&nbsp;(3.3)
<ul>
<li><a href="https://en.wikibooks.org/wiki/Non-Programmer%27s_Tutorial_for_Python_2.6">Non-Programmer's Tutorial for Python 2.6</a>&nbsp;(2.6)</li>
</ul>
</li>
<li><a href="http://www.oreilly.com/programming/free/from-future-import-python.csp">Picking a Python Version: A Manifesto</a>&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://python3porting.com/">Porting to Python 3: An In-Depth Guide</a>&nbsp;(2.6 - 2.x &amp; 3.1 - 3.x)</li>
<li><a href="https://launchpadlibrarian.net/165489933/PracticalProgrammingPython2014.pdf">Practical Programming in Python</a>&nbsp;- Jeffrey Elkner (PDF)</li>
<li><a href="http://interactivepython.org/runestone/static/pythonds/index.html">Problem Solving with Algorithms and Data Structures using Python</a>&nbsp;- Bradley N. Miller and David L. Ranum</li>
<li><a href="http://programarcadegames.com/">Program Arcade Games With Python And Pygame</a>&nbsp;(3.3)</li>
<li><a href="http://programmingcomputervision.com/downloads/ProgrammingComputerVision_CCdraft.pdf">Programming Computer Vision with Python</a>&nbsp;(PDF)</li>
<li><a href="https://docs.python.org/2/download.html">Python 2 Official Documentation</a>&nbsp;(PDF, HTML, TEXT) (2.x)</li>
<li><a href="http://infohost.nmt.edu/tcc/help/pubs/python/web/">Python 2.7 quick reference</a>&nbsp;- New Mexico Tech (2.7)</li>
<li><a href="https://docs.python.org/3/download.html">Python 3 Official Documentation</a>&nbsp;(PDF, EPUB, HTML, TEXT) (3.x)</li>
<li><a href="http://chimera.labs.oreilly.com/books/1230000000393/index.html">Python Cookbook</a>&nbsp;- David Beazley</li>
<li><a href="https://github.com/jakevdp/PythonDataScienceHandbook">Python Data Science Handbook</a>&nbsp;- Jake VanderPlas (HTML, Jupyter Notebooks)</li>
<li><a href="http://www.kevinsheppard.com/images/0/09/Python_introduction.pdf">Python for Econometrics</a>&nbsp;- Kevin Sheppard (PDF) (2.7.5)</li>
<li><a href="http://py4e.com/book.php">Python for Everybody Exploring Data Using Python 3</a>&nbsp;- Charles Severance (PDF, EPUB, HTML)
<ul>
<li><a href="http://www.pythonlearn.com/book.php">Python for Informatics: Exploring Information</a>&nbsp;(2.7.5)</li>
</ul>
</li>
<li><a href="http://pymbook.readthedocs.org/en/latest/">Python for you and me</a>&nbsp;(2.7.3)</li>
<li><a href="http://pymbook.readthedocs.org/en/py3/">Python for you and me</a>&nbsp;(3.x)</li>
<li><a href="http://safehammad.com/downloads/python-idioms-2014-01-16.pdf">Python Idioms</a>&nbsp;(PDF)</li>
<li><a href="http://www.oreilly.com/programming/free/python-in-education.csp">Python in Education</a>&nbsp;<em>(Just fill the fields with any values)</em></li>
<li><a href="http://www.greenteapress.com/pythonhydro/pythonhydro.html">Python in Hydrology</a>&nbsp;- Sat Kumar Tomer</li>
<li><a href="https://github.com/gregmalcolm/python_koans">Python Koans</a>&nbsp;(2.7 or 3.x)</li>
<li><a href="https://pymotw.com/3/">Python Module of the Week</a>&nbsp;(3.x)
<ul>
<li><a href="https://pymotw.com/2/">Python Module of the Week</a>&nbsp;(2.x)</li>
</ul>
</li>
<li><a href="http://books.goalkicker.com/PythonBook/">Python Notes for Professionals</a>&nbsp;- Compiled from StackOverflow documentation (3.x)</li>
<li><a href="http://anandology.com/python-practice-book/index.html">Python Practice Book</a>&nbsp;(2.7.1)</li>
<li><a href="http://pythonpracticeprojects.com/">Python Practice Projects</a></li>
<li><a href="https://upload.wikimedia.org/wikipedia/commons/9/91/Python_Programming.pdf">Python Programming</a>&nbsp;(PDF) (2.6)</li>
<li><a href="http://scipy-lectures.github.io/">Scipy Lecture Notes</a></li>
<li><a href="http://www-inst.eecs.berkeley.edu/~cs61a/sp12/book/">SICP in Python</a>&nbsp;(3.2)</li>
<li><a href="http://www.briggs.net.nz/snake-wrangling-for-kids.html">Snake Wrangling For Kids</a>&nbsp;(3.x)</li>
<li><a href="http://python3porting.com/">Suporting Python 3: An In-Depth Guide</a>&nbsp;(2.6 - 2.x &amp; 3.1 - 3.x)</li>
<li><a href="http://chimera.labs.oreilly.com/books/1234000000754/index.html">Test-Driven Web Development with Python</a>&nbsp;(3.3 - 3.x)</li>
<li><a href="http://gnosis.cx/TPiP/">Text Processing in Python</a>&nbsp;- David Mertz (2.3 - 2.x)</li>
<li><a href="http://www.spronck.net/pythonbook/">The Coder's Apprentice: Learning Programming with Python 3</a>&nbsp;- Pieter Spronck (PDF) (3.x)</li>
<li><a href="http://www.jython.org/jythonbook/en/1.0">The Definitive Guide to Jython, Python for the Java Platform</a>&nbsp;- Josh Juneau, Jim Baker, Victor Ng, Leo Soto, Frank Wierzbicki (2.5)</li>
<li><a href="http://docs.quantifiedcode.com/python-anti-patterns/">The Little Book of Python Anti-Patterns</a>&nbsp;(<a href="https://github.com/quantifiedcode/python-anti-patterns">Source</a>)</li>
<li><a href="http://niche-canada.org/research/niche-digital-infrastructure-project/the-programming-historian/">The Programming Historian</a>&nbsp;- William J. Turkel, Adam Crymble and Alan MacEachern</li>
<li><a href="http://mirnazim.org/writings/python-ecosystem-introduction/">The Python Ecosystem: An Introduction</a></li>
<li><a href="http://python-gtk-3-tutorial.readthedocs.org/en/latest/">The Python GTK+ 3 Tutorial</a></li>
<li><a href="http://effbot.org/librarybook/">The Standard Python Library</a>&nbsp;- Fredrik Lundh</li>
<li><a href="http://greenteapress.com/complexity/">Think Complexity</a>&nbsp;- Allen B. Downey (2nd Edition) (PDF, HTML)</li>
<li><a href="http://web2py.com/book">Web2py: Complete Reference Manual, 6th Edition (pre-release)</a>&nbsp;(2.5 - 2.x)</li>
<li><a href="https://en.wikibooks.org/wiki/Python_Programming">Wikibooks: Python Programming</a>&nbsp;(2.7)</li>
</ul>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/10925/a-brief-bioinformatics-tutorial</guid>
	<pubDate>Wed, 21 May 2014 12:50:09 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/10925/a-brief-bioinformatics-tutorial</link>
	<title><![CDATA[A Brief Bioinformatics Tutorial]]></title>
	<description><![CDATA[<p>This is about how to use a computer to find what is known about a gene of interest and also how to get new insights about it.</p>
<p>The tutorial is divided in three main parts:</p>
<ul>
<li>In the <strong>Sequence </strong>part, you will see how to look efficiently for a particular protein sequence, how to blast it against the database of your choice to find homologues, how to perform a multiple alignment of the homologues you've selected and how to edit this alignment.</li>
<li>The <strong>Structure </strong>part is about molecular visualization, homology modeling and structural domain prediction.</li>
<li>In the <strong>Function </strong>part, you will be introduced to you 3 useful servers to investigate the function of a protein. i.e. finding interactors, co-expressed genes, see a phylogenetic profile, easily access papers citing your gene etc ...</li>
</ul>
<p>During all the three parts, we will use the <em>S. cerevisiae </em>VPS36 protein as an example.</p><p>Address of the bookmark: <a href="http://www.mrc-lmb.cam.ac.uk/rlw/text/bioinfo_tuto/introduction.html" rel="nofollow">http://www.mrc-lmb.cam.ac.uk/rlw/text/bioinfo_tuto/introduction.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/26539/scikit-learn</guid>
	<pubDate>Mon, 29 Feb 2016 17:39:24 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/26539/scikit-learn</link>
	<title><![CDATA[scikit-learn]]></title>
	<description><![CDATA[<p>Machine Learning in Python</p>
<p>Simple and efficient tools for data mining and data analysis<br> Accessible to everybody, and reusable in various contexts<br> Built on NumPy, SciPy, and matplotlib<br> Open source, commercially usable - BSD license</p>
<p>More at&nbsp;http://scikit-learn.org/stable/index.html</p>
<p>&nbsp;</p><p>Address of the bookmark: <a href="http://scikit-learn.org/stable/auto_examples/index.html" rel="nofollow">http://scikit-learn.org/stable/auto_examples/index.html</a></p>]]></description>
	<dc:creator>Jitendra Prajapati</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/14218/pimp-your-brain-bioinformatics</guid>
	<pubDate>Wed, 20 Aug 2014 22:09:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/14218/pimp-your-brain-bioinformatics</link>
	<title><![CDATA[Pimp your brain: Bioinformatics]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/KqelGy6Q8nE" frameborder="0" allowfullscreen></iframe>Jan Lisec from the Max Planck Institute of Molecular Plant Physiology explains, in this "pimp your brain" episode, what bioinformatics is and why bioinformatics is so important and indispensable for biological research.

In the video serial "Pimp your brain" scientists from the Max Planck Institute of Molecular Plant Physiology describe their research. More videos from the 'Pimp your brain' serial are available on www.youtube.com/playlist?list=PL-l9VItC9Gn2Ur2Xj6PTOAkjLUlVPbIOO

More videos are available on www.mpimp-golm.mpg.de]]></description>
	
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/920/bioinformatics-algorithms</guid>
	<pubDate>Tue, 16 Jul 2013 03:35:15 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/920/bioinformatics-algorithms</link>
	<title><![CDATA[Bioinformatics Algorithms]]></title>
	<description><![CDATA[<p>An algorithm is a computable set of steps to achieve a desired result.</p><p>We use algorithms every day. For example, a recipe for baking a cake is an algorithm. Most programs, with the exception of some artificial intelligence applications, consist of algorithms. Inventing elegant algorithms -- algorithms that are simple and require the fewest steps possible -- is one of the principal challenges in programming. An algorithm is a description of a procedure which terminates with a result. In other words an algorithm is a set of instructions, sometimes called a procedure or a function, that is used to perform a certain task. This can be a simple process, such as adding two numbers together, or a complex function, such as adding effects to an image. For example, in order to sharpen a digital photo, the algorithm would need to process each pixel in the image and determine which ones to change and how much to change them in order to make the image look sharper.</p><p>In mathematics, computer science, and related subjects, an algorithm is an effective method for solving a problem using a finite sequence of instructions. Algorithms are used for calculation, data processing, and many other fields.<br />Each algorithm is a list of well-defined instructions for completing a task. Starting from an initial state, the instructions describe a computation that proceeds through a well-defined series of successive states, eventually terminating in a final ending state. The transition from one state to the next is not necessarily deterministic; some algorithms, known as randomized algorithms, incorporate randomness.</p><p><strong>History</strong></p><p>The origin of the term comes from the ancients. The concept becomes more precise with the use of variables in mathematics. Algorithm in the sense of what is now used by computers appeared as soon as first mechanical engines were invented.<br />The word algorithm comes from the name of the 9th century Persian Muslim mathematician Abu Abdullah Muhammad ibn Musa Al-Khwarizmi. The word algorism originally referred only to the rules of performing arithmetic using Hindu-Arabic numerals but evolved via European Latin translation of Al-Khwarizmi's name into algorithm by the 18th century. The use of the word evolved to include all definite procedures for solving problems or performing tasks.<br />The algorithm of Archimedes gives an approximation of the Pi number.<br />Eratosthenes has defined an algorithim for retrieving prime numbers.<br />Averro&egrave;s (1126-1198) was using algorithmic methods for calculations.<br />Adelard de Bath (12 th) introduces the algorismus term, from Al-Khwarizmi.<br />During the 1800's up to the mid-1900's:<br /><br />- George Boole (1847) has invented the binary algebra, the basis of computers. Actually he has unified logic and calculation in a common symbolism.<br /><br />- Gottlob Frege (1879) formula language's, that is a lingua characterica, a language written with special symbols, "for pure thought", that is free from rhetorical embellishments... constructed from specific symbols that are manipulated according to definite rules.<br /><br />- Giuseppe Peano (1888) It's The principles of arithmetic, presented by a new method was the first attempt at an axiomatization of mathematics in a symbolic language.<br /><br />- Alfred North Whitehead and Bertrand Russell in their Principia Mathematica (1910-1913) has further simplified and amplified the work of Frege.<br /><br />- Kurt Go&euml;del (1931) cites the paradox of the liar that completely reduces rules of recursion to numbers.<br /><br />The concept of algorithm was formalized in 1936 through Alan Turing's Turing machines and Alonzo Church's lambda calculus, which in turn formed the foundation of computer science.<br />Stephen C. Kleene (1943) defined his now-famous thesis known as the "Church-Turing Thesis". In this context:<br /><br />" Algorithmic theories... In setting up a complete algorithmic theory, what we do is to describe a procedure, performable for each set of values of the independent variables, which procedure necessarily terminates and in such manner that from the outcome we can read a definite answer, "yes" or "no," to the question, "is the predicate value true?"</p><p><strong>Classification</strong></p><p><strong>Classification by purpose</strong></p><p>Each algorithm has a goal, for example, the purpose of the Quick Sort algorithm is to sort data in ascending or descending order. But the number of goals is infinite, and we have to group them by kind of purposes:</p><p><strong>Classification by implementation</strong></p><p>An algorithm may be implemeted according to different basical principles.</p><ul>
<li>Recursive or iterative</li>
</ul><p>A recursive algorithm is one that calls itself repeatedly until a certain condition matches. It is a method common to functional programming.&nbsp;<br />Iterative algorithms use repetitive constructs like loops.<br />Some problems are better suited for one implementation or the other. For example, the towers of hanoi problem is well understood in recursive implementation. Every recursive version has an iterative equivalent iterative, and vice versa.</p><ul>
<li>Logical or procedural</li>
</ul><p>An algorithm may be viewed as controlled logical deduction.&nbsp;<br />A logic component expresses the axioms which may be used in the computation and a control component determines the way in which deduction is applied to the axioms.&nbsp;<br />This is the basis of the logic programming. In pure logic programming languages the control component is fixed and algorithms are specified by supplying only the logic component.</p><ul>
<li>Serial or parallel</li>
</ul><p>Algorithms are usually discussed with the assumption that computers execute one instruction of an algorithm at a time. This is a serial algorithm, as opposed to parallel algorithms, which take advantage of computer architectures to process several instructions at once. They divide the problem into sub-problems and pass them to several processors. Iterative algorithms are generally parallelizable. Sorting algorithms can be parallelized efficiently.</p><ul>
<li>Deterministic or non-deterministic</li>
</ul><p>Deterministic algorithms solve the problem with a predefined process whereas non-deterministic algorithm must perform guesses of best solution at each step through the use of heuristics.<br /><br /><strong>Classification by design paradigm</strong></p><p>A design paradigm is a domain in research or class of problems that requires a dedicated kind of algorithm:</p><ul>
<li>Divide and conquer</li>
</ul><p>A divide and conquer algorithm repeatedly reduces an instance of a problem to one or more smaller instances of the same problem (usually recursively), until the instances are small enough to solve easily. One such example of divide and conquer is merge sorting. Sorting can be done on each segment of data after dividing data into segments and sorting of entire data can be obtained in conquer phase by merging them.<br />The binary search algorithm is an example of a variant of divide and conquer called decrease and conquer algorithm, that solves an identical subproblem and uses the solution of this subproblem to solve the bigger problem.</p><ul>
<li>Dynamic programming</li>
</ul><p>The shortest path in a weighted graph can be found by using the shortest path to the goal from all adjacent vertices.&nbsp;<br />When the optimal solution to a problem can be constructed from optimal solutions to subproblems, using dynamic programming avoids recomputing solutions that have already been computed.&nbsp;<br />- The main difference with the "divide and conquer" approach is, subproblems are independent in divide and conquer, where as the overlap of subproblems occur in dynamic programming.&nbsp;<br />- Dynamic programming and memoization go together. The difference with straightforward recursion is in caching or memoization of recursive calls. Where subproblems are independent, this is useless. By using memoization or maintaining a table of subproblems already solved, dynamic programming reduces the exponential nature of many problems to polynomial complexity.</p><ul>
<li>The greedy method</li>
</ul><p>A greedy algorithm is similar to a dynamic programming algorithm, but the difference is that solutions to the subproblems do not have to be known at each stage. Instead a "greedy" choice can be made of what looks the best solution for the moment.&nbsp;<br />The most popular greedy algorithm is finding the minimal spanning tree as given by Kruskal.</p><ul>
<li>Linear programming</li>
</ul><p>The problem is expressed as a set of linear inequalities and then an attempt is made to maximize or minimize the inputs. This can solve many problems such as the maximum flow for directed graphs, notably by using the simplex algorithm.&nbsp;<br />A complex variant of linear programming is called integer programming, where the solution space is restricted to all integers.</p><ul>
<li>Reduction also called transform and conquer</li>
</ul><p>Solve a problem by transforming it into another problem. A simple example: finding the median in an unsorted list is first translating this problem into sorting problem and finding the middle element in sorted list. The main goal of reduction is finding the simplest transformation possible.</p><ul>
<li>Using graphs</li>
</ul><p>Many problems, such as playing chess, can be modeled as problems on graphs. A graph exploration algorithms are used.&nbsp;<br />This category also includes the search algorithms and backtracking.<br /><br /><strong>The probabilistic and heuristic paradigm</strong></p><ul>
<li>Probabilistic</li>
</ul><p>Those that make some choices randomly.</p><ul>
<li>Genetic</li>
</ul><p>Attempt to find solutions to problems by mimicking biological evolutionary processes, with a cycle of random mutations yielding successive generations of "solutions". Thus, they emulate reproduction and "survival of the fittest".</p><ul>
<li>Heuristic</li>
</ul><p>Whose general purpose is not to find an optimal solution, but an approximate solution where the time or resources to find a perfect solution are not practical.</p><p><strong>Classification by complexity</strong></p><p>Some algorithms complete in linear time, and some complete in exponential amount of time, and some never complete.</p><p><strong>Algorithms resources on net.</strong></p><p><a href="http://www.cs.uga.edu/~cai/courses/compbio/2008fall/bookchapters/Chapter08/Ch08_GraphsDNAseq.pdf">Graph Algorithms in Bioinformatics</a></p><p><a href="http://zikuladevs.com/notes/Part%20II%20Revision/Bio_Alg_Descriptions[1].pdf">Bioinformatics Algorithms Description</a></p><p><a href="http://users.aims.ac.za/~marshall/BioinformaticsCourse.html">Bioinformatics Algorithms Course Page</a></p><p><a href="http://www.cybertory.org/downloads/bae/BioinformaticsAlgorithmsExcelDoc.pdf">Bioinformatics Algorithm Demonstrations</a></p><p><a href="http://www.cse.sc.edu/~maxal/csce590b/Lect01-02.pdf">Introduction to Bioinformatics Algorithms Lectures 1-2 by Dr. Max Alekseyev USC, 2009</a></p><p><a href="http://lectures.molgen.mpg.de/online_lectures.html">Online Lectures on Bioinformatics</a></p><p><a href="http://www.ks.uiuc.edu/Training/Tutorials/science/bioinformatics-tutorial/bioinformatics.pdf.bak">Sequence Alignment Algorithms</a></p><p><a href="http://www.avatar.se/molbioinfo2001/seqali-dyn.html">Algorithm for sequence alignment: dynamic programming</a></p><p><a href="http://www.4tphi.net/~awalters/PI/pi.pdf">Network Protocol Analysis using Bioinformatics Algorithms</a></p><p><strong>Bioinformatics Algorithms Links</strong></p><p><strong>Dynamic Programming</strong></p><p>Particularly good sites...</p><p>&bull;<a href="http://www.cis.upenn.edu/~sahuguet/MSA/">http://www.cis.upenn.edu/~sahuguet/MSA/</a><br />&bull;<a href="http://www.blc.arizona.edu/courses/bioinformatics/align.html">http://www.blc.arizona.edu/courses/bioinformatics/align.html</a><br />&bull;<a href="http://www.cs.monash.edu.au/~lloyd/tildeStrings/Notes/DPA.html">http://www.cs.monash.edu.au/~lloyd/tildeStrings/Notes/DPA.html</a><br />&bull;<a href="http://www.cs.orst.edu/~schut/cs325/dynamic.htm">http://www.cs.orst.edu/~schut/cs325/dynamic.htm</a><br />&bull;<a href="http://www.catalase.com/dprog.htm">http://www.catalase.com/dprog.htm</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~bioph490/BIOPH2.html#SEQUENCE_COMP">http://bioweb.ncsa.uiuc.edu/~bioph490/BIOPH2.html#SEQUENCE_COMP</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/javascript/dp1/index.html">http://www.qucis.queensu.ca/home/cisc365/javascript/dp1/index.html</a><br />Other sites...<br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~bioph490/dynamic_programming_demo.html">http://bioweb.ncsa.uiuc.edu/~bioph490/dynamic_programming_demo.html</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/365overheads.html">http://www.qucis.queensu.ca/home/cisc365/365overheads.html</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/dp/dp.p01.html">http://www.qucis.queensu.ca/home/cisc365/dp/dp.p01.html</a><br />&bull;<a href="http://www.dgp.toronto.edu/csc270/tut_dp.html">http://www.dgp.toronto.edu/csc270/tut_dp.html</a><br />&bull;<a href="http://queue.ieor.berkeley.edu/~jshu/knapsack/DP/dp.html">http://queue.ieor.berkeley.edu/~jshu/knapsack/DP/dp.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/dynamic/dynamic.html">http://mat.gsia.cmu.edu/classes/dynamic/dynamic.html</a><br />&bull;<a href="http://www.cs.sandia.gov/~scistra/class_3">http://www.cs.sandia.gov/~scistra/class_3</a><br />&bull;<a href="http://levine.sscnet.ucla.edu/Econ101/dynamic.htm">http://levine.sscnet.ucla.edu/Econ101/dynamic.htm</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/stoch_dynamic/stoch_dynamic.html">http://mat.gsia.cmu.edu/classes/stoch_dynamic/stoch_dynamic.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/dynamic/node8.html">http://mat.gsia.cmu.edu/classes/dynamic/node8.html</a><br />&bull;<a href="http://www.maths.mu.oz.au/~moshe/dp/bibl/bibliography.html">http://www.maths.mu.oz.au/~moshe/dp/bibl/bibliography.html</a><br />&bull;<a href="http://cartan.gmd.de/PAPER/ismb95/ismb_html.html">http://cartan.gmd.de/PAPER/ismb95/ismb_html.html</a><br />&bull;<a href="http://screwdriver.bu.edu/bibliography/dynamic_programming.htm">http://screwdriver.bu.edu/bibliography/dynamic_programming.htm</a><br />&bull;<a href="http://www.norvig.com/design-patterns/">http://www.norvig.com/design-patterns/</a><br />&bull;<a href="http://tome.cbs.univ-montp1.fr/htmltxt/Doc/manual/node137.html">http://tome.cbs.univ-montp1.fr/htmltxt/Doc/manual/node137.html</a><br />&bull;<a href="http://poem.princeton.edu/~verdu/dynamic.html">http://poem.princeton.edu/~verdu/dynamic.html</a><br />&bull;<a href="http://www.orca1.com/opushelpweb/opusDynamic_Programming.html">http://www.orca1.com/opushelpweb/opusDynamic_Programming.html</a><br />&bull;<a href="http://screwdriver.bu.edu/cn760-lectures/l7/index.htm">http://screwdriver.bu.edu/cn760-lectures/l7/index.htm</a><br />&bull;<a href="http://www.ms.unimelb.edu.au/~moshe/dp/dp.html">http://www.ms.unimelb.edu.au/~moshe/dp/dp.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/ORCS/0255.html">http://mat.gsia.cmu.edu/ORCS/0255.html</a><br />&bull;<a href="http://aae.wisc.edu/e703/notes/a13dynpr.htm">http://aae.wisc.edu/e703/notes/a13dynpr.htm</a><br />&bull;<a href="http://bioweb.pasteur.fr/docs/modeller/node137.html">http://bioweb.pasteur.fr/docs/modeller/node137.html</a><br />&bull;<a href="http://www2.uwindsor.ca/~lama/my470/ddynamic.htm">http://www2.uwindsor.ca/~lama/my470/ddynamic.htm</a><br />&bull;<a href="http://students.ceid.upatras.gr/~papagel/project/ex5_6_1.htm">http://students.ceid.upatras.gr/~papagel/project/ex5_6_1.htm</a><br />&bull;<a href="http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html">http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html</a><br />&bull;<a href="http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html">http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html</a><br />&bull;<a href="http://www.utdallas.edu/~scniu/documents/7315.htm">http://www.utdallas.edu/~scniu/documents/7315.htm</a><br />&bull;<a href="http://www.ii.uib.no/~pinar/seminar/larry.html">http://www.ii.uib.no/~pinar/seminar/larry.html</a><br />&bull;<a href="http://www.deakin.edu.au/~gecole/books.html">http://www.deakin.edu.au/~gecole/books.html</a><br />&bull;<a href="http://www.cseg.engr.uark.edu/~wessels/algs/notes/dynamic.html">http://www.cseg.engr.uark.edu/~wessels/algs/notes/dynamic.html</a><br />&bull;<a href="http://www.csc.liv.ac.uk/~ped/teachadmin/algor/dyprog.html">http://www.csc.liv.ac.uk/~ped/teachadmin/algor/dyprog.html</a><br />&bull;<a href="http://www.eli.sdsu.edu/courses/fall96/cs660/notes/dynamicProg/dynamicProg.html">http://www.eli.sdsu.edu/courses/fall96/cs660/notes/dynamicProg/dynamicProg.html</a><br />&bull;<a href="http://www.cs.indiana.edu/l/www/ftp/techreports/TR514.html">http://www.cs.indiana.edu/l/www/ftp/techreports/TR514.html</a><br />&bull;<a href="http://www.cs.brandeis.edu/~mairson/poems/node3.html">http://www.cs.brandeis.edu/~mairson/poems/node3.html</a><br />&bull;<a href="http://www.cis.tu-graz.ac.at/igi/oaich/animations/Dynamic2.html">http://www.cis.tu-graz.ac.at/igi/oaich/animations/Dynamic2.html</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~workshop/">http://bioweb.ncsa.uiuc.edu/~workshop/</a></p><p><br />Smith Waterman<br />&bull;<a href="http://genome-www.stanford.edu/Saccharomyces/help/sw_alignment.html">http://genome-www.stanford.edu/Saccharomyces/help/sw_alignment.html</a><br />&bull;<a href="http://genome-www.stanford.edu/Saccharomyces/help/sw_details.html">http://genome-www.stanford.edu/Saccharomyces/help/sw_details.html</a><br />&bull;<a href="http://www.stanford.edu/~sntaylor/bioc218/final.htm">http://www.stanford.edu/~sntaylor/bioc218/final.htm</a><br />&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/sld009.htm">http://www.maths.tcd.ie/~lily/pres2/sld009.htm</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~workshop/Lab_3/Smith-Waterman.htm">http://bioweb.ncsa.uiuc.edu/~workshop/Lab_3/Smith-Waterman.htm</a><br />&bull;<a href="http://www.tigem.it/LOCAL/SW/threshold.html">http://www.tigem.it/LOCAL/SW/threshold.html</a><br />&bull;<a href="http://sgbcd.weizmann.ac.il/genweb/help/smith-waterman.html">http://sgbcd.weizmann.ac.il/genweb/help/smith-waterman.html</a><br />&bull;<a href="http://cbrg.ethz.ch/ServerBooklet/section2_3_5.html">http://cbrg.ethz.ch/ServerBooklet/section2_3_5.html</a><br />Needleman &amp; Wunsch<br />&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/sld003.htm">http://www.maths.tcd.ie/~lily/pres2/sld003.htm</a><br />&bull;<a href="http://acer.gen.tcd.ie/~amclysag/nwswat.html">http://acer.gen.tcd.ie/~amclysag/nwswat.html</a><br />&bull;<a href="http://www.nada.kth.se/~erikw/thesis/chapter2_3.html">http://www.nada.kth.se/~erikw/thesis/chapter2_3.html</a><br />&bull;<a href="http://www.irbm.it/irbm-course95/gb/docs/amps/subsection3_6_1.html">http://www.irbm.it/irbm-course95/gb/docs/amps/subsection3_6_1.html</a><br />&bull;<a href="http://www.ibc.wustl.edu/~zuker/Bio-5495/align-html/node3.html">http://www.ibc.wustl.edu/~zuker/Bio-5495/align-html/node3.html</a></p><p><strong>General (NW vs. SW vs. HMM, etc.)</strong></p><p>&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/">http://www.maths.tcd.ie/~lily/pres2/</a><br />&bull;<a href="http://acer.gen.tcd.ie/~amclysag/nwswat.html">http://acer.gen.tcd.ie/~amclysag/nwswat.html</a><br />&bull;<a href="http://laguerre.psc.edu/biomed/TUTORIALS/SEQUENCE/MULTIPLE/tutorial.html">http://laguerre.psc.edu/biomed/TUTORIALS/SEQUENCE/MULTIPLE/tutorial.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/">http://www.cse.ucsc.edu/research/compbio/</a></p><p><strong>Hmms</strong></p><p>&bull;<a href="http://www.medmicro.mds.qmw.ac.uk/HMMER/main.html">http://www.medmicro.mds.qmw.ac.uk/HMMER/main.html</a><br />&bull;<a href="http://alfredo.wustl.edu/ismb96/abs/p02.html">http://alfredo.wustl.edu/ismb96/abs/p02.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/html_format_papers/hughkrogh96/cabios.html">http://www.cse.ucsc.edu/research/compbio/html_format_papers/hughkrogh96/cabios.html</a><br />&bull;<a href="http://wwwsyseng.anu.edu.au/~jason/hmmlinks.html">http://wwwsyseng.anu.edu.au/~jason/hmmlinks.html</a><br />&bull;<a href="http://www.breadfan.com/markov.html">http://www.breadfan.com/markov.html</a><br />&bull;<a href="http://cslu.cse.ogi.edu/HLTsurvey/ch1node34.html">http://cslu.cse.ogi.edu/HLTsurvey/ch1node34.html</a><br />&bull;<a href="http://www.ibc.wustl.edu/service/hmmalign/glocal.html">http://www.ibc.wustl.edu/service/hmmalign/glocal.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/html_format_papers/ismb94/node5.html">http://www.cse.ucsc.edu/research/compbio/html_format_papers/ismb94/node5.html</a><br />&bull;<a href="http://www.iscs.nus.edu.sg/~luakt/ic3222/lecture/nlp18new/index.htm">http://www.iscs.nus.edu.sg/~luakt/ic3222/lecture/nlp18new/index.htm</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/sam.html">http://www.cse.ucsc.edu/research/compbio/sam.html</a>&nbsp;SAM Software for HMMs</p><p><strong>Genetic Algorithms</strong><br /><br />&bull;<a href="http://www.staff.uiuc.edu/~carroll/ga.html">http://www.staff.uiuc.edu/~carroll/ga.html</a><br />&bull;<a href="http://kal-el.ugr.es/gags.html">http://kal-el.ugr.es/gags.html</a><br />&bull;<a href="http://kal-el.ugr.es/~jmerelo/GAJS.html">http://kal-el.ugr.es/~jmerelo/GAJS.html</a><br />&bull;<a href="http://www.genetic-programming.org/">http://www.genetic-programming.org/</a><br />&bull;<a href="http://www.iitk.ac.in/kangal/deb_tut.shtml">http://www.iitk.ac.in/kangal/deb_tut.shtml</a></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/1515/list-of-pharmacogenomics-companies-in-india</guid>
	<pubDate>Fri, 09 Aug 2013 13:26:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/1515/list-of-pharmacogenomics-companies-in-india</link>
	<title><![CDATA[List of pharmacogenomics companies in India]]></title>
	<description><![CDATA[<p>pharmacogenomics companies in India are making their good impacts. Here is the list of few pharmacogenomics companies. Please add more if not mentioned here.</p><p>Genomics in India <br /><a href="http://www.ganitlabs.in/">www.ganitlabs.in</a> <br /><a href="http://www.sandor.co.in/">www.sandor.co.in</a> <br /><a href="http://www.igib.res.in/">www.igib.res.in</a> <br /><a href="http://www.genotypic.co.in/">www.genotypic.co.in</a> <br /><a href="http://www.ocimumbio.com/">www.ocimumbio.com</a> <br /><a href="http://www.abcgenomics.com/">www.abcgenomics.com</a> <br /><a href="http://www.xcelrisgenomics.com/">www.xcelrisgenomics.com</a> <br /><a href="http://www.ayugen.com/">www.ayugen.com</a> <br /><a href="http://www.geneombiotech.com/">www.geneombiotech.com</a></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/2001/the-ontario-institute-for-cancer-research-oicr-genomics-lab-toronto-canada</guid>
  <pubDate>Mon, 12 Aug 2013 01:43:13 -0500</pubDate>
  <link></link>
  <title><![CDATA[The Ontario Institute for Cancer Research (OICR) Genomics Lab , Toronto, Canada.]]></title>
  <description><![CDATA[
<p>The Human Genome Project led to the development of a wide array of technologies to screen the genome and its products (genes, proteins, metabolites) and molecules that interact with these products (chemicals, RNAi). The existence of these tools resulted in the creation of facilities that use robotics and informatics to generate high-throughput screens of DNA, RNA, protein, tissue, chemicals and other substances.</p>

<p>The genomics platform uses cancer genome sequencing and other high-throughput techniques to identify genes critical to the development of cancer and anomalies in the genomic profile of the tumours.</p>

<p>For more info visit : http://oicr.on.ca/</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/6458/bigre-lab</guid>
  <pubDate>Sun, 17 Nov 2013 10:35:49 -0600</pubDate>
  <link></link>
  <title><![CDATA[BIGRE Lab]]></title>
  <description><![CDATA[
<p>The Laboratoire de Bioinformatique des Génomes et des Réseaux (Genome and Network Bioinformatics) is specialized in the conception, implementation, evaluation and application of bioinformatics approaches for the analysis of genome, transcriptome, proteome and metabolism.<br />Our main activities include</p>

<p>Analysis of regulatory sequences (RSAT project)<br />Classification and analysis of mobile genetic elements (ACLAME project).<br />Analysis of molecular interaction networks (NeAT project)<br />Inference of metabolic pathways from genomic and post-genomic data <br />(metabolic pathfinding, see also metabolic pathfinding in NeAT)<br />Critical assesment of protein interactions (CAPRI)</p>

<p>Lab Page http://www.bigre.ulb.ac.be/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/2349/bioinformatics-understanding-of-living-systems-through-information-science</guid>
	<pubDate>Wed, 14 Aug 2013 11:50:17 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/2349/bioinformatics-understanding-of-living-systems-through-information-science</link>
	<title><![CDATA[Bioinformatics -- Understanding of living systems through  information science]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/6Ovd_GOM9-g" frameborder="0" allowfullscreen></iframe>Recently, the progress of the Human Genome Project, aiming to decode all human DNA sequences, has highlighted a research field called bioinformatics. In this new field, computers and techniques from information science are not just used as tools to advance life science research; they're expected to have a major impact on how we think about the life sciences.

Q. The main feature of bioinformatics is, it utilizes computers to analyze life. One is example is the genome. In all organisms, DNA contains genetic information, and this is called the genome. But the amount of information involved is huge, so recently, it's been read using next-generation sequencers, and analyzed by computers. In bioinformatics research, what we do is utilize those genome information to investigate the principles of life.

As an organism evolves, its genome sequence changes through sudden mutations. Additionally, at the genome level, mutations called rearrangements, such as inversions, transpositions, and duplications, occur. 

The genome comparison system developed by the Sakakibara Lab calculates homologous sequences called anchors, which are conserved between species. If the genome is considered as a long text, then anchors can be thought of as words.

Q. We're coming to understand the genomes of various organisms - not just humans, but monkeys, chimpanzees, bacteria, and so on. The first method used to analyze a genome is comparing it with the genomes of other organisms, to see where it's the same and where it's different. In that way, the content of the genome is decoded bit by bit, using computers. By contrast, in our method, we've developed software called Murasaki, which we also use to analyze large genomes, by comparing them with those of other organisms.

The Sakakibara Lab uses a next-generation sequencer at Keio University, along with a cluster machine with hundreds of CPUs. In this way, the Lab is analyzing genome mutations that cause cancer, and the genome of the natto production strain Bacillus subtilis.

Until now, genome analysis could only be done in national-scale projects. But now, next-generation sequencer development has made genome analysis possible in an ordinary lab. In a world-first achievement, the Sakakibara Lab has decoded the natto bacillus genome, through analysis using Keio's next-generation sequencer.

Q. In the future, biology and the life sciences may become almost entirely information science and computer science. And in healthcare, that may enable us, for example, to predict whether individuals are susceptible to cancer, or to certain lifestyle-related diseases, by understanding their personal genome data. So, I think it's amply possible that we can make use of such information effectively, to help people live longer and be free from disease, by thinking about their lifestyle habits.
 
Bioinformatics is only two decades old. In this field, many areas are still unknown. Professor Sakakibara, having been involved since the beginning, will continue tackling new, challenging research projects.]]></description>
	
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