Single molecule Sequencing (SMS)
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Resolving the complexity of the human genome using single-molecule sequencing
By Rahul Agarwal 3421 days agowww.nature.com - The human genome is arguably the most complete mammalian reference assembly yet more than 160 euchromatic gaps remain and aspects of its structural variation remain poorly understood ten years after its completion. The results in this paper...Assembly and diploid architecture of an individual human genome via single-molecule technologies
By Rahul Agarwal 3421 days agowww.nature.com - The research work shows that it is now possible to integrate single-molecule and high-throughput sequence data to generate de novo assembled genomes that approach reference...Scaffolding of a bacterial genome using MinION nanopore sequencing
By Rahul Agarwal 3425 days agowww.nature.com - Second generation sequencing has revolutionized genomic studies. However, most genomes contain repeated DNA elements that are longer than the read lengths achievable with typical sequencers, so the genomic order of several generated contigs cannot...GraphMap - A highly sensitive and accurate mapper for long, error-prone reads
By Rahul Agarwal 3427 days ago Comments (1)github.com - GraphMap is a novel mapper targeted at aligning long, error-prone third-generation sequencing data.It is designed to handle Oxford Nanopore MinION 1d and 2d reads with very high sensitivity and accuracy, and also presents a significant...
