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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/7568?offset=1330</link>
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	<description><![CDATA[]]></description>
	
	
<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/38383/sidow-lab</guid>
  <pubDate>Fri, 07 Dec 2018 09:06:30 -0600</pubDate>
  <link></link>
  <title><![CDATA[Sidow Lab]]></title>
  <description><![CDATA[
<p>We study mechanisms of cancer evolution by using state-of-the-art genomic approaches at the bench and in analysis. Accurate genome reconstruction is our other major area of interest. We also collaborate on important questions for which our expertise in genomics and computation is relevant. Arend's biosketch highlights some of our past contributions.</p>

<p>http://www.sidowlab.org/</p>
]]></description>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/11656/faculty-post-at-zhejiang-university</guid>
  <pubDate>Tue, 10 Jun 2014 03:40:40 -0500</pubDate>
  <link></link>
  <title><![CDATA[Faculty post at Zhejiang University]]></title>
  <description><![CDATA[
<p>Zhejiang University (ZJU) is seeking faculty candidates for its newly launched, highly competitive and well funded “Hundred Talents Program”. This search covers all colleges and departments at ZJU. Applicants, expected to be about 35 years old, should hold PhD degree, and postdoctoral experiences are preferred for applicants in most fields. Applicants should have demonstrated commitment to excellence in teaching and research at a level comparable to the academic achievement of assistant professor or associate professor in world-renowned universities. Successful candidates must work full-time and are expected to establish internationally competitive and independent research program in cutting-edge areas of the relevant field at ZJU.</p>

<p>As one of the leading research-intensive universities in China, ZJU is located in the beautiful city of Hangzhou. Successful candidates will be employed as Principal Investigators and are qualified to supervise doctoral students. ZJU will offer an internationally competitive salary and the opportunity to purchase university's apartment at a price much lower than the market price, and will provide office and laboratory spaces as well as internationally competitive research startup packages.</p>

<p>Qualified applicants are strongly encouraged to submit their applications electronically to tr@zju.edu.cn. Applicants should include the following materials in pdf format: a comprehensive CV, a statement of research and teaching plan, and a list of 3 to 5 references with detailed contact information.</p>

<p>Contact：Talents Office, ZJU</p>

<p>Tel：+86-571-88981345, +86-571-88981390</p>

<p>Fax：+86-571-88981976</p>

<p>E-mail:tr@zju.edu.cn</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43806/genomicus-genome-browser-that-enables-users-to-navigate-in-genomes-in-several-dimensions</guid>
	<pubDate>Mon, 28 Feb 2022 23:27:37 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43806/genomicus-genome-browser-that-enables-users-to-navigate-in-genomes-in-several-dimensions</link>
	<title><![CDATA[Genomicus: genome browser that enables users to navigate in genomes in several dimensions]]></title>
	<description><![CDATA[<p>Genomicus is a genome browser that enables users to navigate in genomes in several dimensions: linearly along chromosome axes, transversaly across different species, and chronologicaly along evolutionary time.</p>
<p>Once a query gene has been entered, it is displayed in its genomic context in parallel to the genomic context of all its orthologous and paralogous copies in all the other sequenced metazoan genomes. Moreover, Genomicus stores and displays the predicted ancestral genome structure in all the ancestral species within the phylogenetic range of interest.</p>
<p>All the data on extant species displayed in this browser are from&nbsp;<a href="http://www.ensembl.org/">Ensembl</a>.</p>
<p><br><strong>Summary statistics of Genomicus version 105.01:</strong><span>&nbsp;(view species tree in&nbsp;</span><a href="https://www.genomicus.bio.ens.psl.eu/genomicus-105.01/data/SpeciesTree.pdf">pdf</a><span>&nbsp;or&nbsp;</span><a href="https://www.genomicus.bio.ens.psl.eu/genomicus-105.01/data/SpeciesTree.nwk">newick</a><span>)</span><br><br></p>
<table id="introstats">
<tbody>
<tr><th>Number of extant species</th>
<td>200</td>
</tr>
<tr><th>Number of extant genes</th>
<td>4303993</td>
</tr>
<tr><th>&nbsp;</th></tr>
<tr><th>Number of ancestral species</th>
<td>196</td>
</tr>
<tr><th>Number of ancestral genes</th>
<td>4624213</td>
</tr>
<tr><th>Number of ancestral synteny blocks</th>
<td>83342<br><br></td>
</tr>
</tbody>
</table><p>Address of the bookmark: <a href="https://www.genomicus.bio.ens.psl.eu/genomicus-105.01/cgi-bin/search.pl" rel="nofollow">https://www.genomicus.bio.ens.psl.eu/genomicus-105.01/cgi-bin/search.pl</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/11592/xampp-starting-apache-fail-ubuntu</guid>
	<pubDate>Sat, 07 Jun 2014 05:52:35 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/11592/xampp-starting-apache-fail-ubuntu</link>
	<title><![CDATA[XAMPP: Starting Apache fail Ubuntu]]></title>
	<description><![CDATA[<p>Once you install XAMMP on linux, the most common problem you face is Apache failure. To fix the issues please use following command to first stop and then again start it.</p><p>sudo /etc/init.d/apache2 stop</p><p>sudo /etc/init.d/mysql stop</p><p>sudo /etc/init.d/proftpd stop</p><p>sudo /opt/lampp/lampp start</p><p>&nbsp;</p><p><strong>PhpMyAdmin &ldquo;Wrong permissions on configuration file, should not be world writable!&rdquo;</strong></p><p>Once the Xammp is installed, it might be possible to set up the configuration file in writable mode. Try the following steps:</p><p>Just chmod 0755 the file</p><pre>sudo chmod 0755 config.inc.php</pre>]]></description>
	<dc:creator>Ram Yash Pal</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</guid>
	<pubDate>Tue, 04 Mar 2025 12:12:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</link>
	<title><![CDATA[Genetic basis of tail-loss evolution]]></title>
	<description><![CDATA[<p>The paper <em>"On the genetic basis of tail-loss evolution in humans and apes (https://www.nature.com/articles/s41586-024-07095-8)"</em>, published in <em>Nature</em>, investigates the genetic mechanisms that led to the loss of tails in humans and apes. The study suggests that a specific genetic mutation, involving the insertion of an <em>Alu</em> element (a type of transposable DNA sequence), played a critical role in the evolutionary transition from tailed primates to tailless hominoids.</p><h3><strong>Key Findings of the Study:</strong></h3><ol>
<li>
<p><strong>Alu Insertion and Tail Loss:</strong><br /> The researchers discovered an <em>Alu</em>-mediated genetic change in a common ancestor of modern apes and humans. This change disrupted the normal function of a gene involved in tail development, leading to the suppression of tail formation.</p>
</li>
<li>
<p><strong>Gene Disruption Mechanism:</strong><br /> The <em>Alu</em> insertion was found within a regulatory region of the <em>TBXT</em> gene (also known as <em>T</em> or <em>Brachyury</em>), which is crucial for tail development in vertebrates. This insertion likely altered the gene's expression patterns, leading to tail reduction over evolutionary time.</p>
</li>
<li>
<p><strong>Functional Evidence from Model Organisms:</strong><br /> To test their hypothesis, the researchers introduced similar genetic modifications in mice. The modified mice exhibited shortened or absent tails, supporting the idea that the identified mutation played a role in tail loss in hominoids.</p>
</li>
<li>
<p><strong>Evolutionary Implications:</strong><br /> The findings suggest that small, random genomic changes&mdash;such as transposable element insertions&mdash;can have profound effects on body morphology. This study provides evidence that mobile DNA elements (like <em>Alu</em>) can drive major evolutionary transitions.</p>
</li>
<li>
<p><strong>Relevance to Human Evolution:</strong><br /> Understanding the genetic basis of tail loss helps in reconstructing the evolutionary history of hominins (the lineage that includes humans and our extinct relatives). It also sheds light on how genetic variations contribute to anatomical diversity among primates.</p>
</li>
</ol><h3><strong>Significance of the Study:</strong></h3><p>This research highlights the role of transposable elements in shaping evolutionary traits and provides a concrete genetic explanation for a defining characteristic of humans and great apes. It also demonstrates how mutations in regulatory regions of developmental genes can lead to significant anatomical changes.</p>]]></description>
	<dc:creator>LEGE</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/856/papenfuss-lab</guid>
  <pubDate>Sun, 14 Jul 2013 12:22:28 -0500</pubDate>
  <link></link>
  <title><![CDATA[Papenfuss Lab]]></title>
  <description><![CDATA[
<p>The human genome project and similar projects in disease-causing organisms such as Plasmodium falciparum, which causes malaria in humans, have provided new tools for discovery in biology and have accelerated the development of understanding in human disease.</p>

<p>Research Area: <br />Analysis of Next Generation sequence data in cancer<br />Methods for analysis of structural variation in cancer genomes<br />Next Generation sequencing in malaria<br />Computational comparative genomics<br />Sensitive genomic sequence search techniques using hidden Markov models<br />Tasmanian devil facial tumour disease</p>

<p>Link @ http://www.wehi.edu.au/faculty_members/dr_tony_papenfuss</p>
]]></description>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/12594/faculty-positions-at-central-university-of-punjab</guid>
  <pubDate>Mon, 07 Jul 2014 23:33:33 -0500</pubDate>
  <link></link>
  <title><![CDATA[Faculty Positions at Central University of Punjab]]></title>
  <description><![CDATA[
<p>Faculty Positions: Rolling/Open Advertisement Advt.No: T-10 (2013)</p>

<p>Pay Scale: Pay Band Rs.15600-39100 with AGP of Rs.6,000/-</p>

<p>Essential Qualifications for Professors, Associate Professors, and Assistant Professors: As per “UGC REGULATIONS ON MINIMUM QUALIFICATIONS FOR APPOINTMENT OF TEACHERS AND OTHER ACADEMIC STAFF IN UNIVERSITIES AND COLLEGES AND MEASURES FOR THE MAINTENANCE OF STANDARDS IN HIGHER EDUCATION 2010“ and the 2nd Amendments to the regulation issued in June 2013.</p>

<p>For details: http://www.ugc.ac.in/oldpdf/regulations/revised_finalugcregulationfinal10.pdf http://www.ugc.ac.in/pdfnews/8539300_English.pdf and University rules.</p>

<p>Procedure to apply:</p>

<p>Application forms along with API form complete in all respect along with necessary documents and application fee of Rs. 500/-. (Rs. 250/- for Scheduled Caste/Scheduled Tribe/Person with disabilities) should be sent to:</p>

<p>Registrar, Central University of Punjab, City Campus, Mansa Road, Bathinda-151001</p>

<p>For more info visit: http://www.centralunipunjab.com/Teaching/Final%20Details-t10-2013.pdf, http://www.centralunipunjab.com/Teaching/Advertisement-t10-2013.jpg</p>

<p>Last Apply Date: 31 Dec 2014</p>
]]></description>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/869/bioinformatics-phd-studentship-available-in-new-zealand</guid>
  <pubDate>Sun, 14 Jul 2013 13:36:30 -0500</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatics PhD studentship available in New Zealand]]></title>
  <description><![CDATA[
<p>Bioinformatics PhD studentship available in New Zealand</p>

<p>The importance of transcriptional control has been explored in a burgeoning line of research over several decades; nevertheless, we are still far from having a complete picture of the regulatory mechanisms of genes and non-coding RNAs, and their influences on different phenotypes and disease states of a cell. Recent shifts towards large-scale analyses of transcriptional regulation on a sequence and epigenetic level are at the forefront of research, mainly due to sequencing technology advancements and a deeper understanding of the fundamental regulatory processes involved.</p>

<p>Arriving at a better understanding of the influence of specific parts of the overall regulatory machinery on disease states is a high priority of the group’s research agenda.</p>

<p>We are seeking an enthusiastic student to join the group as a PhD student. Applicants must have a BSc(Hons) or MSc degree in a relevant discipline and a willingness to learn and apply new techniques and work in a team. Both local and international students are encouraged to apply.</p>

<p>The studentship covers all university fees and an annual tax-exempt stipend of NZ$22,000 for three years.</p>

<p>Sebastian Schmeier recently joined Massey University and started his own research group in Auckland, New Zealand, a city regularly ranked one of the most livable in the world. This is your chance to experience the amazing Auckland lifestyle and the excitement of joining a young new science team, while staying connected to world class scientific networks.</p>

<p>To apply for the post, please send a cover letter stating your interest in the position and why you think you would be a good candidate, a Curriculum Vitae, a copy of your academic transcript, a sample of your written scientific work, and the names of three referees. Applications will be accepted until the position is filled.</p>

<p>Enquiries and applications to Sebastian Schmeier (s.schmeier@massey.ac.nz).</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/12787/integrative-genomics-viewer-igv-tutorial</guid>
	<pubDate>Sat, 12 Jul 2014 15:16:23 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/12787/integrative-genomics-viewer-igv-tutorial</link>
	<title><![CDATA[Integrative Genomics Viewer (IGV) tutorial]]></title>
	<description><![CDATA[<p>The <a href="http://www.broadinstitute.org/igv/">Integrative Genomics Viewer (IGV)</a> from the Broad Center allows you to view several types of data files involved in any NGS analysis that employs a reference genome, including how reads from a dataset are mapped, gene annotations, and predicted genetic variants.</p>
<p>http://www.broadinstitute.org/igv/</p><p>Address of the bookmark: <a href="https://wikis.utexas.edu/display/bioiteam/Integrative+Genomics+Viewer+%28IGV%29+tutorial" rel="nofollow">https://wikis.utexas.edu/display/bioiteam/Integrative+Genomics+Viewer+%28IGV%29+tutorial</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/file/view/1970/indias-own-first-drug-from-biocon</guid>
	<pubDate>Sun, 11 Aug 2013 16:05:39 -0500</pubDate>
	<link>https://bioinformaticsonline.com/file/view/1970/indias-own-first-drug-from-biocon</link>
	<title><![CDATA[India&#039;s own first drug - from Biocon.]]></title>
	<description><![CDATA[<p><span><span>Psoriasis is immune-mediated disease that effects the skin. the Disease on an average affects about 10-20 million Indians and it attacks the immune system of human beings. In generally occurs, when the immune system mistakes a normal skin cell for a pathogen, and sends out faulty signals that cause overproduction of new skin cells. <a href="http://en.wikipedia.org/wiki/Psoriasis">More at &gt;&gt;</a><br /></span></span></p><p><span><span>Biocon, India's largest publicly-held biotechnology firm, launched its second novel 'lab-to-market' molecule,<strong> Alzumab</strong>, to treat chronic plaque <strong>psoriasis</strong> at a cost 50 per cent lower than the existing one. </span></span></p><p><span><span><span><span>Biocon is bringing Alzumab (a biologic) in the form of a vial after working on it for nearly a decade. The work had initially started in a joint effort with the Center of Molecular Immunology, Havana, but Biocon took control of the programme soon after and also bought out its partner a few years ago. Biocon tell to the media that genotypic played a critical role in functional studies and clinical trial Genomics. </span></span><br /><br />The Biocon drug, at around&nbsp;₹ 7,500 a vial, will cost half as much as the currently available drugs - from Pfizer and J&amp;J - to treat psoriasis, a skin disease that causes rough red areas where the skin comes off in small pieces. A patient is usually prescribed to consume more than 40 vials in a 24-week course.<br /><br /></span></span></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
	<enclosure url="https://bioinformaticsonline.com/file/download/1970" length="90484" type="image/jpeg" />
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