PANNZER (Protein ANNotation with Z-scoRE) is a fully automated service for functional annotation of prokaryotic and eukaryotic proteins of unknown function. The tool is designed to predict the functional description (DE) and GO classes.
PANNZER2 processes bacterial proteomes in minutes and eukaryotic proteomes in an hour. You can use AAI-profiler to summarize a proteome's species neighbors and reveal taxonomic identity or contamination.
http://ekhidna2.biocenter.helsinki.fi/sanspanz/
IterPro is for the beginners
https://www.ebi.ac.uk/interpro/
You can find other comparative info at https://academic.oup.com/view-large/118391389
