DIAMOND is a sequence aligner for protein and translated DNA searches and functions as a drop-in replacement for the NCBI BLAST software tools. It is suitable for protein-protein search as well as DNA-protein search on short reads and longer sequences including contigs and assemblies, providing a speedup of BLAST ranging up to x20,000.
More at file:///home/urbe/Downloads/diamond_manual.pdf
http://www.nature.com/nmeth/journal/v12/n1/full/nmeth.3176.html