BioStar
Bioinformatician
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STRUM: structure-based prediction of protein stability changes upon single-point mutation
By BioStar 2264 days ago
https://zhanglab.ccmb.med.umich.edu/STRUM/
STRUM is a method for predicting the fold stability change (ΔΔG) of protein molecules upon single-point nsSNP mutations. STRUM adopts a gradient boosting regression approch to train the Gibbs free-energy changes on a variety of features at different levels of sequence and structure properties. The unique characteristics of STRUM is the combination of sequence profiles with low-resolution structure models from protein structure prediction, which helps enhance the robustness and accuracy of the method and make it applicable to various protein seqences, including those without experimental structures
