Hercules: a profile HMM-based hybrid error correction algorithm for long reads
...egration of these two technologies. Results: We designed and developed Hercules, the first machine learning-b...nd CH17-227A2), and human brain cerebellum polyA RNA-seq, we show that Hercules-corrected reads have the high...2089 days ago
Hercules: a profile HMM-based hybrid error correction algorithm for long reads
Choosing whether to use second or third generation sequencing platforms can lead to trade-offs between accuracy and read length. Several studies require long and accurate reads including de novo assembly, fusion and structural variation detection. In such cases researchers often combine both tech...Tags: Hercules, profile, HMM-based, hybrid, error, correction, algorithm, long, reads, PacBio
2089 days ago