<![CDATA[BOL: Related items]]> https://bioinformaticsonline.com/related/44648?offset=130 https://bioinformaticsonline.com/bookmarks/view/42672/introduction-to-bioinformatics-and-computational-biology Mon, 25 Jan 2021 01:32:30 -0600 https://bioinformaticsonline.com/bookmarks/view/42672/introduction-to-bioinformatics-and-computational-biology <![CDATA[Introduction to Bioinformatics and Computational Biology]]> This is the course material for STAT115/215 BIO/BST282 at Harvard University.

Xiaole Shirley Liu (lead instructor)
Joshua Starmer
Martin Hemberg
Ting Wang
Feng Yue

Ming Tang
Yang Liu
Jack Kang
Scarlett Ge
Jiazhen Rong
Phillip Nicol
Maartin De Vries

We thank many colleagues in the community, who helped Dr. Liu in prepare the STAT115/215 BIO/BST282 course over the years. 

Address of the bookmark: https://liulab-dfci.github.io/bioinfo-combio/

]]> Jit https://bioinformaticsonline.com/pages/view/42814/bioinformatics-in-africa-part6-sudan Sat, 06 Feb 2021 21:20:59 -0600 https://bioinformaticsonline.com/pages/view/42814/bioinformatics-in-africa-part6-sudan <![CDATA[Bioinformatics in Africa: Part6 - Sudan]]> Commission for Biotechnology & Genetic Engineering ­ Khartoum: The Commission for Biotechnology and Genetic Engineering was established in 9/2/1993 as  research unit. In addition to research activities it acts as focal point for the International Center for  Biotechnology and Genetic Engineering. The commission conducts researches in order to play a part in solving economical, environmental,  health and nutritional problems using modern research techniques with an emphasis on the applied  researches in these areas. The laboratories were well furnished with the essential equipments and the catalyst infrastructure to  facilitate emergence of a successful for research. The Commission equipped with a computer center  and information to serve as informatics and Digital library.

Research Interest and Activities: 1. Plant Genetic Transformations
2. Molecular Population Genetics 3. Detection of human and Animals diseases 4. Breast Cancer­specific protein marker 5. Phytochemical 6. Genomic map 7. Bioremediation 8. Tissue Culture.

Web site and links: www.geocity.cbge.com

]]> BioStar https://bioinformaticsonline.com/bookmarks/view/43431/code-golf Wed, 06 Oct 2021 04:17:29 -0500 https://bioinformaticsonline.com/bookmarks/view/43431/code-golf <![CDATA[Code Golf]]> Code Golf is a game designed to let you show off your code-fu by solving problems in the least number of characters.

Since this is your first time here, I suggest starting with something simple like Fizz Buzz.

Address of the bookmark: https://code.golf/

]]> Abhi https://bioinformaticsonline.com/bookmarks/view/43681/a-guide-to-machine-learning-for-biologists Tue, 28 Dec 2021 01:43:25 -0600 https://bioinformaticsonline.com/bookmarks/view/43681/a-guide-to-machine-learning-for-biologists <![CDATA[A guide to machine learning for biologists]]> Because of the increasing size and inherent complexity of biological data, there has been an increase in the application of machine learning in biology to create useful and predictive models of the underlying biological processes. All machine learning techniques fit models to data; nevertheless, the specific methods are highly variable and can appear baffling at first glance. In this Review, we hope to give readers a moderate introduction to a few fundamental machine learning techniques, including the most recently created and frequently used deep neural network techniques. We illustrate how different algorithms may be adapted to specific types of biological data, as well as some best practises and points to consider when embarking on machine learning studies. There is also discussion of several upcoming directions in machine learning methodology.

Address of the bookmark: https://www.nature.com/articles/s41580-021-00407-0

]]> Abhi https://bioinformaticsonline.com/blog/view/44633/learn-python-with-example Tue, 06 Aug 2024 23:51:51 -0500 https://bioinformaticsonline.com/blog/view/44633/learn-python-with-example <![CDATA[Learn python with example]]>

There are over 21 unique Python project walkthroughs in this content that range from beginner to advanced. See below for the timestamps for these projects:

00:00:00 | How To Navigate These Projects
---
00:01:46 | #1 - Quiz Game (Easy)
Code: https://github.com/techwithtim/5-Python-Projects-For-Beginners/blob/main/quiz_game.py 
---
00:22:00 | #2 - Number Guessing Game (Easy)
Code: https://github.com/techwithtim/5-Python-Projects-For-Beginners/blob/main/number_guesser.py 
---
00:39:49 | #3 - Rock, Paper, Scissors (Easy)
Code: https://github.com/techwithtim/5-Python-Projects-For-Beginners/blob/main/rock_paper_scissors.py 
---
00:54:40 | #4 - Choose Your Own Adventure Game (Easy)
Code: https://github.com/techwithtim/5-Python-Projects-For-Beginners/blob/main/choose_your_own_adventure.py 
---
01:06:47 | #5 - Password Manager (Medium)
Code: https://github.com/techwithtim/5-Python-Projects-For-Beginners/ 
Fernet Cryptography Documentation: https://cryptography.io/en/latest/fernet/ 
---
01:37:37 | #6 - PIG (Medium)
Code: https://github.com/techwithtim/3-Mini-Python-Projects/blob/main/project1.py 
---
01:59:07 | #7 - Madlibs Generator (Medium)
Code: https://github.com/techwithtim/3-Mini-Python-Projects/blob/main/project2.py 
---
02:15:04 | #8 - Timed Math Challenge (Medium)
Code: https://github.com/techwithtim/3-Mini-Python-Projects/blob/main/project3.py 
---
02:28:02 | #9 - Slot Machine (Medium)
Code: https://github.com/techwithtim/Python-Slot-Machine 
---
03:20:43 | #10 - Turtle Racing (Medium)
Code: https://github.com/techwithtim/Turtle-Racing-V2 
Turtle Docs: https://docs.python.org/3/library/turtle.html 
---
04:13:09 | #11 - WPM Typing Test (Medium)
Code: https://github.com/techwithtim/WPM_Typing_Test 
Curses Docs: https://docs.python.org/3/howto/curses.html 
05:09:43 | #12 - Alarm Clock (Easy)
Python Project Idea Blog: https://hackr.io/blog/python-projects 
Sound Effects: https://www.fesliyanstudios.com/royalty-free-sound-effects-download/alarm-203 
---
05:22:07 | #13 - Password Generator (Easy)
Python Project Idea Blog: https://hackr.io/blog/python-projects 
---
05:39:16 | #14 - Shortest Path Finder (Advanced)
Code: https://github.com/techwithtim/3-Mini-Python-Projects-For-Intermediates/blob/main/path-finder.py 
---
06:14:53 | #15 - NBA Stats & Current Scores (Medium)
Code: https://github.com/techwithtim/3-Mini-Python-Projects-For-Intermediates/blob/main/nba-scores.py 
---
06:38:22 | #16 - Currency Converter (Medium)
Code: https://github.com/techwithtim/3-Mini-Python-Projects-For-Intermediates/blob/main/currency-converter.py 
API: https://free.currencyconverterapi.com/
---
06:58:51 | #17 - YouTube Video Downloader (Medium)
Code:  https://github.com/techwithtim/Python-Beginner-Automation-Projects/blob/main/youtube.py 
---
07:09:50 | #18 - Automated File Backup (Medium)
Code: https://github.com/techwithtim/Python-Beginner-Automation-Projects/blob/main/backup.py 
---
07:21:18 | #19 - Mastermind/4 Color Match (Advanced)
---
07:48:20 | #20 - Aim Trainer (Advanced)
Code: https://github.com/techwithtim/Python-Aim-Trainer 
---
08:39:20 | #21 - Advanced Python Scripting (Advanced)
Code: https://github.com/techwithtim/Python-Scripting-Project 

]]> BioStar https://bioinformaticsonline.com/pages/view/35805/python-learning-resources-for-bioinformatics-and-computational-biologist Fri, 02 Mar 2018 06:54:15 -0600 https://bioinformaticsonline.com/pages/view/35805/python-learning-resources-for-bioinformatics-and-computational-biologist <![CDATA[Python learning resources for bioinformatics and computational biologist !]]> Python is a general-purpose language, which means it can be used to build just about anything, which will be made easy with the right tools/libraries.

Professionally, Python is great for backend web development, data analysis, artificial intelligence, and scientific computing. Many developers have also used Python to build productivity tools, games, and desktop apps, so there are plenty of resources to help you learn how to do those as well.

For pros and cons visit http://www.bestprogramminglanguagefor.me/why-learn-python and http://bioinformaticsonline.com/discussion/view/459/python-vs-perl

More resources at https://github.com/CodementorIO/Python-Learning-Resources

Following are the list of useful python programming resources:

]]> Jit https://bioinformaticsonline.com/bookmarks/view/43243/interactive-bioinformatics-resources Thu, 12 Aug 2021 00:09:00 -0500 https://bioinformaticsonline.com/bookmarks/view/43243/interactive-bioinformatics-resources <![CDATA[Interactive Bioinformatics Resources !]]> Learn how to use bioinformatics tools right from your browser.
Everything runs in a sandbox, so you can experiment all you want.

More at sandbox.bio

Address of the bookmark: http://sandbox.bio

]]> Jit https://bioinformaticsonline.com/bookmarks/view/43863/snakemake-tutorials Mon, 09 May 2022 05:20:41 -0500 https://bioinformaticsonline.com/bookmarks/view/43863/snakemake-tutorials <![CDATA[Snakemake Tutorials !]]> A lesson introducing the Snakemake workflow system for bioinformatics analysis.

Prerequisites

This is an intermediate lesson and assumes learners have already done some bioinformatics:

  • Familiarity with the BASH command shell, including concepts like pipes, variables and loops.
  • Knowledge of bioinformatics fundamentals like the FASTQ file format and transcriptome sequencing, in order to understand the example workflow.

No previous knowledge of Snakemake or workflow systems is required.

https://carpentries-incubator.github.io/snakemake-novice-bioinformatics/index.html

Address of the bookmark: https://carpentries-incubator.github.io/snakemake-novice-bioinformatics/aio/index.html

]]> Rahul Nayak https://bioinformaticsonline.com/pages/view/34814/bioinformatics-web-application-development-with-perl Tue, 26 Dec 2017 18:14:11 -0600 https://bioinformaticsonline.com/pages/view/34814/bioinformatics-web-application-development-with-perl <![CDATA[Bioinformatics Web Application Development with Perl]]>

Perl's second wave of adoption came from the growth of the world wide web. Dynamic web pages—the precursor to modern web applications—were easy to create with Perl and CGI. Thanks to Perl's ubiquity as a language for system administrators and its power to manipulate text, it was the default choice for web programming. Its presence everywhere made it popular and, in some ways, the duct tape of the Internet.

Web Application Development

The old days of CGI programs and the simple development style that represented seem clunky. Web pages have become web applications. Development has moved from generating static HTML to both client and server side programming, with rich client interfaces and powerful backends.

Perl is still well suited for developing modern web apps. The language grows more powerful and easier to use every year, the available libraries are wonderful and keep getting better, and the inventions and discoveries available in modern Perl are unsurpassed.

In particular, a modern Perl developer can do amazing things with modern Perl tools. If you still think of Perl web development as a cgi-bin directory full of messy scripts that spew warnings to STDERR, you're a decade out of date. Better yet, you can replace that mess piecemeal, thanks to the new tools and techniques of modern Perl. See, for example, the ever-growing list of technologies Built in Perl.

Modern Perl Web Frameworks

While the old wave of web development may have made the CGI.pm module central, modern Perl web programming follows a stricter separation of business logic, URL and request routing, and output. The days of slinging a string here, an array there, a Perl hash yonder, declaring every variable at the top of the program, and maybe making a subroutine are gone. The Perl world has seen the value of abstraction and ways to mechanize away boilerplate. Perl has dozens of frameworks and toolkits designed to make web development and deployment simpler.

Any of a dozen of these frameworks will help you do great things, but three in particular stand out. You can build web sites and web applications of tremendous value with all three. These are neither the only good possibilities (think of POE or Jifty or Continuity or...) nor the only mechanisms for web programming with Perl (see Mechanize or LWP or Mojo::UserAgent for more). Yet if you want three good options to choose between, start here.

Catalyst

The Catalyst framework is a flexible and powerful system for building small to large web apps. It uses the Moose object system to provide great APIs for extension and further development. It's the most mature of the modern top Perl web frameworks, yet it retains its flexibility and vibrancy. In particular, its plugin and extension ecosystem allows it to evolve to provide new and essential features.

Catalyst has embraced the Plack/PSGI standard for Perl web deployment and recent versions are exploring high-scalability, event-based request handling models.

Dancer

The Dancer framework is deliberately minimal in syntax and scope, but it also has a vibrant plugin ecosystem. Dancer particularly excels for smaller sites and applications, though good programmers can build larger things with it.

The first version of Dancer was easy to use. Dancer 2 continues that ease while improving the internals and robustness of applications.

Mojolicious

The Mojolicious (Mojo) framework has a real-time design based on high performance event handling. Its focus is solving new and interesting problems in simple and effective ways, and the project has produced a lot of new code that does old things in better ways.

In particular, Mojolicious goes to great lengths to support new web standards, such as CSS 3, web sockets, and HTTP 2.

Where Catalyst embraces the CPAN fully, Mojolicious by design provides most of what an average app might need in a single download. It's still fully compatible with the CPAN, but the intention is to provide good working defaults in a package that's easy to start with. Mojo's fans are quick to praise it as fun to develop.

A modern Perl web developer should be familiar with at least one of these frameworks.

Modern Perl Storage Mechanisms

Perl's venerable DBI module has been the focal point of database access since its invention. Its design allows it to provide the same interface to huge relational databases and flat files alike through its DBD extension mechanism. Yet the DBI by itself isn't the be-all, end-all of data storage and access in Perl.

DBIx::Class

DBIx::Class sits on top of DBI to provide an API to your database based on the concept of queries and results. This is often sufficient to remove all but the most complicated of SQL from your code, leaving you to manipulate your business models instead of the small details of how a relational database works. The power and maintainability you receive is well the small cost of the learning curve.

Even better, DBIC can manage (and even generate) your database schema for you.

Recent versions of DBIC have demonstrated that a well-written ORM can perform much better than even clever hand-written code. Because it builds on the Perl DBI, it scales everywhere from SQLite to PostgreSQL, MySQL, Oracle, and more.

Rose::DB

The lesser-known but no less powerful Rose::DB::Object builds on Rose::DB to provide an object-relational mapper for Perl. While its high level features most directly compare to those of DBIx::Class, it's often measurably faster.

NoSQL on the CPAN

Of course the CPAN has modules for almost any NoSQL database or job queue or persistence mechanism you could name, and several you have never heard of. Everything you need is a quick CPAN or cpanm away!

Modern Perl Deployment Strategies

In the early days of the web, deploying a Perl web application meant putting one or more .cgi or .pl files in a special directory and hoping that your system administrator had everything configured correctly. The execution model was often slow and cumbersome, and accessing shared resources such as databases was often tricky.

Modern Perl has better choices. While deployment strategies are the source of many arguments, the return on your investment from learning the modern way is impressive.

Plack/PSGI

The PSGI specification (as exemplified by Plack) describes a strategy for building Perl web apps independent of server and with the possibility to share custom processing behaviors.

In other words, it's a standard for writing Perl apps to take advantage of the huge ecosystem of Perl development available on the CPAN without tying yourself to a server like Apache, Apache 2, nginx, or anything else.

Any good modern Perl web framework (including those listed here) supports PSGI. Several deployment mechanisms exist to meet various business needs which also support PSGI. In particular, you can deploy the same application with a local testing server on your own machine as you can to your production server or servers without changing your application at all.

mod_perl

The older but still viable mod_perl Apache httpd module embeds Perl into the web server. This was the first widespread persistence mechanism for Perl web applications themselves and it's still popular to this day, though PSGI compliance is often the choice for new development. (PSGI handlers to use mod_perl as the backend are available.)

Modern Perl developers should familiarize themselves with PSGI and the wealth of available Plack middleware.

Perl Web Development

Of course no discussion of Perl web development would be complete without mentioning the strength of the CPAN. Almost any project will benefit from the wealth of freely available libraries built to solve real problems. These distributions run the gamut from full-blown web frameworks and content management systems to APIs for web services, development tools, testing systems, and interfaces to document formats and external resources.

For example, if you need to write a web service which accepts JSON data and produces Excel spreadsheets, you can glue together a few CPAN distributions and get the job done early. If you need to consume XML from a remote service and emit a PDF, you're in luck.

Perl's prowess as a general purpose programming language as well as its flexibility and power in managing text and gluing systems together make it a wonderful fit for web development. The community's adoption of modern Perl standards such as PSGI and Plack only enhance your power.

Web application development in Perl is still viable, and modern Perl tools and techniques and libraries make it more powerful and pleasant than ever.

]]> Jit https://bioinformaticsonline.com/news/view/120/user Wed, 10 Jul 2013 14:41:49 -0500 https://bioinformaticsonline.com/news/view/120/user <![CDATA[useR!]]> The R project actively supports two conference series, organized regularly by members from the R community: useR! - providing a forum to the R user community - and DSC - a platform for developers of statistical software.

Recently useR! conference have been organized University of Castilla-La Mancha, Albacete, Spain.

http://www.edii.uclm.es/~useR-2013//

 

]]> Jitendra Narayan