LASTZ is a program for aligning DNA sequences, a pairwise aligner. Originally designed to handle sequences the size of human chromosomes and from different species, it is also useful for sequences produced by NGS sequencing technologies such as Roche 454.
More at http://www.bx.psu.edu/~rsharris/lastz/
Thesis: http://www.bx.psu.edu/~rsharris/rsharris_phd_thesis_2007.pdf
Comments
The latest relase of LastZ at http://www.bx.psu.edu/~rsharris/lastz/newer/
Understanding lastz http://www.bx.psu.edu/~rsharris/rsharris_phd_thesis_2007.pdf