BOL: Category: All

Prof. Chandrasekhar Kanduri Laboratory

Fri, 24 Jun 2016 16:59:43 -0500

Our lab has been interested in understanding how long noncoding RNAs control tumor initiation and progression, in addition to use them as potential biomarkers in diagnosis and therapy. We have been using neuroblastoma, a childhood cancer, as a model system to understand the functional role of long noncoding RNAs in cancer development and progression. By using new RNA sequencing technology on neuroblastoma tumors from a large group of Swedish children including both high-risk and low-risk neuroblastomas (108), we have identified several long noncoding RNAs that could have potential role in diagnosis and therapy. We are currently exploring the functional role of these differentially expressed long noncoding RNA in nuroblastoma progression and development.

The Kingsley Lab

Fri, 03 Jun 2016 09:55:10 -0500

The Molecular Basis of Vertebrate Evolution. Naturally occurring species show spectacular differences in morphology, physiology, behavior, disease susceptibility, and life span. Although the genomes of many organisms have now been completely sequenced, Kingsley lab still know relatively little about the specific DNA sequence changes that underlie interesting species-specific traits. Kingsley lab laboratory is using a combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control evolutionary change in vertebrates.

Navin Lab

Wed, 18 May 2016 16:40:14 -0500

NAvin laboratory has pioneered the development of single cell sequencing technologies. They apply these tools to study complex biological processes that occur in human cancers including tumor initation, clonal evolution, invasion, metastasis and chemoresistance. These processes have previously been difficult to study with genomic technologies using bulk tissues

More at http://www.navinlab.com/navinlab/home.html

Lawley Lab

Mon, 09 May 2016 03:29:51 -0500

Lawley Lab are covered with a complex microbial community, known as our microbiota, which plays important roles in our physiology, immunity, metabolism and sustenance. Within the human gastrointestinal tract alone there are over 1,000 bacterial species, which amounts to approximately 10 times more cells than we harbor in our entire body and 200 times more genes than are found within our genome. Lawley Lab are really a 'supraorganism' consisting of our 'human' and 'microbial' selves.

More at http://www.sanger.ac.uk/science/groups/lawley-lab

Desai Lab

Thu, 21 Apr 2016 10:21:07 -0500

Evolutionary Dynamics and Population Genetics

Natural selection and other evolutionary forces lead to particular patterns of evolutionary dynamics, and they leave characteristic signatures on the genetic variation within populations. We use a combination of theory and experiments to study the dynamics and population genetics of natural selection in asexual populations such as microbes and viruses.

We use both theory and experiments to study evolutionary dynamics and population genetics, particularly in situations where natural selection is pervasive.

http://desailab.oeb.harvard.edu/home