...tivities started since 2007, and supported by several CNR projects. Main interest of BioinfoLab is to deve...nsional data arising from "Multi-omics" applications. In particular, current activities involve the analys...
...ess. Up to 90% of human DNA is estimated to be transcribed into so called non-coding RNAs that are not translated into proteins. Many of them act a...biological processes, including cell proliferation, differentiation, apoptosis and senescen...
They develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
https://www.pmgenomics.ca/hoffmanlab/
TheLab seek to understand the genetic factors contributing to genomic variation and phenotypic diversity....to study evolutionary processes at the level of populations, both experimental and natural, and genomes....
...iation on molecular phenotypes and human disease. We develop methods for integrating diverse functional ge...ions, regulator binding, and their changes across multiple conditions to interpret genetic associations, i...
...lection. As a result, studies of natural variation can provide important insights into evolutionary and genetic mec...while analyses of population variation allow for inferences about events that are too infrequent to b...
We are generally interested in the mechanisms of species o...al perspective. Particularly, we are interested in the role of sex chr...ch is done on birds and mammals. Currently, we focus our research on t...isolation and understand the role of interspecific competition and son...
...s and duplications through analysis of the read depth-of-coverage; (iii) split read analysis, which detects SVs by evaluating gapped sequence alignments; and (iv) sequence assembly,...
...variation within populations. We use a combination of theory and experiments to study the dynamics and po...ulations such as microbes and viruses.
We use both theory and experiments to study evolutionary dynami...
...ity, known as our microbiota, which plays important roles in our physiology, immu...tabolism and sustenance. Within the human gastrointestinal tract alone there are...ately 10 times more cells than we harbor in our entire body and 200 times more ge...