Shruti Paniwala
A Bioinformatician
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GMcloser: closing gaps in assemblies accurately with a likelihood-based selection of contig or long-read alignments
By Shruti Paniwala 2148 days ago
https://academic.oup.com/bioinformatics/article/31/23/3733/209212
GMcloser uses likelihood-based classifiers calculated from the alignment statistics between scaffolds, contigs and paired-end reads to correctly assign contigs or long reads to gap regions of scaffolds, thereby achieving accurate and efficient gap closure. We demonstrate with sequencing data from various organisms that the gap-closing accuracy of GMcloser is 3–100-fold higher than those of other available tools, with similar efficiency.
https://academic.oup.com/bioinformatics/article/31/23/3733/209212
