Thanks Rahul for this information.
It's interesting to know about the involvement of TEs in neuroplasticity of brain. I got a good topic.
Thanks again.
Hi Andaleeb,
Brain research project https://www.humanbrainproject.eu/, open up a whole new area for informatics experts http://bioinformaticsonline.com/videolist/watch/6484/why-neuroinformatics
Best of luck.
Thanks
Hi Andaleeb,
1) A Bioinformatician need to be good mathematician before entering the field of Neuroscience. He should be able to think mathematically and scrutinize research problems.
2) There are several sub-fields in neuroscience where a bioinformatician can excel with his knowledge. Data basing, Algorithm development, Tool development, systems biology of neurological diseases are a few among them.
"I want to pursue my phd in neuroscience of mental disorder" --- You can approach mental disorders examining it at the genetic level(DNA and RNA) or at the neuronal level(Neuronal firing). Building mathematical models or examining the genetical aspects of mental disorders through bioinformatics would be interesting for you.
Best,
Rahul
Hi Andaleeb,
Following links might be useful for you.
Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics http://www.sciencedirect.com/science/article/pii/S0079612306580045
Why Are Computational Neuroscience and Systems Biology So Separate? http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000078
Informatics in neuroscience http://bib.oxfordjournals.org/content/8/6/446.full
Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics. http://www.ncbi.nlm.nih.gov/pubmed/17027692
Thanks
Hi Andaleeb,
In 2013 Society for Neuroscience meeting, the speaker reported TEs are expressed and active in the brain, challenging the dogma that neuronal genomes are static and revealing that they are susceptible to somatic genomic alterations. These new findings on TE expression and function in the CNS have major implications for understanding the neuroplasticity of the brain, which could hypothetically have a role in shaping individual behavior and contribute to vulnerability to disease. Ref: http://www.jneurosci.org/content/33/45/17577.short
It certainly open a new potential area of research for bioinformaticians, to understand indivisual behaviour in greater detail.
Recent Neuroscience Information Framework (NIF) project advances neuroscience by enabling discovery and access to public research data and tools worldwide through an open source, semantically enhanced search portal. Read more at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381282/?tool=pubmed
Note: I have no as such experience in neuroscience area.
Best of luck.
Thanks