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  • PolyPhen-2: Prediction of functional effects of human nsSNPs

PolyPhen-2: Prediction of functional effects of human nsSNPs

http://genetics.bwh.harvard.edu/pph2/

PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations.