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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/44327?offset=40</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42619/metaeuk-sensitive-high-throughput-gene-discovery-and-annotation-for-large-scale-eukaryotic-metagenomics</guid>
	<pubDate>Wed, 13 Jan 2021 19:29:32 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42619/metaeuk-sensitive-high-throughput-gene-discovery-and-annotation-for-large-scale-eukaryotic-metagenomics</link>
	<title><![CDATA[MetaEuk - sensitive, high-throughput gene discovery and annotation for large-scale eukaryotic metagenomics]]></title>
	<description><![CDATA[<p><span>MetaEuk is a modular toolkit designed for large-scale gene discovery and annotation in eukaryotic metagenomic contigs. Metaeuk combines the fast and sensitive homology search capabilities of&nbsp;</span><a href="https://github.com/soedinglab/MMseqs2">MMseqs2</a><span>&nbsp;with a dynamic programming procedure to recover optimal exons sets. It reduces redundancies in multiple discoveries of the same gene and resolves conflicting gene predictions on the same strand. MetaEuk is GPL-licensed open source software that is implemented in C++ and available for Linux and macOS. The software is designed to run on multiple cores.</span></p><p>Address of the bookmark: <a href="https://github.com/soedinglab/metaeuk" rel="nofollow">https://github.com/soedinglab/metaeuk</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41831/merqury-reference-free-quality-and-phasing-assessment-for-genome-assemblies</guid>
	<pubDate>Sat, 06 Jun 2020 05:38:34 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41831/merqury-reference-free-quality-and-phasing-assessment-for-genome-assemblies</link>
	<title><![CDATA[Merqury: reference-free quality and phasing assessment for genome assemblies]]></title>
	<description><![CDATA[<p><span>Often, genome assembly projects have illumina whole genome sequencing reads available for the assembled individual. The k-mer spectrum of this read set can be used for independently evaluating assembly quality without the need of a high quality reference. Merqury provides a set of tools for this purpose.</span></p>
<p><span><a href="https://github.com/marbl/meryl">https://github.com/marbl/meryl</a></span></p><p>Address of the bookmark: <a href="https://github.com/marbl/merqury" rel="nofollow">https://github.com/marbl/merqury</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/34569/ksnp30-snp-detection-and-phylogenetic-analysis-of-genomes-without-genome-alignment-or-reference-genome</guid>
	<pubDate>Fri, 08 Dec 2017 16:48:40 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/34569/ksnp30-snp-detection-and-phylogenetic-analysis-of-genomes-without-genome-alignment-or-reference-genome</link>
	<title><![CDATA[kSNP3.0: SNP detection and phylogenetic analysis of genomes without genome alignment or reference genome]]></title>
	<description><![CDATA[<p><span>Sept. 20, 2017 Version 3.1 released. Major upgrade. Version 3.1 fixes the problems with SNP annotation that arose when NCBI discontinued use of GI numbers. Please read carefully the Preface (page 3) and the File of annotated genomes section (pages 9-10) in the version 3.1 User Guide. Thanks to Tom Slezak for revsing the get_genbank_file3 script and to Tod Stuber (USDA) for testing version 3.1 even though he doesn't need the annotation feature. All users are encouraged to upgrade to version 3.1.&nbsp;<br></span></p><p>Address of the bookmark: <a href="https://sourceforge.net/projects/ksnp/files/" rel="nofollow">https://sourceforge.net/projects/ksnp/files/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/40395/forbio-and-uib-course-introduction-to-phylogenetic-methods</guid>
	<pubDate>Mon, 16 Dec 2019 09:39:12 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/40395/forbio-and-uib-course-introduction-to-phylogenetic-methods</link>
	<title><![CDATA[ForBio and UiB course: Introduction to phylogenetic methods]]></title>
	<description><![CDATA[<p>The is an introductory course that is aimed at students who will need to preform phylogenetic analyses in their work, but who have little or no experience with phylogenetic analyses. The ForBio component of the course is focused on the practical aspects of phylogenetic analyses and students that have not attended the theoretical part of the course are expected to have read the relevant literature. The course will cover all basic aspects of phylogenetic analyses with emphasis on use of DNA data. Students will learn how to prepare their data, explore its properties and how to analyze it using distance, parsimony, likelihood and Bayesian methods. In the last two days students will also get an introduction to molecular dating with focus on the use of BEAST and to comparative methods used to study the evolution of discrete and continuous traits.</p><p><a href="https://www.forbio.uio.no/events/courses/2020/Bergen_Phylogenetics_2020.html">https://www.forbio.uio.no/events/courses/2020/Bergen_Phylogenetics_2020.html</a></p><p><a href="https://uio.us13.list-manage.com/track/click?u=12ea100a4bd384fb9ba660c5e&amp;id=527fe56cca&amp;e=fe181c3ca8" target="_blank">ForBio travel grants</a><br />We have changed our travel grants rules. ForBio offers both incoming and outgoing travel grants to fund collaborations between<strong>&nbsp;ForBio members based in Norway</strong>&nbsp;and taxonomic experts up to<strong>&nbsp;NOK 14,000</strong>. Grants are given for taxonomic training with relevance to the main research project of the applicant, and aim to allow the student to do taxonomic research with specific experts, work with particular collections, or learn new preparation techniques directly from experts.&nbsp; Participation in external courses, conferences, fieldwork or other kinds of activities which are not&nbsp;classified as expert-in-training visits are no longer eligible for support.&nbsp; There are two application deadlines:&nbsp;<strong>March 1st</strong><strong>&nbsp;</strong>2020.</p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/1973/webinar-wednesday-21-august-2013-at-noon-edt</guid>
	<pubDate>Sun, 11 Aug 2013 19:31:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/1973/webinar-wednesday-21-august-2013-at-noon-edt</link>
	<title><![CDATA[Webinar: Wednesday 21 August 2013 at Noon EDT]]></title>
	<description><![CDATA[<p>This webinar will describe the use of combinatorial pooling to reconstruct gene sequences within BACs. Recent work in barley has shown that this level of sequence knowledge is sufficient to support critical end-point objectives such as map-based cloning and marker-assisted breeding.</p><p>http://www.extension.org/pages/67926/upcoming-webinar:-selective-sequencing-through-combinatorial-pooling#.UggsVuHyPqU</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/10392/research-associate-ra-at-institute-of-advanced-study-in-science-and-technology</guid>
  <pubDate>Mon, 05 May 2014 08:44:24 -0500</pubDate>
  <link></link>
  <title><![CDATA[Research Associate (RA) at INSTITUTE OF ADVANCED STUDY IN SCIENCE AND TECHNOLOGY]]></title>
  <description><![CDATA[
<p>INSTITUTE OF ADVANCED STUDY IN SCIENCE AND TECHNOLOGY<br />(An Autonomous Institute under Department of Science and Technology, Govt. of India)<br />Paschim Boragaon, Garchuk, Guwahati-781035</p>

<p>Appointment Adv.No.2</p>

<p>Applications in plain paper are invited from Indian citizens for one/two position each of Research Associate, Traineeship and Studentship for BIF facility, Division of Life Sciences, IASST.</p>

<p>Applications with complete Bio-data containing contact address, e-mail and phone number, two recent passport size photographs and attested copies of mark sheets, certificates etc., should be sent to the Registrar, IASST, Paschim Boragaon, Garchuk, Guwahati – 781035, Assam, so as to reach on or before 5/05/2014.</p>

<p>A. Research Associate:</p>

<p>Number of vacancies: 1 (One)</p>

<p>Qualifications:</p>

<p>PhD in Bioinformatics or allied disciplines with knowledge of Bioinformatics. The candidates who have submitted PhD thesis may also apply.</p>

<p>In case, candidates having PhD are not found, candidates having MSc in Bioinformatics or allied disciplines with sound knowledge of Bioinformatics will be preferred.</p>

<p>Remuneration: Candidate having PhD will get a consolidated remuneration of Rs. 22,000/- +HRA per month. MSc having NET/GATE/SLET qualified candidate will get a remuneration of Rs. 16,000/= and HRA and candidate with only MSc will get a remuneration of Rs.14,000/- and HRA.</p>

<p>Tenure:</p>

<p>The post is initially for one year and may be extended depending on the performance till the tenure of the project.</p>

<p>B. Traineeship:</p>

<p>Number of vacancies: 2 (Two)</p>

<p>Qualifications:</p>

<p>Candidate with a postgraduate degree in Bioinformatics/Biotechnology/Life sciences from a recognised University</p>

<p>Remuneration: Rs. 5000/month for 6 months</p>

<p>C. Studentship:</p>

<p>Number of vacancies: 2 (Two)</p>

<p>Qualifications:</p>

<p>Candidate pursuing M.Sc in bioinformatics in a recognised University.</p>

<p>Remuneration: Rs. 5000/month for 6 months</p>

<p>Advertisement:</p>

<p>http://iasst.gov.in/pdf/recruitment/advt%20no_2_24042014.pdf</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/11195/ncbi-gene-screencast</guid>
	<pubDate>Fri, 30 May 2014 06:21:18 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/11195/ncbi-gene-screencast</link>
	<title><![CDATA[NCBI Gene Screencast]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/WyFIf7YdM8A" frameborder="0" allowfullscreen></iframe>A short walkthrough of the NCBI Gene page]]></description>
	
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/26569/genome-stability-laboratory</guid>
  <pubDate>Mon, 07 Mar 2016 04:16:32 -0600</pubDate>
  <link></link>
  <title><![CDATA[Genome Stability Laboratory]]></title>
  <description><![CDATA[
<p>The bakers yeast, Saccharomyces cerevisiae is an ideal model organism to understand mechanisms of meiotic chromosome segregation. In S. cerevisiae and in mammals, the majority of meiotic crossovers are formed through a highly conserved MSH4p-MSH5p, MLH1p-MLH3p dependent pathway. We are interested in charactering the role of these complexes in crossover formation and distribution among all homolog pairs. Errors in this process are linked to congenital birth defects in humans such as Down's syndrome.Our laboratory is also interested in understanding the effect of genetic background on mutation rate variation using S. cerevisiae as a model. These studies are relevant for understanding cancer progression, genome evolution and architecture. We use high- throughput genomic methods as well as classical genetics to achieve these aims. </p>

<p>More at http://faculty.iisertvm.ac.in/~nishantkt/index.html</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/27961/nearhgt</guid>
	<pubDate>Wed, 22 Jun 2016 05:41:57 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/27961/nearhgt</link>
	<title><![CDATA[NearHGT]]></title>
	<description><![CDATA[<p>Horizontal gene transfer (HGT), the transfer of genetic material between organisms, is crucial for genetic innovation and the evolution of genome architecture. Existing HGT detection algorithms rely on a strong phylogenetic signal distinguishing the transferred sequence from ancestral (vertically derived) genes in its recipient genome. Detecting HGT between closely related species or strains is challenging, as the phylogenetic signal is usually weak and the nucleotide composition is normally nearly identical. Nevertheless, there is a great importance in detecting HGT between congeneric species or strains, especially in clinical microbiology, where understanding the emergence of new virulent and drug-resistant strains is crucial, and often time-sensitive.</p>
<p>We developed a novel, self-contained technique named&nbsp;<em>Near HGT</em>, based on the&nbsp;<em>synteny index</em>, to measure the divergence of a gene from its native genomic environment and used it to identify candidate HGT events between closely related strains. The method confirms candidate transferred genes based on the&nbsp;<em>constant relative mutability</em>&nbsp;(CRM). Using CRM, the algorithm assigns a confidence score based on &ldquo;unusual&rdquo; sequence divergence. A gene exhibiting exceptional deviations according to both synteny and mutability criteria, is considered a validated HGT product. We first employed the technique to a set of three&nbsp;<em>E. coli</em>&nbsp;strains and detected several highly probable horizontally acquired genes. We then compared the method to existing HGT detection tools using a larger strain data set.</p>
<p>When combined with additional approaches our new algorithm provides richer picture and brings us closer to the goal of detecting all newly acquired genes in a particular strain.</p>
<p><strong>Availability:</strong><span>&nbsp;The method is publicly available at</span><a href="http://research.haifa.ac.il/~ssagi/software/nearHGT.zip">http://research.haifa.ac.il/~ssagi/software/nearHGT.zip</a></p><p>Address of the bookmark: <a href="http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004408" rel="nofollow">http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004408</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30459/prodigal-prokaryotic-dynamic-programming-genefinding-algorithm</guid>
	<pubDate>Thu, 29 Dec 2016 03:26:45 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30459/prodigal-prokaryotic-dynamic-programming-genefinding-algorithm</link>
	<title><![CDATA[Prodigal (Prokaryotic Dynamic Programming Genefinding Algorithm)]]></title>
	<description><![CDATA[<p><span>Prodigal (</span><strong>Pro</strong><span>karyotic&nbsp;</span><strong>Dy</strong><span>namic Programming&nbsp;</span><strong>G</strong><span>enefinding&nbsp;</span><strong>Al</strong><span>gorithm) is a microbial (bacterial and archaeal) gene finding program developed at Oak Ridge National Laboratory and the University of Tennessee. Key features of Prodigal include:</span></p>
<ul>
<li><strong>Speed</strong>: Prodigal is an extremely fast gene recognition tool (written in very vanilla C). It can analyze an entire microbial genome in 30 seconds or less.</li>
<li><strong>Accuracy</strong>: Prodigal is a highly accurate gene finder. It correctly locates the 3' end of every gene in the experimentally verified Ecogene data set (except those containing introns). It possesses a very sophisticated ribosomal binding site scoring system that enables it to locate the translation initiation site with great accuracy (96% of the 5' ends in the Ecogene data set are located correctly).</li>
<li><strong>Specificity</strong>: Prodigal's false positive rate compares favorably with other gene identification programs, and usually falls under 5%.</li>
<li><strong>GC-Content Indifferent</strong>: Prodigal performs well even in high GC genomes, with over a 90% perfect match (5'+3') to the&nbsp;<em>Pseudomonas aeruginosa</em>&nbsp;curated annotations.</li>
<li><strong>Metagenomic Version</strong>: Prodigal can run in metagenomic mode and analyze sequences even when the organism is unknown.</li>
<li><strong>Ease of Use</strong>: Prodigal can be run in one step on a single genomic sequence or on a draft genome containing many sequences. It does not need to be supplied with any knowledge of the organism, as it learns all the properties it needs to on its own.</li>
<li><strong>Open Source</strong>: Prodigal source code is freely available under the General Public License.</li>
</ul>
<p>&nbsp;</p>
<div style="text-align: center;"><strong>Download the latest version of Prodigal at&nbsp;<a href="http://github.com/hyattpd/prodigal/releases/">the Prodigal github page.</a></strong>&nbsp;<br>or&nbsp;<br><strong>Browse the&nbsp;<a href="http://github.com/hyattpd/prodigal/wiki">wiki documenation.</a></strong>&nbsp;</div><p>Address of the bookmark: <a href="http://prodigal.ornl.gov/" rel="nofollow">http://prodigal.ornl.gov/</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
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