The bakers yeast, Saccharomyces cerevisiae is an ideal model organism to understand mechanisms of meiotic chromosom...e as a model. These studies are relevant for understanding cancer progression, genome e...
Genetic differences among individuals reflect the combined effects of mutation, recom...important insights into evolutionary and genetic mechanisms: as examples, DNA sequence conservation among distantly...
...overy and analysis of structural variation (SVs) from genomic sequence data. As part of the 1000 Genomes Project and other endeavors, w...) split read analysis, which detects SVs by evaluating gapped sequence alignments; and (iv) sequence...
...vior, disease susceptibility, and life span. Although the genomes of many organisms have now been completely sequenced, Kingsley lab still know relatively little about the specific DNA sequence changes that underlie interes...
...ructure, function and evolution of the human genome. Our group is one of the pion...omparative genomics. We proposed the compact genome of the fugu (Takifugu rubripe...366: 265-268, 1993) and determined its whole genomesequence in 2002 (Science 297: 1301-13...
...al biology lab that develops novel methods for analysis of DNA and RNA sequences. Our research includes software for aligning and assembling RNA-seq data, whole-genome assembly, and microbiome analys...
The mission of our lab is to develop and apply new technologies and methods for genetics, genomics and molecular bi...ics
Translating Genomics to the Clinic
Genetic Basis of Human Disease
Genome S...
...he lab is to understand mammalian genomes using comparative genomic an...lude: the evolution of regulatory sequences, the role of transposable...gene regulation and the impact of genome rearrangements in evolution a...for the functional annotation of genomes with a special emphasis on seq...
The Rogers lab studies evolution of genome structure. We explore the ways that complex mutations like duplications, deletions, rearrangements, and retrogenes can create new...