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LEGE on Basic command-line to run BLAST (1312 days ago): Understanding the...- BioStar on How to install Perl modules manually, using CPAN command, and other quick ways (1330 days ago): If using conda conda create --name perlENV perlconda activate perlENV conda...
- BioStar on How to install Perl modules manually, using CPAN command, and other quick ways (1330 days ago): Installing in CONDA env You can check using which perl - it...
- BioStar on Calculate the significance of the difference between two trends (1332 days ago): Useful reading material https://statsandr.com/blog/anova-in-r/
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Can AI Decide Which Genomic Model to Trust?
By BioStar 12 days agoImagine you're sitting with a genomic dataset of some sort (thousands of SNPs), a set of plant phenotypes and the one very simple question: can we predict what these plants will become? The first thing you'd probably do is reach for machine...Uncovering Evolution’s Blueprint: How ntSynt Is Changing Comparative Genomics
By Jitendra Narayan 17 days agoOver millions of years, evolution has shaped all life on Earth, leaving clues in the DNA of every organism. While different species look and act very differently, their genomes still hold signs of a shared evolutionary past. These connections show...The Variant Everyone Ignored
By BioStar 31 days agoConsider a scenario in which a patient's genome has been sequenced. Among billions of DNA bases, a structural alteration may explain the patient's disease. Multiple advanced algorithms analyze the data, yet only one detects the variant, while the...Finding the Hidden Switches: The Story of KiNext and Protein Kinases
By LEGE 42 days agoEvery newly sequenced genome contains thousands of proteins, but identifying what each protein does is a much harder task. Among these proteins are protein kinases, important molecular regulators that control processes such as cell growth,...Simulating the Unseen: New Tools Reshaping Metagenomic Research
By LEGE 43 days agoBenchmarking a new metagenomic pipeline often begins with a fundamental challenge. Imagine a bioinformatician preparing to benchmark a new metagenomic pipeline. There is no shortage of real sequencing data, but one problem quickly appears: the exact...DNA in Pieces, Survival in Progress: The Rotifer’s Incredible Secret
By Jitendra Narayan 48 days agoA creature smaller than a grain of sand has discovered a surprising method of surviving damage that can break its DNA apart. It lives in the mosses and lichens, in the thin films of water that show up after rain and disappear when the area dries...From Genes to Algorithms: The AI Revolution in Bioinformatics
By Jitendra Narayan 50 days agoModern sequencing technologies have turned biology into a data-heavy science. The human genome has about three billion DNA base pairs, and sequencing can produce massive datasets quickly. Bioinformatics helps organize and interpret this information,...nf-core/mag v5: Advancing Genome-Resolved Metagenomics
By LEGE 53 days agoMetagenomics is rapidly moving beyond short-read sequencing. With the increasing adoption of long-read technologies, researchers can generate more contiguous assemblies—but converting these reads into reliable metagenome-assembled genomes (MAGs)...When Genes Leave Clues: Reading the Evolutionary Footprints of Life
By LEGE 54 days agoThis idea, known as phylogenetic profiling, is the foundation of Profylo (https://github.com/MartinSchoenstein/Profylo), an open-source Python toolkit developed for comparing evolutionary profiles and discovering co-evolving genes. Profylo brings...The Genes That Travel Together: A Genomic Detective Story
By BioStar 55 days agoImagine looking through thousands of microbial genomes and discovering two genes that repeatedly appear together. The obvious conclusion is that they must somehow be connected—that perhaps they work together, participate in the same pathway, or...
