Cogent is a tool for reconstructing the coding genome using high-quality full-length transcriptome sequences. It is designed to be used on Iso-Seq data and in cases where there is no reference genome or the ref genome is highly incomplete.
See a recent presentation on Cogent being applied to the Cuttlefish Iso-Seq data.
Cogent preliminary draft paper (updated 2016Dec version), Supplementary
Please see wiki for details on usage.