Read this research paper http://www.ncbi.nlm.nih.gov/pubmed/20643738 which explain impact and origin of human immunodeficiency virus type 1 (HIV-1) virus.
Hi Ruchira,
You should read following papers for an overview of last decade updates:
Bioinformatics in the post-sequence era http://www.nature.com/ng/journal/v33/n3s/full/ng1109.html
A decade of web server updates at the bioinformatics links...