Our research group is primarily focused on the analysis of whole genome sequence data to identify genetic variation (primarily structuralvariation) and examine their potential functional impact in di...
Research. Research in the lab focuses on mathematical, statistical, and computational p...Long-term interests of the lab include topics such as:
Human genetic variation
Inference of human evolu...
...Lab research is focused on Bioinformatics and Computational Biology.
Current research interests include next-generation DNA sequencing, structuralvariation, genome rearrangements in can...
The bakers yeast, Saccharomyces cerevisiae is an ideal model organism to understand mec...nterested in understanding the effect of genetic background on mutation rate variation using S. cerevisiae as a mode...
A major focus of our lab is understanding the effects of genetic variation on molecular phenotypes and human disease. We develop methods for integrating diverse functional genomic datasets of transcript...
Genetic differences among individuals reflect the combined e...atural selection. As a result, studies of natural variation can provide important insight...ted in lab settings, while analyses of population variation allow for inferences about ev...
The laboratory is focused on the discovery and analysis of structuralvariation (SVs) from genomic sequence data. As part of the 1000 Genomes Project and other endeavors, we have helped prod...
Evolutionary Dynamics and Population Genetics
Natural selection and other evolutiona...olutionary dynamics, and they leave characteristic signatures on the genetic variation within populations. We use a...
The goal of the lab is to understand mammalian genomes using comparative genomic and ep...our work involves examining billions of DNA base pairs and interpreting how variation impacts basic biology and dis...