There was a lot of buzz about Oxford Nanopore Technologies® is developing the GridION™ system and miniaturised MinION™ device. These are a new generation of electronic molecular analysis system for use in scientific research, personalised medicine, crop science, security/defence and more. The platform technology uses nanopores to analyse single molecules including DNA/RNA and proteins. With a broad patent portfolio, the Oxford Nanopore pipeline includes biological nanopores and solid-state nanopores.
Is this available, or still under trial mode?
https://www.nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/the-minion-device-a-miniaturised-sensing-system
There has been little information lately - rumors have indicated that the sequence quality has not been satisfactory yet. However, Oxford Nanopore CTO Clive Brown will give a keynote address at the UK Genome Science meeting 2013 (Sept 2-4), and it's possible that selected collaborators have already trialed the technology. If so, we might see some "real world" data soon.
More NIH grants on Nanopore sequencing technology for 2-4 years to eight organizations. The new target is sequencing under USD 100.
Source:
Recently,the grants -- nearly $17 million to eight research teams -- are the latest awarded through the National Human Genome Research Institute (NHGRI)'s Advanced DNA Sequencing Technology program. The main focus of grants awarded by the National Institutes of Health to the use of nanopore technology aimed at more accurate and efficient DNA sequencing.
"Nanopore technology shows great promise, but it is still a new area of science. We have much to learn about how nanopores can work effectively as a DNA sequencing technology, which is why five of the program's eight grants are exploring this approach," said Jeffery A. Schloss, Ph.D., program director for NHGRI's Advanced DNA Sequencing Technology program and director of the Division of Genome Sciences.
Reference http://www.eurekalert.org/pub_releases/2013-09/nhgr-nna090613.php
The current “alpha” version of the Genia consumable contains 264 sensors. The anticipated beta version will contain 100,000 sensors, and the commercial version, about one million. The device will use a DNA polymerase and a sequencing-by-synthesis approach, as in the current paper, but it will use different chemistries.
http://www.biocompare.com/Editorial-Articles/126329-Next-Gen-Sequencing/
http://www.nature.com/srep/2012/120921/srep00684/full/srep00684.html
Oxford Nanopore in user test mode from late November
http://www.bloomberg.com/news/2013-10-23/oxford-nanopore-to-let-customers-test-handheld-sequencer.html
http://pathogenomics.bham.ac.uk/blog/2013/10/the-oxford-nanopore-golden-ticket/
http://www.fiercebiotechit.com/story/oxford-nanopore-readying-user-tests-handheld-sequencing-device/2013-10-28
Hi Nanopore enthusiast,
For those interested in doing DNA sequencing via your USB port: it is possible to get early access to the Oxford Nanopore MinION system, they now appear to be taking applications. See here for more details:
https://www.nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/the-minion-device-a-miniaturised-sensing-system
https://www.nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/minion-access-programme
https://www.nanoporetech.com/technology/the-minion-device-a-miniaturised-sensing-system/map-application-form
Cheers
Recently data from pocket-sized genome sequencer unveiled. Results from Oxford Nanopore's MinION are promising, but fall short of high expectations http://www.nature.com/news/data-from-pocket-sized-genome-sequencer-unveiled-1.14724
Results from Oxford Nanopore's MinION are promising, but fall short of high expectations. Find more at nature news http://www.nature.com/news/data-from-pocket-sized-genome-sequencer-unveiled-1.14724
Another Nanopore sequencing based startup come into market:
Quantapore Inc.,
Address: 1455 Adams Drive, Suite 1081, Menlo Park, CA 94025, Email: info@quantapore.com
http://www.bizjournals.com/sanfrancisco/blog/biotech/2014/05/quantapore-dna-sequencing-ilmn-pacb-tmo.html?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+industry_6+(Industry+Health+Care)
Nanopore reads from MinION Sequencer (Oxford Nanopore)
http://figshare.com/articles/A_P_aeruginosa_serotype_defining_single_read_from_our_first_Oxford_Nanopore_run/1052996
http://www.nanowerk.com/nanotechnology-news/newsid=36061.php
http://www.nature.com/ncomms/2014/140616/ncomms5171/full/ncomms5171.html
Long reads are here to rule. Thanks to Nick Loman from Birmingham UK, now we can have our first look at long reads from Oxford Nanopore. http://nextgenseek.com/2014/06/behold-oxford-nanopore-reads-are-here/
USB 'critically flawed' after bug discovery, researchers say http://www.bbc.com/news/technology-28701124
Oxford Nanopore announced that it has raised $59 Million (£35 million) from both new and existing investors in the UK, US and mainland Europe. In its last fund raising round in 2013, Oxford Nanopore raised $64 million. These additional funds will allow to accelerate and scale the adoption of our MinION™ devices.
The next generation science standards meet nanopore sequencing http://scienceblogs.com/digitalbio/2014/10/08/the-next-generation-science-standards-meet-nanopore-sequencing/
A blog post by Aaron Krol discuss more about "Nanopore Sequencing Is Here to Stay" http://www.bio-itworld.com/2014/12/22/nanopore-sequencing-here-stay.html
Nanopore DNA sequencing technology can diagnose infection and detect drug-resistance
http://www.laboratorytalk.com/news/usb-stick-could-revolutionise-gene-sequencing/407180.article
Nanopore DNA sequencing technology can diagnose infection and detect drug-resistance
http://www.laboratorytalk.com/news/usb-stick-could-revolutionise-gene-sequencing/407180.article
Some useful links on Nanopore:
Decoding long nanopore sequencing reads of natural DNA:http://www.nature.com/nbt/journal/v32/n8/full/nbt.2950.html
Related links:
- Data from pocket-sized genome sequencer unveiled http://www.nature.com/news/data-from-pocket-sized-genome-sequencer-unveiled-1.14724
Long read nanopore sequencing for detection of HLA and CYP2D6 variants and haplotypes
http://f1000research.com/articles/4-17/v1
