Recently published Nature commentary on "So you want to be a computational biologist?" by Nick Loman & Mick Watson give advice when starting out on computational projects. http://www.nature.com/nbt/journal/v31/n11/full/nbt.2740.html
Corpas M, Fatumo S, Schneider R. (2012) How not to be a bioinformatician. Source Code Biol Med. 7(1):3. [link]
Wilson G, Aruliah DA, Brown CT, Chue Hong NP, Davis M, Guy RT, Haddock SHD, Huff K, Mitchell IM, Plumbley M, Waugh B, White EP,...