Results for "haplotigs"
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HapSolo, that identifies secondary contigs and defines a primary assembly based on multiple pairwise contig alignment metrics. HapSolo evaluates candidate primary assemb...1108 days ago
Purge Haplotigs: Pipeline to help with curating heterozygous diploid genome assemblies
.... Canu, FALCON or FALCON-Unzip primary contigs) or on a phased-diploid assembly (i.e. FALCON-Unzip primary contigs + haplotigs). Here are two examples of how Purge Haplotigs can improve a haploid and dip...1981 days ago
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Purge Haplotigs: Pipeline to help with curating heterozygous diploid genome assemblies
Some parts of a genome may have a very high degree of heterozygosity. This causes contigs for both haplotypes of that part of the genome to be assembled as separate primary contigs, rather than as a contig and an associated haplotig. This can be an issue for downstream analysis whether you're wor...Tags: Purge, Haplotigs, Pipeline, curate, heterozygous, diploid, genome, assemblies
1981 days ago
- Despite marked recent improvements in long-read sequencing technology, the assembly of diploid genomes remains a difficult task. A major obstacle is distinguishing between alternative contigs that represent highly heterozygous regions. If primary and secondary contigs are not properly identified,...
Tags: HapSolo, optimization, approach, remove, secondary, haplotigs, diploid, genome, assembly, scaffolding
1302 days ago
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