BOL: Related items

Blast on Docker, Google Cloud, Amazon Cloud

LEGE — Thu, 09 Jul 2020 02:57:11 -0500

As announced in a previous post, we offer a Docker version of NCBI BLAST+ that you can use locally or on the Google Cloud where we have pre-loaded BLAST databases. We are happy to announce that the same functionality is now available on the Amazon Cloud. In addition, we now offer 23 different BLAST databases on each cloud platform.

As mentioned before, working with BLAST+ in Docker and the cloud has several advantages:

Docker manages installation and maintenance of the BLAST programs and databases.
Docker makes it is easier to integrate BLAST with other tools in your pipelines.
NCBI BLAST databases are pre-loaded now on the both the Google Cloud and Amazon Cloud, providing fast access.

You can also use the BLAST+ Docker image on any Docker-enabled platform, such as another cloud platform or on your local computer.

See the BLAST+ in the Cloud and database information documentation to get started.

If you have any questions, please email us at blast-help@ncbi.nlm.nih.gov

Source:Dave Arndt

New Release of RefSeq !

Abhi — Tue, 16 Jul 2024 10:09:21 -0500

Check out RefSeq release 225, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets.

What’s included in this release?

As of July 8, 2024, this full release incorporates genomic, transcript, and protein data containing:

448,507,905 records
334,845,613 proteins
63,542,774 RNAs
Sequences from 152,668 organisms

The release is provided in several directories as a complete dataset and also as divided by logical groupings.

DNA Bending Propensity in the Presence of Base Mismatches: Implications for DNA Repair

Jitendra Narayan — Mon, 19 Aug 2013 16:01:44 -0500

Understanding how the human body recognizes damaged DNA and initiates repair fascinates Michael Feig, professor of biochemistry and molecular biology at Michigan State University. Feig studies the proteins MutS and MSH2-MSH6, which recognize defective DNA and initiate DNA repair. Natural DNA repair occurs when proteins like MutS (the primary protein responsible for recognizing a variety of DNA mismatches) scan the DNA, identify a defect, and recruit other enzymes to carry out the actual repair.

Results from computer simulations show that it is energetically less expensive to bend mismatch-containing, defective DNA (G:T, C:C, C:T, G:A, G:G, T:T, A:A, A+:C) vs. non-defective DNA (containing A:T or G:C base pairs). DNA repair mechanisms likely take advantage of this feature to detect defective DNA based on an increased bending propensity.

http://www.tacc.utexas.edu/news/feature-stories/2013/how-dna-repair-helps-prevent-cancer

http://pubs.acs.org/doi/abs/10.1021/jp403127a

Pandey Lab

Fri, 20 Sep 2013 13:19:18 -0500

The Pandey Lab at Johns Hopkins University is a Systems Biology lab that combines molecular biology, analytical chemistry and computational biology with various "Omics" technologies including genomics and proteomics to understand signaling pathways and to identify therapeutic targets and biomarkers in a number of cancers.

More at http://pandeylab.igm.jhmi.edu/

http://scholar.google.com/citations?user=OhuG0FcAAAAJ&hl=en

PhD opportunity at Université de Liège - Belgium

Sat, 02 Aug 2014 01:12:43 -0500

PhD opportunity at Université de Liège - Belgium

The Bioinformatics and Systems Biology Unit of Université de Liège (Belgium) is looking for a highly motivated master student with programming skills for a PhD thesis project (4 years, fully funded) with the goal of designing computational tools that use literature, genomic and structural data in order to infer regulatory and metabolic networks.

Applicants are invited to send their resume and a recommendation letter to Prof. Patrick Meyer (more details at www.biosys.ulg.ac.be )

For more information : www.biosys.ulg.ac.be

Bioinformatician's summer vacation !!!

Jit — Wed, 03 Sep 2014 13:11:50 -0500

Yes, the bioinformatician do spend their summer vacation like this. They spend more time on cheking the JOBS running on various servers.

Interview with a bioinformatician series ...

Jitendra Narayan — Sat, 27 Dec 2014 13:30:15 -0600

The aim of this series to interviews some notable bioinformaticians to get their views on various aspects of bioinformatics research. Hopefully these answers will prove useful to others in the field, especially to those who are just starting their bioinformatics careers.

This series will be available at BOL every fortnight.

Scripted DNA !!!

Jit — Mon, 17 Aug 2015 17:44:04 -0500

As per bioinformatician DNA is partially scripted ;) You dont believe in it. Please have a look at image carefully:)

MAKER

Jitendra Narayan — Sun, 07 Feb 2016 15:59:24 -0600

MAKER is a portable and easily configurable genome annotation pipeline.Its purpose is to allow smaller eukaryotic and prokaryotic genome projects to independently annotate their genomes and to create genome databases. MAKER identifies repeats, aligns ESTs and proteins to a genome, produces ab-initio gene predictions and automatically synthesizes these data into gene annotations having evidence-based quality values.

More at http://www.yandell-lab.org/software/maker.html

Address of the bookmark: http://www.yandell-lab.org/software/maker.html

Wellcome Trust/DBT India Alliance Margdarshi Fellowships 2016

Tue, 29 Mar 2016 17:47:39 -0500

The Wellcome Trust/DBT India Alliance invites application for the Margdarshi Fellowship scheme. The scheme provides a unique opportunity for visionary biomedical scientists to lead and nucleate a cutting edge research program in India in collaboration with Indian Host Institution(s). The potential candidates and the Host Institution are encouraged to make a synergistic effort towards establishing a centre of excellence that aims to improve the existing scientific breadth and utilizes the experience of the lead applicant for developing new research platforms. In addition to this, under this programme two eligible Indian institutions may also come together towards creating a new program under the leadership of a visionary scientist.

Eligibility

Interested applicants must

Have around 10 years of experience as independent investigator, and can be of any age or nationality
Have Sponsor(s) at not-for-profit Host Institution(s) in India, who is willing to extend the desired commitment and resources for program implementation
Provisions

The 5 year Fellowship provides

Generous personal support for the Fellow
Salary support for personnel, which may include Assistant Professors
Large quantum of funds for equipment, animals and consumables
Funds to attend scientific gatherings, for collaborative visits and to organize meetings
Overheads for the Host Institution
Process

A joint online application is invited from the Applicant and the Sponsor(s). The details of the scheme and the funding mechanism are available on the website at http://wellcomedbt.org/fellowshiptype/margdarshi-fellowships.

Application form can be accessed at https://fellowships.wellcomedbt.org/Login.aspx

Sponsored applications due by 2 May 2016

Send your inquiries to margdarshi@wellcomedbt.org