Owner: Rahul Agarwal
Group members: 7
Metabolomics is the comprehensive and quantitative analysis of multiple metabolites in biological samples.
Metabolome is the complete set of small-molecule metabolites found within a single biological
system
Targeted metabolomics aims to quantify a set of predefined metabolites in a sample.
Untargeted (sometimes termed ‘global’) metabolomics aims to quantitatively measure the levels of all metabolites.
Metabolomics Biomarkers may be useful for four main purposes:
1) controlled trials
2) dietary intakes in observational studies
3) explaining the biological effects of the diet
4) characterizing a specific genotype or phenotype
Pipeline of Metabolomics study:
http://www.nutrigenomics.biz/downloadattachment/33374/Brown.pdf
http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201301004/205
Alignment tools for this include:
mz-Mine
XCMS (R code script), and Metalign
Metabolomics databases for searching the potential candidates biomarkers:
- hmdb-http://www.hmdb.ca
- metlin -http://metlin.scripps.edu/metabo_search_alt2.php
- Metfusion: http://msbi.ipb-halle.de/MetFusion/
- Chemspider-http://www.chemspider.com/
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