In a lot of my work in bioinformatics, I have been using hidden Markov models (HMMs). As a postdoc with David Haus...here the group is working on methods for structure prediction from sequence. To read...
...roaches including: (i) paired-end mapping (or read pair analysis) based on abnormally mapped pairs of clone ends; (ii) read-depth analysis, which detects delet...and duplications through analysis of the readdepth-of-coverage; (iii) split read...
They are using the latest DNA sequencing technology to read the genetic makeup of cancer cells within tumours in ever greater detail, teasing out patterns of evolution (evolutionar...