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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/923?offset=140</link>
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	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43791/comparative-genomics-visualisation-tools</guid>
	<pubDate>Thu, 17 Feb 2022 05:37:55 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43791/comparative-genomics-visualisation-tools</link>
	<title><![CDATA[Comparative genomics visualisation tools !]]></title>
	<description><![CDATA[<p>Comparative genomics visualisation tools !</p><p>Address of the bookmark: <a href="https://cmdcolin.github.io/awesome-genome-visualization/?latest=true&amp;selected=%23BRIG&amp;tag=Comparative" rel="nofollow">https://cmdcolin.github.io/awesome-genome-visualization/?latest=true&amp;selected=%23BRIG&amp;tag=Comparative</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/45177/installing-crossroad-on-ubuntu</guid>
	<pubDate>Fri, 29 May 2026 05:19:45 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/45177/installing-crossroad-on-ubuntu</link>
	<title><![CDATA[Installing croSSRoad on Ubuntu !]]></title>
	<description><![CDATA[<p><strong>(base) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ conda</strong><br />usage: conda [-h] [-v] [--no-plugins] [-V] COMMAND ...</p><p>conda is a tool for managing and deploying applications, environments and packages.</p><p>options:<br /> -h, --help Show this help message and exit.<br /> -v, --verbose Can be used multiple times. Once for detailed output, twice for INFO logging, thrice for DEBUG logging, four times for TRACE logging.<br /> --no-plugins Disable all plugins that are not built into conda.<br /> -V, --version Show the conda version number and exit.</p><p>commands:<br /> The following built-in and plugins subcommands are available.</p><p>COMMAND<br /> activate Activate a conda environment.<br /> clean Remove unused packages and caches.<br /> commands List all available conda subcommands (including those from plugins). Generally only used by tab-completion.<br /> compare Compare packages between conda environments.<br /> config Modify configuration values in .condarc.<br /> create Create a new conda environment from a list of specified packages.<br /> deactivate Deactivate the current active conda environment.<br /> doctor Display a health report for your environment.<br /> env Create and manage conda environments.<br /> export Export a given environment<br /> info Display information about current conda install.<br /> init Initialize conda for shell interaction.<br /> install Install a list of packages into a specified conda environment.<br /> list List installed packages in a conda environment.<br /> notices Retrieve latest channel notifications.<br /> package Create low-level conda packages. (EXPERIMENTAL)<br /> remove (uninstall) Remove a list of packages from a specified conda environment.<br /> rename Rename an existing environment.<br /> repoquery Advanced search for repodata.<br /> run Run an executable in a conda environment.<br /> search Search for packages and display associated information using the MatchSpec format.<br /> update (upgrade) Update conda packages to the latest compatible version.<br />(base) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ conda create -n jitENV<br />Retrieving notices: done<br />Channels:<br /> - ursky<br /> - bioconda<br /> - conda-forge<br />Platform: linux-64<br />Collecting package metadata (repodata.json): done<br />Solving environment: done</p><p><br />==&gt; WARNING: A newer version of conda exists. &lt;==<br /> current version: 25.7.0<br /> latest version: 26.5.0</p><p>Please update conda by running</p><p>$ conda update -n base -c conda-forge conda</p><p>&nbsp;</p><p>## Package Plan ##</p><p>environment location: /home/hp/miniforge3/envs/jitENV</p><p>&nbsp;</p><p>Proceed ([y]/n)? y</p><p><br />Downloading and Extracting Packages:</p><p>Preparing transaction: done<br />Verifying transaction: done<br />Executing transaction: done<br />#<br /># To activate this environment, use<br />#<br /># $ conda activate jitENV<br />#<br /># To deactivate an active environment, use<br />#<br /># $ conda deactivate</p><p><strong>(base) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ conda activate jitENV</strong><br /><strong>(jitENV) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ conda install conda-forge::mamba</strong><br />Channels:<br /> - ursky<br /> - bioconda<br /> - conda-forge<br />Platform: linux-64<br />Collecting package metadata (repodata.json): done<br />Solving environment: done</p><p><br />==&gt; WARNING: A newer version of conda exists. &lt;==<br /> current version: 25.7.0<br /> latest version: 26.5.0</p><p>Please update conda by running</p><p>$ conda update -n base -c conda-forge conda</p><p>&nbsp;</p><p>## Package Plan ##</p><p>environment location: /home/hp/miniforge3/envs/jitENV</p><p>added / updated specs:<br /> - conda-forge::mamba</p><p><br />The following packages will be downloaded:</p><p>package | build<br /> ---------------------------|-----------------<br /> ca-certificates-2026.5.20 | hbd8a1cb_0 127 KB conda-forge<br /> cpp-expected-1.3.1 | h171cf75_0 24 KB conda-forge<br /> fmt-12.1.0 | hff5e90c_0 193 KB conda-forge<br /> libarchive-3.8.7 | gpl_hc2c16d8_101 869 KB conda-forge<br /> libcurl-8.20.0 | hcf29cc6_0 458 KB conda-forge<br /> libgcc-15.2.0 | he0feb66_19 1017 KB conda-forge<br /> libgcc-ng-15.2.0 | h69a702a_19 27 KB conda-forge<br /> libgomp-15.2.0 | he0feb66_19 590 KB conda-forge<br /> libmamba-2.6.2 | hd28c85e_0 2.7 MB conda-forge<br /> libmsgpack-c-6.1.0 | h54a6638_6 39 KB conda-forge<br /> libsolv-0.7.38 | h9463b59_0 509 KB conda-forge<br /> libstdcxx-15.2.0 | h934c35e_19 5.6 MB conda-forge<br /> libxml2-2.15.3 | h49c6c72_0 46 KB conda-forge<br /> libxml2-16-2.15.3 | hca6bf5a_0 547 KB conda-forge<br /> mamba-2.6.2 | hce6dcdd_0 553 KB conda-forge<br /> ncurses-6.6 | hdb14827_0 897 KB conda-forge<br /> nlohmann_json-abi-3.12.0 | h0f90c79_1 4 KB conda-forge<br /> reproc-14.2.7.post0 | hb03c661_1 35 KB conda-forge<br /> reproc-cpp-14.2.7.post0 | hecca717_1 26 KB conda-forge<br /> simdjson-4.6.4 | hb700be7_0 310 KB conda-forge<br /> spdlog-1.17.0 | hab81395_1 192 KB conda-forge<br /> ------------------------------------------------------------<br /> Total: 14.6 MB</p><p>The following NEW packages will be INSTALLED:</p><p>_openmp_mutex conda-forge/linux-64::_openmp_mutex-4.5-20_gnu <br /> bzip2 conda-forge/linux-64::bzip2-1.0.8-hda65f42_9 <br /> c-ares conda-forge/linux-64::c-ares-1.34.6-hb03c661_0 <br /> ca-certificates conda-forge/noarch::ca-certificates-2026.5.20-hbd8a1cb_0 <br /> cpp-expected conda-forge/linux-64::cpp-expected-1.3.1-h171cf75_0 <br /> fmt conda-forge/linux-64::fmt-12.1.0-hff5e90c_0 <br /> icu conda-forge/linux-64::icu-78.3-h33c6efd_0 <br /> keyutils conda-forge/linux-64::keyutils-1.6.3-hb9d3cd8_0 <br /> krb5 conda-forge/linux-64::krb5-1.22.2-ha1258a1_0 <br /> libarchive conda-forge/linux-64::libarchive-3.8.7-gpl_hc2c16d8_101 <br /> libcurl conda-forge/linux-64::libcurl-8.20.0-hcf29cc6_0 <br /> libedit conda-forge/linux-64::libedit-3.1.20250104-pl5321h7949ede_0 <br /> libev conda-forge/linux-64::libev-4.33-hd590300_2 <br /> libgcc conda-forge/linux-64::libgcc-15.2.0-he0feb66_19 <br /> libgcc-ng conda-forge/linux-64::libgcc-ng-15.2.0-h69a702a_19 <br /> libgomp conda-forge/linux-64::libgomp-15.2.0-he0feb66_19 <br /> libiconv conda-forge/linux-64::libiconv-1.18-h3b78370_2 <br /> liblzma conda-forge/linux-64::liblzma-5.8.3-hb03c661_0 <br /> libmamba conda-forge/linux-64::libmamba-2.6.2-hd28c85e_0 <br /> libmsgpack-c conda-forge/linux-64::libmsgpack-c-6.1.0-h54a6638_6 <br /> libnghttp2 conda-forge/linux-64::libnghttp2-1.68.1-h877daf1_0 <br /> libsolv conda-forge/linux-64::libsolv-0.7.38-h9463b59_0 <br /> libssh2 conda-forge/linux-64::libssh2-1.11.1-hcf80075_0 <br /> libstdcxx conda-forge/linux-64::libstdcxx-15.2.0-h934c35e_19 <br /> libxml2 conda-forge/linux-64::libxml2-2.15.3-h49c6c72_0 <br /> libxml2-16 conda-forge/linux-64::libxml2-16-2.15.3-hca6bf5a_0 <br /> libzlib conda-forge/linux-64::libzlib-1.3.2-h25fd6f3_2 <br /> lz4-c conda-forge/linux-64::lz4-c-1.10.0-h5888daf_1 <br /> lzo conda-forge/linux-64::lzo-2.10-h280c20c_1002 <br /> mamba conda-forge/linux-64::mamba-2.6.2-hce6dcdd_0 <br /> ncurses conda-forge/linux-64::ncurses-6.6-hdb14827_0 <br /> nlohmann_json-abi conda-forge/noarch::nlohmann_json-abi-3.12.0-h0f90c79_1 <br /> openssl conda-forge/linux-64::openssl-3.6.2-h35e630c_0 <br /> reproc conda-forge/linux-64::reproc-14.2.7.post0-hb03c661_1 <br /> reproc-cpp conda-forge/linux-64::reproc-cpp-14.2.7.post0-hecca717_1 <br /> simdjson conda-forge/linux-64::simdjson-4.6.4-hb700be7_0 <br /> spdlog conda-forge/linux-64::spdlog-1.17.0-hab81395_1 <br /> yaml-cpp conda-forge/linux-64::yaml-cpp-0.8.0-h3f2d84a_0 <br /> zstd conda-forge/linux-64::zstd-1.5.7-hb78ec9c_6</p><p><br />Proceed ([y]/n)? y</p><p><br />Downloading and Extracting Packages:<br /> <br />Preparing transaction: done <br />Verifying transaction: done <br />Executing transaction: done <br />(jitENV) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ mamba install -c jitendralab -c bioconda -c conda-forge crossroad -y <br />jitendralab/noarch ??.?MB @ ??.?MB/s 0.3s<br />jitendralab/linux-64 ??.?MB @ ??.?MB/s 0.4s<br />bioconda/linux-64 5.6MB @ 2.9MB/s 1.9s<br />bioconda/noarch 5.6MB @ 2.5MB/s 2.2s<br />conda-forge/noarch 26.4MB @ 6.0MB/s 4.5s<br />conda-forge/linux-64 53.8MB @ 6.7MB/s 8.2s</p><p><br />Transaction <br /> <br /> Prefix: /home/hp/miniforge3/envs/jitENV <br /> <br /> Updating specs: <br /> <br /> - crossroad</p><p>Package Version Build Channel Size<br />─────────────────────────────────────────────────────────────────────────────────────────────────<br /> Install:<br />─────────────────────────────────────────────────────────────────────────────────────────────────</p><p>+ annotated-doc 0.0.4 pyhcf101f3_0 conda-forge Cached<br /> + annotated-types 0.7.0 pyhd8ed1ab_1 conda-forge Cached<br /> + anyio 4.13.0 pyhcf101f3_0 conda-forge 147kB<br /> + argcomplete 3.6.3 pyhd8ed1ab_0 conda-forge Cached<br /> + aws-c-auth 0.10.3 h3aafcba_1 conda-forge 134kB<br /> + aws-c-cal 0.9.14 h8e43964_1 conda-forge 57kB<br /> + aws-c-common 0.13.1 hb03c661_0 conda-forge 242kB<br /> + aws-c-compression 0.3.2 h16e98cb_1 conda-forge 22kB<br /> + aws-c-event-stream 0.7.1 h9be7a74_1 conda-forge 59kB<br /> + aws-c-http 0.11.0 hcbcd92d_1 conda-forge 230kB<br /> + aws-c-io 0.26.3 h955231c_3 conda-forge 182kB<br /> + aws-c-mqtt 0.15.2 h8af55cf_3 conda-forge 222kB<br /> + aws-c-s3 0.12.3 h00bea6e_2 conda-forge 153kB<br /> + aws-c-sdkutils 0.2.4 h16e98cb_5 conda-forge 59kB<br /> + aws-checksums 0.2.10 h16e98cb_1 conda-forge 102kB<br /> + aws-crt-cpp 0.38.3 h7b0d4b4_2 conda-forge 413kB<br /> + aws-sdk-cpp 1.11.747 h5a171d8_5 conda-forge 4MB<br /> + azure-core-cpp 1.16.2 h206d751_0 conda-forge 349kB<br /> + azure-identity-cpp 1.13.3 hed0cdb0_1 conda-forge 251kB<br /> + azure-storage-blobs-cpp 12.17.0 hf824e48_1 conda-forge 587kB<br /> + azure-storage-common-cpp 12.13.0 ha7a2c86_0 conda-forge 159kB<br /> + azure-storage-files-datalake-cpp 12.15.0 h1e5b466_0 conda-forge 304kB<br /> + backports.zstd 1.5.0 py314h680f03e_0 conda-forge 8kB<br /> + bedtools 2.31.1 h13024bc_3 bioconda Cached<br /> + biopython 1.87 py314h5bd0f2a_0 conda-forge 3MB<br /> + brotli 1.2.0 hed03a55_1 conda-forge Cached<br /> + brotli-bin 1.2.0 hb03c661_1 conda-forge Cached<br /> + brotli-python 1.2.0 py314h3de4e8d_1 conda-forge 367kB<br /> + certifi 2026.5.20 pyhd8ed1ab_0 conda-forge 134kB<br /> + charset-normalizer 3.4.7 pyhd8ed1ab_0 conda-forge Cached<br /> + click 8.4.1 pyhc90fa1f_0 conda-forge 105kB<br /> + colorama 0.4.6 pyhd8ed1ab_1 conda-forge Cached<br /> + contourpy 1.3.3 py314h97ea11e_4 conda-forge 324kB<br /> + crossroad 0.3.6 pyh7e60211_0 jitendralab 2MB<br /> + cycler 0.12.1 pyhcf101f3_2 conda-forge Cached<br /> + dnspython 2.8.0 pyhcf101f3_0 conda-forge Cached<br /> + email-validator 2.3.0 pyhd8ed1ab_0 conda-forge 47kB<br /> + email_validator 2.3.0 hd8ed1ab_0 conda-forge 7kB<br /> + exceptiongroup 1.3.1 pyhd8ed1ab_0 conda-forge Cached<br /> + expat 2.8.1 hecca717_0 conda-forge 148kB<br /> + fastapi 0.136.3 h5ddb490_0 conda-forge 5kB<br /> + fastapi-cli 0.0.23 pyhcf101f3_0 conda-forge 19kB<br /> + fastapi-core 0.136.3 pyhcf101f3_0 conda-forge 96kB<br /> + fastar 0.11.0 py314h0b738fb_0 conda-forge 423kB<br /> + font-ttf-dejavu-sans-mono 2.37 hab24e00_0 conda-forge Cached<br /> + font-ttf-inconsolata 3.000 h77eed37_0 conda-forge Cached<br /> + font-ttf-source-code-pro 2.038 h77eed37_0 conda-forge Cached<br /> + font-ttf-ubuntu 0.83 h77eed37_3 conda-forge Cached<br /> + fontconfig 2.18.0 h27c8c51_0 conda-forge 281kB<br /> + fonts-conda-forge 1 hc364b38_1 conda-forge Cached<br /> + fonttools 4.63.0 pyh7db6752_0 conda-forge 846kB<br /> + freetype 2.14.3 ha770c72_0 conda-forge Cached<br /> + gflags 2.2.2 h5888daf_1005 conda-forge 120kB<br /> + glog 0.7.1 hbabe93e_0 conda-forge 143kB<br /> + h11 0.16.0 pyhcf101f3_1 conda-forge 39kB<br /> + h2 4.3.0 pyhcf101f3_0 conda-forge Cached<br /> + hpack 4.1.0 pyhd8ed1ab_0 conda-forge Cached<br /> + httpcore 1.0.9 pyh29332c3_0 conda-forge Cached<br /> + httptools 0.7.1 py314h5bd0f2a_1 conda-forge 99kB<br /> + httpx 0.28.1 pyhd8ed1ab_0 conda-forge Cached<br /> + hyperframe 6.1.0 pyhd8ed1ab_0 conda-forge Cached<br /> + idna 3.17 pyhcf101f3_0 conda-forge 57kB<br /> + jinja2 3.1.6 pyhcf101f3_1 conda-forge Cached<br /> + kaleido-core 0.2.1 h3644ca4_0 conda-forge Cached<br /> + kiwisolver 1.5.0 py314h97ea11e_0 conda-forge 77kB<br /> + lcms2 2.19.1 h0c24ade_0 conda-forge 251kB<br /> + ld_impl_linux-64 2.45.1 default_hbd61a6d_102 conda-forge Cached<br /> + lerc 4.1.0 hdb68285_0 conda-forge Cached<br /> + libabseil 20260107.1 cxx17_h7b12aa8_0 conda-forge 1MB<br /> + libarrow 24.0.0 h6f10b76_3_cpu conda-forge 7MB<br /> + libarrow-acero 24.0.0 h635bf11_3_cpu conda-forge 592kB<br /> + libarrow-compute 24.0.0 h53684a4_3_cpu conda-forge 3MB<br /> + libarrow-dataset 24.0.0 h635bf11_3_cpu conda-forge 592kB<br /> + libarrow-substrait 24.0.0 hb4dd7c2_3_cpu conda-forge 502kB<br /> + libblas 3.11.0 8_h4a7cf45_openblas conda-forge 19kB<br /> + libbrotlicommon 1.2.0 hb03c661_1 conda-forge Cached<br /> + libbrotlidec 1.2.0 hb03c661_1 conda-forge Cached<br /> + libbrotlienc 1.2.0 hb03c661_1 conda-forge Cached<br /> + libcblas 3.11.0 8_h0358290_openblas conda-forge 19kB<br /> + libcrc32c 1.1.2 h9c3ff4c_0 conda-forge Cached<br /> + libdeflate 1.25 h17f619e_0 conda-forge Cached<br /> + libevent 2.1.12 hf998b51_1 conda-forge Cached<br /> + libexpat 2.8.1 hecca717_0 conda-forge 77kB<br /> + libffi 3.5.2 h3435931_0 conda-forge Cached<br /> + libfreetype 2.14.3 ha770c72_0 conda-forge Cached<br /> + libfreetype6 2.14.3 h73754d4_0 conda-forge Cached<br /> + libgfortran 15.2.0 h69a702a_19 conda-forge 28kB<br /> + libgfortran5 15.2.0 h68bc16d_19 conda-forge 2MB<br /> + libgoogle-cloud 3.5.0 h25dbb67_0 conda-forge 3MB<br /> + libgoogle-cloud-storage 3.5.0 hdbdcf42_0 conda-forge 780kB<br /> + libgrpc 1.78.1 h1d1128b_0 conda-forge 7MB<br /> + libjpeg-turbo 3.1.4.1 hb03c661_0 conda-forge Cached<br /> + liblapack 3.11.0 8_h47877c9_openblas conda-forge 19kB<br /> + libmpdec 4.0.0 hb03c661_1 conda-forge 92kB<br /> + libopenblas 0.3.33 pthreads_h94d23a6_0 conda-forge 6MB<br /> + libopentelemetry-cpp 1.26.0 h9692893_0 conda-forge 934kB<br /> + libopentelemetry-cpp-headers 1.26.0 ha770c72_0 conda-forge 396kB<br /> + libparquet 24.0.0 h7376487_3_cpu conda-forge 1MB<br /> + libpng 1.6.58 h421ea60_0 conda-forge 318kB<br /> + libprotobuf 6.33.5 h6eeba95_1 conda-forge 4MB<br /> + libre2-11 2025.11.05 h0dc7533_1 conda-forge 213kB<br /> + libsqlite 3.53.1 h0c1763c_0 conda-forge 955kB<br /> + libstdcxx-ng 15.2.0 hdf11a46_19 conda-forge 28kB<br /> + libthrift 0.22.0 h7d032f7_2 conda-forge 424kB<br /> + libtiff 4.7.1 h9d88235_1 conda-forge Cached<br /> + libutf8proc 2.11.3 hfe17d71_0 conda-forge 86kB<br /> + libuuid 2.42.1 h5347b49_0 conda-forge 40kB<br /> + libuv 1.52.1 h280c20c_0 conda-forge 420kB<br /> + libwebp-base 1.6.0 hd42ef1d_0 conda-forge Cached<br /> + libxcb 1.17.0 h8a09558_0 conda-forge Cached<br /> + markdown-it-py 4.2.0 pyhd8ed1ab_0 conda-forge 69kB<br /> + markupsafe 3.0.3 py314h67df5f8_1 conda-forge 27kB<br /> + mathjax 2.7.7 ha770c72_3 conda-forge Cached<br /> + matplotlib-base 3.10.9 py314h1194b4b_0 conda-forge 9MB<br /> + mdurl 0.1.2 pyhd8ed1ab_1 conda-forge Cached<br /> + munkres 1.0.7 py_1 bioconda Cached<br /> + narwhals 2.21.2 pyhcf101f3_0 conda-forge 284kB<br /> + nlohmann_json 3.12.0 h54a6638_1 conda-forge 136kB<br /> + nspr 4.38 h29cc59b_0 conda-forge Cached<br /> + nss 3.118 h445c969_0 conda-forge Cached<br /> + numpy 2.4.6 py314h2b28147_0 conda-forge 9MB<br /> + openjpeg 2.5.4 h55fea9a_0 conda-forge Cached<br /> + orc 2.3.0 h21090e2_0 conda-forge 1MB<br /> + packaging 26.2 pyhc364b38_0 conda-forge 92kB<br /> + pandas 3.0.3 py314hb4ffadd_0 conda-forge 15MB<br /> + perf_ssr 0.4.8 py_0 jitendralab 720kB<br /> + pillow 12.2.0 py314h8ec4b1a_0 conda-forge 1MB<br /> + pip 26.1.1 pyh145f28c_0 conda-forge 1MB<br /> + plotly 6.6.0 pyhd8ed1ab_0 conda-forge Cached<br /> + plotly-upset-hd 0.0.2 py_0 jitendralab 356kB<br /> + prometheus-cpp 1.3.0 ha5d0236_0 conda-forge 200kB<br /> + pthread-stubs 0.4 hb9d3cd8_1002 conda-forge Cached<br /> + pyarrow 24.0.0 py314hdafbbf9_0 conda-forge 27kB<br /> + pyarrow-core 24.0.0 py314h969be7f_0_cpu conda-forge 5MB<br /> + pydantic 2.13.4 pyhcf101f3_0 conda-forge 347kB<br /> + pydantic-core 2.46.4 py314h2e6c369_0 conda-forge 2MB<br /> + pydantic-extra-types 2.11.2 pyhcf101f3_0 conda-forge 74kB<br /> + pydantic-settings 2.14.1 pyhcf101f3_0 conda-forge 52kB<br /> + pygments 2.20.0 pyhd8ed1ab_0 conda-forge Cached<br /> + pyparsing 3.3.2 pyhcf101f3_0 conda-forge Cached<br /> + pysocks 1.7.1 pyha55dd90_7 conda-forge Cached<br /> + python 3.14.5 habeac84_100_cp314 conda-forge 37MB<br /> + python-dateutil 2.9.0.post0 pyhe01879c_2 conda-forge Cached<br /> + python-dotenv 1.2.2 pyhcf101f3_0 conda-forge Cached<br /> + python-kaleido 0.2.1 pyhd8ed1ab_0 conda-forge Cached<br /> + python-multipart 0.0.29 pyhcf101f3_0 conda-forge 38kB<br /> + python_abi 3.14 8_cp314 conda-forge 7kB<br /> + pyyaml 6.0.3 py314h67df5f8_1 conda-forge 202kB<br /> + qhull 2020.2 h434a139_5 conda-forge Cached<br /> + re2 2025.11.05 h5301d42_1 conda-forge 27kB<br /> + readline 8.3 h853b02a_0 conda-forge Cached<br /> + requests 2.34.2 pyhcf101f3_0 conda-forge 69kB<br /> + rich 15.0.0 pyhcf101f3_0 conda-forge Cached<br /> + rich-argparse 1.8.0 pyhd8ed1ab_0 conda-forge 27kB<br /> + rich-click 1.9.8 pyh8f84b5b_0 conda-forge 64kB<br /> + rich-toolkit 0.19.10 pyhcf101f3_0 conda-forge 33kB<br /> + s2n 1.7.3 hc5a330e_0 conda-forge 388kB<br /> + seqkit 2.13.0 he881be0_0 bioconda Cached<br /> + seqtk 1.5 h577a1d6_1 bioconda 142kB<br /> + shellingham 1.5.4 pyhd8ed1ab_2 conda-forge Cached<br /> + six 1.17.0 pyhe01879c_1 conda-forge Cached<br /> + snappy 1.2.2 h03e3b7b_1 conda-forge Cached<br /> + sniffio 1.3.1 pyhd8ed1ab_2 conda-forge Cached<br /> + sqlite 3.53.1 hbc0de68_0 conda-forge 205kB<br /> + starlette 1.1.0 pyhcf101f3_0 conda-forge 64kB<br /> + tk 8.6.13 noxft_h366c992_103 conda-forge Cached<br /> + tomli 2.4.1 pyhcf101f3_0 conda-forge 22kB<br /> + tqdm 4.67.3 pyh8f84b5b_0 conda-forge Cached<br /> + typer 0.26.3 pyhcf101f3_0 conda-forge 184kB<br /> + typing-extensions 4.15.0 h396c80c_0 conda-forge Cached<br /> + typing-inspection 0.4.2 pyhcf101f3_2 conda-forge 21kB<br /> + typing_extensions 4.15.0 pyhcf101f3_0 conda-forge Cached<br /> + tzdata 2025c hc9c84f9_1 conda-forge Cached<br /> + unicodedata2 17.0.1 py314h5bd0f2a_0 conda-forge 410kB<br /> + upsetplot 0.9.0 pyhd8ed1ab_1 conda-forge 28kB<br /> + urllib3 2.7.0 pyhd8ed1ab_0 conda-forge 104kB<br /> + uvicorn 0.48.0 pyhc90fa1f_0 conda-forge 56kB<br /> + uvicorn-standard 0.48.0 he364bde_0 conda-forge 4kB<br /> + uvloop 0.22.1 py314h5bd0f2a_1 conda-forge 593kB<br /> + watchfiles 1.2.0 py314ha5689aa_0 conda-forge 416kB<br /> + websockets 16.0 py314h0f05182_1 conda-forge 383kB<br /> + xorg-libxau 1.0.12 hb03c661_1 conda-forge Cached<br /> + xorg-libxdmcp 1.1.5 hb03c661_1 conda-forge Cached<br /> + yaml 0.2.5 h280c20c_3 conda-forge Cached<br /> + zlib 1.3.2 h25fd6f3_2 conda-forge Cached<br /> + zlib-ng 2.3.3 hceb46e0_1 conda-forge Cached</p><p>Summary:</p><p>Install: 186 packages</p><p>Total download: 142MB</p><p>─────────────────────────────────────────────────────────────────────────────────────────────────</p><p>&nbsp;</p><p>Transaction starting<br />libgrpc 7.0MB @ 2.3MB/s 3.0s<br />numpy 8.9MB @ 2.3MB/s 3.8s<br />matplotlib-base 8.5MB @ 2.0MB/s 4.2s<br />libarrow 6.5MB @ 2.3MB/s 2.8s<br />pandas 15.3MB @ 2.5MB/s 6.2s<br />libopenblas 5.9MB @ 2.3MB/s 2.5s<br />pyarrow-core 4.8MB @ 1.6MB/s 3.0s<br />libprotobuf 3.7MB @ 2.4MB/s 1.6s<br />aws-sdk-cpp 3.6MB @ 3.1MB/s 1.2s<br />biopython 3.4MB @ 2.0MB/s 1.7s<br />libgfortran5 2.5MB @ 2.6MB/s 1.0s<br />libgoogle-cloud 2.6MB @ 2.4MB/s 1.1s<br />pydantic-core 1.9MB @ 2.7MB/s 0.7s<br />libarrow-compute 3.0MB @ 1.9MB/s 1.6s<br />orc 1.5MB @ 2.8MB/s 0.5s<br />libparquet 1.4MB @ 3.1MB/s 0.5s<br />pip 1.2MB @ 2.9MB/s 0.4s<br />libabseil 1.4MB @ 2.2MB/s 0.6s<br />pillow 1.1MB @ 2.7MB/s 0.4s<br />libsqlite 955.0kB @ 2.9MB/s 0.3s<br />libgoogle-cloud-storage 779.6kB @ 2.7MB/s 0.3s<br />fonttools 846.0kB @ 2.1MB/s 0.4s<br />libopentelemetry-cpp 934.3kB @ 1.8MB/s 0.5s<br />libarrow-acero 592.3kB @ 2.2MB/s 0.2s<br />uvloop 593.4kB @ 1.3MB/s 0.4s<br />libarrow-dataset 592.2kB @ 2.7MB/s 0.2s<br />libarrow-substrait 501.9kB @ 1.8MB/s 0.2s<br />azure-storage-blobs-cpp 587.1kB @ 1.6MB/s 0.3s<br />libthrift 423.9kB @ 2.8MB/s 0.2s<br />crossroad 1.8MB @ 663.3kB/s 2.6s<br />libuv 419.9kB @ 2.3MB/s 0.2s<br />fastar 423.4kB @ 966.7kB/s 0.3s<br />aws-crt-cpp 412.5kB @ 2.9MB/s 0.1s<br />watchfiles 415.6kB @ 1.6MB/s 0.3s<br />unicodedata2 409.6kB @ 1.8MB/s 0.2s<br />libopentelemetry-cpp-headers 396.4kB @ 2.2MB/s 0.2s<br />s2n 388.1kB @ 2.5MB/s 0.1s<br />brotli-python 367.4kB @ 1.7MB/s 0.1s<br />websockets 383.0kB @ 1.3MB/s 0.3s<br />azure-core-cpp 348.7kB @ 2.7MB/s 0.1s<br />pydantic 346.5kB @ 1.9MB/s 0.2s<br />contourpy 324.0kB @ 2.3MB/s 0.1s<br />libpng 317.7kB @ 1.8MB/s 0.2s<br />azure-storage-files-datalake-cpp 303.8kB @ 1.9MB/s 0.1s<br />narwhals 284.3kB @ 1.8MB/s 0.2s<br />fontconfig 280.9kB @ 866.6kB/s 0.2s<br />python 36.7MB @ 3.0MB/s 12.0s<br />azure-identity-cpp 250.5kB @ 1.5MB/s 0.1s<br />lcms2 251.1kB @ 2.0MB/s 0.1s<br />aws-c-common 242.3kB @ 2.8MB/s 0.1s<br />libre2-11 213.1kB @ 66.4kB/s 0.1s<br />aws-c-http 230.3kB @ 1.7MB/s 0.1s<br />aws-c-mqtt 221.7kB @ 307.2kB/s 0.1s<br />sqlite 205.4kB @ ??.?MB/s 0.1s<br />perf_ssr 720.0kB @ 247.3kB/s 2.3s<br />prometheus-cpp 199.5kB @ 962.8kB/s 0.1s<br />pyyaml 202.4kB @ 1.6MB/s 0.1s<br />typer 184.4kB @ 1.9MB/s 0.1s<br />aws-c-io 181.6kB @ 1.9MB/s 0.1s<br />aws-c-s3 153.0kB @ 2.2MB/s 0.1s<br />azure-storage-common-cpp 159.1kB @ 1.8MB/s 0.1s<br />expat 148.2kB @ ??.?MB/s 0.0s<br />anyio 146.8kB @ 2.2MB/s 0.1s<br />glog 143.5kB @ 2.6MB/s 0.1s<br />seqtk 141.8kB @ 1.8MB/s 0.1s<br />nlohmann_json 136.2kB @ 2.1MB/s 0.1s<br />aws-c-auth 134.4kB @ 1.5MB/s 0.1s<br />certifi 134.2kB @ 1.8MB/s 0.1s<br />click 105.0kB @ 1.5MB/s 0.1s<br />gflags 119.7kB @ 148.2kB/s 0.1s<br />urllib3 103.6kB @ ??.?MB/s 0.0s<br />aws-checksums 101.6kB @ ??.?MB/s 0.0s<br />fastapi-core 95.5kB @ ??.?MB/s 0.0s<br />libmpdec 92.4kB @ ??.?MB/s 0.0s<br />packaging 91.6kB @ ??.?MB/s 0.0s<br />libutf8proc 86.0kB @ ??.?MB/s 0.0s<br />kiwisolver 77.4kB @ ??.?MB/s 0.0s<br />libexpat 77.3kB @ 885.4kB/s 0.1s<br />pydantic-extra-types 73.9kB @ ??.?MB/s 0.0s<br />markdown-it-py 69.0kB @ ??.?MB/s 0.0s<br />requests 68.7kB @ ??.?MB/s 0.0s<br />rich-click 64.4kB @ ??.?MB/s 0.0s<br />aws-c-event-stream 59.3kB @ ??.?MB/s 0.0s<br />starlette 63.7kB @ ??.?MB/s 0.0s<br />aws-c-sdkutils 59.1kB @ ??.?MB/s 0.0s<br />aws-c-cal 56.9kB @ ??.?MB/s 0.0s<br />idna 56.9kB @ ??.?MB/s 0.0s<br />uvicorn 56.3kB @ ??.?MB/s 0.0s<br />pydantic-settings 52.3kB @ ??.?MB/s 0.0s<br />email-validator 46.8kB @ ??.?MB/s 0.0s<br />libuuid 40.2kB @ ??.?MB/s 0.0s<br />h11 39.1kB @ ??.?MB/s 0.0s<br />python-multipart 37.8kB @ ??.?MB/s 0.0s<br />rich-toolkit 32.9kB @ ??.?MB/s 0.0s<br />upsetplot 28.0kB @ ??.?MB/s 0.0s<br />libstdcxx-ng 27.8kB @ ??.?MB/s 0.0s<br />libgfortran 27.7kB @ ??.?MB/s 0.0s<br />re2 27.5kB @ ??.?MB/s 0.0s<br />markupsafe 27.4kB @ ??.?MB/s 0.0s<br />pyarrow 26.8kB @ ??.?MB/s 0.0s<br />aws-c-compression 22.0kB @ ??.?MB/s 0.0s<br />tomli 21.6kB @ ??.?MB/s 0.0s<br />typing-inspection 20.9kB @ ??.?MB/s 0.0s<br />fastapi-cli 18.9kB @ ??.?MB/s 0.0s<br />libblas 18.8kB @ ??.?MB/s 0.0s<br />httptools 99.0kB @ ??.?MB/s 0.4s<br />liblapack 18.8kB @ ??.?MB/s 0.0s<br />libcblas 18.8kB @ ??.?MB/s 0.0s<br />email_validator 7.1kB @ ??.?MB/s 0.0s<br />backports.zstd 7.5kB @ ??.?MB/s 0.0s<br />python_abi 7.0kB @ ??.?MB/s 0.0s<br />fastapi 4.8kB @ ??.?MB/s 0.0s<br />uvicorn-standard 4.1kB @ ??.?MB/s 0.0s<br />rich-argparse 26.8kB @ ??.?MB/s 0.2s<br />plotly-upset-hd 356.0kB @ 181.5kB/s 1.8s<br />Linking seqkit-2.13.0-he881be0_0<br />Linking bedtools-2.31.1-h13024bc_3<br />Linking seqtk-1.5-h577a1d6_1<br />Linking libuuid-2.42.1-h5347b49_0<br />Linking readline-8.3-h853b02a_0<br />Linking libexpat-2.8.1-hecca717_0<br />Linking nspr-4.38-h29cc59b_0<br />Linking mathjax-2.7.7-ha770c72_3<br />Linking libuv-1.52.1-h280c20c_0<br />Linking yaml-0.2.5-h280c20c_3<br />Linking ld_impl_linux-64-2.45.1-default_hbd61a6d_102<br />Linking libmpdec-4.0.0-hb03c661_1<br />Linking libwebp-base-1.6.0-hd42ef1d_0<br />Linking zlib-ng-2.3.3-hceb46e0_1<br />Linking libstdcxx-ng-15.2.0-hdf11a46_19<br />Linking pthread-stubs-0.4-hb9d3cd8_1002<br />Linking xorg-libxau-1.0.12-hb03c661_1<br />Linking xorg-libxdmcp-1.1.5-hb03c661_1<br />Linking libgfortran5-15.2.0-h68bc16d_19<br />Linking libpng-1.6.58-h421ea60_0<br />Linking libbrotlicommon-1.2.0-hb03c661_1<br />Linking libjpeg-turbo-3.1.4.1-hb03c661_0<br />Linking libdeflate-1.25-h17f619e_0<br />Linking lerc-4.1.0-hdb68285_0<br />Linking libsqlite-3.53.1-h0c1763c_0<br />Linking libffi-3.5.2-h3435931_0<br />Linking tk-8.6.13-noxft_h366c992_103<br />Linking azure-core-cpp-1.16.2-h206d751_0<br />Linking libabseil-20260107.1-cxx17_h7b12aa8_0<br />Linking libutf8proc-2.11.3-hfe17d71_0<br />Linking libopentelemetry-cpp-headers-1.26.0-ha770c72_0<br />Linking zlib-1.3.2-h25fd6f3_2<br />Linking snappy-1.2.2-h03e3b7b_1<br />Linking nlohmann_json-3.12.0-h54a6638_1<br />Linking aws-c-common-0.13.1-hb03c661_0<br />Linking s2n-1.7.3-hc5a330e_0<br />Linking gflags-2.2.2-h5888daf_1005<br />Linking libevent-2.1.12-hf998b51_1<br />Linking expat-2.8.1-hecca717_0<br />Linking libcrc32c-1.1.2-h9c3ff4c_0<br />Linking qhull-2020.2-h434a139_5<br />Linking libxcb-1.17.0-h8a09558_0<br />Linking libgfortran-15.2.0-h69a702a_19<br />Linking libfreetype6-2.14.3-h73754d4_0<br />Linking libbrotlienc-1.2.0-hb03c661_1<br />Linking libbrotlidec-1.2.0-hb03c661_1<br />Linking libtiff-4.7.1-h9d88235_1<br />Linking sqlite-3.53.1-hbc0de68_0<br />Linking nss-3.118-h445c969_0<br />Linking azure-identity-cpp-1.13.3-hed0cdb0_1<br />Linking azure-storage-common-cpp-12.13.0-ha7a2c86_0<br />Linking libprotobuf-6.33.5-h6eeba95_1<br />Linking libre2-11-2025.11.05-h0dc7533_1<br />Linking prometheus-cpp-1.3.0-ha5d0236_0<br />Linking aws-c-compression-0.3.2-h16e98cb_1<br />Linking aws-checksums-0.2.10-h16e98cb_1<br />Linking aws-c-sdkutils-0.2.4-h16e98cb_5<br />Linking aws-c-cal-0.9.14-h8e43964_1<br />Linking glog-0.7.1-hbabe93e_0<br />Linking libthrift-0.22.0-h7d032f7_2<br />Linking libopenblas-0.3.33-pthreads_h94d23a6_0<br />Linking libfreetype-2.14.3-ha770c72_0<br />Linking brotli-bin-1.2.0-hb03c661_1<br />Linking lcms2-2.19.1-h0c24ade_0<br />Linking openjpeg-2.5.4-h55fea9a_0<br />Linking azure-storage-blobs-cpp-12.17.0-hf824e48_1<br />Linking re2-2025.11.05-h5301d42_1<br />Linking aws-c-io-0.26.3-h955231c_3<br />Linking libblas-3.11.0-8_h4a7cf45_openblas<br />Linking fontconfig-2.18.0-h27c8c51_0<br />Linking freetype-2.14.3-ha770c72_0<br />Linking brotli-1.2.0-hed03a55_1<br />Linking azure-storage-files-datalake-cpp-12.15.0-h1e5b466_0<br />Linking libgrpc-1.78.1-h1d1128b_0<br />Linking aws-c-event-stream-0.7.1-h9be7a74_1<br />Linking aws-c-http-0.11.0-hcbcd92d_1<br />Linking libcblas-3.11.0-8_h0358290_openblas<br />Linking liblapack-3.11.0-8_h47877c9_openblas<br />Linking libopentelemetry-cpp-1.26.0-h9692893_0<br />Linking aws-c-auth-0.10.3-h3aafcba_1<br />Linking aws-c-mqtt-0.15.2-h8af55cf_3<br />Linking libgoogle-cloud-3.5.0-h25dbb67_0<br />Linking aws-c-s3-0.12.3-h00bea6e_2<br />Linking libgoogle-cloud-storage-3.5.0-hdbdcf42_0<br />Linking aws-crt-cpp-0.38.3-h7b0d4b4_2<br />Linking aws-sdk-cpp-1.11.747-h5a171d8_5<br />Linking python_abi-3.14-8_cp314<br />Linking font-ttf-dejavu-sans-mono-2.37-hab24e00_0<br />Linking tzdata-2025c-hc9c84f9_1<br />Linking font-ttf-ubuntu-0.83-h77eed37_3<br />Linking font-ttf-inconsolata-3.000-h77eed37_0<br />Linking font-ttf-source-code-pro-2.038-h77eed37_0<br />Linking fonts-conda-forge-1-hc364b38_1<br />Linking orc-2.3.0-h21090e2_0<br />Linking python-3.14.5-habeac84_100_cp314<br />Linking kaleido-core-0.2.1-h3644ca4_0<br />Linking libarrow-24.0.0-h6f10b76_3_cpu<br />Linking libparquet-24.0.0-h7376487_3_cpu<br />Linking libarrow-compute-24.0.0-h53684a4_3_cpu<br />Linking libarrow-acero-24.0.0-h635bf11_3_cpu<br />Linking libarrow-dataset-24.0.0-h635bf11_3_cpu<br />Linking libarrow-substrait-24.0.0-hb4dd7c2_3_cpu<br />Linking pip-26.1.1-pyh145f28c_0<br />Linking tomli-2.4.1-pyhcf101f3_0<br />Linking six-1.17.0-pyhe01879c_1<br />Linking pysocks-1.7.1-pyha55dd90_7<br />Linking hyperframe-6.1.0-pyhd8ed1ab_0<br />Linking hpack-4.1.0-pyhd8ed1ab_0<br />Linking backports.zstd-1.5.0-py314h680f03e_0<br />Linking pyparsing-3.3.2-pyhcf101f3_0<br />Linking cycler-0.12.1-pyhcf101f3_2<br />Linking sniffio-1.3.1-pyhd8ed1ab_2<br />Linking mdurl-0.1.2-pyhd8ed1ab_1<br />Linking narwhals-2.21.2-pyhcf101f3_0<br />Linking packaging-26.2-pyhc364b38_0<br />Linking charset-normalizer-3.4.7-pyhd8ed1ab_0<br />Linking certifi-2026.5.20-pyhd8ed1ab_0<br />Linking idna-3.17-pyhcf101f3_0<br />Linking pygments-2.20.0-pyhd8ed1ab_0<br />Linking shellingham-1.5.4-pyhd8ed1ab_2<br />Linking annotated-doc-0.0.4-pyhcf101f3_0<br />Linking colorama-0.4.6-pyhd8ed1ab_1<br />Linking typing_extensions-4.15.0-pyhcf101f3_0<br />Linking click-8.4.1-pyhc90fa1f_0<br />Linking tqdm-4.67.3-pyh8f84b5b_0<br />Linking python-kaleido-0.2.1-pyhd8ed1ab_0<br />Linking python-multipart-0.0.29-pyhcf101f3_0<br />Linking python-dotenv-1.2.2-pyhcf101f3_0<br />Linking argcomplete-3.6.3-pyhd8ed1ab_0<br />Linking python-dateutil-2.9.0.post0-pyhe01879c_2<br />Linking h2-4.3.0-pyhcf101f3_0<br />Linking dnspython-2.8.0-pyhcf101f3_0<br />Linking markdown-it-py-4.2.0-pyhd8ed1ab_0<br />Linking plotly-6.6.0-pyhd8ed1ab_0<br />Linking exceptiongroup-1.3.1-pyhd8ed1ab_0<br />Linking typing-inspection-0.4.2-pyhcf101f3_2<br />Linking typing-extensions-4.15.0-h396c80c_0<br />Linking h11-0.16.0-pyhcf101f3_1<br />Linking email-validator-2.3.0-pyhd8ed1ab_0<br />Linking rich-15.0.0-pyhcf101f3_0<br />Linking anyio-4.13.0-pyhcf101f3_0<br />Linking annotated-types-0.7.0-pyhd8ed1ab_1<br />Linking uvicorn-0.48.0-pyhc90fa1f_0<br />Linking email_validator-2.3.0-hd8ed1ab_0<br />Linking rich-toolkit-0.19.10-pyhcf101f3_0<br />Linking typer-0.26.3-pyhcf101f3_0<br />Linking rich-click-1.9.8-pyh8f84b5b_0<br />Linking rich-argparse-1.8.0-pyhd8ed1ab_0<br />Linking httpcore-1.0.9-pyh29332c3_0<br />Linking starlette-1.1.0-pyhcf101f3_0<br />Linking httpx-0.28.1-pyhd8ed1ab_0<br />Linking pyarrow-core-24.0.0-py314h969be7f_0_cpu<br />Linking unicodedata2-17.0.1-py314h5bd0f2a_0<br />Linking brotli-python-1.2.0-py314h3de4e8d_1<br />Linking pillow-12.2.0-py314h8ec4b1a_0<br />Linking kiwisolver-1.5.0-py314h97ea11e_0<br />Linking fastar-0.11.0-py314h0b738fb_0<br />Linking markupsafe-3.0.3-py314h67df5f8_1<br />Linking websockets-16.0-py314h0f05182_1<br />Linking uvloop-0.22.1-py314h5bd0f2a_1<br />Linking pyyaml-6.0.3-py314h67df5f8_1<br />Linking httptools-0.7.1-py314h5bd0f2a_1<br />Linking numpy-2.4.6-py314h2b28147_0<br />Linking pydantic-core-2.46.4-py314h2e6c369_0<br />Linking watchfiles-1.2.0-py314ha5689aa_0<br />Linking pyarrow-24.0.0-py314hdafbbf9_0<br />Linking contourpy-1.3.3-py314h97ea11e_4<br />Linking biopython-1.87-py314h5bd0f2a_0<br />Linking pandas-3.0.3-py314hb4ffadd_0<br />Linking munkres-1.0.7-py_1<br />Linking urllib3-2.7.0-pyhd8ed1ab_0<br />Linking jinja2-3.1.6-pyhcf101f3_1<br />Linking pydantic-2.13.4-pyhcf101f3_0<br />Linking uvicorn-standard-0.48.0-he364bde_0<br />Linking fonttools-4.63.0-pyh7db6752_0<br />Linking requests-2.34.2-pyhcf101f3_0<br />Linking pydantic-settings-2.14.1-pyhcf101f3_0<br />Linking pydantic-extra-types-2.11.2-pyhcf101f3_0<br />Linking fastapi-core-0.136.3-pyhcf101f3_0<br />Linking fastapi-cli-0.0.23-pyhcf101f3_0<br />Linking fastapi-0.136.3-h5ddb490_0<br />Linking plotly-upset-hd-0.0.2-py_0<br />Linking matplotlib-base-3.10.9-py314h1194b4b_0<br />Linking upsetplot-0.9.0-pyhd8ed1ab_1<br />Linking perf_ssr-0.4.8-py_0<br />Linking crossroad-0.3.6-pyh7e60211_0</p><p>Transaction finished</p><p><strong>(jitENV) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$ crossroad -h</strong><br /> <br /> Usage: crossroad [OPTIONS] <br /> <br /> Run the main croSSRoad analysis pipeline, or manage jobs. <br /> <br />╭─ Options ────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --version -v Show version, logo, citation, and links. │<br />│ --install-completion Install completion for the current shell. │<br />│ --show-completion Show completion for the current shell, to copy it or customize the installation. │<br />│ --help -h Show this message and exit. │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ Mode Selection ─────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --api -a Run the Crossroad web API server. │<br />│ --slurm -s Submit the analysis job to a Slurm cluster. │<br />│ --job-status JOB_ID Query the status of a specific job ID. │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ Input Files (provide --input-dir OR --fasta) ───────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --input-dir -i PATH Directory containing: `all_genome.fa`, ``, ``. Exclusive with `--fasta`. │<br />│ --fasta -fa PATH Input FASTA file (e.g., `all_genome.fa`). Alternative to `--input-dir`. │<br />│ --categories -c PATH Genome categories TSV file. Optional if using `--fasta`. Ignored if `--input-dir` is used (looks for `genome_categories.tsv` inside). │<br />│ --gene-bed -b PATH Gene BED file for SSR-gene analysis. Optional. If `--input-dir` is used, looks for `gene.bed` inside. │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ Analysis Parameters ────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --reference-id -ref TEXT Reference genome ID for comparative analysis. Optional parameter for reference-based comparisons. │<br />│ --output-dir -o DIRECTORY Base output directory for jobs. Overrides CROSSROAD_JOB_DIR env var. │<br />│ --flanks -f Process flanking regions. │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ PERF SSR Detection Parameters ──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --mono INTEGER Mononucleotide repeat threshold. [default: 12] │<br />│ --di INTEGER Dinucleotide repeat threshold. [default: 6] │<br />│ --tri INTEGER Trinucleotide repeat threshold. [default: 4] │<br />│ --tetra INTEGER Tetranucleotide repeat threshold. [default: 3] │<br />│ --penta INTEGER Pentanucleotide repeat threshold. [default: 3] │<br />│ --hexa INTEGER Hexanucleotide repeat threshold. [default: 2] │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ Filtering Parameters ───────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --min-len -l INTEGER Minimum genome length for filtering. [default: 1000] │<br />│ --max-len -L INTEGER Maximum genome length for filtering. [default: 10000000] │<br />│ --unfair -u INTEGER Maximum number of N's allowed per genome for Crossroad analysis. [default: 0] │<br />│ --repeat-threshold -rc INTEGER Repeat count Threshold for hotspot filtering (keeps records &gt; this value). [default: 1] │<br />│ --genome-threshold -g INTEGER Genome count Threshold for hotspot filtering (keeps records &gt; this value). [default: 2] │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯<br />╭─ Performance &amp; Output ───────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╮<br />│ --threads -t INTEGER Number of threads for Crossroad analysis. [default: 50] │<br />│ --plots -p Enable plot generation. │<br />│ --intrim-dir TEXT Name for the intermediate files directory (within the main job output dir). [default: intrim] │<br />╰──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────╯</p><p>(jitENV) hp@hp-HP-Z2-Tower-G9-Workstation-Desktop-PC:~/jitendraTEST$</p><p>&nbsp;</p>]]></description>
	<dc:creator>ComBioX</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/32465/tetra-nucleotide-analysis</guid>
	<pubDate>Thu, 04 May 2017 05:07:41 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/32465/tetra-nucleotide-analysis</link>
	<title><![CDATA[Tetra-Nucleotide Analysis]]></title>
	<description><![CDATA[<p>A tetra-nucleotide is a fragment of DNA sequence with 4 bases (e.g. AGTC or TTGG). Pride&nbsp;<em>et al.</em>&nbsp;(2003) showed that the frequency of tetra-nucleotides in bacterial genomes contain useful, albeit weak, phylogenetic signals. Even though tetra-nucleotide analysis (TNA) utilizes the information of whole genome, it is evident that it cannot replace other alignment-based phylogenetic methods such as&nbsp;<a href="https://chunlab.wordpress.com/orthoani/">OrthoANI</a>&nbsp;or&nbsp;16S rRNA phylogeny. However, TNA can be useful for&nbsp;phylogenetic characterization when whole genome or 16S rRNA gene information is not available. For example, a partial genomic fragment obtained from a metagenome can be identified by TNA (Teeling&nbsp;<em>et al.</em>, 2004). TNA is also fast enough that it can be&nbsp;used&nbsp;as a search engine against a large genome database.</p><p>Address of the bookmark: <a href="https://chunlab.wordpress.com/tetra-nucleotide-analysis/" rel="nofollow">https://chunlab.wordpress.com/tetra-nucleotide-analysis/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/2261/best-book-titles-for-learning-bionformatics</guid>
	<pubDate>Tue, 13 Aug 2013 17:31:51 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/2261/best-book-titles-for-learning-bionformatics</link>
	<title><![CDATA[Best book Titles for Learning Bionformatics]]></title>
	<description><![CDATA[<p>Nothing can add to our intellect more than reading a book. &nbsp;In books, we can experience new things that we would not normally be able to experience. It is proved that books can change our lives and other people&rsquo;s lives. Reading can make us more intelligent, updated, imaginative. Without reading we wouldn&rsquo;t know anything that we know today. There are several book, online and offile to read and I can't mentioned all of them here in the list. Therefore, I mentioned some bioinformatics and its related books in subgroups. Hope you will like the list.&nbsp;</p><p>Sequence Analysis and General Bioinformatics</p><ul>
<li>BLAST, Ian Korf, Mark Yandell, Joseph Bedell, 2003, O'Reilly</li>
<li>Sequence Analysis in a Nutshell: A Guide to Common Tools and Databases, Scott Markel, Darryl Leon, 2003, O'Reilly</li>
<li>Bioinformatics for Geneticists, Michael Barnes, Ian C Gray (Editors), 2003, John Wiley &amp; Sons</li>
<li>Bioinformatics for Dummies, Jean-Michel Claverie, Cedric Notredame, 2003, John Wiley &amp; Sons</li>
<li>Mathematics of Genome Analysis, Jerome K. Percus, 2002, Cambridge Univ Press</li>
<li>Bioinformatics Computing, Bryan P. Bergeron, 2002, Prentice Hall</li>
<li>Evolutionary Computation in Bioinformatics, Gary B. Fogel, David W. Corne (Editors), 2002, Morgan Kaufmann</li>
<li>Introduction to Bioinformatics, Arthur M. Lesk, 2002, Oxford University Press</li>
<li>Instant Notes in Bioinformatics, D.R. Westhead, J. H. Parish, R.M. Twyman, 2002, Bios Scientific Pub</li>
<li>Fundamental Concepts of Bioinformatics, Dan E. Krane, Michael L. Raymer, Michaeel L. Raymer, Elaine Nicpon Marieb, 2002, Benjamin/Cummings</li>
<li>Essentials of Genomics and Bioinformatics, C. W. Sensen (Editor), 2002, John Wiley &amp; Sons</li>
<li>Current Topics in Computational Molecular Biology (Computational Molecular Biology), Tao Jiang, Ying Xu, Michael Zhang (Editors), 2002, MIT Press</li>
<li>Hidden Markov Models for Bioinformatics, Timo Koski, Timo Koskinen, 2001, Kluwer Academic Publishers</li>
<li>Bioinformatics: From Genomes to Drugs, Thomas Lengauer (Editor), 2001, John Wiley &amp; Sons</li>
<li>Statistical Methods in Bioinformatics: An Introduction (Statistics for Biology and Health), Warren Ewens, Gregory Grant, 2001, Springer Verlag</li>
<li>Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition, Andreas D. Baxevanis, B. F. Francis Ouellette, 2001, Wiley-Interscience</li>
<li>Bioinformatics: The Machine Learning Approach, Second Edition (Adaptive Computation and Machine Learning), Pierre Baldi, Soren Brunak, Sren Brunak, 2001, MIT Press</li>
<li>Introduction to Bioinformatics, T eresa Attwood, David Parry-Smith, 2001, Prentice Hall</li>
<li>Bioinformatics: A Primer, Charles Staben, 2001, Jones &amp; Bartlett Pub</li>
<li>Data Analysis and Classification for Bioinformatics, Arun Jagota, 2000, AKJ Academics</li>
<li>Bioinformatics: Sequence and Genome Analysis, David W. Mount, 2001, Cold Spring Harbor Laboratory Press</li>
<li>Bioinformatics: A Biologist's Guide to Biocomputing and the Internet, Stuart M. Brown, 2000, Eaton Pub Co</li>
<li>Bioinformatics: Sequence, Structure and Databanks: A Practical Approach (The Practical Approach Series, 236), Des Higgins (Editor), Willie Taylor (Editor), 2000, Oxford Univ Press</li>
<li>Neural Networks and Genome Informatics, Cathy H. Wu, Jerry W. McLarty, 2000, Elsevier Science</li>
<li>Computational Molecular Biology: An Introduction (Wiley Series in Mathematical and Computational Biology), Peter Clote and Rolf Backofen, 2000, John Wiley &amp; Sons</li>
<li>Computational Molecular Biology: An Algorithmic Approach, Pavel A. Pevzner, 2000, MIT Press</li>
<li>Post-Genome Informatics, Minoru Kanehisa, 2000, Oxford Univ Press</li>
<li>Mathematical and Computational Biology: Computational Morphogenesis, Hierarchical Complexity, and Digital Evolution, Chrystopher L. Nehaniv, 1999, American Mathematical Society</li>
<li>Pattern Discovery in Biomolecular Data: Tools, Techniques, and Applications, Jason T. L. Wang, Bruce A. Shapiro, Dennis Elliott Shasha (Editors), 1999, Oxford Univ Press</li>
<li>Time Warps, String Edits, and Macromolecules: The Theory and Practice of Sequence Comparison, David Sankoff and Joseph Kruskal (Editors), 1999, Cambridge University Press</li>
<li>Bioinformatics Basics: Applications in Biological Science and Medicine, Hooman Rashidi, 1999, CRC Press</li>
<li>Bioinformatics: Methods and Protocols (Methods in Molecular Biology, Vol 132), Stephen Misener and Stephen A. Krawetz (Editors),1999, Humana Press</li>
<li>Bioinformatics: Databases and Systems, Stanley Letovsky (Editor),1999, Kluwer Academic Publishers</li>
<li>Computational Molecular Biology, P. Green, 1998, Blackwell Science Inc.</li>
<li>Computational Methods in Molecular Biology (New Comprehensive Biochemistry, V. 32), Steven L. Salzberg, David B. Searls, Simon Kasif (Editors), 1998, Elsevier Science Ltd.</li>
<li>Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids, Richard Durbin, S. Eddy, A. Krogh, G. Mitchison, 1998, Cambridge University Press</li>
<li>Guide to Human Genome Computing, M. J. Bishop (Editor), 1998, Academic Press</li>
<li>Introduction to Computational Molecular Biology, Joao Meidanis, Joao C. Setabal, 1997, PWS Pub. Co.</li>
<li>Algorithms on Strings, Trees, and Sequences: Computer Science and Computational Biology, Dan Gusfield, 1997, Cambridge University Press</li>
<li>Sequence Data Analysis Guidebook, Simon R. Swindell (Editor), 1997, Humana Press</li>
<li>High Performance Computational Methods for Biological Sequence Analysis, Tieng K. Yap, Ophir Frieder, Robert L. Martino, 1996, Kluwer Academic Pub.</li>
<li>Computer Methods for Macromolecular Sequence Analysis, Methods in Enzymology, volume 266, Russell F. Doolittle (Editor), 1996, Academic Press</li>
<li>DNA and Protein Sequence Analysis: A Practical Approach (Practical Approach Series , No 171), 1996, M. J. Bishop and C. J. Rawlings (Editors), 1996, IRL Press</li>
<li>Molecular Bioinformatics: Algorithms and Applications, Steffen Schulze-Kremer, 1995, Walter De Gruyter</li>
<li>Introduction to Computational Biology - Maps, sequences and genomes, Michael S. Waterman, 1995, Chapman &amp; Hall</li>
<li>Computer Analysis of Sequence Data, Annette M. Griffin and Hugh G. Griffin (Editors), 1994, Humana Press</li>
<li>Artificial Intelligence and Molecular Biology, Lawrence Hunter (Editor), 1993, AAAI Press</li>
<li>Sequence Analysis Primer, Michael Gribskov and John Devereux (Editors), 1992, Oxford University Press</li>
<li>Mathematical Methods of Analysis of Biopolymer Sequences (Dimacs Series in Discrete Mathematics and Theoretical Computer Science ; Volume 8), S. G. Gindikin, 1992, American Mathematical Society</li>
<li>Mathematical Methods for DNA Sequences, Michael S. Waterman (Editor), 1989, CRC Press</li>
</ul><p>Programming Books for Bioinformatics</p><ul>
<li>Mastering Perl for Bioinformatics, James D. Tisdall, 2003, O'Reilly</li>
<li>Genomic Perl: From Bioinformatics Basics to Working Code, Rex A. Dwyer, 2002, Cambridge University Press</li>
<li>Beginning Perl for Bioinformatics, James Tisdall, 2001, O'Reilly</li>
<li>Developing Bioinformatics Computer Skills, Cynthia Gibas, Per Jambeck, 2001, O'Reilly</li>
</ul><p>General Genomics</p><ul>
<li>Functional Microbial Genomics (Volume 33), Brendan Wren, Nick Dorrell, 2003, Academic Press</li>
<li>Discovering Genomics, Proteomics, and Bioinformatics, A. Malcolm Campbell, Laurie J. Heyer, 2002, Benjamin/Cummings</li>
<li>Genomes, Terence A. Brown, 2002, John Wiley &amp; Sons</li>
<li>Essentials of Medical Genomics, Stuart M. Brown , 2002, John Wiley &amp; Sons</li>
<li>A Primer of Genome Science, Greg Gibson, Spencer V. Muse, 2002, Sinauer Associates</li>
<li>Pathogen Genomics: Impact on Human Health, Karen Joy, Phd Shaw (Editors), 2002, Humana Press</li>
<li>Genomics, John E. Antonopoulos, 2000, Xlibris Corporation</li>
<li>Genomics and Proteomics: Functional and Computational Aspects, Sandor Suhai (Editor), 2000, Plenum Pub Corp</li>
<li>Functional Genomics: A Practical Approach (The Practical Approach Series, 235), S. Hunt and F. Livesey (Editors), 2000, Oxford Univ Press</li>
<li>Human Molecular Genetics, Andrew P. Read, Tom Strachan 1999, BIOS Scientific Publishers Ltd.</li>
<li>Genomics: The Science and Technology Behind the Human Genome Project, Charles R. Cantor and Cassandra L. Smith, 1999, John Wiley &amp; Sons</li>
<li>Cells: A Laboratory Manual, 3 volumes, David L. Spector, Robert D. Goldman, Leslie A. Leinwand, 1998, Cold Spring Harbor Laboratory Press</li>
<li>Genome Analysis: A Laboratory Manual, 4 volumes, Bruce Birren, et al. (Editors), 1997, Cold Spring Harbor Laboratory Press</li>
<li>The Human Genome Project, N. G. Cooper (Editor), 1994, University Science Books</li>
</ul><p>Comparative Genomics</p><ul>
<li>Handbook of Comparative Genomics: Principles and Methodology, Cecilia Saccone, Graziano Pesole, 2003, Wiley-Liss</li>
<li>Sequence - Evolution - Function: Computational Approaches in Comparative Genomics, Eugene V. Koonin, Michael Y. Galperin, 2002, Kluwer Academic Publishers</li>
<li>Comparative Genomics - Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families, David Sankoff and Joseph H. Nadeau, 2000, Kluwer Academic Pub</li>
<li>Comparative Genomics, Melody Clark (Editor), 2000, Kluwer Academic Pub</li>
</ul><p>Proteomics</p><ul>
<li>Proteins and Proteomics: A Laboratory Manual, Richard J. Simpson (Editor), Cold Spring Harbor Laboratory</li>
<li>Proteomics in Practice: A Laboratory Manual of Proteome Analysis , Reiner Westermeier, Tom Naven, 2002, John Wiley &amp; Sons</li>
<li>Posttranslational Modifications of Proteins: Tools for Functional Proteomics (Methods in Molecular Biology, Vol 194) , Christoph Kannicht (Editor), 2002, Humana Press</li>
<li>Peptide Arrays on Membrane Supports: Synthesis and Applications (Springer Lab Manual), Joachim Koch, Michael Mahler (Editors), 2002, Springer Verlag</li>
<li>Proteomics , Timothy Palzkill, 2002, Kluwer Academic Publishers</li>
<li>Introduction to Proteomics: Tools for the New Biology , Daniel C. Liebler (Editor), 2001, Humana Press</li>
<li>Proteome Research: Mass Spectrometry (Principles and Practice) , P. James (Editor), 2001, Springer Verlag</li>
<li>Interpreting Protein Mass Spectra: A Comprehensive Resource , A. Peter Snyder, 2000, American Chemical Society</li>
<li>Protein Sequencing and Identification Using Tandem Mass Spectrometry , Michael Kinter, Nicholas E. Sherman, 2000, Wiley-Interscience</li>
<li>From Genome to Proteome: Advances in the Practice and Application of Proteomics, Michael J. Dunn (Editor), 2000, Vch Verlagsgesellschaft Mbh</li>
<li>Proteomics: From Protein Sequence to Function, S. Pennington (Editor), M. Dunn (Editor), 2000, Springer Verlag</li>
<li>Proteome Research: Two-Dimensional Gel Electrophoresis and Detection Methods (Principles and Practice), T. Rabilloud (Editor), 2000, Springer Verlag</li>
<li>Proteome and Protein Analysis, R. M. Kamp, D. Kyriakidis, th Choli-Papadopoulou (Editor), 1999, Springer Verlag</li>
<li>Proteome Research: New Frontiers in Functional Genomics, M. R. Wilkins, et al. (Editors), 1997, Springer Verlag</li>
</ul><p>Protein Structure</p><ul>
<li>Structural Bioinformatics, Philip E. Bourne, Helge Weissig (Editors), 2003, John Wiley &amp; Sons</li>
<li>Protein Structure Prediction: Bioinfomatic Approach, I.F. Tsigelny, 2002, International University Line</li>
<li>Introduction to Protein Architecture: The Structural Biology of Proteins, Arthur M. Lesk, 2001, Oxford University Press</li>
<li>Protein Structure Prediction: Methods and Protocols, David M. Webster (Editor), 2000, Humana Press</li>
<li>Introduction to Protein Structure, Carl-Ivar Branden, John Tooze, 1999, Garland Publishing</li>
<li>Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding, Alan Fersht, 1999, Freeman</li>
</ul><p>Pharmacogenomics</p><ul>
<li>Pharmacogenomics: Social, Ethical, and Clinical Dimensions, Mark A. Rothstein (Editor), 2003, Wiley-Liss</li>
<li>Pharmacogenomics: The Search for Individualized Therapies, Julio Licinio, Ma-Li Wong (Editors), 2002, John Wiley &amp; Sons</li>
<li>Pharmacogenomics, Werner Kalow, Urs A. Meyer, Rachel Tyndale (Editors), 2001, Marcel Dekker</li>
<li>Pharmacogenetics and Pharmcogenomics: Recent Conceptual and Technical Advances (Pharmacology, Volume 61, Number 3, 2000), Elliot S. Vesell (Editor), 2000, S. Karger Publishing</li>
<li>Pharmacogenetics, Wendell Weber, 1997, Oxford University Press</li>
</ul><p>DNA Microarrays</p><ul>
<li>Statistical Analysis of Gene Expression Microarray Data, T. P. Speed (Editor), 2003, CRC Press</li>
<li>Microarray Gene Expression Data Analysis: A Beginner's Guide, Helen C. Causton, John Quackenbush, Alvis Brazma, 2003, Blackwell Publishers</li>
<li>The Analysis of Gene Expression Data (Statistics for Biology and Health), G. Parmigiani, E. S. Garrett, R. A. Irizarry, S. Zeger , Graeme Clark (Editors), 2003, Springer Verlag</li>
<li>A Practical Approach to Microarray Data Analysis, Daniel P. Berrar, Werner Dubitzky, Martin Granzow (Editors), 2002, Kluwer Academic Publishers</li>
<li>DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling, Pierre Baldi, G. Wesley Hatfield, 2002, Cambridge University Press</li>
<li>DNA Microarrays: A Molecular Cloning Manual, David Bowtell, Joseph Sambrook (Editors), 2002, Cold Spring Harbor Laboratory</li>
<li>DNA Array Image Analysis: Nuts &amp; Bolts, Gerda Kamberova, Shishir Shah, 2002, DNA Press</li>
<li>Microarray Analysis, Mark Schena, 2002, John Wiley &amp; Sons</li>
<li>A Biologist's Guide to Analysis of DNA Microarray Data, Steen Knudsen, 2002, John Wiley &amp; Sons</li>
<li>Microarrays for an Integrative Genomics (Computational Molecular Biology), Isaac S. Kohane, Alvin Kho, Atul J. Butte, 2002, MIT Press</li>
<li>Microarrays for the Neurosciences: An Essential Guide (Cellular and Molecular Neuroscience), Daniel H. Geschwind, Jeffrey P. Gregg (Editors), 2002, MIT Press</li>
<li>DNA Microarrays: Gene Expression Applications, Bertrand Jordan (Editor), 2001, Springer Verlag</li>
<li>DNA Arrays: Methods and Protocols (Methods in Molecular Biology, Volume 170), Jang B. Rampal (Editor), 2001, Humana Press</li>
<li>DNA Arrays: Technologies and Experimental Strategies, Elena V. Grigorenko (Editor), 2001, CRC Press</li>
<li>Microarray Biochip Technology, Mark Schena (Editor), 2000, Eaton Pub</li>
<li>Expression Genetics: Accelerated and High-Throughput Methods (Biotechniques Update Series), Michael McClelland (Editor), Arthur B. Pardee (Editor), 1999, Eaton Pub</li>
<li>DNA Microarrays: A Practical Approach (Practical Approach Series 205), Mark Schena (Editor), 1999, Oxford Univ Press</li>
<li>cDNA Preparation and Characterization (Methods in Enzymology Volume 303), S.M. Weissman (Editor), 1999, Academic Press</li>
</ul><p>Systems Biology, Genetic and Biochemical Network</p><ul>
<li>Handbook of Graphs and Networks : From the Genome to the Internet, Stefan Bornholdt, Heinz Georg Schuster (Editors), 2003, Vch Verlagsgesellschaft Mbh</li>
<li>Computational Cell Biology, Christopher Fall, Eric Marland, John Wagner, John Tyson (Editors), 2002, Springer Verlag</li>
<li>Gene Regulation and Metabolism: Post-Genomic Computational Approaches (Computational Molecular Biology), Julio Collado-Vides, Ralf Hofestadt (Editors), 2002, MIT Press</li>
<li>Foundations of Systems Biology, Hiroaki Kitano (Editor), 2001, MIT Press</li>
<li>Genomic Regulatory Systems: Development and Evolution, Eric H. Davidson , 2001, Academic Press</li>
<li>Genes &amp; Signals, Mark Ptashne, Alexander Gann, 2001, Cold Spring Harbor Laboratory</li>
<li>Computational Modeling of Genetic and Biochemical Networks (Computational Molecular Biology), James M. Bower and Hamid Bolouri (Editors), 2001, MIT Press</li>
<li>Protein-Protein Interactions: A Molecular Cloning Manual, Erica Golemis (Editor), 2001, Cold Spring Harbor Laboratory</li>
<li>Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists, Eberhard O. Voit, 2000, Cambridge University Press</li>
<li>Mathematical Physiology, James P. Keener, James Sneyd, 1998, Springer Verlag</li>
</ul><p>&nbsp;</p><p>DNA Sequencing</p><ul>
<li>DNA Sequencing: From Experimental Methods to Bioinformatics (Introduction to Biotechniques Series), Luke Alphey, 1997, Springer Verlag</li>
<li>Automated DNA sequencing and analysis, Adams M.D., Fields C., Venter J.C. (Editors), 1994, Academic Press</li>
</ul><p>&nbsp;</p><p>Apart from above mentioned books, you can also find some useful books links at following mentioned URLs:</p><p>&nbsp;</p><p><a href="http://www.amazon.com/Biological-Sequence-Analysis-Probabilistic-Proteins/dp/0521629713">http://www.amazon.com/Biological-Sequence-Analysis-Probabilistic-Proteins/dp/0521629713</a></p><p><a href="http://www.amazon.com/Bioinformatics-Genes-Proteins-Computers-Advanced/dp/1859960545">http://www.amazon.com/Bioinformatics-Genes-Proteins-Computers-Advanced/dp/1859960545</a></p><p><a href="http://www.amazon.com/Introduction-Bioinformatics-Algorithms-Computational-Molecular/dp/0262101068">http://www.amazon.com/Introduction-Bioinformatics-Algorithms-Computational-Molecular/dp/0262101068</a></p><p><a href="http://books.google.no/books?id=pxSM7R1sdeQC&amp;dq=Pierre+baldi+%2B+bioinformatics&amp;printsec=frontcover&amp;source=bn&amp;hl=en&amp;ei=IoGRS6uCIJT-NYLA8Z0N&amp;sa=X&amp;oi=book_result&amp;ct=result&amp;redir_esc=y#v=onepage&amp;q&amp;f=false">http://books.google.no/books?id=pxSM7R1sdeQC&amp;dq=Pierre+baldi+%2B+bioinformatics&amp;printsec=frontcover&amp;source=bn&amp;hl=en&amp;ei=IoGRS6uCIJT-NYLA8Z0N&amp;sa=X&amp;oi=book_result&amp;ct=result&amp;redir_esc=y#v=onepage&amp;q&amp;f=false</a></p><p><a href="http://www.amazon.com/Statistical-Methods-Bioinformatics-Introduction-Statistics/dp/0387400826">http://www.amazon.com/Statistical-Methods-Bioinformatics-Introduction-Statistics/dp/0387400826</a></p><p>&nbsp;</p><p>If you think your favourite books are not listed then please write it down in comment section for the benefits of other users.&nbsp;Feel free to add many more books in comment section.&nbsp;</p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/26629/computer-simulation-of-genetic-mechanism</guid>
	<pubDate>Sun, 13 Mar 2016 09:29:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/26629/computer-simulation-of-genetic-mechanism</link>
	<title><![CDATA[Computer simulation of genetic mechanism !!]]></title>
	<description><![CDATA[<p>Computer simulation is the discipline of designing a model of an actual or theoretical physical/biological system, executing the model on a digital computer, and analyzing the execution output. Simulation embodies the principle of ``learning by doing'' --- to learn about the system we must first build a model of some sort and then operate the model. The use of simulation is an activity that is as natural as a child who role plays. Children understand the world around them by simulating (with toys and figurines) most of their interactions with other people, animals and objects. As adults, we lose some of this childlike behavior but recapture it later on through computer simulation. To understand reality and all of its complexity, we must build artificial objects and dynamically act out roles with them. Computer simulation is the electronic equivalent of this type of role playing and it serves to drive synthetic environments and virtual worlds. Within the overall task of simulation, there are three primary sub-fields: model design, model execution and model analysis<br /><br />Simulation models have become important tools in Bioinformatics studies. There are many reasons for this, but we emphasize three of the more important:</p><p>(1) they enable exploration of hypotheses, and as such, have become invaluable means to guide research;</p><p>(2) they are unique approaches to integrate (in the literal term of the word) biological knowledge, in the form of experimental results; and</p><p>(3) they enable connecting biology with other fields of study ranging from physiology to genomics;</p><p>This blog, and this software list, is intended to guide the potential user of simulation models.<br />It is not, in any way, meant to be comprehensive on the very diverse simulation tools that already exist, but focuses on mechanistic, dynamic models. Similarly, it is not meant to provide any coverage of the breadth of applications; however, for interested readers, we provide references to use as a possible starting point.<br /><br />Simulation models are meant to answer questions which scientists have in a dynamic, quantitative, and often, a pictorial way. Much of the bioinformatics research and its applications, in particular, involve a large number of components, actors, and factors. Assembling these in a coherent framework may seem a daunting task, especially for beginners, and can lead to confusion, even for experienced scientists, especially if the objectives of such an exercise are not well defined. Followings are the list of tools bioinformatician may use to analyze and provide answers to complex biological mechanisms and related problems.</p><p style="margin-bottom: 0in;">&nbsp;</p><table width="718" cellspacing="0" cellpadding="2"><colgroup><col width="134"> <col width="501"> </colgroup>
<tbody>
<tr><th style="border: none; padding: 0in;">
<p>Software Resource</p>
</th><th style="border: none; padding: 0in;">
<p>Brief Description and Homepage</p>
</th></tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/aladyn/">Aladyn </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Tools to investigate how demographic parameters, populations genetics and abiotic conditions affect the rate of adaptation <br /><a href="http://www.katja-schiffers.eu/research.html">http://www.katja-schiffers.eu/research.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/alf/">ALF </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A Simulation Framework for Genome Evolution <br /><a href="http://www.cbrg.ethz.ch/alf">http://www.cbrg.ethz.ch/alf</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/art/">ART </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>ART is a set of simulation tools to generate synthetic next-generation sequencing data by mimicking real sequencing process with empirical error models or quality profiles. <br /><a href="http://www.niehs.nih.gov/research/resources/software/biostatistics/art/">http://www.niehs.nih.gov/research/resources/software/biostatistics/art/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bamsurgeon/">BAMSurgeon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Methods for realistic simulation of mutations in real data. <br /><a href="https://github.com/adamewing/bamsurgeon">https://github.com/adamewing/bamsurgeon</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bayesian-serial-simcoal/">Bayesian Serial SimCoal </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Bayesian Serial SimCoal, (BayeSSC) is a modification of SIMCOAL 1.0, a program written by Laurent Excoffier, John Novembre, and Stefan Schneider. <br /><a href="http://www.stanford.edu/group/hadlylab/ssc/index.html">http://www.stanford.edu/group/hadlylab/ssc/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/baysics/">BaySICS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An integral platform with a graphical interface for statistical inference based on approximate Bayesian computation. <br /><a href="https://sites.google.com/site/baysicsabc/">https://sites.google.com/site/baysicsabc/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/beers/">BEERS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BEERS was designed to benchmark RNA-Seq alignment algorithms and also algorithms that aim to reconstruct different isoforms and alternate splicing from RNA-Seq data <br /><a href="http://cbil.upenn.edu/BEERS/">http://cbil.upenn.edu/beers/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bottleneck/">BOTTLENECK </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Bottleneck is a program for detecting recent effective population size reductions from allele data frequencies <br /><a href="http://www.ensam.inra.fr/URLB/bottleneck/bottleneck.html">http://www.ensam.inra.fr/urlb/bottleneck/bottleneck.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/bottlesim/">BottleSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BottleSim is a computer simulation program for simulating the process of population bottlenecks <br /><a href="http://chkuo.name/software/BottleSim.html">http://chkuo.name/software/bottlesim.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cass/">CASS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Protein Sequence Simulation <br /><a href="https://liberles.cst.temple.edu/Software/CASS/index.html">https://liberles.cst.temple.edu/software/cass/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cdpop/">CDPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>CDPOP is a landscape genetics tool for simulating the emergence of spatial genetic structure in populations resulting from specified landscape processes governing organism movement behavior. <br /><a href="http://cel.dbs.umt.edu/CDPOP">http://cel.dbs.umt.edu/cdpop</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/classical-genetics-simulator/">Classical Genetics Simulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Web-based simulation software <br /><a href="http://www.cgslab.com/">http://www.cgslab.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/coasim/">CoaSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>CoaSim is a tool for simulating the coalescent process with recombination and geneconversion under various demographic models. <br /><a href="http://users-birc.au.dk/mailund/CoaSim/index.html">http://users-birc.au.dk/mailund/coasim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cosi/">cosi </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The cosi package is written in C and is available as a tar file. <br /><a href="http://www.broadinstitute.org/%7Esfs/cosi/">http://www.broadinstitute.org/~sfs/cosi/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/cs-pseq-gen/">CS-PSeq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program to simulate the evolution of protein sequences under the constraints of the information of a particular reconstructed phylogeny <br /><a href="http://bioserv.rpbs.univ-paris-diderot.fr/software/CS-PSeq-Gen/">http://bioserv.rpbs.univ-paris-diderot.fr/software/cs-pseq-gen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/dawg/">DAWG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An application designed to simulate the evolution of recombinant DNA sequences in continuous time <br /><a href="http://scit.us/projects/dawg">http://scit.us/projects/dawg</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/easypop/">Easypop </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EASYPOP is an individual based model intended to simulate datasets under a very broad range of conditions <br /><a href="http://www.unil.ch/dee/en/home/menuinst/softwares--dataset/softwares/easypop.html">http://www.unil.ch/dee/en/home/menuinst/softwares--dataset/softwares/easypop.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/egglib/">EggLib </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EggLib is a C++/Python library and program package for evolutionary genetics and genomics. <br /><a href="http://egglib.sourceforge.net/">http://egglib.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/episim/">EpiSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>EpiSIM: simulation of multiple epistasis, linkage disequilibrium patterns and haplotype blocks for genome-wide interaction analysis <br /><a href="https://sourceforge.net/projects/episimsimulator/files/">https://sourceforge.net/projects/episimsimulator/files/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/evolsimulator/">EvolSimulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation test bed for hypotheses of genome evolution <br /><a href="http://acb.qfab.org/acb/evolsim/">http://acb.qfab.org/acb/evolsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/evolveagene/">EvolveAGene </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A realistic coding sequence simulation program that separates mutation from selection and allows the user to set selection conditions <br /><a href="http://bellinghamresearchinstitute.com/software/index.html">http://bellinghamresearchinstitute.com/software/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fastsimcoal/">fastsimcoal </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A continuous-&shy;‐time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios <br /><a href="http://cmpg.unibe.ch/software/fastsimcoal/">http://cmpg.unibe.ch/software/fastsimcoal/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fastslink/">FastSLINK </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of Marker and Phenotype Data in Pedigrees <br /><a href="https://watson.hgen.pitt.edu/">https://watson.hgen.pitt.edu/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ffpopsim/">FFPopSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>C++/Python library for population genetics. <br /><a href="http://webdav.tuebingen.mpg.de/ffpopsim/">http://webdav.tuebingen.mpg.de/ffpopsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/flux-simulator/">FLUX SIMULATOR </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The Flux Simulator aims at providing a deterministic in silico reproduction of the experimental pipelines for RNA-Seq, employing a minimal set of parameters. <br /><a href="http://sammeth.net/confluence/display/SIM/Home">http://sammeth.net/confluence/display/sim/home</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forqs/">forqs </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Forward-in-time simulation of Recombination, Quantitative Traits, and Selection <br /><a href="https://bitbucket.org/dkessner/forqs">https://bitbucket.org/dkessner/forqs</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forsim/">ForSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>ForSim: A Forward Evolutionary Computer Simulation <br /><a href="http://anth.la.psu.edu/research/weiss-lab/research/research">http://anth.la.psu.edu/research/weiss-lab/research/research</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/forwsim/">ForwSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The program given below is based on the algorithm described in Padhukasahasram et al. 2008 to simulate genetic drift in a standard Wright-Fisher process. <br /><a href="http://badri-populationgeneticsimulators.blogspot.com/">http://badri-populationgeneticsimulators.blogspot.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fpg/">FPG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Forward Population Genetic simulation <br /><a href="https://bio.cst.temple.edu/%7Ehey/software/software.htm#FPG">https://bio.cst.temple.edu/~hey/software/software.htm#fpg</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fregene/">FREGENE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>FREGENE is a C++ program that simulates sequence-like data over large genomic regions in large diploid populations. <br /><a href="http://www.ebi.ac.uk/projects/BARGEN">http://www.ebi.ac.uk/projects/bargen</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/frequency-based-insilico-genome-generator-figg/">FIGG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>FIGG is a genome simulation tool that uses known or theorized variation frequency, per a given fragment size and grouped by GC content across a genome to model new genomes in FASTA format while tracking applied mutations for use in analysis <br /><a href="http://insilicogenome.sourceforge.net/">http://insilicogenome.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/fwdpp/">fwdpp </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A C++ template library for implementing efficient forward simulations. <br /><a href="http://molpopgen.github.io/fwdpp/">http://molpopgen.github.io/fwdpp/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gametes/">GAMETES </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genetic Architecture Model Emulator for Testing and Evaluating Software: Simulates complex SNP models with pure, strict epistatic interactions with n-loci. <br /><a href="http://sourceforge.net/projects/gametes/?source=navbar">http://sourceforge.net/projects/gametes/?source=navbar</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gasp/">GASP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genometric Analysis Simulation Program. A software tool for testing and investigating methods in statistical genetics by generating samples of family data based on user specified models. <br /><a href="http://research.nhgri.nih.gov/gasp/">http://research.nhgri.nih.gov/gasp/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gcta/">GCTA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Genome-wide Complex Trait Analysis <br /><a href="http://www.complextraitgenomics.com/software/gcta/download.html">http://www.complextraitgenomics.com/software/gcta/download.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gemsim/">GemSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Next generation sequencing read simulator <br /><a href="http://sourceforge.net/projects/gemsim/">http://sourceforge.net/projects/gemsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/geneartisan/">GeneArtisan </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of Markers in Case-Control Study Designs <br /><a href="http://www.rannala.org/?page_id=241">http://www.rannala.org/?page_id=241</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genome/">GENOME </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A rapid coalescent-based whole genome simulator <br /><a href="http://www.sph.umich.edu/csg/liang/genome/">http://www.sph.umich.edu/csg/liang/genome/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genomepop2/">GenomePop2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>GenomePop2 is a specialization of the program GenomePop just to manage SNPs under more flexible and useful settings. If you need models with more than 2 alleles please use the GenomePop program version. <br /><a href="https://ritchielab.psu.edu/research/research-areas/statistical-genetics-and-gen-epi/methods/genomesimla">https://ritchielab.psu.edu/research/research-areas/statistical-genetics-and-gen-epi/methods/genomesimla</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/genomesimla/">GenomeSimla </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>GenomeSIMLA is currently under development- however, we have a beta release that we are asking to be tested <br /><a href="http://chgr.mc.vanderbilt.edu/genomeSIMLA/">http://chgr.mc.vanderbilt.edu/genomesimla/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gens2/">GENS2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates interactions among two genetic and one environmental factor and also allows for epistatic interactions. <br /><a href="https://sourceforge.net/projects/gensim/">https://sourceforge.net/projects/gensim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/gwasimulator/">GWAsimulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A rapid whole genome simulation program <br /><a href="http://biostat.mc.vanderbilt.edu/wiki/Main/GWAsimulator">http://biostat.mc.vanderbilt.edu/wiki/main/gwasimulator</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hap-sample/">HAP-SAMPLE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An association simulator for candidate regions or genome scans <br /><a href="http://www.hapsample.org/">http://www.hapsample.org/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapgen/">HAPGEN </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulator for the simulation of case control datasets at SNP markers <br /><a href="https://mathgen.stats.ox.ac.uk/genetics_software/hapgen/hapgen2.html">https://mathgen.stats.ox.ac.uk/genetics_software/hapgen/hapgen2.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapsim/">HapSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients <br /><a href="http://cran.r-project.org/web/packages/hapsim/index.html">http://cran.r-project.org/web/packages/hapsim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/hapsimu/">HAPSIMU </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program that simulates heterogeneous populations with various known and controllable structures under the continuous migration model or the discrete model <br /><a href="http://l.web.umkc.edu/liujian/">http://l.web.umkc.edu/liujian/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ibdsim/">IBDsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>IBDSim is a computer package for the simulation of genotypic data under general isolation by distance models. <br /><a href="http://raphael.leblois.free.fr/">http://raphael.leblois.free.fr/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/indel-seq-gen/">indel-Seq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A biological sequence simulation program that simulates highly divergent DNA sequences and protein superfamilies <br /><a href="http://bioinfolab.unl.edu/%7Ecstrope/iSG/">http://bioinfolab.unl.edu/~cstrope/isg/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/indelible/">Indelible </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A powerful and flexible simulator of biological evolution <br /><a href="http://abacus.gene.ucl.ac.uk/software/indelible/">http://abacus.gene.ucl.ac.uk/software/indelible/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/invertfregene/">invertFREGENE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>InvertFREGENE is a forward-in-time simulator of inversions in population genetic data <br /><a href="http://www.ebi.ac.uk/projects/BARGEN/">http://www.ebi.ac.uk/projects/bargen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/kernalpop/">kernalPop </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A spatially explicit population genetic simulation engine <br /><a href="http://cran.r-project.org/src/contrib/Archive/kernelPop/">http://cran.r-project.org/src/contrib/archive/kernelpop/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/macs/">MaCS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Markovian Coalescent Simulator <br /><a href="http://www-hsc.usc.edu/%7Egarykche/">http://www-hsc.usc.edu/~garykche/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/marlin/">Marlin </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Marlin provides a user-friendly interface for performing forward-in-time population genetic simulations. <br /><a href="http://www.patrickmeirmans.com/software/Marlin.html">http://www.patrickmeirmans.com/software/marlin.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mason/">Mason </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A package for the simulation of nucleotide data. <br /><a href="http://www.seqan.de/projects/mason/">http://www.seqan.de/projects/mason/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mbs/">mbs </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection <br /><a href="http://www.sendou.soken.ac.jp/esb/innan/InnanLab/software.html">http://www.sendou.soken.ac.jp/esb/innan/innanlab/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mendels-accountant/">Mendel's Accountant </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Mendel's Accountant (MENDEL) is an advanced numerical simulation program for modeling genetic change over time and was developed collaboratively by Sanford, Baumgardner, Brewer, Gibson and ReMine <br /><a href="http://mendelsaccount.sourceforge.net/">http://mendelsaccount.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/metapopgen/">MetaPopGen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates genetics in large size metapopulations <br /><a href="https://sites.google.com/site/marcoandrello/metapopgen">https://sites.google.com/site/marcoandrello/metapopgen</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/metasim/">MetaSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A tool to generate collections of synthetic reads that reflect the diverse taxonomical composition of typical metagenome data sets <br /><a href="http://ab.inf.uni-tuebingen.de/software/metasim/">http://ab.inf.uni-tuebingen.de/software/metasim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mlcoalsim/">mlcoalsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Multilocus Coalescent Simulations <br /><a href="http://code.google.com/p/mlcoalsim-v1/">http://code.google.com/p/mlcoalsim-v1/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/ms/">ms </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The purpose of this program is to allow one to investigate the statistical properties of such samples, to evaluate estimators or statistical tests, and generally to aid in the interpretation of polymorphism data sets. <br /><a href="http://home.uchicago.edu/%7Erhudson1/source/mksamples.html">http://home.uchicago.edu/~rhudson1/source/mksamples.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/mshot/">msHOT </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>The purpose of this program is to allow one to investigate the statistical properties of such samples, to evaluate estimators or statistical tests, and generally to aid in the interpretation of polymorphism data sets. <br /><a href="http://home.uchicago.edu/%7Erhudson1/">http://home.uchicago.edu/~rhudson1/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/msms/">msms </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent Simlation tool with selection. <br /><a href="http://www.mabs.at/ewing/msms/index.shtml">http://www.mabs.at/ewing/msms/index.shtml</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/myssp/">MySSP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program for the simulation of DNA sequence evolution across a phylogenetic tree <br /><a href="http://www.rosenberglab.net/software.html">http://www.rosenberglab.net/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/nemo/">Nemo </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A forward-time, individual-based, genetically explicit, and stochastic simulation program designed to study the evolution of genetic markers, life history traits, and phenotypic traits in a flexible (meta-)population framework. <br /><a href="http://nemo2.sourceforge.net/">http://nemo2.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/netrecodon/">NetRecodon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of coding DNA sequences with recombination (inter and intracodon), migration and demography <br /><a href="http://code.google.com/p/netrecodon/">http://code.google.com/p/netrecodon/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/oncosimulr/">OncoSimulR </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>BioConductor package for Forward Genetic Simulation of Cancer Progresion with Epistasis <br /><a href="https://github.com/rdiaz02/OncoSimul">https://github.com/rdiaz02/oncosimul</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/pedagog/">PEDAGOG </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Software for simulating eco-evolutionary population dynamics <br /><a href="https://bcrc.bio.umass.edu/pedigreesoftware/node/5">https://bcrc.bio.umass.edu/pedigreesoftware/node/5</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/phenosim/">phenosim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A tool to add phenotypes to simulated genotypes <br /><a href="http://evoplant.uni-hohenheim.de/doku.php?id=software:software">http://evoplant.uni-hohenheim.de/doku.php?id=software:software</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/phylosim/">PhyloSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An R package for the Monte Carlo simulation of sequence evolution <br /><a href="http://www.ebi.ac.uk/goldman-srv/phylosim/">http://www.ebi.ac.uk/goldman-srv/phylosim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/pirs/">pIRS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Profile-based Illumina pair-end reads simulator <br /><a href="https://code.google.com/p/pirs/">https://code.google.com/p/pirs/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/proteinevolver/">ProteinEvolver </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulation of protein evolution along phylogenies under structure-based substitution models <br /><a href="http://code.google.com/p/proteinevolver/">http://code.google.com/p/proteinevolver/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/qmsim/">QMSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>QTL and Marker Simulator <br /><a href="http://www.aps.uoguelph.ca/%7Emsargol/qmsim/">http://www.aps.uoguelph.ca/~msargol/qmsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/quantinemo/">quantiNEMO </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An individual-based program for the analysis of quantitative traits with explicit genetic architecture potentially under selection in a structured population <br /><a href="http://www2.unil.ch/popgen/softwares/quantinemo/">http://www2.unil.ch/popgen/softwares/quantinemo/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/recoal/">RECOAL </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulates new haplotype data from a reference population of haplotypes. <br /><a href="ftp://popgen.usc.edu/">ftp://popgen.usc.edu/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/recodon/">Recodon </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of coding DNA sequences with recombination, migration and demography <br /><a href="http://code.google.com/p/recodon/">http://code.google.com/p/recodon/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rlsim/">rlsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A package for simulating RNA-seq library preparation with parameter estimation <br /><a href="http://bit.ly/rlsim-git">http://bit.ly/rlsim-git</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rmetasim/">Rmetasim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Rmetasim is a front-end for the metasim engine that is implemented as a package that runs in the statistical computing environment R <br /><a href="http://cran.r-project.org/web/packages/rmetasim/index.html">http://cran.r-project.org/web/packages/rmetasim/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rna-seq-simulator/">RNA Seq Simulator </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>RSS takes SAM alignment files from RNA-Seq data and simulates over dispersed, multiple replica, differential, non-stranded RNA-Seq datasets. <br /><a href="http://useq.sourceforge.net/cmdLnMenus.html#RNASeqSimulator">http://useq.sourceforge.net/cmdlnmenus.html#rnaseqsimulator</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/rose/">Rose </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Random model of sequence evolution <br /><a href="http://bibiserv.techfak.uni-bielefeld.de/rose/">http://bibiserv.techfak.uni-bielefeld.de/rose/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/scrm/">scrm </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent simulator optimized for long sequences and large samples. <br /><a href="https://scrm.github.io/">https://scrm.github.io/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/selsim/">SelSim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recom- bining region within which a single bi-allelic site has experienced natural selection <br /><a href="http://www.well.ox.ac.uk/%7Espencer/SelSim/">http://www.well.ox.ac.uk/~spencer/selsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seq-gen/">Seq-Gen </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An application for the Monte Carlo simulation of molecular sequence evolution along phylogenetic trees. <br /><a href="http://tree.bio.ed.ac.uk/software/seqgen/">http://tree.bio.ed.ac.uk/software/seqgen/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seqpower/">SEQPower </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Statistical power analysis for sequence-based association studies <br /><a href="http://bioinformatics.org/spower/">http://bioinformatics.org/spower/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/seqsimla/">SeqSIMLA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SeqSIMLA can simulate sequence data with user-specified disease and quantitative trait models. Family or unrelated case-control data can be simulated. <br /><a href="http://seqsimla.sourceforge.net/">http://seqsimla.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/serial-netevolve/">Serial NetEvolve </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A flexible utility for generating serially-sampled sequences along a tree or recombinant network <br /><a href="http://biorg.cis.fiu.edu/SNE/">http://biorg.cis.fiu.edu/sne/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sfs_code/">SFS_CODE </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SFS_CODE can perform forward population genetic simulations under a general Wright-Fisher model with arbitrary migration, demographic, selective, and mutational effects. <br /><a href="http://sfscode.sourceforge.net/SFS_CODE/index/index.html">http://sfscode.sourceforge.net/sfs_code/index/index.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sibsim/">SIBSIM </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Quantitative phenotype simulation in extended pedigrees <br /><a href="http://sourceforge.net/projects/sibsim/">http://sourceforge.net/projects/sibsim/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simadapt/">SimAdapt </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A spatially explicit, individual-based, forward-time, landscape-genetic simulation model combined with a landscape cellular automaton. <br /><a href="https://www.openabm.org/model/3137">https://www.openabm.org/model/3137</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simcoal2/">SIMCOAL2 </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A coalescent program for the simulation of complex recombination patterns over large genomic regions under various demographic models <br /><a href="http://cmpg.unibe.ch/software/simcoal2/">http://cmpg.unibe.ch/software/simcoal2/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simcopy/">SimCopy </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>An R package simulating the evolution of copy number profiles along a tree. <br /><a href="http://bit.ly/simcopy">http://bit.ly/simcopy</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simla/">SIMLA </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SIMLA is a SIMuLAtion program that generates data sets of families for use in Linkage and Association studies. <br /><a href="http://dmpi.duke.edu/simla-simulation-software-version-32">http://dmpi.duke.edu/simla-simulation-software-version-32</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simped/">SimPed </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A Simulation Program to Generate Haplotype and Genotype Data for Pedigree Structures <br /><a href="http://bioinformatics.org/simped/">http://bioinformatics.org/simped/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simprot/">Simprot </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A program to simulate protein evolution by substitution, insertion and deletion <br /><a href="http://www.uhnresearch.ca/labs/tillier/software.htm#3">http://www.uhnresearch.ca/labs/tillier/software.htm#3</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simrare/">SimRare </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Rare variant simulation and analysis tool <br /><a href="http://code.google.com/p/simrare/">http://code.google.com/p/simrare/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simugwas/">simuGWAS </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A forward-time simulator that simulates realistic samples for genome-wide association studies. <br /><a href="http://simupop.sourceforge.net/Cookbook/SimuGWAS">http://simupop.sourceforge.net/cookbook/simugwas</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/simupop/">simuPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>simuPOP is a general-purpose individual-based forward-time population genetics simulation environment. <br /><a href="http://simupop.sourceforge.net/">http://simupop.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sissi/">SISSI </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A software tool to generate data of related sequences along a given phylogeny, taking into account user defined system of neighbourhoods and instantaneous rate matrices. <br /><a href="http://www.cibiv.at/software/sissi/">http://www.cibiv.at/software/sissi/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/smartpop/">SMARTPOP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulating Mating Alliance as a Reproductive Tactic for Populations <br /><a href="http://smartpop.sourceforge.net/">http://smartpop.sourceforge.net/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/snpsim/">SNPsim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Coalescent simulation of hotspot recombination <br /><a href="http://code.google.com/p/phylosoftware/">http://code.google.com/p/phylosoftware/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/spip/">SPIP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SPIP simulates the transmission of genes from parents to offspring in a population having demographic structure defined by the user <br /><a href="http://swfsc.noaa.gov/textblock.aspx?Division=FED&amp;id=3434">http://swfsc.noaa.gov/textblock.aspx?division=fed&amp;id=3434</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/splatche/">Splatche </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Spatial and Temporal Coalescences in Heterogeneous Environment <br /><a href="http://www.splatche.com/">http://www.splatche.com/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/srv/">srv </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Simulator of Rare Varaints (srv) is a simulator for the simulation of the introduction and evolution of (rare) genetic variants. <br /><a href="http://simupop.sourceforge.net/Cookbook/SimuRareVariants">http://simupop.sourceforge.net/cookbook/simurarevariants</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/sup/">SUP </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>SLINK/FastSLINK utility program <br /><a href="http://mlemire.freeshell.org/software.html">http://mlemire.freeshell.org/software.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/treesimj/">TreesimJ </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A flexible, forward-time population genetic simulator <br /><a href="http://code.google.com/p/treesimj/">http://code.google.com/p/treesimj/</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/variant-simulation-tools/">Variant Simulation Tools </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>A simulation tool for post-GWAS genetic epidemiological studies using whole-genome or whole-exome next-gen sequencing data, with an emphasis on user-friendliness and reproducibility. <br /><a href="http://varianttools.sourceforge.net/Simulation/HomePage">http://varianttools.sourceforge.net/simulation/homepage</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/vortex/">Vortex </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>VORTEX is an individual-based simulation model for population viability analysis (PVA). <br /><a href="http://www.vortex9.org/vortex.html">http://www.vortex9.org/vortex.html</a></p>
</td>
</tr>
<tr><th style="border: none; padding: 0in;">
<p><a href="https://popmodels.cancercontrol.cancer.gov/gsr/packages/wessim/">Wessim </a></p>
</th>
<td style="border: none; padding: 0in;">
<p>Whole Exome Sequencing SIMulator <br /><a href="http://sak042.github.io/Wessim/">http://sak042.github.io/wessim/</a></p>
</td>
</tr>
</tbody>
</table><p style="margin-bottom: 0in;">&nbsp;</p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/3868/next-generation-sequencing-ngs-tutorials</guid>
	<pubDate>Sat, 24 Aug 2013 06:01:37 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/3868/next-generation-sequencing-ngs-tutorials</link>
	<title><![CDATA[Next Generation Sequencing (NGS) Tutorials]]></title>
	<description><![CDATA[<p>Institute of computational biomedicine, Cornell University provide an NGS workshop tutorial at&nbsp;<a href="http://chagall.med.cornell.edu/NGScourse/">http://chagall.med.cornell.edu/NGScourse/</a>&nbsp;</p>
<p>You can also add your favourite NGS educational material, or workshop tutorial by commenting on this bookmarks for user benefit.&nbsp;</p>
<p>Understanding the basics of genome sequencing:</p>
<p>Tutorial by Luke Jostins.</p>
<p>http://www.genetic-inference.co.uk/blog/2009/04/basics-sequencing-dna-part-1/</p>
<p>http://www.genetic-inference.co.uk/blog/2009/08/basics-sequencing-dna-part-2/</p>
<p>A window into third-generation sequencing</p>
<p>http://hmg.oxfordjournals.org/content/19/R2/R227.full.pdf</p>
<p>==============================================</p>
<p>NGS data analysis pipelines</p>
<ul>
<li><strong>Detecting and annotating genetic variations using the HugeSeq pipeline</strong>&nbsp; DOI: <a href="http://dx.doi.org/10.1038/nbt.2134">10.1038/nbt.2134</a></li>
<li><strong> NARWHAL, a primary analysis pipeline for NGS data</strong> <a href="http://bioinformatics.oxfordjournals.org/cgi/content/abstract/28/2/284?etoc">http://bioinformatics.oxfordjournals.org/cgi/content/abstract/28/2/284?etoc</a></li>
<li><strong>RseqFlow: Workflows for RNA-Seq data analysis</strong>&nbsp; DOI: <a href="http://dx.doi.org/10.1093/bioinformatics/btr441">10.1093/bioinformatics/btr441</a></li>
<li><strong>ngs_backbone: a pipeline for read cleaning, mapping and SNP calling using Next Generation Sequence</strong>&nbsp;&nbsp;<a href="http://dx.doi.org/10.1186/1471-2164-12-285">10.1186/1471-2164-12-285</a></li>
<li><strong>A framework for variation discovery and genotyping using next-generation DNA sequencing data</strong>&nbsp; PubMed: <a href="http://www.ncbi.nlm.nih.gov/pubmed/21478889">21478889</a></li>
<li><strong>SNiPlay: a web-based tool for detection, management and analysis of SNPs. Application to grapevine diversity projects</strong>&nbsp; DOI: <a href="http://dx.doi.org/10.1186/1471-2105-12-134">10.1186/1471-2105-12-134</a> Abstract: <a href="http://www.biomedcentral.com/1471-2105/12/134/abstract">http://www.biomedcentral.com/1471-2105/12/134/abstract</a></li>
<li><strong>WEP: a high-performance analysis pipeline for whole-exome data&nbsp;</strong>http://www.biomedcentral.com/1471-2105/14/S7/S11</li>
<li><strong>DDBJ read annotation pipeline: a cloud computing-based pipeline for high-throughput analysis of next-generation sequencing data.&nbsp;</strong>http://www.ncbi.nlm.nih.gov/pubmed/23657089</li>
<li><strong>GATK: a Toolkit for Genome Analysis&nbsp;</strong>http://www.broadinstitute.org/gatk/</li>
<li><strong>Metagenomics</strong>:http://www.nbic.nl/education/nbic-phd-school/course-schedule/ngsmetagenomics/</li>
<li><strong>RNASeq</strong>:http://www.nbic.nl/education/nbic-phd-school/course-schedule/ngsrnaseq/</li>
<li><strong>Bioinformatics and Seq courses</strong>:&nbsp;http://www.isb-sib.ch/training/training-activities-schedule/archive-2013.html</li>
<li><strong>Variant Detection (Model organism) Advanced tutorial</strong> https://docs.google.com/document/pub?id=1CuKkKylVDb03tnN7RSWl5EUzleetn0ctjmvaidPKLxM</li>
<li><strong>Variant Detection Introductory tutorial</strong> https://docs.google.com/document/pub?id=1ZRzrjjOCvtAu3m-IKL-rbJ1f4On60dDL_IEwG7oejdI</li>
<li><strong>Microbial de novo Assembly for Illumina Data Introductory tutorial</strong> https://docs.google.com/document/pub?id=1N3AB9ptISUu4zULqe1kXpVF0BDyGb5f5yzxWSJd_WNM</li>
<li><strong>RNAseq Differential Gene Expression Introductory tutorial</strong> https://docs.google.com/document/pub?id=1KbTiBHtvHLfPRZ39AY3uriazrINA8TJzgjjwn1zPP7Y</li>
</ul>
<blockquote>
<p>" Please add your favourite NGS link below in comment section for the benefit of bioinformatics community ".&nbsp;</p>
</blockquote><p>Address of the bookmark: <a href="http://chagall.med.cornell.edu/NGScourse/" rel="nofollow">http://chagall.med.cornell.edu/NGScourse/</a></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/10925/a-brief-bioinformatics-tutorial</guid>
	<pubDate>Wed, 21 May 2014 12:50:09 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/10925/a-brief-bioinformatics-tutorial</link>
	<title><![CDATA[A Brief Bioinformatics Tutorial]]></title>
	<description><![CDATA[<p>This is about how to use a computer to find what is known about a gene of interest and also how to get new insights about it.</p>
<p>The tutorial is divided in three main parts:</p>
<ul>
<li>In the <strong>Sequence </strong>part, you will see how to look efficiently for a particular protein sequence, how to blast it against the database of your choice to find homologues, how to perform a multiple alignment of the homologues you've selected and how to edit this alignment.</li>
<li>The <strong>Structure </strong>part is about molecular visualization, homology modeling and structural domain prediction.</li>
<li>In the <strong>Function </strong>part, you will be introduced to you 3 useful servers to investigate the function of a protein. i.e. finding interactors, co-expressed genes, see a phylogenetic profile, easily access papers citing your gene etc ...</li>
</ul>
<p>During all the three parts, we will use the <em>S. cerevisiae </em>VPS36 protein as an example.</p><p>Address of the bookmark: <a href="http://www.mrc-lmb.cam.ac.uk/rlw/text/bioinfo_tuto/introduction.html" rel="nofollow">http://www.mrc-lmb.cam.ac.uk/rlw/text/bioinfo_tuto/introduction.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/14218/pimp-your-brain-bioinformatics</guid>
	<pubDate>Wed, 20 Aug 2014 22:09:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/14218/pimp-your-brain-bioinformatics</link>
	<title><![CDATA[Pimp your brain: Bioinformatics]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/KqelGy6Q8nE" frameborder="0" allowfullscreen></iframe>Jan Lisec from the Max Planck Institute of Molecular Plant Physiology explains, in this "pimp your brain" episode, what bioinformatics is and why bioinformatics is so important and indispensable for biological research.

In the video serial "Pimp your brain" scientists from the Max Planck Institute of Molecular Plant Physiology describe their research. More videos from the 'Pimp your brain' serial are available on www.youtube.com/playlist?list=PL-l9VItC9Gn2Ur2Xj6PTOAkjLUlVPbIOO

More videos are available on www.mpimp-golm.mpg.de]]></description>
	
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/21443/a-guide-for-complete-r-beginners-getting-data-into-r</guid>
	<pubDate>Tue, 24 Feb 2015 20:15:08 -0600</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/21443/a-guide-for-complete-r-beginners-getting-data-into-r</link>
	<title><![CDATA[A guide for complete R beginners :- Getting data into R]]></title>
	<description><![CDATA[<p>For a beginner this can be is the hardest part, it is also the most important to get right.</p><p>It is possible to create a vector by typing data directly into R using the combine function &lsquo;c&rsquo;</p><blockquote><p><strong>x </strong></p></blockquote><p>same as</p><blockquote><p><strong>x </strong></p></blockquote><p>creates the vector x with the numbers between 1 and 5.</p><p>You can see what is in an object at any time by typing its name;</p><blockquote><p><strong>x</strong></p></blockquote><p>will produce the output<strong> &lsquo;[1] 1 2 3 4 5&prime;</strong></p><p>Note that names need to be quoted</p><blockquote><p><strong>daysofweek </strong><strong>&larr; c(&lsquo;Monday&rsquo;, &lsquo;Tuesday&rsquo;, &lsquo;Wednesday&rsquo;, &lsquo;Thursday&rsquo;, &lsquo;Friday&rsquo;);</strong></p></blockquote><p>Usually however you want to input from a file. We have touched on the &lsquo;read.table&rsquo; function already.</p><blockquote><p><strong>mydata </strong></p></blockquote><p>Now <strong>mydata</strong> is a data frame with multiple vectors</p><p>each vector can be identified by the default syntax</p><p>#if any of these are typed it will print to screen</p><blockquote><p><strong>mydata$V1 mydata$V2 mydata$V3 </strong></p></blockquote><p>By default the function assumes certain things from the file</p><ul>
<li>The file is a plain text file (there are function to read excel files: <em>not covered here</em>)</li>
<li>columns are separated by any number of tabs or spaces</li>
<li>there is the same number of data points in each column</li>
<li>there is no header row (labels for the columns)</li>
<li>there is no column with names for the rows** [I&rsquo;ll explain].</li>
</ul><p><span style="text-decoration: underline;">If any of these are false, we need to tell that to the function</span></p><p>If it has a header column</p><blockquote><p><strong>mydata <em>header=T also works</em></strong></p></blockquote><p>Note that there is a comma between different parts of the functions arguments</p><p>If there is one less column in the header row, then R assumes that the 1<sup>st</sup> column of data after the header are the row names</p><p>Now the vectors (columns) are identified by their name</p><p>#if any of these are typed it will print to screen</p><blockquote><p><strong>mydata$A mydata$B mydata$C </strong></p></blockquote><p># Summary about the whole data frame</p><blockquote><p><strong>summary(mydata)</strong></p></blockquote><p># Summary information of column A</p><blockquote><p><strong>summary(mydata$A) </strong></p></blockquote><p>We can shortcut having to type the data frame each time by attaching it</p><blockquote><p><strong>attach(mydata)</strong></p></blockquote><p># summary of column B as &lsquo;mydata&rsquo; is attached</p><blockquote><p><strong>summary(B)</strong></p></blockquote><p><span style="text-decoration: underline;">Two other important options for </span><em><span style="text-decoration: underline;">read.table</span></em></p><p>If is is separated only by tabs and has a header</p><blockquote><p><strong>mydata </strong></p></blockquote><p>Really useful if you have spaces in the contents of some columns, so R does not mess up reading the columns . However if the columns or of an uneven length it will tell you.</p><p>If you know that the file has uneven columns</p><blockquote><p><strong>mydata </strong></p></blockquote><p>This causes R to fill empty spaces in a columns with &lsquo;NA&rsquo; .</p><p>The last two examples will still work with our file and give the same result as with only headers=T</p><p><span style="text-decoration: underline;">Graphs</span></p><p>to get an idea of what R is capable of type</p><blockquote><p><strong>demo(graphics)</strong></p></blockquote><p>steps through the examples, and the code is printed to the screen</p><p>We will work with simpler examples that have immediate use to biologists.</p><p>Remember to get more information about the options to a function type &lsquo;?function&rsquo;</p><p><span style="text-decoration: underline;">Histogram of A</span><span style="text-decoration: underline;"></span></p><blockquote><p><strong>hist(mydata$A)</strong></p></blockquote><p>If there was more data we could increase the number of vertical columns with the option, breaks=50 (or another relevant number).</p><blockquote><p><strong>boxplot(mydata)</strong></p></blockquote><p>We can get rid of the need to type the data frame each time by using the <strong>attach</strong> function</p><p># if not already done so</p><blockquote><p><strong>attach(mydata) </strong></p><p><strong>boxplot(mydata$A, mydata$B, name=c(&ldquo;Value A&rdquo;, &ldquo;Value B&rdquo;) , ylab=&ldquo;Count of Something&rdquo;)</strong></p></blockquote><p>same as</p><blockquote><p><strong>boxplot(A, B, name=c(&ldquo;Value A&rdquo;, &ldquo;Value B&rdquo;) , ylab=&ldquo;Count of Something&rdquo;)</strong></p></blockquote><p><span style="text-decoration: underline;">Scatter plot</span></p><p># if not already done so</p><blockquote><p><strong>attach(mydata) </strong></p><p><strong>plot(A,B) # or plot(mydata$A, mydata$B)</strong></p></blockquote><p><strong><span style="text-decoration: underline;">SAVING an image</span></strong></p><p>Windows users (Rgui) RIGHT click on image and select which you want.</p><p><span style="text-decoration: underline;">These instructions work for everyone.</span></p><p>You need to create a new device of the type of file you need, then send the data to that device</p><p>to save as a png file (easy to load into the likes of powerpoint, also great for web applications.</p><blockquote><p><strong>png(&lsquo;filename&rsquo;) </strong></p><p><strong>boxplot(A, B, name=c(&ldquo;Value A&rdquo;, &ldquo;Value B&rdquo;) , ylab=&ldquo;Count of Something&rdquo;)</strong></p></blockquote><p>or to save as a pdf</p><blockquote><p><strong>pdf(&lsquo;filename&rsquo;) </strong></p><p><strong>boxplot(A, B, name=c(&ldquo;Value A&rdquo;, &ldquo;Value B&rdquo;) , ylab=&ldquo;Count of Something&rdquo;)</strong></p></blockquote><p><span style="text-decoration: underline;">Note</span></p><ul>
<li>Nothing will appear on screen, the output is going to the file</li>
<li>Also it may not be saved immediately but will once the device (or R) is turned quit.</li>
</ul><p>To quit R type</p><p><strong>q() # </strong>If you save your session, next time you start R, you will have your data preloaded.</p><p>Or if you want to remain in R</p><blockquote><pre><strong>dev.off() #</strong>turns of the png (or pdf etc) device, thus forces the data to save</pre></blockquote>]]></description>
	<dc:creator>Archana Malhotra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/23160/opencpu</guid>
	<pubDate>Sun, 05 Jul 2015 18:34:46 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/23160/opencpu</link>
	<title><![CDATA[OpenCPU]]></title>
	<description><![CDATA[<p>OpenCPU is a system for embedded scientific computing and reproducible research. The OpenCPU server provides a reliable and interoperable <a href="https://www.opencpu.org/api.html">HTTP API</a> for data analysis based on R.</p><p>The OpenCPU <a href="https://www.opencpu.org/jslib.html">JavaScript client library</a> provides the most seamless integration of R and JavaScript available today.</p><p>OpenCPU uses standard R packaging to develop, ship and deploy web applications. Several open source <a href="https://www.opencpu.org/apps.html">example apps</a> are available from Github.</p><p>Installing your own OpenCPU server is <a href="https://www.opencpu.org/download.html">super easy</a> and only takes a few minutes.</p><p>More at https://www.opencpu.org/</p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
</item>

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