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LEGE on Basic command-line to run BLAST (1158 days ago): Understanding the...- BioStar on How to install Perl modules manually, using CPAN command, and other quick ways (1176 days ago): If using conda conda create --name perlENV perlconda activate perlENV conda...
- BioStar on How to install Perl modules manually, using CPAN command, and other quick ways (1176 days ago): Installing in CONDA env You can check using which perl - it...
- BioStar on Calculate the significance of the difference between two trends (1179 days ago): Useful reading material https://statsandr.com/blog/anova-in-r/
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Trust But Verify: Sequencing Your Cell Lines Might Reveal an Uninvited Guest
By LEGE 366 days agoHigh-throughput sequencing has become indispensable in cell biology, enabling detailed insights into chromatin structure, gene expression, and regulatory dynamics. Yet, when faced with unexpectedly low mapping rates to the human genome,...Basics of DESeq2: Differential Expression Made Simple
By LEGE 373 days agoDESeq2 is a powerful and widely-used R package that identifies differentially expressed genes (DEGs) from RNA-seq data. Whether you're comparing treated vs untreated samples, disease vs healthy conditions, or wild-type vs mutant strains, DESeq2...Magic Wormhole: The Easiest Way to Send Files Securely
By LEGE 373 days agoIn a world increasingly dependent on digital data exchange, secure and user-friendly file transfer solutions are more important than ever. Enter Magic Wormhole, a deceptively simple yet powerful tool that makes it trivial to send files and...Unlocking Evolutionary Secrets: A Dive into Comparative Genomics Methods
By LEGE 381 days agoComparative genomics is the art and science of comparing genomes—across species, within species, or even among individuals—to unravel evolutionary relationships, functional elements, and genetic adaptations. As sequencing technologies have advanced...HiBC: Human Intestinal Bacteria Collection
By BioStar 394 days agoThe human gut is home to trillions of microorganisms, forming one of the most complex and dynamic microbial ecosystems known to science. The Human Intestinal Bacteria Collection (HiBC) is a pioneering initiative aimed at cataloging, preserving,...Kallisto vs Salmon: Choosing the Right Tool for RNA-Seq Quantification
By BioStar 399 days agoIn the world of transcriptomics, quantifying gene and transcript expression accurately and efficiently is crucial. With the explosion of RNA-Seq data, researchers have turned to fast, alignment-free tools that streamline the quantification process...When Chromosomes Shift: Understanding Chromosome Rearrangement and Human Disease
By BioStar 420 days agoIn the vast and complex world of genetics, our chromosomes are like carefully arranged bookshelves — each holding critical information that defines who we are. But what happens when those books are shuffled, inverted, or swapped? The answer lies in...Genomic architecture surrounding the fusion site of human chromosome 2
By LEGE 457 days agoThis fusion event is a key evolutionary marker distinguishing humans from other great apes, as humans have 46 chromosomes while chimpanzees, gorillas, and orangutans possess 48. The fusion occurred through an end-to-end joining of two ancestral...Genetic basis of tail-loss evolution
By LEGE 457 days agoThe study suggests that a specific genetic mutation, involving the insertion of an Alu element (a type of transposable DNA sequence), played a critical role in the evolutionary transition from tailed primates to tailless hominoids.NVIDIA and Arc Institute Unveil Evo 2: A Breakthrough AI for DNA Design
By BioStar 468 days agoNVIDIA and the Arc Institute have introduced Evo 2, a groundbreaking AI model designed to understand, predict, and generate DNA sequences. This marks a major advancement in computational biology, offering scientists an unprecedented tool to decode...
