BOL

Imagine looking through thousands of microbial genomes and discovering two genes that repeatedly appear together. The obvious conclusion is that they must somehow be connected—that perhaps they work together, participate in the same pathway, or...

A recent study by Webster and Chapman introduces Buscogeny, an open-source bioinformatics pipeline designed to make this process easier. The tool uses BUSCO (Benchmarking Universal Single-Copy Orthologs), which identifies conserved genes that are...

A recent study published in PLOS Computational Biology introduces REvolutionH-tl 2.0 (https://pypi.org/project/revolutionhtl/), a computational tool designed to help solve this mystery. The software analyzes protein sequences and identifies...

When scientists find an AMR gene, it shows that resistance exists. However, it does not always reveal where the gene is or what is around it. This genetic context can give important clues about how resistance genes work, change over time, and...

Imagine comparing humans and chimpanzees to discover which genes make us different. You have millions of RNA-sequencing reads—but there is a catch: the computer may align these reads more easily to one species' genome than the other.

Researchers developed GIPSy2, a computer tool that acts like a detective. It scans bacterial DNA and looks for unusual patterns that might show where a genomic island is hiding.

The bigger lesson is simple: better biological discoveries often begin with better data.

Imagine opening a metagenomic dataset and finding millions of DNA fragments, each carrying a tiny piece of information about the microbial world inside a sample. The challenge is not generating the data — it is turning that data into a meaningful...

In the sprawling universe of modern science, bioinformatics stands as one of the most transformative and empowering fields of our time. It is where biology meets computation, where data becomes meaning, and where curiosity becomes discovery. If...

In the genomic era, the ability to predict the virulence potential of pathogens has become an indispensable part of infectious disease research. With the exponential growth of microbial genome data, bioinformatics tools now enable scientists to...