...the molecular mechanisms that regulate mRNA translation, localizatio...ss. Up to 90% of human DNA is estimated to be transcribed into so ca...non-coding RNAs that are not translated into proteins. Many of them...ological disorders and hold great potential as drug targets, disease...
They develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
https://www.pmgenomics.ca/hoffmanlab/
...lar and bioinformatic tools to study evolutionary processes at the level of populations, both experimental and natural, and genomes. Our research interests encompass a wide range o...
...ation on molecular phenotypes and human disease. We develop methods for integrating diverse functional gen...ons, regulator binding, and their changes across multiple conditions to interpret genetic associations, id...
...ic mechanisms: as examples, DNA sequence conservation among distantly related species can help identify functional roles too subtle to be detected in lab settings, while an...
We are generally interested in the mechanisms of species origin from a molec...nd ecological perspective. Particularly, we are interested in the role of sex chro...enomic and ecological approaches we try to elucidate the genetic architecture of r...
...abnormally mapped pairs of clone ends; (ii) read-depth analysis, which detects deletions and duplications...nalysis of the read depth-of-coverage; (iii) split read analysis, which detects SVs by evaluating gapped s...
Evolutionary Dynamics and Population Genetics
Natural selection and other evolutionary forces lead to particular patterns of evolutionary dynamics, and they leave characteristic signatures on the genetic...
...a complex microbial community, known as our microbiota, which plays important roles in our physiology, immunity, metabolism and sustenance. Within the human gastrointestinal tract alone there are o...
NAvin laboratory has pioneered the development of single cell sequencing technologies. They apply these t...ce. These processes have previously been difficult to study with genomic technologies using bulk tissues...