BOL: Group activity

Comparative Genomics !!

This group is dedicated to Comparative genomics ... Dramatic results have emerged from the rapidly developing field of comparative genomics. Comparison of the fruit fly genome with the human genome reveals that about sixty percent of genes are conserved (Adams et al. 2000). That is, the two organisms appear to share a core set of genes. Researchers have also found that two-thirds of human genes known to be involved in cancer have counterparts in the fruit fly.

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Group activity

- Jit@jit.aber
Jit commented on a bookmark Method in Comparative genomics !! 2786 days ago

I found this PPT tutorial useful http://schatzlab.cshl.edu/teaching/AssemblyClass/06.%20Whole%20Genome%20Alignment.pdf
- Jit@jit.aber
Jit commented on a bookmark Method in Comparative genomics !! 2928 days ago

A PhD thesis on comparative genomics "METHODS FOR HIGH-THROUGHPUT COMPARATIVE GENOMICS AND DISTRIBUTED SEQUENCE...
- Abhimanyu Singh@abhimanyu
Abhimanyu Singh commented on a bookmark Comparative genomics educational material and papers bookmarks 2934 days ago

An intersting paper explaining comparative genomics in metazoan eukaryotes "COMPARATIVE GENOMICS: GENOME-WIDE ANALYSIS IN METAZOAN EUKARYOTES" https://www.cs.rice.edu/~devika/comp470/papers/ureta-vidal2003.pdf
- Abhimanyu Singh@abhimanyu
Abhimanyu Singh commented on a bookmark Comparative genomics educational material and papers bookmarks 2934 days ago

An intersting paper reviewed "An applications-focused review of comparative genomics tools: Capabilities, limitations and future challenges" http://bib.oxfordjournals.org/content/4/2/105.full.pdf
- Jit@jit.aber
Jit commented on a bookmark Comparative genomics educational material and papers bookmarks 2934 days ago

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and...
- Jit@jit.aber
Jit bookmarked Method in Comparative genomics !! 2934 days ago

We present methods for the automatic determination of genome correspondence. The algorithms enabled the automatic identification of orthologs for more than 90% of genes and intergenic regions across the four species despite the large number of...

http://web.mit.edu/manoli/www/publications/Kellis_JCB_04.pdf
Comments
- Jit@jit.aber
  
  Jit 2928 days ago
  A PhD thesis on comparative genomics "METHODS FOR HIGH-THROUGHPUT COMPARATIVE GENOMICS AND DISTRIBUTED SEQUENCE ANALYSIS" @ http://drum.lib.umd.edu/bitstream/handle/1903/11669/Angiuoli_umd_0117E_12062.pdf;jsessionid=A30813F9A1A23A54D917BC34109FE38D?sequence=1
- Jit@jit.aber
  
  Jit 2786 days ago
  I found this PPT tutorial useful
  http://schatzlab.cshl.edu/teaching/AssemblyClass/06.%20Whole%20Genome%20Alignment.pdf
- Jit@jit.aber
Jit commented on a bookmark Comparative genomics educational material and papers bookmarks 2934 days ago

Korean researchers have sequenced and have begun analyzing the genome of the Far Eastern Amur leopard, Panthera pardus orientalis, an endangered sub-species of leopard found in southern Russia and northern...
- Jit@jit.aber
Jit commented on a bookmark Comparative genomics educational material and papers bookmarks 2934 days ago

Innate immune genes tend to be highly conserved in metazoans, even in early divergent lineages such as Cnidaria (jellyfish, corals, hydroids and sea anemones) and Porifera (sponges). However, constant and diverse selection pressures on the immune...
- Jit@jit.aber
Jit bookmarked Comparative genomics educational material and papers bookmarks 2934 days ago

Alignment of the porcine genome against seven other mammalian genomes (Supplementary Information) identified homologous synteny blocks (HSBs). Using porcine HSBs and stringent filtering criteria, 192 pig-specific evolutionary breakpoint regions...

http://www.nature.com/nature/journal/v491/n7424/abs/nature11622.html
Comments
- Jit@jit.aber
  
  Jit 2934 days ago
  A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
  http://vosshall.rockefeller.edu/reprints/RubinLewisScience00.pdf
- Abhimanyu Singh@abhimanyu
  
  Abhimanyu Singh 2934 days ago
  An intersting paper reviewed "An applications-focused review of comparative genomics tools: Capabilities, limitations and future challenges" http://bib.oxfordjournals.org/content/4/2/105.full.pdf
- Abhimanyu Singh@abhimanyu
  
  Abhimanyu Singh 2934 days ago
  An intersting paper explaining comparative genomics in metazoan eukaryotes "COMPARATIVE GENOMICS: GENOME-WIDE ANALYSIS IN METAZOAN EUKARYOTES" https://www.cs.rice.edu/~devika/comp470/papers/ureta-vidal2003.pdf
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