<![CDATA[BOL: Category: researchlabs:Bioinformatics]]> https://bioinformaticsonline.com/researchlabs/view/34681/genomic-approaches-to-study-global-regulation-of-gene-expression-in-the-mouse-immune-system? https://bioinformaticsonline.com/researchlabs/view/34681/genomic-approaches-to-study-global-regulation-of-gene-expression-in-the-mouse-immune-system Fri, 15 Dec 2017 22:10:12 -0600 <![CDATA[Genomic approaches to study global regulation of gene expression in the mouse immune system]]> This group seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

This lab focuses on two main areas: (1) transcription factors and the regulation of gene expression, and (2) physical protein-protein interactions and protein complexes

This group also aim to elucidate transcriptional regulatory networks orchestrating T helper cell differentiation and plasticity. Using the T helper cell system, we want to answer questions such as: What is the hierarchy and kinetics of molecular events that contribute to changes in gene expression? Are the kinetics of these interactions graded or switch-like?

http://www.sanger.ac.uk/science/groups/teichmann-group

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