BOL: Related items

Genome Sequencing Technologies: Impacts on Personalized Medicine

Thu, 13 Mar 2014 12:04:49 -0500

This video segment is a component of a Worcester Polytechnic Institute (WPI) Interactive Qualifying Project (IQP), completed May 2012. If you have any comments or suggestions, feel free to email imgentech12@gmail.com. For those who are interested in using any of our videos in their courses, you can request the supplemental assignments created for these videos by emailing us at imgentech12@gmail.com.

The New York Genome Center and IBM Watson Group Announce Collaboration to Advance Genomic Medicine

Thu, 20 Mar 2014 02:05:35 -0500

The New York Genome Center (NYGC) and IBM announced an initiative to accelerate a new era of genomic medicine with the use of IBM's Watson cognitive system. IBM and NYGC will test a unique Watson prototype designed specifically for genomic research as a tool to help oncologists deliver more personalized care to cancer patients.

CIRM Spotlight on Genomics | A Step to Personalized Medicine

Mon, 07 Oct 2013 14:42:47 -0500

This seminar, presented to the California Institute for Regenerative Medicine governing board on January 17th, 2012, provides a glimpse into a future of personalized medicine in which genomics, the study of genes and their function, is applied to pinpoint specific treatments for patients. Speakers included Craig Venter, president and founder of the J. Craig Venter Institute, Catriona Jamieson, director for stem cell research at the UCSD Moores Cancer Center, and Sandra Dillon, a clinical trial participant.

Dr. Ken Buetow: IS & Personalized Medicine Lecture-Part 1

Sun, 29 Sep 2013 20:11:09 -0500

Full Lecture Abstract Creating an Evidence Engine to Support Personalized Medicine Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capacity to routinely perform comprehensive molecular characterization. Nowhere is this change happening faster than in the field of cancer. Increasingly sophisticated technology provides the capacity to describe, in multiple molecular dimensions, the tumor and the individual in which it has developed. These technologies identify the millions of variants present in normal individuals and thousands of alterations that occur during the course of the disease process. The generation of this unprecedented amount of data presents us with the challenge contextualizing that data and converting into actionable information. Currently, the context is drawn from fragmented research literature generated by "siloed" reductionist basic science investigations, t incomplete outcomes of clinical research designed for regulatory approval, t out-of-date recommendations made by bodies of experts, and day-to-day clinical experience of the practitioner. The integration and interpretation of this complex multidimensional information into the evidence necessary to support clinical care exceeds the raw human cognitive capacity. Information systems have the capacity to provide the needed "tool" to tackle this challenge -- to generate the necessary evidence to support the delivery of personalized medicine. Arizona State University's (ASU) Complex Adaptive Systems team is building such an Evidence Engine in its Next Generation Cyber Capability (NGCC). The ASU NGCC -- composed of networks, hardware, software, and people transforms "Big Data" to information and creates the evidence necessary to enable personalized medicine. Bio Dr. Buetow currently serves as Director of Computational Sciences and Informatics within Arizona State University's (ASU) Complex Adaptive Systems Initiative (CASI). CASI applies systems approaches that leverage ASU's interdisciplinary research strengths to address complex global challenges. The Computational Sciences and Informatics program is developing and applying information technology to connect and enhance trans-disciplinary knowledge both within ASU and across the broader knowledge-generating ecosystem to address problems in biomedicine, the environment, and national security. Dr. Buetow previously served as the Director of the Center for Biomedical Informatics and Information Technology within the National Institutes of Health's National Cancer Institute (NCI). In that capacity he initiated and oversaw the NCI's efforts to connect the global cancer community through community-developed, standards-based, interoperable informatics capabilities that enable secure exchange and use of biomedical data. Buetow designed and built one of the largest biomedical computing efforts in the world. He was responsible for coordinating biomedical informatics and information technology. The NCI center he led focused on speeding scientific discovery and facilitated translational research by coordinating, developing and deploying biomedical informatics systems, infrastructure, tools and data in support of NCI research initiatives. The primary focus of the Buetow laboratory is the application of computational technologies to solve major biomedical challenges, particularly the role of genetics in complex human diseases such as cancer. It undertakes this mission through a systems approach in which genetic analytic approaches are applied to multiple high-throughput molecular characterizations integrated through informatics. The Buetow laboratory approaches diseases such as cancer as a complex adaptive system. The Buetow laboratory has a long history of developing and applying bioinformatics methods to find genetic components underlying complex traits. The laboratory was instrumental in the earliest studies developing and applying linkage disequilibrium methods as genetic mapping tools. The laboratory also developed methods and pipelines to generate and apply genome-wide genetic maps. In early work with genome-wide gene sequence data, the laboratory developed approaches to efficiently and accurately computationally identify variants. More recently, the analytic approaches have been extended to systematically identify insertion/deletion variation, translocations, and rearrangements. In application to transcriptome data, these methods facilitate identification of splicing and alternative transcripts. More information available at: https://sols.asu.edu/people/kenneth-buetow-0

If your genes revealed you would get a disease, would you want to know?

Wed, 30 Oct 2013 19:35:31 -0500

A massive, groundbreaking new study underway at Kaiser Permanente and the University of California San Francisco may shed light one day on the genetic roots of diseases such as Parkinson's, cancer, Alzheimer's. We asked people in San Francisco's Union Square for their take on this question: If a genetic test revealed you were at high risk for getting a disease, would want to know?

Molecular Genetics Lecture

Rahul Agarwal — Fri, 27 Sep 2013 04:24:45 -0500

"Robert Sapolsky makes interdisciplinary connections between behavioral biology and molecular genetic influences. He relates protein synthesis and point mutations to microevolutionary change, and discusses conflicting theories of gradualism and punctuated equilibrium and the influence of epigenetics on development theories."

"Robert Sapolsky is an American neuroendocrinologist, professor of biology, neuroscience, and neurosurgery at Stanford University, researcher and author" ----Wikipedia

Address of the bookmark: http://www.youtube.com/watch?v=_dRXA1_e30o

The Future of Personalized Medicine

Thu, 06 Feb 2014 00:21:26 -0600

Howard Jacob speaking on Personalize Medicine at the Illumina Meeting in Feb. of 2013.

Personalised Medicine - Animation

Tue, 27 Aug 2013 10:07:24 -0500

Two animated case scenarios set now and in the future. These highlight potential differences in the way patients are treated now, and how they might be treated as healthcare becomes more tailored.

Sharing a million genomes: Yves Moreau at TEDxbrussels

Sun, 03 Nov 2013 19:04:25 -0600

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)