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Question: Question: What a bioinformatician should must know ?

Jai Singh
3942 days ago

Question: What a bioinformatician should must know ?

As a bioinformatician, we learn several progamming languages, complex biological mechanism, and many more. But, there have been always a curiosity to know that what should a bioinformatician MUST read and learn.

Best Answer
4
There's a wide range of topics that are useful if you're interested in pursuing bioinformatics, and it's not possible to learn them all. However, in our conversations with scientists working at companies, we've picked up on the following "core requirements" for bioinformaticians:
  • You should have a fairly deep background in some aspect of molecular biology. It can be biochemistry, molecular biology, molecular biophysics, or even molecular modeling, but without a core of knowledge of molecular biology you will, as one person told us, "run into brick walls too often."
  • You must absolutely understand the central dogma of molecular biology. Understanding how and why DNA sequence is transcribed into RNA and translated into protein is vital. 
  • You should have substantial experience with at least one or two major molecular biology software packages, either for sequence analysis or molecular modeling. The experience of learning one of these packages makes it much easier to learn to use other software quickly.
  • You should be comfortable working in a command-line computing environment. Working in Linux or Unix will provide this experience.
  • You should have experience with programming in a computer language such as C/C++, as well as in a scripting language such as Perl or Python.
There are a variety of other advanced skill sets that can add value to this background: molecular evolution and systematics; physical chemistry--kinetics, thermodynamics and statistical mechanics; statistics and probabilistic methods; database design and implementation; algorithm development; molecular biology laboratory methods; and others.

Other Answers
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Install Linux and learn command lines, make, bash. Start exploring the biological databases using ftp.

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Knowing a little of everything is often better than having one expert skill. Learn as much as you can. Learn new bioinformatics tools, techniques, complex biological rules, programming logics .. etc.  

Neelam, 
I have different view on this topic. Bioinformatician should first decide their area of interest and then start learning it's related stuff. For example, drug designer should learn docking not NGS techiques. :) 

Jai Singh 3939 days ago

0

Hmm this question/answer will help me to decide and learn bioinformatics stuf in future. However, currently I started learning basics of Linux OS, and wish to install all the required software soon. Thanks to all.