Our group works on various problems connected with the functioning and evolution of biological syste...tools, coming from statistics and combinatorics, algorithmic to...enomics
Transcriptomics andsequence analysis
Protein evolution and inter...
...on the analysis of whole genome sequence data to identify genetic variation (primarily structuralvariation) and examine their potential functional...gh modern sequencing approaches and which may exhibit interesting mecha...the application of whole genome sequence analysis in clinical diagnosti...
Research. Research in the lab focuses on mathematical, statistical, and computational problems in evolutionary biology and human genetics. Long-term interests...opics such as:
Human genetic variatio...The relationship between gene trees and species trees
The role of huma...
...arch is focused on Bioinformatics and Computational Biology.
Current re...e next-generation DNA sequencing, structuralvariation, genome rearrangements in cancer and evolution, and network analys...in comparative genomics, multiple sequence alignment, and motif finding.
More athttp://com...
The Bioinformatics Centre at BISR has created an infrastructure for providing facil...ection as well latest Bioinformatics software for sequenceand structure analysis. The centre pro...omized training in Bioinformatics for researchers and facul...
The bakers yeast, Saccharomyces cerevisiae is an ideal model organism to understand mechanisms of meiotic chromos...plexes in crossover formation and distribution among all homolo...c background on mutation rate variatio...udies are relevant for understanding cancer progression, genome evolu...
A major focus of our lab is understanding the effects of genetic variation on molecular phenotypes and human disease. We develop methods f...f transcription, chromatin modifications, regulator binding, and their changes across multiple condi...
...mbination, population history and natural selection. As a result, studies of natural variation can provide important insights into evolutionary and genetic mechanisms: as examples, DNA sequence conservation among distantly...ut the dynamics of adaptation and the determinants of recombination a...
...y is focused on the discovery and analysis of structuralvariation (SVs) from genomic sequence data. As part of the 1000 Genomes Project and other endeavors, we have helped pr...ects SVs by evaluating gapped sequence alignments; and (iv) sequence...
TheLab seek to understand the genetic factors contributing to genomic variationand phenotypic diversity. To this end, we employ molecular and bioinformatic tools to study...the fitness and phenotypic consequences of mutation in evolution. For...