Pros and cons of HairSplitter Limitations of HairSplitter:
Not very fast: it re-polishes the whole assembly
Limited in the number of haplotypes
Strengths of HairSplitter:
Very modular, can be used with any assembler
Naive: makes no assumption on ploidy, parameter-free
Safe: won’t artificially duplicate contigs
HairSplitter splits collapsed assemblies from “draft” assemblies obtained by any means
HairSplitter can recover haplotypes and distinguish repeated elements
Only needs sequencing reads, potentially error-prone
HairSplitter splits collapsed assemblies from “draft” assemblies obtained by any means
HairSplitter can recover haplotypes and distinguish repeated elements
Only needs sequencing reads, potentially error-prone
Not really available yet (github.com/RolandFaure/HairSplitter)
https://hal.archives-ouvertes.fr/hal-03864075/file/RolandFaure_presentation_SeqBIM_2022.pdf
