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	<title><![CDATA[BOL: Related items]]></title>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/20504/chromevol</guid>
	<pubDate>Sun, 25 Jan 2015 00:33:11 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/20504/chromevol</link>
	<title><![CDATA[ChromEvol]]></title>
	<description><![CDATA[<p>Chromosome number is a remarkably dynamic feature of eukaryotic evolution. Chromosome numbers can change by a duplication of the whole genome (a process termed polyploidy), or by single chromosome changes (ascending dysploidy via, e.g., chromosome fission or descending dysploidy via, e.g., chromosome fusion).<br> Of the various mechanisms of chromosome number change, polyploidy has received significant attention because of the impact such an event may have on the organism.<br> ChromEvol implements a series of likelihood models for the evolution of chromosome numbers. By comparing the fit of the different models to biological data, it may be possible to gain insight regarding the pathways by which the evolution of chromosome number proceeds. For each model, the program estimates the rates for the possible transitions assumed by the model, infers the set of ancestral chromosome numbers, and estimates the location along the tree for which polyploidy events (and other chromosome number changes) occurred. For further methodological details, see the publications and manual on the Downloads page.</p>
<p>http://www.tau.ac.il/~itaymay/cp/chromEvol/about.html</p><p>Address of the bookmark: <a href="http://www.tau.ac.il/~itaymay/cp/chromEvol/downloads.html" rel="nofollow">http://www.tau.ac.il/~itaymay/cp/chromEvol/downloads.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/26629/computer-simulation-of-genetic-mechanism</guid>
	<pubDate>Sun, 13 Mar 2016 09:29:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/26629/computer-simulation-of-genetic-mechanism</link>
	<title><![CDATA[Computer simulation of genetic mechanism !!]]></title>
	<description><![CDATA[<p>Computer simulation is the discipline of designing a model of an actual or theoretical physical/biological system, executing the model on a digital computer, and analyzing the execution output. Simulation embodies the principle of ``learning by doing'' --- to learn about the system we must first build a model of some sort and then operate the model. The use of simulation is an activity that is as natural as a child who role plays. Children understand the world around them by simulating (with toys and figurines) most of their interactions with other people, animals and objects. As adults, we lose some of this childlike behavior but recapture it later on through computer simulation. To understand reality and all of its complexity, we must build artificial objects and dynamically act out roles with them. Computer simulation is the electronic equivalent of this type of role playing and it serves to drive synthetic environments and virtual worlds. Within the overall task of simulation, there are three primary sub-fields: model design, model execution and model analysis<br /><br />Simulation models have become important tools in Bioinformatics studies. There are many reasons for this, but we emphasize three of the more important:</p><p>(1) they enable exploration of hypotheses, and as such, have become invaluable means to guide research;</p><p>(2) they are unique approaches to integrate (in the literal term of the word) biological knowledge, in the form of experimental results; and</p><p>(3) they enable connecting biology with other fields of study ranging from physiology to genomics;</p><p>This blog, and this software list, is intended to guide the potential user of simulation models.<br />It is not, in any way, meant to be comprehensive on the very diverse simulation tools that already exist, but focuses on mechanistic, dynamic models. Similarly, it is not meant to provide any coverage of the breadth of applications; however, for interested readers, we provide references to use as a possible starting point.<br /><br />Simulation models are meant to answer questions which scientists have in a dynamic, quantitative, and often, a pictorial way. Much of the bioinformatics research and its applications, in particular, involve a large number of components, actors, and factors. Assembling these in a coherent framework may seem a daunting task, especially for beginners, and can lead to confusion, even for experienced scientists, especially if the objectives of such an exercise are not well defined. Followings are the list of tools bioinformatician may use to analyze and provide answers to complex biological mechanisms and related problems.</p><p style="margin-bottom: 0in;">&nbsp;</p><table width="718" cellspacing="0" cellpadding="2"><colgroup><col width="134"> <col width="501"> </colgroup>
<tbody>
<tr><th style="border: none; padding: 0in;">
<p>Software Resource</p>
</th><th style="border: none; padding: 0in;">
<p>Brief Description and Homepage</p>
</th></tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/aladyn/">Aladyn </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Tools to investigate how demographic parameters, populations genetics and abiotic conditions affect the rate of adaptation <br /><a href="http://www.katja-schiffers.eu/research.html">http://www.katja-schiffers.eu/research.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/alf/">ALF </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A Simulation Framework for Genome Evolution <br /><a href="http://www.cbrg.ethz.ch/alf">http://www.cbrg.ethz.ch/alf</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/art/">ART </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>ART is a set of simulation tools to generate synthetic next-generation sequencing data by mimicking real sequencing process with empirical error models or quality profiles. <br /><a href="http://www.niehs.nih.gov/research/resources/software/biostatistics/art/">http://www.niehs.nih.gov/research/resources/software/biostatistics/art/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bamsurgeon/">BAMSurgeon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Methods for realistic simulation of mutations in real data. <br /><a href="https://github.com/adamewing/bamsurgeon">https://github.com/adamewing/bamsurgeon</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bayesian-serial-simcoal/">Bayesian Serial SimCoal </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Bayesian Serial SimCoal, (BayeSSC) is a modification of SIMCOAL 1.0, a program written by Laurent Excoffier, John Novembre, and Stefan Schneider. <br /><a href="http://www.stanford.edu/group/hadlylab/ssc/index.html">http://www.stanford.edu/group/hadlylab/ssc/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/baysics/">BaySICS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An integral platform with a graphical interface for statistical inference based on approximate Bayesian computation. <br /><a href="https://sites.google.com/site/baysicsabc/">https://sites.google.com/site/baysicsabc/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/beers/">BEERS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BEERS was designed to benchmark RNA-Seq alignment algorithms and also algorithms that aim to reconstruct different isoforms and alternate splicing from RNA-Seq data <br /><a href="http://cbil.upenn.edu/BEERS/">http://cbil.upenn.edu/beers/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bottleneck/">BOTTLENECK </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Bottleneck is a program for detecting recent effective population size reductions from allele data frequencies <br /><a href="http://www.ensam.inra.fr/URLB/bottleneck/bottleneck.html">http://www.ensam.inra.fr/urlb/bottleneck/bottleneck.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bottlesim/">BottleSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BottleSim is a computer simulation program for simulating the process of population bottlenecks <br /><a href="http://chkuo.name/software/BottleSim.html">http://chkuo.name/software/bottlesim.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cass/">CASS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Protein Sequence Simulation <br /><a href="https://liberles.cst.temple.edu/Software/CASS/index.html">https://liberles.cst.temple.edu/software/cass/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cdpop/">CDPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>CDPOP is a landscape genetics tool for simulating the emergence of spatial genetic structure in populations resulting from specified landscape processes governing organism movement behavior. <br /><a href="http://cel.dbs.umt.edu/CDPOP">http://cel.dbs.umt.edu/cdpop</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/classical-genetics-simulator/">Classical Genetics Simulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Web-based simulation software <br /><a href="http://www.cgslab.com/">http://www.cgslab.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/coasim/">CoaSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>CoaSim is a tool for simulating the coalescent process with recombination and geneconversion under various demographic models. <br /><a href="http://users-birc.au.dk/mailund/CoaSim/index.html">http://users-birc.au.dk/mailund/coasim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cosi/">cosi </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The cosi package is written in C and is available as a tar file. <br /><a href="http://www.broadinstitute.org/%7Esfs/cosi/">http://www.broadinstitute.org/~sfs/cosi/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cs-pseq-gen/">CS-PSeq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program to simulate the evolution of protein sequences under the constraints of the information of a particular reconstructed phylogeny <br /><a href="http://bioserv.rpbs.univ-paris-diderot.fr/software/CS-PSeq-Gen/">http://bioserv.rpbs.univ-paris-diderot.fr/software/cs-pseq-gen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/dawg/">DAWG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An application designed to simulate the evolution of recombinant DNA sequences in continuous time <br /><a href="http://scit.us/projects/dawg">http://scit.us/projects/dawg</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/easypop/">Easypop </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EASYPOP is an individual based model intended to simulate datasets under a very broad range of conditions <br /><a href="http://www.unil.ch/dee/en/home/menuinst/softwares--dataset/softwares/easypop.html">http://www.unil.ch/dee/en/home/menuinst/softwares--dataset/softwares/easypop.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/egglib/">EggLib </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EggLib is a C++/Python library and program package for evolutionary genetics and genomics. <br /><a href="http://egglib.sourceforge.net/">http://egglib.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/episim/">EpiSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EpiSIM: simulation of multiple epistasis, linkage disequilibrium patterns and haplotype blocks for genome-wide interaction analysis <br /><a href="https://sourceforge.net/projects/episimsimulator/files/">https://sourceforge.net/projects/episimsimulator/files/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/evolsimulator/">EvolSimulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation test bed for hypotheses of genome evolution <br /><a href="http://acb.qfab.org/acb/evolsim/">http://acb.qfab.org/acb/evolsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/evolveagene/">EvolveAGene </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A realistic coding sequence simulation program that separates mutation from selection and allows the user to set selection conditions <br /><a href="http://bellinghamresearchinstitute.com/software/index.html">http://bellinghamresearchinstitute.com/software/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fastsimcoal/">fastsimcoal </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A continuous-&shy;‐time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios <br /><a href="http://cmpg.unibe.ch/software/fastsimcoal/">http://cmpg.unibe.ch/software/fastsimcoal/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fastslink/">FastSLINK </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of Marker and Phenotype Data in Pedigrees <br /><a href="https://watson.hgen.pitt.edu/">https://watson.hgen.pitt.edu/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ffpopsim/">FFPopSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>C++/Python library for population genetics. <br /><a href="http://webdav.tuebingen.mpg.de/ffpopsim/">http://webdav.tuebingen.mpg.de/ffpopsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/flux-simulator/">FLUX SIMULATOR </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The Flux Simulator aims at providing a deterministic in silico reproduction of the experimental pipelines for RNA-Seq, employing a minimal set of parameters. <br /><a href="http://sammeth.net/confluence/display/SIM/Home">http://sammeth.net/confluence/display/sim/home</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forqs/">forqs </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Forward-in-time simulation of Recombination, Quantitative Traits, and Selection <br /><a href="https://bitbucket.org/dkessner/forqs">https://bitbucket.org/dkessner/forqs</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forsim/">ForSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>ForSim: A Forward Evolutionary Computer Simulation <br /><a href="http://anth.la.psu.edu/research/weiss-lab/research/research">http://anth.la.psu.edu/research/weiss-lab/research/research</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forwsim/">ForwSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The program given below is based on the algorithm described in Padhukasahasram et al. 2008 to simulate genetic drift in a standard Wright-Fisher process. <br /><a href="http://badri-populationgeneticsimulators.blogspot.com/">http://badri-populationgeneticsimulators.blogspot.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fpg/">FPG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Forward Population Genetic simulation <br /><a href="https://bio.cst.temple.edu/%7Ehey/software/software.htm#FPG">https://bio.cst.temple.edu/~hey/software/software.htm#fpg</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fregene/">FREGENE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>FREGENE is a C++ program that simulates sequence-like data over large genomic regions in large diploid populations. <br /><a href="http://www.ebi.ac.uk/projects/BARGEN">http://www.ebi.ac.uk/projects/bargen</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/frequency-based-insilico-genome-generator-figg/">FIGG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>FIGG is a genome simulation tool that uses known or theorized variation frequency, per a given fragment size and grouped by GC content across a genome to model new genomes in FASTA format while tracking applied mutations for use in analysis <br /><a href="http://insilicogenome.sourceforge.net/">http://insilicogenome.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fwdpp/">fwdpp </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A C++ template library for implementing efficient forward simulations. <br /><a href="http://molpopgen.github.io/fwdpp/">http://molpopgen.github.io/fwdpp/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gametes/">GAMETES </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genetic Architecture Model Emulator for Testing and Evaluating Software: Simulates complex SNP models with pure, strict epistatic interactions with n-loci. <br /><a href="http://sourceforge.net/projects/gametes/?source=navbar">http://sourceforge.net/projects/gametes/?source=navbar</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gasp/">GASP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genometric Analysis Simulation Program. A software tool for testing and investigating methods in statistical genetics by generating samples of family data based on user specified models. <br /><a href="http://research.nhgri.nih.gov/gasp/">http://research.nhgri.nih.gov/gasp/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gcta/">GCTA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genome-wide Complex Trait Analysis <br /><a href="http://www.complextraitgenomics.com/software/gcta/download.html">http://www.complextraitgenomics.com/software/gcta/download.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gemsim/">GemSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Next generation sequencing read simulator <br /><a href="http://sourceforge.net/projects/gemsim/">http://sourceforge.net/projects/gemsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/geneartisan/">GeneArtisan </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of Markers in Case-Control Study Designs <br /><a href="http://www.rannala.org/?page_id=241">http://www.rannala.org/?page_id=241</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genome/">GENOME </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A rapid coalescent-based whole genome simulator <br /><a href="http://www.sph.umich.edu/csg/liang/genome/">http://www.sph.umich.edu/csg/liang/genome/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genomepop2/">GenomePop2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>GenomePop2 is a specialization of the program GenomePop just to manage SNPs under more flexible and useful settings. If you need models with more than 2 alleles please use the GenomePop program version. <br /><a href="https://ritchielab.psu.edu/research/research-areas/statistical-genetics-and-gen-epi/methods/genomesimla">https://ritchielab.psu.edu/research/research-areas/statistical-genetics-and-gen-epi/methods/genomesimla</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genomesimla/">GenomeSimla </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>GenomeSIMLA is currently under development- however, we have a beta release that we are asking to be tested <br /><a href="http://chgr.mc.vanderbilt.edu/genomeSIMLA/">http://chgr.mc.vanderbilt.edu/genomesimla/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gens2/">GENS2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates interactions among two genetic and one environmental factor and also allows for epistatic interactions. <br /><a href="https://sourceforge.net/projects/gensim/">https://sourceforge.net/projects/gensim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gwasimulator/">GWAsimulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A rapid whole genome simulation program <br /><a href="http://biostat.mc.vanderbilt.edu/wiki/Main/GWAsimulator">http://biostat.mc.vanderbilt.edu/wiki/main/gwasimulator</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hap-sample/">HAP-SAMPLE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An association simulator for candidate regions or genome scans <br /><a href="http://www.hapsample.org/">http://www.hapsample.org/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapgen/">HAPGEN </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulator for the simulation of case control datasets at SNP markers <br /><a href="https://mathgen.stats.ox.ac.uk/genetics_software/hapgen/hapgen2.html">https://mathgen.stats.ox.ac.uk/genetics_software/hapgen/hapgen2.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapsim/">HapSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients <br /><a href="http://cran.r-project.org/web/packages/hapsim/index.html">http://cran.r-project.org/web/packages/hapsim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapsimu/">HAPSIMU </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program that simulates heterogeneous populations with various known and controllable structures under the continuous migration model or the discrete model <br /><a href="http://l.web.umkc.edu/liujian/">http://l.web.umkc.edu/liujian/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ibdsim/">IBDsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>IBDSim is a computer package for the simulation of genotypic data under general isolation by distance models. <br /><a href="http://raphael.leblois.free.fr/">http://raphael.leblois.free.fr/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/indel-seq-gen/">indel-Seq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A biological sequence simulation program that simulates highly divergent DNA sequences and protein superfamilies <br /><a href="http://bioinfolab.unl.edu/%7Ecstrope/iSG/">http://bioinfolab.unl.edu/~cstrope/isg/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/indelible/">Indelible </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A powerful and flexible simulator of biological evolution <br /><a href="http://abacus.gene.ucl.ac.uk/software/indelible/">http://abacus.gene.ucl.ac.uk/software/indelible/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/invertfregene/">invertFREGENE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>InvertFREGENE is a forward-in-time simulator of inversions in population genetic data <br /><a href="http://www.ebi.ac.uk/projects/BARGEN/">http://www.ebi.ac.uk/projects/bargen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/kernalpop/">kernalPop </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A spatially explicit population genetic simulation engine <br /><a href="http://cran.r-project.org/src/contrib/Archive/kernelPop/">http://cran.r-project.org/src/contrib/archive/kernelpop/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/macs/">MaCS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Markovian Coalescent Simulator <br /><a href="http://www-hsc.usc.edu/%7Egarykche/">http://www-hsc.usc.edu/~garykche/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/marlin/">Marlin </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Marlin provides a user-friendly interface for performing forward-in-time population genetic simulations. <br /><a href="http://www.patrickmeirmans.com/software/Marlin.html">http://www.patrickmeirmans.com/software/marlin.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mason/">Mason </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A package for the simulation of nucleotide data. <br /><a href="http://www.seqan.de/projects/mason/">http://www.seqan.de/projects/mason/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mbs/">mbs </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection <br /><a href="http://www.sendou.soken.ac.jp/esb/innan/InnanLab/software.html">http://www.sendou.soken.ac.jp/esb/innan/innanlab/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mendels-accountant/">Mendel's Accountant </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Mendel's Accountant (MENDEL) is an advanced numerical simulation program for modeling genetic change over time and was developed collaboratively by Sanford, Baumgardner, Brewer, Gibson and ReMine <br /><a href="http://mendelsaccount.sourceforge.net/">http://mendelsaccount.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/metapopgen/">MetaPopGen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates genetics in large size metapopulations <br /><a href="https://sites.google.com/site/marcoandrello/metapopgen">https://sites.google.com/site/marcoandrello/metapopgen</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/metasim/">MetaSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A tool to generate collections of synthetic reads that reflect the diverse taxonomical composition of typical metagenome data sets <br /><a href="http://ab.inf.uni-tuebingen.de/software/metasim/">http://ab.inf.uni-tuebingen.de/software/metasim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mlcoalsim/">mlcoalsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Multilocus Coalescent Simulations <br /><a href="http://code.google.com/p/mlcoalsim-v1/">http://code.google.com/p/mlcoalsim-v1/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ms/">ms </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The purpose of this program is to allow one to investigate the statistical properties of such samples, to evaluate estimators or statistical tests, and generally to aid in the interpretation of polymorphism data sets. <br /><a href="http://home.uchicago.edu/%7Erhudson1/source/mksamples.html">http://home.uchicago.edu/~rhudson1/source/mksamples.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mshot/">msHOT </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The purpose of this program is to allow one to investigate the statistical properties of such samples, to evaluate estimators or statistical tests, and generally to aid in the interpretation of polymorphism data sets. <br /><a href="http://home.uchicago.edu/%7Erhudson1/">http://home.uchicago.edu/~rhudson1/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/msms/">msms </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent Simlation tool with selection. <br /><a href="http://www.mabs.at/ewing/msms/index.shtml">http://www.mabs.at/ewing/msms/index.shtml</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/myssp/">MySSP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program for the simulation of DNA sequence evolution across a phylogenetic tree <br /><a href="http://www.rosenberglab.net/software.html">http://www.rosenberglab.net/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/nemo/">Nemo </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A forward-time, individual-based, genetically explicit, and stochastic simulation program designed to study the evolution of genetic markers, life history traits, and phenotypic traits in a flexible (meta-)population framework. <br /><a href="http://nemo2.sourceforge.net/">http://nemo2.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/netrecodon/">NetRecodon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of coding DNA sequences with recombination (inter and intracodon), migration and demography <br /><a href="http://code.google.com/p/netrecodon/">http://code.google.com/p/netrecodon/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/oncosimulr/">OncoSimulR </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BioConductor package for Forward Genetic Simulation of Cancer Progresion with Epistasis <br /><a href="https://github.com/rdiaz02/OncoSimul">https://github.com/rdiaz02/oncosimul</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/pedagog/">PEDAGOG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Software for simulating eco-evolutionary population dynamics <br /><a href="https://bcrc.bio.umass.edu/pedigreesoftware/node/5">https://bcrc.bio.umass.edu/pedigreesoftware/node/5</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/phenosim/">phenosim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A tool to add phenotypes to simulated genotypes <br /><a href="http://evoplant.uni-hohenheim.de/doku.php?id=software:software">http://evoplant.uni-hohenheim.de/doku.php?id=software:software</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/phylosim/">PhyloSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An R package for the Monte Carlo simulation of sequence evolution <br /><a href="http://www.ebi.ac.uk/goldman-srv/phylosim/">http://www.ebi.ac.uk/goldman-srv/phylosim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/pirs/">pIRS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Profile-based Illumina pair-end reads simulator <br /><a href="https://code.google.com/p/pirs/">https://code.google.com/p/pirs/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/proteinevolver/">ProteinEvolver </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of protein evolution along phylogenies under structure-based substitution models <br /><a href="http://code.google.com/p/proteinevolver/">http://code.google.com/p/proteinevolver/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/qmsim/">QMSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>QTL and Marker Simulator <br /><a href="http://www.aps.uoguelph.ca/%7Emsargol/qmsim/">http://www.aps.uoguelph.ca/~msargol/qmsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/quantinemo/">quantiNEMO </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An individual-based program for the analysis of quantitative traits with explicit genetic architecture potentially under selection in a structured population <br /><a href="http://www2.unil.ch/popgen/softwares/quantinemo/">http://www2.unil.ch/popgen/softwares/quantinemo/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/recoal/">RECOAL </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates new haplotype data from a reference population of haplotypes. <br /><a href="ftp://popgen.usc.edu/">ftp://popgen.usc.edu/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/recodon/">Recodon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of coding DNA sequences with recombination, migration and demography <br /><a href="http://code.google.com/p/recodon/">http://code.google.com/p/recodon/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rlsim/">rlsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A package for simulating RNA-seq library preparation with parameter estimation <br /><a href="http://bit.ly/rlsim-git">http://bit.ly/rlsim-git</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rmetasim/">Rmetasim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Rmetasim is a front-end for the metasim engine that is implemented as a package that runs in the statistical computing environment R <br /><a href="http://cran.r-project.org/web/packages/rmetasim/index.html">http://cran.r-project.org/web/packages/rmetasim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rna-seq-simulator/">RNA Seq Simulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>RSS takes SAM alignment files from RNA-Seq data and simulates over dispersed, multiple replica, differential, non-stranded RNA-Seq datasets. <br /><a href="http://useq.sourceforge.net/cmdLnMenus.html#RNASeqSimulator">http://useq.sourceforge.net/cmdlnmenus.html#rnaseqsimulator</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rose/">Rose </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Random model of sequence evolution <br /><a href="http://bibiserv.techfak.uni-bielefeld.de/rose/">http://bibiserv.techfak.uni-bielefeld.de/rose/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/scrm/">scrm </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent simulator optimized for long sequences and large samples. <br /><a href="https://scrm.github.io/">https://scrm.github.io/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/selsim/">SelSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recom- bining region within which a single bi-allelic site has experienced natural selection <br /><a href="http://www.well.ox.ac.uk/%7Espencer/SelSim/">http://www.well.ox.ac.uk/~spencer/selsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seq-gen/">Seq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An application for the Monte Carlo simulation of molecular sequence evolution along phylogenetic trees. <br /><a href="http://tree.bio.ed.ac.uk/software/seqgen/">http://tree.bio.ed.ac.uk/software/seqgen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seqpower/">SEQPower </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Statistical power analysis for sequence-based association studies <br /><a href="http://bioinformatics.org/spower/">http://bioinformatics.org/spower/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seqsimla/">SeqSIMLA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SeqSIMLA can simulate sequence data with user-specified disease and quantitative trait models. Family or unrelated case-control data can be simulated. <br /><a href="http://seqsimla.sourceforge.net/">http://seqsimla.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/serial-netevolve/">Serial NetEvolve </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A flexible utility for generating serially-sampled sequences along a tree or recombinant network <br /><a href="http://biorg.cis.fiu.edu/SNE/">http://biorg.cis.fiu.edu/sne/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sfs_code/">SFS_CODE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SFS_CODE can perform forward population genetic simulations under a general Wright-Fisher model with arbitrary migration, demographic, selective, and mutational effects. <br /><a href="http://sfscode.sourceforge.net/SFS_CODE/index/index.html">http://sfscode.sourceforge.net/sfs_code/index/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sibsim/">SIBSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Quantitative phenotype simulation in extended pedigrees <br /><a href="http://sourceforge.net/projects/sibsim/">http://sourceforge.net/projects/sibsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simadapt/">SimAdapt </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A spatially explicit, individual-based, forward-time, landscape-genetic simulation model combined with a landscape cellular automaton. <br /><a href="https://www.openabm.org/model/3137">https://www.openabm.org/model/3137</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simcoal2/">SIMCOAL2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent program for the simulation of complex recombination patterns over large genomic regions under various demographic models <br /><a href="http://cmpg.unibe.ch/software/simcoal2/">http://cmpg.unibe.ch/software/simcoal2/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simcopy/">SimCopy </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An R package simulating the evolution of copy number profiles along a tree. <br /><a href="http://bit.ly/simcopy">http://bit.ly/simcopy</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simla/">SIMLA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SIMLA is a SIMuLAtion program that generates data sets of families for use in Linkage and Association studies. <br /><a href="http://dmpi.duke.edu/simla-simulation-software-version-32">http://dmpi.duke.edu/simla-simulation-software-version-32</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simped/">SimPed </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A Simulation Program to Generate Haplotype and Genotype Data for Pedigree Structures <br /><a href="http://bioinformatics.org/simped/">http://bioinformatics.org/simped/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simprot/">Simprot </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program to simulate protein evolution by substitution, insertion and deletion <br /><a href="http://www.uhnresearch.ca/labs/tillier/software.htm#3">http://www.uhnresearch.ca/labs/tillier/software.htm#3</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simrare/">SimRare </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Rare variant simulation and analysis tool <br /><a href="http://code.google.com/p/simrare/">http://code.google.com/p/simrare/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simugwas/">simuGWAS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A forward-time simulator that simulates realistic samples for genome-wide association studies. <br /><a href="http://simupop.sourceforge.net/Cookbook/SimuGWAS">http://simupop.sourceforge.net/cookbook/simugwas</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simupop/">simuPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>simuPOP is a general-purpose individual-based forward-time population genetics simulation environment. <br /><a href="http://simupop.sourceforge.net/">http://simupop.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sissi/">SISSI </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A software tool to generate data of related sequences along a given phylogeny, taking into account user defined system of neighbourhoods and instantaneous rate matrices. <br /><a href="http://www.cibiv.at/software/sissi/">http://www.cibiv.at/software/sissi/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/smartpop/">SMARTPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulating Mating Alliance as a Reproductive Tactic for Populations <br /><a href="http://smartpop.sourceforge.net/">http://smartpop.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/snpsim/">SNPsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of hotspot recombination <br /><a href="http://code.google.com/p/phylosoftware/">http://code.google.com/p/phylosoftware/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/spip/">SPIP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SPIP simulates the transmission of genes from parents to offspring in a population having demographic structure defined by the user <br /><a href="http://swfsc.noaa.gov/textblock.aspx?Division=FED&amp;id=3434">http://swfsc.noaa.gov/textblock.aspx?division=fed&amp;id=3434</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/splatche/">Splatche </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Spatial and Temporal Coalescences in Heterogeneous Environment <br /><a href="http://www.splatche.com/">http://www.splatche.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/srv/">srv </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulator of Rare Varaints (srv) is a simulator for the simulation of the introduction and evolution of (rare) genetic variants. <br /><a href="http://simupop.sourceforge.net/Cookbook/SimuRareVariants">http://simupop.sourceforge.net/cookbook/simurarevariants</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sup/">SUP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SLINK/FastSLINK utility program <br /><a href="http://mlemire.freeshell.org/software.html">http://mlemire.freeshell.org/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/treesimj/">TreesimJ </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A flexible, forward-time population genetic simulator <br /><a href="http://code.google.com/p/treesimj/">http://code.google.com/p/treesimj/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/variant-simulation-tools/">Variant Simulation Tools </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation tool for post-GWAS genetic epidemiological studies using whole-genome or whole-exome next-gen sequencing data, with an emphasis on user-friendliness and reproducibility. <br /><a href="http://varianttools.sourceforge.net/Simulation/HomePage">http://varianttools.sourceforge.net/simulation/homepage</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/vortex/">Vortex </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>VORTEX is an individual-based simulation model for population viability analysis (PVA). <br /><a href="http://www.vortex9.org/vortex.html">http://www.vortex9.org/vortex.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/wessim/">Wessim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Whole Exome Sequencing SIMulator <br /><a href="http://sak042.github.io/Wessim/">http://sak042.github.io/wessim/</a></p>
</td>
</tr>
</tbody>
</table><p style="margin-bottom: 0in;">&nbsp;</p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/35125/eugene-v-koonin-lab</guid>
  <pubDate>Tue, 09 Jan 2018 05:01:15 -0600</pubDate>
  <link></link>
  <title><![CDATA[Eugene V. Koonin Lab]]></title>
  <description><![CDATA[
<p>Interested in understanding the evolution of life. To obtain glimpses of such understanding, we employ existing and new methods of computational biology to perform research in several major areas.</p>

<p>https://www.ncbi.nlm.nih.gov/research/groups/koonin/</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/42326/edanchin-lab</guid>
  <pubDate>Thu, 19 Nov 2020 08:00:07 -0600</pubDate>
  <link></link>
  <title><![CDATA[Edanchin Lab]]></title>
  <description><![CDATA[
<p>My main topics of interest are:</p>

<p>The impact of non tree-like evolution such as horizontal gene transfers and hybridization on species biology<br />Evolution and adaptation of animals in the absence of sexual reproduction and the underlying mechanisms<br />Genomic signatures of adaptation to a parasitic life-style</p>

<p>More at https://edanchin.org/</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/43762/vicoso-group</guid>
  <pubDate>Wed, 02 Feb 2022 02:51:27 -0600</pubDate>
  <link></link>
  <title><![CDATA[Vicoso group]]></title>
  <description><![CDATA[
<p>The Vicoso group investigates how sex chromosomes evolve over time, and what biological forces are driving their patterns of differentiation.</p>

<p>The Vicoso group is interested in understanding several aspects of the biology of sex chromosomes, and the evolutionary processes that shape their peculiar features. By combining the use of next-generation sequencing technologies with studies in several model and non-model organisms, they can address a variety of standing questions, such as: Why do some Y chromosomes degenerate while others remain homomorphic, and how does this relate to the extent of sexual dimorphism of the species? What forces drive some species to acquire global dosage compensation of the X, while others only compensate specific genes? What are the frequency and molecular dynamics of sex-chromosome turnover?</p>

<p>More at https://ist.ac.at/en/research/vicoso-group/<br />http://pub.ist.ac.at/~bvicoso/</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44614/online-resources-on-must-read-papers-in-evolutionary-biology</guid>
	<pubDate>Fri, 26 Jul 2024 01:39:14 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44614/online-resources-on-must-read-papers-in-evolutionary-biology</link>
	<title><![CDATA[Online resources on must-read papers in evolutionary biology]]></title>
	<description><![CDATA[<pre>Online resources on must-read papers in evolutionary biology, for a literature club.<br /><br />Below is a summary of all answers that we received.

All the best,

Jana and Xiaoyan

1.       *Nick Barton:*

- The textbook "Evolution" by Nick Barton, with resources for
  exploring the literature: Barton, N. H., Briggs, D. E. G., Eisen, J.
  A., Goldstein, D. B., &amp; Patel, N. H. (2007). Evolution. Cold Spring
  Harbor Laboratory Press.

- Papers from a course named "Classics in Evolutionary Biology":

Evolutionary Synthesis
1. Haldane, J. B. S. 1932. The causes of evolution. Longmans. New York.
   (esp. Ch. IV).
2. Fisher, R. A. 1930. The genetical theory of natural selection. Oxford
   University Press, Oxford. Selected Sections - Fundamental Theorem.

Genetic Variation
1a. Lewontin, R. C., and J. L. Hubby. 1966. A molecular approach to
the study of genic heterozygosity in natural populations. II. Amount
of variation and degree of heterozygosity in natural populations of
Drosophila pseudoobscura. Genetics. 54:595-609.

1b. Sachidandam et al. 2001. A map of human genome sequence variation
containing 1.42 million single nucleotide polymorphisms. 409: 928-33.

2. Wright S., Dobzhansky T., Hovanitz W. 1942 Genetics of natural
populations VII The allelism of lethals in the third chromosome of
Drosophila pseudoobscura. Genetics 27: 363-394.

Recombination and evolution
1. Hill, W. G., and A. Robertson. 1966. The effect of linkage on limits
to artificial selection. Genet. Res. 8:269-294.

2. Maynard Smith and Haigh. 1974. The hitch-hiking effect of a favourable
gene. Genet. Res. 23: 23-35.

Understanding sequence variation
1. Begun D. J., Aquadro C. F., 1992 Levels of naturally occurring DNA
polymorphism correlate with recombination rate in Drosophila melanogaster.
Nature 356: 519-520.

2. Green R. E., Reich D., P&auml;&auml;bo S., 2010 A draft sequence of the
Neandertal genome. Science 328: 710-722.

Quantitative Genetics:  variation in complex traits
1. Galton F., 1877 Typical laws of heredity. Nature 15: 492-495-
512-514- 532-533.

2. Turelli M., 1984 Heritable genetic variation via
mutation-selection balance: Lerch's Zeta meets the abdominal
bristle. Theor. Popul. Biol. 25: 138-193.

Quantitative Genetics:  finding the genes
1. Shrimpton A. E., Robertson A., 1988 The Isolation of polygenic factors
controlling bristle score in Drosophila melanogaster II Distribution of
third chromosome bristle effects within chromosome sections. Genetics
118: 445-459.

2. Boyle E. A., Li Y. I., Pritchard J. K., 2017 An expanded view of
complex traits: from polygenic to omnigenic. Cell 169: 1177-1186.

Neutral Evolution
1. Kimura, M. 1968. Evolutionary rate at the molecular level. Science.
217:624-626.

2a. Kern A. D., Hahn M. W., 2018 The Neutral Theory in Light of Natural
Selection. Molecular Biology and Evolution 110: 21077-6.

2b. Jensen J. D., Payseur B. A., Stephan W., Aquadro C. F., Lynch M.,
Charlesworth D., Charlesworth B., 2018 The importance of the Neutral Theory
in 1968 and 50 years on: a response to Kern and Hahn 2018. Evolution 112:
2109-4.

2c. Ellegren &amp; Galtier. 2016. Determinants of genetic diversity. Nature
Reviews Genetics.

Mutation and Genetic Variability
1. Luria, S. E., and M. Delbr&uuml;ck. 1943. Mutations of Bacteria from Virus
Sensitivity to Virus Resistance. Genetics. 28(6):491-511.

2. Hill, W G. 1982. "Rates of Change in Quantitative Traits From Fixation
of New Mutations." Proceedings of the National Academy of Sciences (U.S.A.)
79: 142-45.

Testing for selection
1. McDonald &amp; Kreitman. 1991. Adaptive protein evolution at the Adh locus
in Drosophila. Nature.

2. Begun, et al. Mol. Biol. Evol. 16, 1816-1819 (1999).

3. Siddiq et al. 2016. Experimental test and refutation of a classic case
of molecular adaptation in Drosophila melanogaster.  Nature Ecology &amp;
Evolution.

The shifting balance
1. Wright, S. 1932. The roles of mutation, inbreeding, crossbreeding and
selection in evolution. Proceedings of the VI International Congress of
Genetics: 1. pp 356-366.

2. Coyne, J.A., N.H. Barton, and M. Turelli. 1997. A critique of Wright's
shifting balance theory of evolution.  Evolution 51: 643-671.

3. Barton. 2016. Sewall Wright on Evolution in Mendelian Populations and
the "Shifting Balance". Genetics.

Evolution of Sex
1.  Muller, H.J. 1964. The relation of recombination to mutational advance.
Mutation Res. 1(1):2-9

2. McDonald et al. 2016. Sex speeds adaptation by altering the dynamics of
molecular evolution. Nature.

Kin Selection, Cooperation, and Conflict
1. Hamilton, W. D. 1964. The genetical evolution of social behaviour I.
Journal of Theoretical Biology. 7:1-52.

2. Trivers, R. L. 1974 Parent-offspring conflict. American Zoologist.
14(1):249-264.

Sexual Selection
1. Zahavi, A. 1975. Mate selection - a selection of a handicap. J. Theor.
Biol. 53:205-214.

2. Kirkpatrick, M., and Ryan, M.J. 1991. The evolution of mating
preferences and the paradox of the lek. Nature. 350:33-38.

Fitness Landscapes
1. Dean, A. 1995. A Molecular Investigation of Genotype by Environment
Interactions. Genetics. 139:19-33.

2. Costanzo et al. 2010. The Genetic Landscape of a Cell. Science.

Speciation
1. Coyne, J. A., and H. A. Orr. 1989. Patterns of speciation in Drosophila.
Evolution. 43:362-381.

2. Corbett-Detig et al. 2013. Genetic incompatibilities are widespread
within species. Nature.

2.       *Marcos Antezana:*

Valen, L. v. 1975. Energy and Evolution. University of Chicago, Department
of Biology.

3.       *Remco Folkertsma:*

1. The work by Hopi Hoekstra on local adaptation and oldfield mice

2. Poelstra, J. W., Vijay, N., Bossu, C. M., Lantz, H., Ryll, B., M&uuml;ller,
I., ... &amp; Wolf, J. B. (2014). The genomic landscape underlying phenotypic
integrity in the face of gene flow in crows. Science, 344(6190), 1410-1414.

4.       *Joshka Kaufmann and Leslie Turner*

They offer us a link to 'papers every evolutionary biologist should read',
the papers are collected by Leslie Turner.
https://static1.squarespace.com/static/53e8cb7ce4b02c4bc3aeeee4/t/5ab8fcb670a6ad55c67fcdf4/1522072758665/EvoBioClassicsRefList.pdf

5.       *Sarah Stockwell*

Matt Ridley collected classic papers in evolutionary biology and printed
part of these papers in his book Evolution (see Matt Ridley. Evolution
(Univ. of Oxford Press, 2nd edition, 2004))
</pre>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44934/genomic-basis-of-evolutionary-innovations-gevol</guid>
	<pubDate>Sat, 06 Dec 2025 06:11:00 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44934/genomic-basis-of-evolutionary-innovations-gevol</link>
	<title><![CDATA[Genomic Basis of Evolutionary Innovations (GEvol)]]></title>
	<description><![CDATA[<p>The Priority Programme (SPP 2349) funded by German Science Foundation (DFG) started 2022: &bdquo;Genomic Basis of Evolutionary Innovations (GEvol)&ldquo;</p>
<p>GEvol is unique as it will use, for the first time, a large taxonomic group to focus on one goal: to characterise the dynamics and mechanisms of genomic innovations underlying novel traits using comparative evolutionary genomics (and related data).<br>Thus, projects participating in GEvol we will ask fundamental evolutionary questions such as:<br>1. At what level is evolution repeatable?<br>2. How does genomic plasticity interfere with phenotypic plasticity during evolution?<br>3. How do inter- and intra-specific interactions influence genomic architectures?<br>4. How predictable is phenotypic variation given some knowledge about the dynamics and mechanisms of underlying genome evolution?</p><p>Address of the bookmark: <a href="https://g-evol.uni-muenster.de/open-positions/" rel="nofollow">https://g-evol.uni-muenster.de/open-positions/</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/35752/hejnol-group</guid>
  <pubDate>Thu, 22 Feb 2018 16:02:53 -0600</pubDate>
  <link></link>
  <title><![CDATA[Hejnol Group]]></title>
  <description><![CDATA[
<p>The group studies a broad range of animal taxa using morphological and molecular tools to unravel the evolution and development of animal organ systems.</p>

<p>To understand the evolution of the biodiversity seen on planet earth is one of the major goals in biology. How animals explored new habitats from only being confined to the marine environment and the how the forms diversified is still one of the most tremendous questions to be answered.</p>

<p>http://www.sars.no/research/HejnolGrp.php</p>
]]></description>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/38551/gupta-lab</guid>
  <pubDate>Sat, 29 Dec 2018 13:18:31 -0600</pubDate>
  <link></link>
  <title><![CDATA[Gupta Lab]]></title>
  <description><![CDATA[
<p>Work include (i) understanding the evolutionary relationships among different prokaryotic and eukaryotic organisms; (ii) Understanding the cellular functions of these lineage-specific signature proteins as well as lineage-specific conserved inserts and deletions in important housekeeping proteins by genetic and biochemical studies; (iii) Development of novel diagnostic methods (PCR based and immunological) for identification of different groups of organisms based upon these signature proteins and conserved indels; (iv) The use of these lineage-specific probes with predicitive ability to identify/explore the presence of different groups of organisms in metagenomic sequences from various environments.</p>

<p>https://fhs.mcmaster.ca/gupta-lab/index.html</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42798/what-is-the-hologenome-concept-of-evolution</guid>
	<pubDate>Wed, 03 Feb 2021 12:23:54 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42798/what-is-the-hologenome-concept-of-evolution</link>
	<title><![CDATA[What is the hologenome concept of evolution?]]></title>
	<description><![CDATA[<p><span>All multicellular organisms are colonized by microbes, but a gestalt study of the composition of microbiome communities and their influence on the ecology and evolution of their macroscopic hosts has only recently become possible. One approach to thinking about the topic is to view the host&ndash;microbiome ecosystem as a &ldquo;holobiont&rdquo;.</span></p><p>Address of the bookmark: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198262/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198262/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>

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