Comparison of the two major classes of #assembly algorithms: overlap–layout–consensus and de-bruijn-graph https://academic.oup.com/bfg/article/11/1/25/191455
#Calculate The #Frequency Of Letters In A Biological Sequence, Or The #Consensus Matrix Of A Set Of Sequences https://www.rdocumentation.org/packages/Biostrings/versions/2.40.2/topics/letterFrequency